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Article ; Online: Jack J. Kanski (1939-2019)-the prominent educator in ophthalmology.

Turno-Kręcicka, Anna / Zimmer, Katarzyna / Misiuk-Hojło, Marta / Grzybowski, Andrzej

2020 Volume 35, Issue 3, Page(s) 709–713

MeSH term(s)	Humans ; Ophthalmology
Language	English
Publishing date	2020-10-30
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-020-01230-1
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Article: Comparison of young male mice of two different strains (C57BL/6J and the hybrid B6129SF1/J) in selected behavior tests: a small scale study.

Hansen, Kristine Eraker Aasland / Hudecová, Alexandra M / Haugen, Fred / Skjerve, Eystein / Ropstad, Erik / Zimmer, Karin E

Laboratory animal research

2022 Volume 38, Issue 1, Page(s) 30

Abstract: ... the hybrid B6129SF1/J, and gained knowledge on their performance in three different behavioral tests; open ...

Abstract	Background: All mouse strains are different, before choosing a strain for a large study, a small scale study should be done. In this study, we compared young males of two mouse strains, C57BL/6J and the hybrid B6129SF1/J, and gained knowledge on their performance in three different behavioral tests; open field (OF) test, Barnes maze (BM) test and a restraint stress test. Results: We found that the young males of the C57BL/6J strain spent more time moving in the OF. In the BM, the hybrid covered less ground before reaching the goal box during the first three sessions, than the C57BL/6J. The hybrid left more fecal pellets than C57BL/6J both in OF and BM. During the stress test, the C57BL/6J had a lower corticosterone response than the hybrid. Conclusions: Our findings indicate that the C57BL/6J has a presumably higher locomotor activity and/or explorative behavior than the hybrid, while the hybrid appeared more sensitive to stress.
Language	English
Publishing date	2022-10-02
Publishing country	England
Document type	Journal Article
ZDB-ID	2623220-0
ISSN	2233-7660 ; 1738-6055
ISSN (online)	2233-7660
ISSN	1738-6055
DOI	10.1186/s42826-022-00140-5
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Article ; Online: Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice.

Johanson, Silje M / Swann, Jonathan R / Umu, Özgün C O / Aleksandersen, Mona / Müller, Mette H B / Berntsen, Hanne F / Zimmer, Karin E / Østby, Gunn C / Paulsen, Jan E / Ropstad, Erik

Chemosphere

2020 Volume 252, Page(s) 126484

Abstract: ... on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly ...

Abstract	An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to POPs on colorectal cancer and gut microbiota. This study characterized the influence of exposure to a human relevant mixture of POPs during gestation and lactation on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly, the maternal POP exposure decreased colonic tumor burden, as shown by light microscopy and histopathological evaluation, indicating a restriction of colorectal carcinogenesis.
MeSH term(s)	Animals ; Carcinogenesis ; Carcinogens/metabolism ; Carcinogens/toxicity ; Colonic Neoplasms ; Colorectal Neoplasms/chemically induced ; Environmental Pollutants/metabolism ; Environmental Pollutants/toxicity ; Female ; Gastrointestinal Microbiome/genetics ; Humans ; Lactation ; Maternal Exposure/statistics & numerical data ; Metabolomics ; Mice ; Mice, Inbred Strains ; Microbiota ; RNA, Ribosomal, 16S
Chemical Substances	Carcinogens ; Environmental Pollutants ; RNA, Ribosomal, 16S
Language	English
Publishing date	2020-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2020.126484
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Article ; Online: A mixture of Persistent Organic Pollutants (POPs) and Azoxymethane (AOM) show potential synergistic effects on intestinal tumorigenesis in the A/J Min/+ mouse model.

Hansen, K E Aa / Johanson, S M / Steppeler, C / Sødring, M / Østby, G C / Berntsen, H F / Zimmer, K E / Aleksandersen, M / Paulsen, J E / Ropstad, E

Chemosphere

2018 Volume 214, Page(s) 534–542

Abstract: ... whether a mixture of POPs could affect intestinal tumorigenesis in the A/J Min/+ mouse, a model for human ... intestinal tumorigenesis in the A/J Min/+ mouse model. ...

Abstract	A multitude of cancer types, including breast, testicular, liver and colorectal cancer, have associations with exposure to Persistent Organic Pollutants (POPs). The present study aimed to investigate whether a mixture of POPs could affect intestinal tumorigenesis in the A/J Min/+ mouse, a model for human colorectal cancer (CRC). Pollutants were selected for their presence in Scandinavian food products and the mixture was designed based on defined human estimated daily intake levels. Mice were exposed through the diet, at control, low and high mixture concentrations, for 10 weeks. In a separate experiment, mice also received one subcutaneous injection of Azoxymethane (AOM) to explore whether this carcinogenic compound influenced the effect of the POPs. Intestinal tumorigenesis was examined by surface microscopy and histopathology. Moderate and dose-dependent increases in tumorigenesis were observed after dietary POP exposure. The AOM treatment alone stimulated the growth of colonic lesions, but did not increase the formation of new lesions. Combined AOM treatment and POP exposure demonstrated a synergistic effect on lesion formation in the colon, and to a lesser extent in the small intestine. This synergy was also evident by an increased number of malignant colonic tumors (carcinomas). In conclusion, the study shows that a mixture of POPs interacted synergistically with a known carcinogen (AOM), causing increased intestinal tumorigenesis in the A/J Min/+ mouse model.
MeSH term(s)	Animals ; Azoxymethane/toxicity ; Carcinogenesis/chemically induced ; Carcinogenesis/pathology ; Carcinogens/toxicity ; Colonic Neoplasms/chemically induced ; Colonic Neoplasms/pathology ; Diet/adverse effects ; Disease Models, Animal ; Drug Synergism ; Environmental Pollutants/toxicity ; Female ; Intestines/drug effects ; Intestines/pathology ; Liver/drug effects ; Liver/pathology ; Male ; Mice ; Mice, Inbred A ; Organic Chemicals/chemistry
Chemical Substances	Carcinogens ; Environmental Pollutants ; Organic Chemicals ; Azoxymethane (MO0N1J0SEN)
Language	English
Publishing date	2018-09-24
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2018.09.126
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Article ; Online: Corrigendum to "Staging of oropharyngeal squamous cell carcinoma of the head and neck: Prognostic features and power of the 8th edition of the UICC staging manual" [Eur. J. Surg. Oncol. 45 (6) (2019) 1046-1053].

Beltz, Anna / Gösswein, Dorothée / Zimmer, Stefanie / Limburg, Ivonne / Wünsch, Desirée / Gribko, Alena / Deichelbohrer, Maximilian / Hagemann, Jan / Stauber, Roland H / Künzel, Julian

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2019 Volume 45, Issue 9, Page(s) 1755–1756

Language	English
Publishing date	2019-07-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2019.07.006
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Article: A mixture of Persistent Organic Pollutants (POPs) and Azoxymethane (AOM) show potential synergistic effects on intestinal tumorigenesis in the A/J Min/+ mouse model

Hansen, K.E.Aa / S.M. Johanson / C. Steppeler / M. Sødring / G.C. Østby / H.F. Berntsen / K.E. Zimmer / M. Aleksandersen / J.E. Paulsen / E. Ropstad

Chemosphere. 2019 Jan., v. 214

2019

Abstract: ... whether a mixture of POPs could affect intestinal tumorigenesis in the A/J Min/+ mouse, a model for human ... intestinal tumorigenesis in the A/J Min/+ mouse model. ...

Abstract	A multitude of cancer types, including breast, testicular, liver and colorectal cancer, have associations with exposure to Persistent Organic Pollutants (POPs). The present study aimed to investigate whether a mixture of POPs could affect intestinal tumorigenesis in the A/J Min/+ mouse, a model for human colorectal cancer (CRC). Pollutants were selected for their presence in Scandinavian food products and the mixture was designed based on defined human estimated daily intake levels. Mice were exposed through the diet, at control, low and high mixture concentrations, for 10 weeks. In a separate experiment, mice also received one subcutaneous injection of Azoxymethane (AOM) to explore whether this carcinogenic compound influenced the effect of the POPs. Intestinal tumorigenesis was examined by surface microscopy and histopathology. Moderate and dose-dependent increases in tumorigenesis were observed after dietary POP exposure. The AOM treatment alone stimulated the growth of colonic lesions, but did not increase the formation of new lesions. Combined AOM treatment and POP exposure demonstrated a synergistic effect on lesion formation in the colon, and to a lesser extent in the small intestine. This synergy was also evident by an increased number of malignant colonic tumors (carcinomas). In conclusion, the study shows that a mixture of POPs interacted synergistically with a known carcinogen (AOM), causing increased intestinal tumorigenesis in the A/J Min/+ mouse model.
Keywords	animal models ; azoxymethane ; breasts ; carcinogenesis ; carcinogens ; carcinoma ; colon ; colorectal neoplasms ; diet ; dose response ; foods ; histopathology ; humans ; liver ; mice ; microscopy ; persistent organic pollutants ; small intestine ; subcutaneous injection ; synergism ; testes
Language	English
Dates of publication	2019-01
Size	p. 534-542.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2018.09.126
Database	NAL-Catalogue (AGRICOLA)

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Article: Maternal exposure to a human relevant mixture of persistent organic pollutants reduces colorectal carcinogenesis in A/J Min/+ mice

Johanson, Silje M / Swann, Jonathan R / Umu, Özgün C.O / Aleksandersen, Mona / Müller, Mette H.B / Berntsen, Hanne F / Zimmer, Karin E / Østby, Gunn C / Paulsen, Jan E / Ropstad, Erik

Chemosphere. 2020 Mar. 12,

2020

Abstract: ... on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly ...

Abstract	An increased risk of developing colorectal cancer has been associated with exposure to persistent organic pollutants (POPs) and alteration in the gut bacterial community. However, there is limited understanding about the impact of maternal exposure to POPs on colorectal cancer and gut microbiota. This study characterized the influence of exposure to a human relevant mixture of POPs during gestation and lactation on colorectal cancer, intestinal metabolite composition and microbiota in the A/J Min/+ mouse model. Surprisingly, the maternal POP exposure decreased colonic tumor burden, as shown by light microscopy and histopathological evaluation, indicating a restriction of colorectal carcinogenesis. 1H nuclear magnetic resonance spectroscopy-based metabolomic analysis identified alterations in the metabolism of amino acids, lipids, glycerophospholipids and energy in intestinal tissue. In addition, 16S rRNA sequencing of gut microbiota indicated that maternal exposure modified fecal bacterial composition. In conclusion, the results showed that early-life exposure to a mixture of POPs reduced colorectal cancer initiation and promotion, possibly through modulation of the microbial and biochemical environment. Further studies should focus on the development of colorectal cancer after combined maternal and dietary exposures to environmentally relevant low-dose POP mixtures.
Keywords	amino acids ; animal models ; bacterial communities ; carcinogenesis ; colorectal neoplasms ; energy ; histopathology ; humans ; intestinal microorganisms ; intestines ; lactation ; light microscopy ; lipids ; maternal exposure ; metabolism ; metabolites ; metabolomics ; mice ; nuclear magnetic resonance spectroscopy ; persistent organic pollutants ; pregnancy ; ribosomal RNA ; sequence analysis
Language	English
Dates of publication	2020-0312
Publishing place	Elsevier Ltd
Document type	Article
Note	Pre-press version
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2020.126484
Database	NAL-Catalogue (AGRICOLA)

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Article: Unusual Causes of Lead Poisoning, with Report of a Case.

Zimmer, John

Buffalo medical journal

2023 Volume 42, Issue 6, Page(s) 393–397

Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	426473-3
ISSN	1040-3817
ISSN	1040-3817
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Book ; Thesis: Die Rolle von C-Type Lectin Domain Family 4 Member E bei der Entstehung der Aortenklappenstenose

Nordsiek, Julia / Zimmer, Sebastian

2021

Institution	Rheinische Friedrich-Wilhelms-Universität Bonn
Author's details	Julia Nordsiek ; 1. Gutachter: Prof. Dr. med. Sebastian Zimmer
Language	German
Size	107 Seiten, Diagramme
Publishing place	Bonn
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
HBZ-ID	HT021087856
Database	Catalogue ZB MED Medicine, Health

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Shelf mark	Loan status	Location
2022 D 344	order for loan	Magazin

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Book ; Online ; E-Book: Funktionelle Anatomie

Zimmer, Philipp / Appell, Hans-Joachim

Grundlagen sportlicher Leistung und Bewegung

2021

Abstract: Intro -- Vorwort zur 1. Auflage -- Vorwort zur 5. Auflage -- Inhaltsverzeichnis -- Über die Autoren -- 1: Einführung -- 1.1 Zur Einordnung der Funktionellen Anatomie -- 1.2 Die anatomische Nomenklatur -- 1.3 Übersicht über den Bauplan des Körpers -- 2: ... ...

Author's details	Philipp Zimmer, Hans-Joachim Appell
Abstract	Intro -- Vorwort zur 1. Auflage -- Vorwort zur 5. Auflage -- Inhaltsverzeichnis -- Über die Autoren -- 1: Einführung -- 1.1 Zur Einordnung der Funktionellen Anatomie -- 1.2 Die anatomische Nomenklatur -- 1.3 Übersicht über den Bauplan des Körpers -- 2: Allgemeine Anatomie des Bewegungsapparates -- 2.1 Skelettmuskulatur -- 2.1.1 Muskelkontraktion -- 2.1.2 Muskelfasern -- 2.1.3 Bau des Muskels -- 2.1.4 Funktion des Muskels -- 2.1.5 Wachstum und Trainingsanpassung -- 2.2 Binde- und Stützgewebe -- 2.2.1 Grundkomponenten -- 2.2.2 Sehnen und Faszien -- 2.2.3 Knochengewebe -- 2.2.4 Knorpelgewebe -- 2.3 Bau der Gelenke -- 2.3.1 Achsen und Ebenen -- 2.3.2 Formen echter Gelenke -- 3: Funktionelle Anatomie des Bewegungsapparates -- 3.1 Rumpf -- 3.1.1 Wirbelsäule -- 3.1.2 Beckengürtel -- 3.1.3 Brustkorb -- 3.1.4 Muskeln des Rumpfes -- 3.2 Obere Extremität -- 3.2.1 Schultergürtel und Schultergelenk -- 3.2.2 Muskeln des Schultergürtels -- 3.2.3 Die „tragende Rolle" des Schultergürtels -- 3.2.4 Ellenbogengelenk -- 3.2.5 Muskeln des Armes -- 3.2.6 Gelenke der Hand -- 3.2.7 Muskeln des Unterarmes und der Hand -- 3.2.8 Die obere Extremität als komplexes Bewegungssystem -- 3.3 Untere Extremität -- 3.3.1 Hüftgelenk -- 3.3.2 Hüftmuskeln -- 3.3.3 Statik des Oberschenkels -- 3.3.4 Kniegelenk -- 3.3.5 Oberschenkelmuskeln -- 3.3.6 Unterschenkel und Fuß -- 3.3.7 Unterschenkel- und Fußmuskeln -- 3.3.8 Fußgewölbe -- 3.3.9 Der Fuß in Bewegung -- 4: Bewegungskontrolle und -steuerung durch das Zentralnervensystem -- 4.1 Grundlagen -- 4.1.1 Neuron und Synapse -- 4.1.2 Afferenz und Efferenz -- 4.1.3 Funktioneller Bau von Gehirn und Rückenmark -- 4.2 Spinale Steuerung -- 4.2.1 Muskelspindeln -- 4.2.2 Sehnenspindeln -- 4.2.3 Spinale Fremdreflexe -- 4.3 Supraspinale Steuerung -- 4.3.1 Vestibularorgan -- 4.3.2 Motorische Zentren.
Keywords	Electronic books
Language	German
Size	1 Online-Ressource (xi, 182 Seiten), Illustrationen
Edition	5., vollständig überarbeitete Auflage
Publisher	Springer
Publishing place	Berlin
Publishing country	Germany
Document type	Book ; Online ; E-Book
Note	Description based on publisher supplied metadata and other sources
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT021052497
ISBN	978-3-662-61482-2 ; 9783662614815 ; 3-662-61482-0 ; 3662614812
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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