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  1. Book ; Thesis: Auswirkungen des JAK1/2 Inhibitors Ruxolitinib auf den Gewichtsverlauf bei Patienten mit primärer und sekundärer Myelofibrose

    Vonnahme, Maria / Heine, Annkristin

    2023  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Maria Vonnahme ; 1. Gutachterin: Prof. Dr. med. Annkristin Heine
    Language German
    Size 78 Seiten, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2023
    HBZ-ID HT021743095
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2023 D 331 order for loan Magazin

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  2. Book ; Thesis: Einfluss der Inhibition des Signaling Lymphocyte Activation Molecule (SLAMF7/CS1/CRACC) durch Elotuzumab auf humane dendritische Zellen

    Strauß, Leon Dominik / Heine, Annkristin

    2021  

    Institution Rheinische Friedrich-Wilhelms-Universität Bonn
    Author's details Leon Dominik Strauß ; 1. Gutachterin: Prof. Dr. Annkristin Heine
    Language German
    Size 121 Seiten, Illustrationen, Diagramme
    Publishing place Bonn
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Rheinische Friedrich-Wilhelms-Universität Bonn, 2021
    HBZ-ID HT021122131
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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  3. Book ; Online ; Thesis: Dynamische Regulation von Differenzierungsmarkern in murinen Melanom-Zelllinien

    Matthaei, Maria [Verfasser] / Landsberg, Jennifer [Akademischer Betreuer] / Heine, Annkristin [Gutachter]

    2023  

    Author's details Eva-Maria Charlotte Matthaei ; Gutachter: Annkristin Heine ; Betreuer: Jennifer Landsberg
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  4. Article ; Online: Intramedullary leukocytoclastic vasculitis and neutrophil extracellular trap (NET) formation in POEMS syndrome.

    Aderhold, Wiebke / Lenz, Benjamin / Hübner, Marc P / Schaefer, Hans-Eckart / Gaertner, Florian C / Heine, Annkristin / Gütgemann, Ines

    Annals of hematology

    2024  Volume 103, Issue 4, Page(s) 1415–1417

    MeSH term(s) Humans ; Extracellular Traps ; POEMS Syndrome ; Vasculitis, Leukocytoclastic, Cutaneous ; Neutrophils
    Language English
    Publishing date 2024-03-04
    Publishing country Germany
    Document type Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-024-05651-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.181: Show issues Location:
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  5. Article ; Online: ROCKing Chronic Graft-Versus-Host Disease.

    Heine, Annkristin / Holderried, Tobias A W / Wolf, Dominik

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 29, Page(s) 3308

    MeSH term(s) Chronic Disease ; Graft vs Host Disease/etiology ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.21.01081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 650: Show issues

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  6. Article ; Online: Vemurafenib as bridging therapy of hairy cell leukemia in a Jehovah's Witness patient.

    Schlaweck, Sebastian / Brossart, Peter / Heine, Annkristin

    Annals of hematology

    2021  Volume 101, Issue 1, Page(s) 217–218

    MeSH term(s) Adult ; Antineoplastic Agents/therapeutic use ; Female ; Humans ; Jehovah's Witnesses ; Leukemia, Hairy Cell/drug therapy ; Precision Medicine ; Vemurafenib/therapeutic use
    Chemical Substances Antineoplastic Agents ; Vemurafenib (207SMY3FQT)
    Language English
    Publishing date 2021-01-12
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 1064950-5
    ISSN 1432-0584 ; 0939-5555 ; 0945-8077
    ISSN (online) 1432-0584
    ISSN 0939-5555 ; 0945-8077
    DOI 10.1007/s00277-021-04403-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Two cases of EBV infection preceding lymphoma.

    Saal, Jonas / Aboudan, Busher / Brossart, Peter / Heine, Annkristin

    Journal of cancer research and clinical oncology

    2022  Volume 148, Issue 10, Page(s) 2929–2932

    Abstract: Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for developing lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in diffuse large B-cell lymphoma (DLBCL) to 100% ...

    Abstract Infection of lymphocytes with the Epstein-Barr virus (EBV) is a well-documented risk factor for developing lymphoma. The incidence of EBV positivity in lymphoma depends on the subtype and can range from 10% in diffuse large B-cell lymphoma (DLBCL) to 100% in endemic Burkitt lymphoma (BL), (Shannon-Lowe and Rickinson, Front Oncol 9:713, 2019). However, in most cases, EBV infection remains unnoticed until diagnosis of lymphoma is made. EBV seropositivity is present in > 90% of the world's population. Although mostly asymptomatic, in some cases, EBV can cause clinical symptoms, the most common of which are fever, lymphadenopathy and pharyngitis in infectious mononucleosis. Less common presentations include lymphomatoid granulomatosis and mucocutaneous ulcer. Here we report two cases of patients, who were initially diagnosed with localized EBV infection and reactive B-cell proliferation. After B-cell-directed treatment, both patients developed overt lymphoma, in one case classical Hodgkin's lymphoma (cHL) and in the other case angioimmunoblastic T-cell lymphoma (AITL).
    MeSH term(s) Epstein-Barr Virus Infections/complications ; Herpesvirus 4, Human ; Hodgkin Disease ; Humans ; Incidence ; Lymphoma, Large B-Cell, Diffuse/diagnosis ; Lymphoma, Large B-Cell, Diffuse/pathology
    Language English
    Publishing date 2022-06-22
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-022-04145-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination.

    Heine, Annkristin / Lemmermann, Niels A W / Flores, Chrystel / Becker-Gotot, Janine / Garbi, Natalio / Brossart, Peter / Kurts, Christian

    Frontiers in immunology

    2024  Volume 15, Page(s) 1338499

    Abstract: Introduction: Prophylactic vaccines generate strong and durable immunity to avoid future infections, whereas post-exposure vaccinations are intended to establish rapid protection against already ongoing infections. Antiviral cytotoxic CD8: Hypothesis!# ...

    Abstract Introduction: Prophylactic vaccines generate strong and durable immunity to avoid future infections, whereas post-exposure vaccinations are intended to establish rapid protection against already ongoing infections. Antiviral cytotoxic CD8
    Hypothesis: Here we asked whether a vaccination protocol that combines two adjuvants, a toll-like receptor ligand (TLR) and a natural killer T cell activator, to induce two signal 0 chemokines, synergistically accelerates CTL activation.
    Methods: We used a well-characterized vaccination model based on the model antigen ovalbumin, the TLR9 ligand CpG and the NKT cell ligand
    Results: We found that CTL induced by both adjuvants obtained a head-start that allowed them to functionally differentiate further and generate higher numbers of protective CTL 1-2 days earlier. Such signal 0-optimized post-exposure vaccination hastened clearance of experimental adenovirus and cytomegalovirus infections.
    Conclusion: Our findings show that signal 0 chemokine-inducing adjuvant combinations gain time in the race against rapidly replicating microbes, which may be especially useful in post-exposure vaccination settings during viral epi/pandemics.
    MeSH term(s) Mice ; Animals ; CD8-Positive T-Lymphocytes ; Ligands ; Chemokines ; Adjuvants, Immunologic/pharmacology ; Vaccination/methods ; Virus Diseases
    Chemical Substances Ligands ; Chemokines ; Adjuvants, Immunologic
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1338499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Severe autoimmune hemolytic anemia following immunotherapy with checkpoint inhibitors in two patients with metastatic melanoma: a case report.

    Fetter, Tanja / Fietz, Simon / Bertlich, Maya / Braegelmann, Christine / de Vos-Hillebrand, Luka / Wenzel, Joerg / Heine, Annkristin / Landsberg, Jennifer / Jansen, Philipp

    Frontiers in immunology

    2024  Volume 15, Page(s) 1342845

    Abstract: Introduction: Over the past decade, immune checkpoint inhibitors such as antibodies against cytotoxicity T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become an important armamentarium against a broad ... ...

    Abstract Introduction: Over the past decade, immune checkpoint inhibitors such as antibodies against cytotoxicity T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death protein 1 (PD-1) have become an important armamentarium against a broad spectrum of malignancies. However, these specific inhibitors can cause adverse autoimmune reactions by impairing self-tolerance. Hematologic side effects of immune checkpoint inhibitors, including autoimmune hemolytic anemia (AIHA), are rare but can be life-threatening.
    Case report: Herein, we report two patients on immune checkpoint inhibitors for metastatic melanoma who developed AIHA with symptoms of dyspnea and fatigue. In the first patient, symptoms alleviated after discontinuation of combined anti CTLA-4 and anti-PD-1 therapy, initiation of corticosteroids and application of a single red blood cell transfusion. Due to subsequent progress of melanoma, combinational anti-PD-1 and tyrosine kinase inhibitor therapy was initiated based on multidisciplinary tumor board decision. After two months, she again developed the described hematological and clinical signs of AIHA leading to cessation of anti-PD-1 therapy and initiation of corticosteroids, which again resulted in an alleviation of her symptoms. Due to further progression, the patient received dacarbazine for several months before she decided to stop any therapy other than palliative supportive care. In the second patient, discontinuation of anti-PD-1 therapy and initiation of corticosteroids entailed a complete alleviation of his symptoms. After refusing chemotherapy due to subsequent melanoma progression, he received radiotherapy of bone metastases and is currently enrolled in a clinical trial. The patient did not develop AIHA ever since.
    Conclusion: Hematologic immune-related adverse events due to treatment with immune checkpoint inhibitors are rare but can have life-threatening consequences. If dyspnea and other clinical symptoms are present, AIHA should be considered as a potential cause and treated promptly in a multidisciplinary setting. An expanded comprehension of risk factors and pathogenesis of AIHA is needed to identify high-risk patients beforehand, leading to more effective predictive and reactive treatment approaches.
    MeSH term(s) Humans ; Male ; Female ; Melanoma/drug therapy ; Melanoma/etiology ; Anemia, Hemolytic, Autoimmune/chemically induced ; Anemia, Hemolytic, Autoimmune/therapy ; Immune Checkpoint Inhibitors/adverse effects ; Immunotherapy/adverse effects ; Immunotherapy/methods ; Neoplasms, Second Primary/etiology ; Dyspnea/etiology ; Adrenal Cortex Hormones/therapeutic use
    Chemical Substances Immune Checkpoint Inhibitors ; Adrenal Cortex Hormones
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Case Reports ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2024.1342845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Elotuzumab spares dendritic cell integrity and functionality.

    Schlaweck, Sebastian / Strauss, Leon / Daecke, Solveig / Brossart, Peter / Heine, Annkristin

    Journal of cancer research and clinical oncology

    2021  Volume 147, Issue 7, Page(s) 2167–2170

    MeSH term(s) Antibodies, Monoclonal, Humanized/pharmacology ; Antineoplastic Agents, Immunological/pharmacology ; Biomarkers ; Dendritic Cells/drug effects ; Dendritic Cells/physiology ; Humans ; Immunophenotyping
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Immunological ; Biomarkers ; elotuzumab (1351PE5UGS)
    Language English
    Publishing date 2021-03-02
    Publishing country Germany
    Document type Letter
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-021-03572-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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