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Article ; Online: Semi-circular Depression on the Leg Diagnosed by High-frequency Ultrasound: A Quiz.

Taleb, Eyal / Goldberg, Ilan / Sprecher, Eli / Geller, Shamir

2021 Volume 101, Issue 8, Page(s) adv00524

Language	English
Publishing date	2021-08-24
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/00015555-3889
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Ui VI Zs.101: Show issues

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Article ; Online: Superimposed type 2 segmental atopic dermatitis: case series and review of the literature.

Bar-Ilan, Efrat / Mashiah, Jacob / Alkalay, Ronen / Ingber, Arieh / Zahavi, Keren Or / Bar, Jonathan / Zeeli, Tal / Gat, Andrea / Samuelov, Liat / Sprecher, Eli / Goldberg, Ilan

Clinical and experimental dermatology

2022 Volume 47, Issue 9, Page(s) 1703–1706

Abstract: Generalized acquired dermatoses can seldom manifest more prominently or exclusively along the lines of Blaschko. Six individuals with segmental atopic dermatitis (AD) have been reported to date. We present three additional cases of segmental cutaneous ... ...

Abstract	Generalized acquired dermatoses can seldom manifest more prominently or exclusively along the lines of Blaschko. Six individuals with segmental atopic dermatitis (AD) have been reported to date. We present three additional cases of segmental cutaneous manifestations superimposed on generalized AD, and review the relevant literature.
MeSH term(s)	Dermatitis, Atopic/complications ; Dermatitis, Atopic/diagnosis ; Humans
Language	English
Publishing date	2022-05-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	195504-4
ISSN	1365-2230 ; 0307-6938
ISSN (online)	1365-2230
ISSN	0307-6938
DOI	10.1111/ced.15196
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Zs.A 1278: Show issues

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Article ; Online: Patch testing versus interferon-gamma release assay in evaluation of drug eruptions.

Kaplan, Yehonatan / Goldberg, Ilan / Sprecher, Eli / Slodownik, Dan

Fundamental & clinical pharmacology

2021 Volume 36, Issue 2, Page(s) 414–420

Abstract: Delayed-onset T-cell-mediated cutaneous adverse drug reactions are an uncommon but potentially serious result of medication exposures. Identification of culprit medications is crucial, but clinical diagnosis is often difficult. Patch tests and interferon- ...

Abstract	Delayed-onset T-cell-mediated cutaneous adverse drug reactions are an uncommon but potentially serious result of medication exposures. Identification of culprit medications is crucial, but clinical diagnosis is often difficult. Patch tests and interferon-gamma release assays (IFNγ-RA) were previously reported as potentially useful ancillary tests, while rechallenges remain the reference standard test. We compared the number of positive test results with patch testing and IFNγ-RA for drugs implicated as possible causes of cutaneous reactions. Fifty-one patients with a suspected cutaneous drug eruption underwent patch testing and IFNγ-RA for suspected drugs. Participants were followed up at least 9 months after the onset of the rash with results compared with the clinical diagnosis. Forty-two patients presented with morbilliform/eczematous eruptions; five were diagnosed with fixed drug eruption (FDE) and four with erythema multiforme. None had positive patch testing to the drugs tested. A total of 8/51 (15.6%) patients had positive reaction by the IFNγ-RA, and an additional 11 (21.6%) patients had borderline results. Positive or borderline results were more likely in patients with FDE (80%) than morbilliform/eczematous eruptions (30.9%) or erythema multiforme (25%). Our study emphasizes the necessity of additional effective ancillary tests in the evaluation of drug eruptions and supports the use of IFNγ-RA for drug testing as a tool for identifying medications associated with cutaneous drug eruptions.
MeSH term(s)	Drug Eruptions/diagnosis ; Drug Eruptions/etiology ; Erythema Multiforme/complications ; Erythema Multiforme/diagnosis ; Humans ; Interferon-gamma Release Tests ; Patch Tests/methods ; Skin
Language	English
Publishing date	2021-10-26
Publishing country	England
Document type	Journal Article
ZDB-ID	639134-5
ISSN	1472-8206 ; 0767-3981
ISSN (online)	1472-8206
ISSN	0767-3981
DOI	10.1111/fcp.12733
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Zs.A 2247: Show issues

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Article ; Online: A Longitudinal Assessment of the Natural Change in Haemoglobin, Haematocrit, and Mean Corpuscular Volume with Age.

Goldberg, Idan / Cohen, Eytan / Gafter-Gvili, Anat / Shochat, Tzippy / Kugler, Eitan / Margalit, Ili / Goldberg, Elad / Raanani, Pia / Krause, Ilan

Acta haematologica

2023 Volume 146, Issue 3, Page(s) 206–213

Abstract: Introduction: We aimed to assess the natural annual trends in the levels of haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults, together with the influence of different clinical parameters on these trends.: Methods: ...

Abstract	Introduction: We aimed to assess the natural annual trends in the levels of haemoglobin, haematocrit, and mean corpuscular volume (MCV) in a population of adults, together with the influence of different clinical parameters on these trends. Methods: A retrospective analysis was carried out on data from a large cohort of subjects attending a screening centre in Israel. For each subject, the yearly average change of haemoglobin, haematocrit, and MCV was calculated. Statistical analysis was performed for the whole cohort and for different subgroups. Results: The study included 3,551 subjects. The average annual rates of decline were found to be -0.0550 g/dL (95% confidence interval [CI] -0.0590 g/dL to -0.0503 g/dL) and -0.097% (95% CI -0.112% to -0.083%) for haemoglobin and haematocrit, respectively. An average annual increase in the MCV level by 0.184 fL (95% CI 0.168 fL-0.200 fL) was found. Among men, the rate of decline in haemoglobin was found to be twice as high compared with women -0.06 g/dL versus -0.03 g/dL, respectively (p = 0.0063). In a multivariate analysis, gender remained the only parameter significantly associated with the annual decline of haemoglobin (p = 0.0001). Conclusion: An annual average decrease in the levels of haemoglobin and haematocrit together with an annual increase in MCV was found. These changes were more prominent in men.
MeSH term(s)	Male ; Adult ; Female ; Humans ; Erythrocyte Indices ; Hematocrit ; Retrospective Studies ; Hemoglobins/analysis ; Israel
Chemical Substances	Hemoglobins
Language	English
Publishing date	2023-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	80008-9
ISSN	1421-9662 ; 0001-5792
ISSN (online)	1421-9662
ISSN	0001-5792
DOI	10.1159/000529356
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Article ; Online: Proton pump inhibitor use and its effect on vitamin B12 and homocysteine levels among men and women: A large cross-sectional study.

Lerman, Tsahi T / Cohen, Eytan / Sochat, Tzippy / Goldberg, Elad / Goldberg, Idan / Krause, Ilan

The American journal of the medical sciences

2022 Volume 364, Issue 6, Page(s) 746–751

Abstract: Background: Previous studies have demonstrated an association between proton pump inhibitors (PPI) use and vitamin B12 deficiency. However, data regarding PPI use and elevated serum homocysteine level, an important marker of vitamin B12 deficiency, are ... ...

Abstract	Background: Previous studies have demonstrated an association between proton pump inhibitors (PPI) use and vitamin B12 deficiency. However, data regarding PPI use and elevated serum homocysteine level, an important marker of vitamin B12 deficiency, are scant. Methods: Data were collected from medical records of subjects examined at a screening center in Israel. Cross sectional analysis was conducted on 25,953 subjects. Levels of vitamin B12 and homocysteine were compared between subjects who consumed PPI medications and those who did not. Results: The mean age of the study population was 45 years and 33% were females. Subjects who received PPI medications had a minor higher vitamin B12 levels (320 pmol/L vs 300 pmol/L, p=0.024). Levels of vitamin B12 remained higher in females receiving PPI medications after performing a stratified analysis according to subjects' gender. Homocysteine levels were higher in subjects receiving PPI medications as compared to those who did not (12.0 μmol/L vs 11.6 0 μmol/L, p<0.001). Levels remained higher in female subjects after performing a stratified analysis according to subjects' sex. There was no statistically significant difference in the prevalence of vitamin B12 deficiency (according to two cutoffs: vitamin B12≤200 or ≤140 pmol/L) as well as the prevalence of hyperhomocysteinemia (defined as homocysteine >15.0 μmol/L) between the two groups. Conclusions: According to our study, no association was found between PPI medication use and vitamin B12 deficiency or hyperhomocysteinemia. Patients receiving PPI medications had slightly higher levels of vitamin B12 and homocysteine, however these differences were too small to have any clinical relevance.
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Vitamin B 12 ; Cross-Sectional Studies ; Hyperhomocysteinemia/chemically induced ; Hyperhomocysteinemia/epidemiology ; Proton Pump Inhibitors/adverse effects ; Vitamin B 12 Deficiency/chemically induced ; Vitamin B 12 Deficiency/epidemiology ; Homocysteine ; Folic Acid
Chemical Substances	Vitamin B 12 (P6YC3EG204) ; Proton Pump Inhibitors ; Homocysteine (0LVT1QZ0BA) ; Folic Acid (935E97BOY8)
Language	English
Publishing date	2022-07-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1016/j.amjms.2022.07.006
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Ua VI Zs.2/10: Show issues

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Article ; Online: Nuclear localization of heparanase 2 (Hpa2) attenuates breast carcinoma growth and metastasis.

Hilwi, Maram / Shulman, Katherina / Naroditsky, Inna / Feld, Sari / Gross-Cohen, Miriam / Boyango, Ilanit / Soboh, Soaad / Vornicova, Olga / Farhoud, Malik / Singh, Preeti / Bar-Sela, Gil / Goldberg, Hadassah / Götte, Martin / Sharrocks, Andrew D / Li, Yaoyong / Sanderson, Ralph D / Ilan, Neta / Vlodavsky, Israel

Cell death & disease

2024 Volume 15, Issue 3, Page(s) 232

Abstract: Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we found that ... ...

Abstract	Unlike the intense research effort devoted to exploring the significance of heparanase in cancer, very little attention was given to Hpa2, a close homolog of heparanase. Here, we explored the role of Hpa2 in breast cancer. Unexpectedly, we found that patients endowed with high levels of Hpa2 exhibited a higher incidence of tumor metastasis and survived less than patients with low levels of Hpa2. Immunohistochemical examination revealed that in normal breast tissue, Hpa2 localizes primarily in the cell nucleus. In striking contrast, in breast carcinoma, Hpa2 expression is not only decreased but also loses its nuclear localization and appears diffuse in the cell cytoplasm. Importantly, breast cancer patients in which nuclear localization of Hpa2 is retained exhibited reduced lymph-node metastasis, suggesting that nuclear localization of Hpa2 plays a protective role in breast cancer progression. To examine this possibility, we engineered a gene construct that directs Hpa2 to the cell nucleus (Hpa2-Nuc). Notably, overexpression of Hpa2 in breast carcinoma cells resulted in bigger tumors, whereas targeting Hpa2 to the cell nucleus attenuated tumor growth and tumor metastasis. RNAseq analysis was performed to reveal differentially expressed genes (DEG) in Hpa2-Nuc tumors vs. control. The analysis revealed, among others, decreased expression of genes associated with the hallmark of Kras, beta-catenin, and TNF-alpha (via NFkB) signaling. Our results imply that nuclear localization of Hpa2 prominently regulates gene transcription, resulting in attenuation of breast tumorigenesis. Thus, nuclear Hpa2 may be used as a predictive parameter in personalized medicine for breast cancer patients.
MeSH term(s)	Humans ; Female ; Glucuronidase/genetics ; Glucuronidase/metabolism ; Breast Neoplasms/genetics ; Signal Transduction ; Cell Nucleus/metabolism
Chemical Substances	heparanase (EC 3.2.1.-) ; Glucuronidase (EC 3.2.1.31)
Language	English
Publishing date	2024-03-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2541626-1
ISSN	2041-4889 ; 2041-4889
ISSN (online)	2041-4889
ISSN	2041-4889
DOI	10.1038/s41419-024-06596-8
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Article: [Parapsoriasis--to be or not be (mycosis fungoides)].

Goldberg, Ilan

Harefuah

2012 Volume 151, Issue 10, Page(s) 581–4, 604

Abstract: Mycosis fungoides (MF) is the most prevalent cutaneous lymphoma, characterized by uncontrolled growth of T cells within the skin. The diagnosis in the early stages may be difficult, since, in these stages, the disease can imitate benign inflammatory ... ...

Abstract	Mycosis fungoides (MF) is the most prevalent cutaneous lymphoma, characterized by uncontrolled growth of T cells within the skin. The diagnosis in the early stages may be difficult, since, in these stages, the disease can imitate benign inflammatory processes, both clinically and histologically. One of the difficulties in determining diagnostic criteria for early MF is the existing terminology of parapsoriasis. There is disagreement concerning the exact definition and whether it is a chronic benign condition with similar clinical and histological characteristics as MF, or rather it is part of the disease spectrum itself. There is a need for uniformity in the definition for treatment decisions, for epidemiological purposes and for clinical and experimental research. This article reviews the different approaches to parapsoriasis as part of MF over the years.
MeSH term(s)	Cell Proliferation ; Dermatology/classification ; Diagnosis, Differential ; Early Detection of Cancer ; Humans ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/pathology ; Neoplasm Staging ; Parapsoriasis/diagnosis ; Parapsoriasis/pathology ; Skin/cytology ; Skin/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; T-Lymphocytes/physiology ; Terminology as Topic
Language	Hebrew
Publishing date	2012-10
Publishing country	Israel
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	953872-0
ISSN	0017-7768
ISSN	0017-7768
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Zs.B 291: Show issues

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Article ; Online: Reducing SAR in 7T brain fMRI by circumventing fat suppression while removing the lipid signal through a parallel acquisition approach.

Seginer, Amir / Furman-Haran, Edna / Goldberg, Ilan / Schmidt, Rita

Scientific reports

2021 Volume 11, Issue 1, Page(s) 15371

Abstract: Ultra-high-field functional magnetic resonance imaging (fMRI) offers a way to new insights while increasing the spatial and temporal resolution. However, a crucial concern in 7T human MRI is the increase in power deposition, supervised through the ... ...

Abstract	Ultra-high-field functional magnetic resonance imaging (fMRI) offers a way to new insights while increasing the spatial and temporal resolution. However, a crucial concern in 7T human MRI is the increase in power deposition, supervised through the specific absorption rate (SAR). The SAR limitation can restrict the brain coverage or the minimal repetition time of fMRI experiments. In the majority of today's studies fMRI relies on the well-known gradient-echo echo-planar imaging (GRE-EPI) sequence, which offers ultrafast acquisition. Commonly, the GRE-EPI sequence comprises two pulses: fat suppression and excitation. This work provides the means for a significant reduction in the SAR by circumventing the fat-suppression pulse. Without this fat-suppression, however, lipid signal can result in artifacts due to the chemical shift between the lipid and water signals. Our approach exploits a reconstruction similar to the simultaneous-multi-slice method to separate the lipid and water images, thus avoiding undesired lipid artifacts in brain images. The lipid-water separation is based on the known spatial shift of the lipid signal, which can be detected by the multi-channel coils sensitivity profiles. Our study shows robust human imaging, offering greater flexibility to reduce the SAR, shorten the repetition time or increase the volume coverage with substantial benefit for brain functional studies.
MeSH term(s)	Brain/diagnostic imaging ; Brain/pathology ; Brain/ultrastructure ; Brain Mapping ; Humans ; Lipids/chemistry ; Magnetic Resonance Imaging/trends ; Models, Theoretical ; Neuroimaging/trends ; Phantoms, Imaging/trends ; Water/chemistry
Chemical Substances	Lipids ; Water (059QF0KO0R)
Language	English
Publishing date	2021-07-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-94692-6
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Article ; Online: Segmental Pigmentation Disorder: Clinical Manifestations and Epidemiological Features in 144 patients, a Retrospective Case-control Study.

Oren-Shabtai, Meital / Metzker, Aryeh / Ben Amitai, Dan / Sprecher, Eli / Goldberg, Ilan

Acta dermato-venereologica

2022 Volume 102, Page(s) adv00707

Abstract: Segmental pigmentation disorder (SPD) is characterized by hypo- or hyper-pigmented patches segmentally distributed, present in infancy, more prominently in darker-skinned children. The aim of this study was to define the demographic and clinical ... ...

Abstract	Segmental pigmentation disorder (SPD) is characterized by hypo- or hyper-pigmented patches segmentally distributed, present in infancy, more prominently in darker-skinned children. The aim of this study was to define the demographic and clinical characteristics of SPD in a large series of patients. This was a retrospective case-control study at 2 paediatric dermatology centres in Israel. Data were collected through a telephone questionnaire and medical records. The study group consisted of 144 individuals with SPD and 144 individuals visiting the same institutions matched for age and sex. Median age of onset of SPD was near birth; 51% of patients were Sephardic Jews, and patients were followed up for a median period of 27 years. The patches were located on the torso (43%), mostly hypopigmented (52%), and remained of the same intensity and size in 55% and 41% of cases, accordingly. No differences in extracutaneous morbidities were found between SPD and control patients. This study delineates the demographic and clinical characteristics of SPD, confirms that cutaneous findings in SPD are more prominent in darker skin, tends not to expand in size or accentuate throughout the years, nor to be associated with extracutaneous morbidities.
MeSH term(s)	Adult ; Case-Control Studies ; Child ; Humans ; Israel/epidemiology ; Pigmentation Disorders/diagnosis ; Pigmentation Disorders/epidemiology ; Retrospective Studies ; Surveys and Questionnaires
Language	English
Publishing date	2022-05-10
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	80007-7
ISSN	1651-2057 ; 0001-5555
ISSN (online)	1651-2057
ISSN	0001-5555
DOI	10.2340/actadv.v102.399
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Ui VI Zs.101: Show issues

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Article ; Online: T-Cell Monoclonality in the Blood and the Skin Correlates With Poor Response to Treatment in Mycosis Fungoides.

Geller, Shamir / Tel-Dan, Shira F / Solar, Irit / Sprecher, Eli / Goldberg, Ilan

Clinical lymphoma, myeloma & leukemia

2022 Volume 23, Issue 2, Page(s) 123–126

Abstract: Background: The prognostic value of skin and blood T-cell receptor clonality in mycosis fungoides is a matter of debate. Our aim was to ascertain the relation between the presence of a monoclonal T-cell population in the blood and in the skin with ... ...

Abstract	Background: The prognostic value of skin and blood T-cell receptor clonality in mycosis fungoides is a matter of debate. Our aim was to ascertain the relation between the presence of a monoclonal T-cell population in the blood and in the skin with response to treatment in patients with mycosis fungoides. Patients and methods: Clinical features and follow-up data were retrospectively collected and analyzed in 94 patients with mycosis fungoides seen at a cutaneous lymphoma clinic in a single tertiary center. All patients had results of polymerase chain reaction analysis of T-cell receptor gamma gene rearrangement in lesional skin and in peripheral blood at time of diagnosis. Association of response to treatment with clonality in the tissue and in the blood was assessed. Results: T-cell monoclonality was detected in the skin in 30 of 94 patients, in the blood in 12 of 94 cases and the same clone was found in both tissues in 6 of 94 patients. The presence of a polyclonal T-cell population in the circulation was associated with complete response (P = .006). Lack of response to treatment (stable disease or progression of disease) was associated with T-cell clonality in skin (P = .009), in blood (P = .002) and in both tissues (P < .001). A multivariate analysis showed that T-cell monoclonality in the skin is independently associated with lack of response of mycosis fungoides to therapy. Conclusion: Blood and skin should be studied for T-cell clonality as part of the routine initial workup, even in patients with early-stage disease.
MeSH term(s)	Humans ; T-Lymphocytes ; Retrospective Studies ; Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor ; Polymerase Chain Reaction/methods ; Mycosis Fungoides/diagnosis ; Mycosis Fungoides/therapy ; Skin Neoplasms/pathology
Language	English
Publishing date	2022-11-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2540992-X
ISSN	2152-2669 ; 2152-2650
ISSN (online)	2152-2669
ISSN	2152-2650
DOI	10.1016/j.clml.2022.10.011
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