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  1. Article ; Online: Did Laos really control the transmission of SARS-CoV-2 in 2020?

    Flower, Barnaby / Marks, Michael

    The Lancet regional health. Western Pacific

    2021  Volume 13, Page(s) 100202

    Language English
    Publishing date 2021-07-20
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2021.100202
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  2. Article ; Online: Did Laos really control the transmission of SARS-CoV-2 in 2020?

    Barnaby Flower / Michael Marks

    The Lancet Regional Health. Western Pacific, Vol 13, Iss , Pp 100202- (2021)

    2021  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: SARS-CoV-2 antibody seroprevalence in patients receiving dialysis in the USA.

    Flower, Barnaby / Atchison, Christina

    Lancet (London, England)

    2020  Volume 396, Issue 10259, Page(s) 1308–1309

    MeSH term(s) Antibodies, Viral ; COVID-19 ; Humans ; Renal Dialysis/adverse effects ; SARS-CoV-2 ; Seroepidemiologic Studies ; United States/epidemiology
    Chemical Substances Antibodies, Viral
    Keywords covid19
    Language English
    Publishing date 2020-09-25
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)32006-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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  4. Article ; Online: Treatment of Cryptococcal Meningitis: How Have We Got Here and Where are We Going?

    Ngan, Nguyen Thi Thuy / Flower, Barnaby / Day, Jeremy N

    Drugs

    2022  Volume 82, Issue 12, Page(s) 1237–1249

    Abstract: Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but symptomatic infection only occurs in a minority, in most cases, months or ...

    Abstract Cryptococcal meningitis is a devastating brain infection cause by encapsulated yeasts of the Cryptococcus genus. Exposure, through inhalation, is likely universal by adulthood, but symptomatic infection only occurs in a minority, in most cases, months or years after exposure. Disease has been described in almost all tissues, but it is the organism's tropism for the central nervous system that results in the most devastating illness. While invasive disease can occur in the immunocompetent, the greatest burden by far is in immunocompromised individuals, particularly people living with human immunodeficiency virus (HIV), organ transplant recipients and those on glucocorticoid therapy or other immunosuppressive drugs. Clinical presentation is variable, but diagnosis is usually straightforward, with cerebrospinal fluid microscopy, culture, and antigen testing proving significantly more sensitive than diagnostic tests for other brain infections. Although disease incidence has reduced since the advent of effective HIV therapy, mortality when disease occurs remains extremely high, and has changed little in recent decades. This Therapy in Practice review is an update of a talk first given by JND at the European Congress on Clinical Microbiology and Infectious Diseases in 2019 in the Netherlands. The review contextualizes the most recently published World Health Organization (WHO) guidelines for the treatment of HIV-associated cryptococcal meningitis in terms of the data from large, randomized, controlled trials published between 1997 and 2022. We discuss the rationale for induction and maintenance therapy and the efficacy and undesirable effects of the current therapeutic armamentarium of amphotericin, flucytosine and fluconazole. We address recent research into repurposed drugs such as sertraline and tamoxifen, and potential future treatment options, including the novel antifungals fosmanogepix, efungumab and oteseconazole, and non-pharmaceutical solutions such as neurapheresis cerebrospinal fluid filtration.
    MeSH term(s) Adult ; Amphotericin B/adverse effects ; Antifungal Agents ; Fluconazole/adverse effects ; Flucytosine/therapeutic use ; Glucocorticoids/therapeutic use ; HIV Infections/drug therapy ; Humans ; Meningitis, Cryptococcal/diagnosis ; Meningitis, Cryptococcal/drug therapy ; Meningitis, Cryptococcal/microbiology ; Sertraline/therapeutic use ; Tamoxifen/therapeutic use
    Chemical Substances Antifungal Agents ; Glucocorticoids ; Tamoxifen (094ZI81Y45) ; Amphotericin B (7XU7A7DROE) ; Fluconazole (8VZV102JFY) ; Flucytosine (D83282DT06) ; Sertraline (QUC7NX6WMB)
    Language English
    Publishing date 2022-09-16
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-022-01757-5
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: SARS-CoV-2 antibody seroprevalence in patients receiving dialysis in the USA

    Flower, Barnaby / Atchison, Christina

    The Lancet

    2020  Volume 396, Issue 10259, Page(s) 1308–1309

    Keywords General Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/s0140-6736(20)32006-7
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Seroprevalence of Hepatitis B, C and D in Vietnam: A systematic review and meta-analysis.

    Flower, Barnaby / Du Hong, Duc / Vu Thi Kim, Hang / Pham Minh, Khue / Geskus, Ronald B / Day, Jeremy / Cooke, Graham S

    The Lancet regional health. Western Pacific

    2022  Volume 24, Page(s) 100468

    Abstract: Background: Vietnam has one of the greatest disease burdens from chronic viral hepatitis. Comprehensive prevalence data are essential to support its elimination as a public health threat.: Methods: We searched Medline and Embase from 1990 to 2021 for ...

    Abstract Background: Vietnam has one of the greatest disease burdens from chronic viral hepatitis. Comprehensive prevalence data are essential to support its elimination as a public health threat.
    Methods: We searched Medline and Embase from 1990 to 2021 for seroprevalence data relating to Hepatitis B (HBV), C (HCV) and D (HDV) in Vietnam. We estimated pooled prevalence with a DerSimonian-Laird random-effects model and stratified study populations into i) low-risk ii) high-risk exposure and iii) liver disease. We further estimated prevalence by decade and region and rates of HIV-coinfection.
    Findings: We analysed 72 studies, including 120 HBV, 114 HCV and 23 HDV study populations. Pooled HBV prevalence was low in blood donors (1.86% [1.82-1.90]) but high in antenatal populations (10.8% [10.1-11.6]) and adults in the general population (10.5% [10.0-11.0]). It was similar or modestly increased in groups at highest risk of exposure, suggesting the epidemic is largely driven by chronic infections acquired in childhood. HCV pooled prevalence in the general population was lower than historical estimates: 0.26% (0.09-0.51) have active infection defined by detectable antigen or HCV RNA. In contrast, there is an extremely high prevalence of active HCV infection in people who inject drugs (PWID) (57.8% [56.5-59.1]), which has persisted through the decades despite harm-reduction interventions. HDV appears mainly confined to high-risk groups.
    Interpretation: Blood safety has improved, but renewed focus on HBV vaccination at birth and targeted HCV screening and treatment of PWID are urgently required to meet elimination targets. Large cross-sectional studies are needed to better characterize HDV prevalence, but mass screening may not be warranted.
    Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
    Language English
    Publishing date 2022-05-04
    Publishing country England
    Document type Journal Article
    ISSN 2666-6065
    ISSN (online) 2666-6065
    DOI 10.1016/j.lanwpc.2022.100468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Global surveillance, research, and collaboration needed to improve understanding and management of long COVID.

    Ward, Helen / Flower, Barnaby / Garcia, Patricia J / Ong, Sean Wei Xiang / Altmann, Daniel M / Delaney, Brendan / Smith, Nikki / Elliott, Paul / Cooke, Graham

    Lancet (London, England)

    2021  Volume 398, Issue 10316, Page(s) 2057–2059

    MeSH term(s) COVID-19/complications ; Chronic Disease ; Cognitive Dysfunction/etiology ; Disease Management ; Fatigue/etiology ; Humans ; Population Surveillance ; Research ; Post-Acute COVID-19 Syndrome
    Language English
    Publishing date 2021-11-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)02444-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.5: Show issues Location:
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  9. Article ; Online: Seroprevalence of Hepatitis B, C and D in Vietnam

    Barnaby Flower / Duc Du Hong / Hang Vu Thi Kim / Khue Pham Minh / Ronald B Geskus / Jeremy Day / Graham S Cooke

    The Lancet Regional Health. Western Pacific, Vol 24, Iss , Pp 100468- (2022)

    A systematic review and meta-analysis

    2022  

    Abstract: Summary: Background: Vietnam has one of the greatest disease burdens from chronic viral hepatitis. Comprehensive prevalence data are essential to support its elimination as a public health threat. Methods: We searched Medline and Embase from 1990 to 2021 ...

    Abstract Summary: Background: Vietnam has one of the greatest disease burdens from chronic viral hepatitis. Comprehensive prevalence data are essential to support its elimination as a public health threat. Methods: We searched Medline and Embase from 1990 to 2021 for seroprevalence data relating to Hepatitis B (HBV), C (HCV) and D (HDV) in Vietnam. We estimated pooled prevalence with a DerSimonian-Laird random-effects model and stratified study populations into i) low-risk ii) high-risk exposure and iii) liver disease. We further estimated prevalence by decade and region and rates of HIV-coinfection. Findings: We analysed 72 studies, including 120 HBV, 114 HCV and 23 HDV study populations. Pooled HBV prevalence was low in blood donors (1.86% [1.82-1.90]) but high in antenatal populations (10.8% [10.1-11.6]) and adults in the general population (10.5% [10.0-11.0]). It was similar or modestly increased in groups at highest risk of exposure, suggesting the epidemic is largely driven by chronic infections acquired in childhood. HCV pooled prevalence in the general population was lower than historical estimates: 0.26% (0.09-0.51) have active infection defined by detectable antigen or HCV RNA. In contrast, there is an extremely high prevalence of active HCV infection in people who inject drugs (PWID) (57.8% [56.5-59.1]), which has persisted through the decades despite harm-reduction interventions. HDV appears mainly confined to high-risk groups. Interpretation: Blood safety has improved, but renewed focus on HBV vaccination at birth and targeted HCV screening and treatment of PWID are urgently required to meet elimination targets. Large cross-sectional studies are needed to better characterize HDV prevalence, but mass screening may not be warranted. Funding: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
    Keywords Hepatitis B/epidemiology ; Hepatitis C/epidemiology ; Delta virus ; HIV ; Vietnam ; Prevalence ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2022-07-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Treatment optimisation for hepatitis C in the era of combination direct-acting antiviral therapy: a systematic review and meta-analysis.

    Jones, Christopher R / Flower, Barnaby F / Barber, Ella / Simmons, Bryony / Cooke, Graham S

    Wellcome open research

    2019  Volume 4, Page(s) 132

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2019-09-06
    Publishing country England
    Document type Systematic Review
    ISSN 2398-502X
    ISSN 2398-502X
    DOI 10.12688/wellcomeopenres.15411.1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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