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Article ; Online: Father figure: Study of the age progression process from old pictures and its value in forensic sciences.

Donato, Laura / Ubelaker, Douglas H / Marsella, Luigi / Camatti, Jessika / Treglia, Michele / Cecchi, Rossana

2024 Volume 68, Page(s) 102421

Abstract: The application of age progression to the search for missing persons demonstrates its usefulness in being able to reconstruct the aged face based on the current age of a person who has been missing for many years. Age progression takes into account ... ...

Abstract	The application of age progression to the search for missing persons demonstrates its usefulness in being able to reconstruct the aged face based on the current age of a person who has been missing for many years. Age progression takes into account facial physiognomic elements and their changes over time. Based on these premises, the present study aims to investigate the evolution of somatic features, from childhood to adulthood, of one of the authors' father using photos at different ages of him. Sixteen photos were collected depicting an individual of Italian origin between the age of 1 and 72. The photos were processed in Adobe© Photoshop software to graphically highlight the shape development of individual physiognomic elements. The shape of the face, eyebrows, eyes, nose, mouth, and cheeks were analysed in detail using a morphological approach. The ageing processes that occurred in this case were discussed on the basis of the literature. The present study demonstrates the in-depth analysis of the dynamics of facial growth in a single case. Nonetheless, aging is different for each individual, so further studies are necessary to observe facial development on as many subjects as possible.
MeSH term(s)	Humans ; Male ; Face/anatomy & histology ; Aging/physiology ; Adult ; Aged ; Forensic Sciences/methods ; Child ; Photography ; Child, Preschool ; Middle Aged ; Infant ; Adolescent ; Young Adult ; Fathers
Language	English
Publishing date	2024-02-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	2019555-2
ISSN	1873-4162 ; 1344-6223
ISSN (online)	1873-4162
ISSN	1344-6223
DOI	10.1016/j.legalmed.2024.102421
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Article ; Online: Immune tolerance with combined allogeneic haplo-identical haematopoietic stem cell transplant and renal transplant.

Doucette, Kimberley / Shah, Neil J / Donato, Michele L / Siegel, David S / Rowley, Scott D / Vesole, David H

British journal of haematology

2021 Volume 194, Issue 4, Page(s) 779–783

MeSH term(s)	Graft Survival ; Hematopoietic Stem Cell Transplantation ; Humans ; Immune Tolerance ; Kidney Transplantation ; Male ; Tissue Donors ; Transplantation, Homologous ; Young Adult
Language	English
Publishing date	2021-06-16
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	80077-6
ISSN	1365-2141 ; 0007-1048
ISSN (online)	1365-2141
ISSN	0007-1048
DOI	10.1111/bjh.17540
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Article ; Online: The forensic imaging technique of age progression used within missing people cases: The Italian Missing Children association realizing age progression for Missing Child Kenya.

Donato, Laura / Ubelaker, Douglas H / Marsella, Luigi / Munyendo, Maryana / Treglia, Michele / Camatti, Jessika / Dagoli, Sara / Cecchi, Rossana

Science & justice : journal of the Forensic Science Society

2024 Volume 64, Issue 2, Page(s) 210–215

Abstract: The age progression technique allows to update identification photos of individuals who have been missing for years. This method is based on the study of the facial variation and on the dynamics of facial growth. Knowledge about changes in the ... ...

Abstract	The age progression technique allows to update identification photos of individuals who have been missing for years. This method is based on the study of the facial variation and on the dynamics of facial growth. Knowledge about changes in the distribution of facial fat and the tone of the cartilage allows realistic predictions of the facial appearance after many years. Beside these elements, age progression is also supported by similar characters between family members. This is why photos of the missing and family members are used to create an age progression, making the new identikit accurate. Non-profit associations are crucial for the dissemination of information on the problem of missing persons. In Italy, the Italian Missing Children association provides for free an age progression service with the support of forensic anthropology. With the activation of a protocol, consisting of guidelines, and a form for the request for age progression by family members, the Italian Missing Children has started a collaboration with Missing Child Kenya. It allowed to disseminate up-to-date photos of the presumed current appearance of the missing children in Kenya. Thus, in the present study some cases are reported, in which age progression technique was applied. The photos provided by Italian Missing Children were shown in video documentaries made by Missing Child Kenya, allowing to continue the dissemination of age progression photo during the Covid quarantines and to keep the population active in the search for the missing.
MeSH term(s)	Child ; Humans ; Forensic Imaging ; Kenya ; Forensic Anthropology/methods ; Face/anatomy & histology ; Italy/epidemiology
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1230910-2
ISSN	1876-4452 ; 1355-0306
ISSN (online)	1876-4452
ISSN	1355-0306
DOI	10.1016/j.scijus.2024.02.002
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Article: Comparing annual and biennial crop cycle on the growth, yield and quality of saffron using three corm dimensions

Cardone, Loriana / Candido, Vincenzo / Castronuovo, Donato / Perniola, Michele / Cicco, Nunzia

Scientia horticulturae. 2021 Oct. 15, v. 288

2021

Abstract: Saffron (Crocus sativus L.) is a geophyte plant belonging to the Iridaceae family and it is ...

Abstract	Saffron (Crocus sativus L.) is a geophyte plant belonging to the Iridaceae family and it is appreciated for its red dried stigmas used as cooking spice and flavouring agent. Effects of crop cycle length and mother corm dimension, as well as their interaction, have been evaluated on the flowering (morphological traits of flowers, days to flowering, flowering interval and flower production), quantitative traits (stigma and daughter corm yield), vegetative development (leaf and daughter corm traits) and qualitative characteristics (coloring, bittering and aromatic powers) of spice. A two-year field study (2017–2019) was conducted to compare annual and biennial crop cycle of saffron using three corm dimensional classes (D1: 2.0–2.5 cm, D2: 2.6–3.5 cm and D3: 3.6–4.5 cm) according a split-plot design with 3 replications. The results showed that the corms of D3 class, planted in annual crop cycle, produced flowers with the highest stigma length (42.2 mm), and dry weight of stigmas (7.4 mg), stamens (11.4 mg) and tepals (40.7 mg). The highest number of flowers per m² (311.8) and stigma yield (20.7 kg ha⁻¹) were found when corms belonging to D2 class were planted in biennial crop cycle, meanwhile the highest daughter corms production (35.9 t ha⁻¹) was obtained when corms belonged to D3 class were planted in annual crop cycle. Number of daughter corms per m² with a horizontal diameter from 3.1 to 4.5 cm and weight from 10.1 to > 25 g decreased as increasing the crop cycle length. In biennial crop cycle, corms of D1 class produced more daughter corms belonged to 3.1–3.5 cm diameter class and to 15.1–20 g weight class compared to D2 and D3 classes. Regarding to the spice quality, coloring and bittering powers were positively influenced by biennial crop cycle. According to International Standardization Organization (ISO 3632) references, the maximum values of color (306.3 A1cm1% 440 nm) and taste (116.2 A1cm1% 257 nm) were reached in spice obtained from “biennial crop cycle x D2 class” interaction. No significant effect of all experimental factors on aromatic power was found. It was concluded that the evaluation of combination between crop cycle length and corm dimension is necessary in the saffron management in order to achieve the optimum yield of stigmas and corms, to improve the qualitative traits of spice and to enhance the by-products as corms of D1 class.
Keywords	Crocus sativus ; annuals ; color ; corms ; experimental design ; flowers ; geophytes ; leaves ; saffron ; stigma ; taste
Language	English
Dates of publication	2021-1015
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2021.110393
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Article ; Online: Treatment of Smoldering Myeloma: Problems With Study Design as well as Biological and Clinical Implications.

Biran, Noa / Vesole, David H / Donato, Michele L / Ip, Andrew / Kaur, Gurbakhash / Goldberg, Stuart / Siegel, David S

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2020 Volume 38, Issue 12, Page(s) 1367–1368

MeSH term(s)	Biological Products ; Disease Progression ; Humans ; Lenalidomide ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Smoldering Multiple Myeloma
Chemical Substances	Biological Products ; Lenalidomide (F0P408N6V4)
Language	English
Publishing date	2020-03-11
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.19.02972
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Article ; Online: Evaluation of corm origin and climatic conditions on saffron (Crocus sativus L.) yield and quality.

Cardone, Loriana / Castronuovo, Donato / Perniola, Michele / Cicco, Nunzia / Candido, Vincenzo

Journal of the science of food and agriculture

2019 Volume 99, Issue 13, Page(s) 5858–5869

Abstract: Background: Crocus sativus L. is an autumn-flowering geophyte belonging to the Iridaceae family ... a.s.l.), Genzano di Lucania (40° 50' N, 16° 08' E, 344 m a.s.l.), and Villa d'Agri (40° 22' N, 15° 48' ... E, 638 m a.s.l.).: Results: The highest yields were obtained in the second year ...

Abstract	Background: Crocus sativus L. is an autumn-flowering geophyte belonging to the Iridaceae family, known for the medicinal and coloring uses of the spice from its dried stigmas. It is cultivated in countries with different pedoclimatic conditions. This paper reports on a two-year research project carried out in the Basilicata region of southern Italy on the question of how to obtain the highest performance from saffron. It considers corms from three different geographical origins - 'Sardinia', 'Abruzzo' and 'Kozani' at three different cultivation sites, namely Castelgrande (40° 46' N, 15° 26' E, 781 m a.s.l.), Genzano di Lucania (40° 50' N, 16° 08' E, 344 m a.s.l.), and Villa d'Agri (40° 22' N, 15° 48' E, 638 m a.s.l.). Results: The highest yields were obtained in the second year by the combination of 'Genzano di L. × Sardinia' and 'Castelgrande × Abruzzo' with 28.1 and 23.9 kg ha Conclusion: This study demonstrated, through principal component analysis (PCA), that the cultivation site with higher air temperature and without excessive rain during the flowering period generated the best stigma yield with high-quality traits. © 2019 Society of Chemical Industry.
MeSH term(s)	Carotenoids/analysis ; Climate ; Crocus/chemistry ; Crocus/growth & development ; Cyclohexenes/analysis ; Flowers/chemistry ; Flowers/growth & development ; Glucosides/analysis ; Italy ; Plant Extracts/analysis ; Quality Control ; Rain ; Temperature ; Terpenes/analysis
Chemical Substances	Cyclohexenes ; Glucosides ; Plant Extracts ; Terpenes ; Carotenoids (36-88-4) ; safranal (4393FR07EA) ; crocin (877GWI46C2) ; picrocrocin (ON5B022511)
Language	English
Publishing date	2019-07-10
Publishing country	England
Document type	Journal Article
ZDB-ID	184116-6
ISSN	1097-0010 ; 0022-5142
ISSN (online)	1097-0010
ISSN	0022-5142
DOI	10.1002/jsfa.9860
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Article ; Online: Sustained Hematopoietic Engraftment Potential after Prolonged Storage of Cryopreserved Hematopoietic Stem Cells Used in Salvage Autologous Stem Cell Transplantation.

Makhani, Sarah S / Oza, Samir P / Reich-Slotky, Ronit / Munshi, Pashna N / Biran, Noa / Donato, Michele L / Siegel, David S / Vesole, David H / Naam, Suzan / Rowley, Scott D

Transplantation and cellular therapy

2022 Volume 28, Issue 6, Page(s) 306.e1–306.e7

Abstract: Salvage autologous hematopoietic stem cell transplantation (HSCT) is an effective treatment for patients with relapsed multiple myeloma (MM). Peripheral blood stem cells (PBSCs), a source of hematopoietic stem cells (HSCs), are collected before the first ...

Abstract	Salvage autologous hematopoietic stem cell transplantation (HSCT) is an effective treatment for patients with relapsed multiple myeloma (MM). Peripheral blood stem cells (PBSCs), a source of hematopoietic stem cells (HSCs), are collected before the first transplantation, and adequate quantities of PBSCs can be collected and stored potentially for years to support at least 2 transplantations for eligible patients. To ensure the safety of salvage HSCT in the treatment of patients in subsequent relapse, PBSCs must retain the potential to engraft even after several years of cryopreservation. Although PBSC viability has been studied extensively using in vitro techniques, few publications describe the most rigorous functional potency measure, of patients receiving a myeloablative conditioning regimen. This study describes a large single-institution experience evaluating the engraftment kinetics of PBSCs used in salvage transplantation after multiple years of storage compared with first transplantation for the same patients in the treatment of MM. A retrospective chart review of patients with MM undergoing HSCT between 2000 and 2021 identified 89 patients who received salvage autologous PBSCs stored for >1 year after first HSCT. PBSCs were cryopreserved and stored in vapor-phase liquid nitrogen refrigerators at ≤-150°C. All patients received a PBSC product from the same collection cycle for both transplantations. Differences in CD34
MeSH term(s)	Cryopreservation/methods ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells ; Humans ; Nitrogen ; Retrospective Studies ; Transplantation, Autologous/methods
Chemical Substances	Nitrogen (N762921K75)
Language	English
Publishing date	2022-03-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3062231-1
ISSN	2666-6367
ISSN (online)	2666-6367
DOI	10.1016/j.jtct.2022.02.023
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Article ; Online: Position paper ANMCO: L’amiloidosi per il cardiologo clinico. Un “clinical primer” dell’Area Malattie Rare ANMCO.

Chimenti, Cristina / Grego, Susanna / Di Fusco, Stefania / De Luca, Leonardo / Caldarola, Pasquale / Cannillo, Margherita / Cipriani, Manlio / Di Lenarda, Andrea / Donato, Domenica / Leone, Simona / Limongelli, Giuseppe / Navazio, Alessandro / Riccio, Carmine / Valente, Serafina / Gulizia, Michele Massimo / Gabrielli, Domenico / Oliva, Fabrizio / Colivicchi, Furio

Giornale italiano di cardiologia (2006)

2023 Volume 24, Issue 2, Page(s) 127–135

Abstract: Cardiac amyloidosis, in the three forms of immunoglobulin light chain (AL), transthyretin (ATTR) wild type (ATTRwt) and mutated (ATTRv) amyloidosis, is an increasingly known and recognized disease in the cardiovascular setting. The first stage of the ... ...

Title translation	ANMCO Position paper: Amyloidosis for the clinical cardiologist. A "clinical primer" from the ANMCO Rare Disease Working Group.
Abstract	Cardiac amyloidosis, in the three forms of immunoglobulin light chain (AL), transthyretin (ATTR) wild type (ATTRwt) and mutated (ATTRv) amyloidosis, is an increasingly known and recognized disease in the cardiovascular setting. The first stage of the patient's journey is the clinical suspicion of the disease, which is placed, in presence of a hypertrophic phenotype, by the identification of red flags, both extracardiac and cardiac clues whose presence increase the probability of being faced with a patient with this disease. The second stage is represented by diagnosis, which occurs with certainty through the identification of amyloid substance in cardiac tissue. This stage is spotted in wo parts, i.e. disease confirmation and disease etiology definition (AL vs ATTRwt vs ATTRv). However, it is possible in some selected cases to make a diagnosis of ATTR without the need for tissue assessment, in presence of a positive grade 2-3 bisphosphonate scintigraphy and absence of monoclonal component. Once the diagnosis has been made, the third stage is the assessment of prognosis, the fourth is the patient therapy pathway and fifth is the follow-up plan. Prognosis evaluation is based on different staging systems at the onset of the disease, whose applicability in the era of new effective therapies is still to be defined. To date, the transthyretin tetramer stabilizer tafamidis is the only approved treatment for both wild-type and mutant ATTR cardiomyopathy without polyneuropathy, while ATTRv with associated neuropathy can benefit from treatment with patisiran, an inhibitor of hepatic protein synthesis. Therapies for complications and comorbidities, must be addressed individually, due to the lack of specific clinical trials on this category of patients. In fact, it is important to take into consideration the risks linked to the use of some drugs due to the infiltration of the conduction tissue by the amyloid substance, which increases the risk of bradycardia and heart blocks, the tendency towards hypotension and the increased thromboembolic risk. It is also essential to follow the course of the disease and the efficacy of the treatment in affected patients with a standardized follow-up, and to identify early the signs/symptoms of the disease in asymptomatic TTR mutation carriers.This ANMCO position paper on amyloidosis aims to provide the clinical cardiologist with a practical summary of the disease, to accompany the patient with amyloidosis in the various stages of his journey.
MeSH term(s)	Humans ; Amyloid Neuropathies, Familial/complications ; Amyloid Neuropathies, Familial/diagnosis ; Amyloid Neuropathies, Familial/genetics ; Prealbumin/therapeutic use ; Amyloid/therapeutic use ; Cardiologists ; Rare Diseases
Chemical Substances	Prealbumin ; Amyloid
Language	Italian
Publishing date	2023-01-17
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/3963.39421
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Article: Saffron (Crocus sativus L.), the king of spices: An overview

Cardone, Loriana / Castronuovo, Donato / Perniola, Michele / Cicco, Nunzia / Candido, Vincenzo

Scientia horticulturae. 2020 Oct. 15, v. 272

2020

Abstract: Saffron is obtained from the dried red stigmas of Crocus sativus L., an autumnal herbaceous ...

Abstract	Saffron is obtained from the dried red stigmas of Crocus sativus L., an autumnal herbaceous flowering plant belonging to the Iridaceae family. It is largely cultivated in Iran, India, Afghanistan, Greece, Morocco, Spain and Italy. Saffron global production is estimated at 418 t y⁻¹ on 121,338 ha. It is known as the most expensive spice in the world and as beneficial for human health due to three main bioactive compounds: crocin, picrocrocin and safranal. The demand for saffron is increasing worldwide for its interesting role in cuisine, medicine and cosmetics. Due to the reduction of its production, recent investigations have been conducted to study how to improve stigma yield, quality and antioxidant activity by selecting of corm geographical origin and climatic conditions, using biostimulants such as mycorrhizal fungi as well as choosing irrigation regimes, drying methods and storage processes. New research activities have been focused on the medicinal properties of this spice, such as its neuroprotection in the context of ocular disease, free radical scavenging and detoxifying capacities. This work offers an overview of the historical, economic, genetic, botanical, agronomic and qualitative traits of saffron as well as the properties, traditional and recent uses of the spice as well as its by-products such as tepals, stamens, styles, corms and leaves.
Keywords	Crocus sativus ; antioxidant activity ; corms ; cosmetics ; cuisine ; eye diseases ; free radicals ; human health ; medicine ; neuroprotective effect ; provenance ; saffron ; stigma ; Afghanistan ; Greece ; India ; Iran ; Italy ; Morocco ; Spain
Language	English
Dates of publication	2020-1015
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	185557-8
ISSN	0304-4238
ISSN	0304-4238
DOI	10.1016/j.scienta.2020.109560
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Article ; Online: Studies on the efficacy of electrolysed oxidising water to control Aspergillus carbonarius and ochratoxin A contamination on grape.

Magistà, Donato / Cozzi, Giuseppe / Gambacorta, Lucia / Logrieco, Antonio F / Solfrizzo, Michele / Perrone, Giancarlo

International journal of food microbiology

2020 Volume 338, Page(s) 108996

Abstract: ... compared with Switch® fungicide treatment (0.8 g/l). Black Aspergilli conidia were killed on plate assay ... after 2 min of treatment by EOW containing >0.4 g/l of active chlorine. EOW (0.6 g/l active chlorine ...

Abstract	Ochratoxin A (OTA) occurrence in grapes is caused by black Aspergilli (Aspergillus carbonarius followed by A. niger) vineyards contamination. It depends on climatic conditions, geographical regions, damage by insects, and grape varieties. Good agricultural practices, pesticides, and fungicides seem adequate to manage the problem during low OTA risk vintages, but the development of new strategies is always encouraged, especially when an extremely favourable condition occurs in the vineyard. Electrolysed oxidising water (EOW) has become an interesting alternative to chemicals in agriculture, mainly during the post-harvest phase. This study tested the fungicidal efficacy of EOW generated by potassium chloride, in vitro, on black Aspergilli conidia, and detached grape berries infected by A. carbonarius. Then, during field trials on Primitivo cv vineyard treated with EOW, A. carbonarius contamination, and OTA levels were compared with Switch® fungicide treatment (0.8 g/l). Black Aspergilli conidia were killed on plate assay after 2 min of treatment by EOW containing >0.4 g/l of active chlorine. EOW (0.6 g/l active chlorine) treatment reduced the rate of A. carbonarius infections in vitro of about 87-92% on detached berries and, more than half in the field trials, although Switch® showed better performance. A significant reduction in the OTA concentration was observed for the EOW and Switch® treatments in vitro (92% and 96%, respectively), while in the field trials, although the average decrease in OTA was recorded in the treated grapes, it was not statistically significant. These results highlighted that EOW could be considered effective, as a substitute for fungicides, to reduce the contamination of A. carbonarius and OTA on grapes.
MeSH term(s)	Aspergillus/drug effects ; Food Contamination/prevention & control ; Food Microbiology/methods ; Fungicides, Industrial/chemistry ; Ochratoxins/chemistry ; Vitis/microbiology ; Water/chemistry ; Water/pharmacology
Chemical Substances	Fungicides, Industrial ; Ochratoxins ; Water (059QF0KO0R) ; ochratoxin A (1779SX6LUY)
Language	English
Publishing date	2020-11-27
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	87122-9
ISSN	1879-3460 ; 0168-1605
ISSN (online)	1879-3460
ISSN	0168-1605
DOI	10.1016/j.ijfoodmicro.2020.108996
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