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  1. Article ; Online: Chronic Lymphogranuloma Venereum Proctocolitis Masquerading as Inflammatory Bowel Disease.

    Ghanta, Sai Nikhila / Saccente, Michael

    Journal of investigative medicine high impact case reports

    2022  Volume 10, Page(s) 23247096221107233

    Abstract: Rectal infection with the L1, L2, and L3 serovars ... ...

    Abstract Rectal infection with the L1, L2, and L3 serovars of
    MeSH term(s) Chronic Disease ; Homosexuality, Male ; Humans ; Inflammatory Bowel Diseases/complications ; Lymphogranuloma Venereum/diagnosis ; Lymphogranuloma Venereum/etiology ; Male ; Proctocolitis/complications ; Proctocolitis/diagnosis ; Sexual and Gender Minorities
    Language English
    Publishing date 2022-06-28
    Publishing country United States
    Document type Journal Article ; Case Reports
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/23247096221107233
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  2. Article ; Online: Comparison of Blood (1->3)-β-d-Glucan Levels in AIDS-Related Pneumocystis jirovecii Pneumonia and AIDS-Related Progressive Disseminated Histoplasmosis.

    Saccente, Michael / Krishnan, Gayathri

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2021  Volume 73, Issue 6, Page(s) 1100–1102

    Abstract: In this retrospective study, (1->3)-β-d-glucan (B-glucan) was an unreliable marker for AIDS-related Pneumocystis jirovecii pneumonia (PCP) because a high percentage of participants with progressive disseminated histoplasmosis and respiratory symptoms had ...

    Abstract In this retrospective study, (1->3)-β-d-glucan (B-glucan) was an unreliable marker for AIDS-related Pneumocystis jirovecii pneumonia (PCP) because a high percentage of participants with progressive disseminated histoplasmosis and respiratory symptoms had a positive B-glucan result. Where histoplasmosis is common, attributing B-glucan positivity to PCP without further testing risks misdiagnosis.
    MeSH term(s) Acquired Immunodeficiency Syndrome ; Glucans ; Histoplasmosis/diagnosis ; Humans ; Pneumocystis carinii ; Pneumonia, Pneumocystis/diagnosis ; Retrospective Studies ; beta-Glucans
    Chemical Substances Glucans ; beta-Glucans
    Language English
    Publishing date 2021-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciab277
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  3. Article ; Online: Chronic Lymphogranuloma Venereum Proctocolitis Masquerading as Inflammatory Bowel Disease

    Sai Nikhila Ghanta / Michael Saccente

    Journal of Investigative Medicine High Impact Case Reports, Vol

    2022  Volume 10

    Abstract: Rectal infection with the L1, L2, and L3 serovars of Chlamydia trachomatis can cause lymphogranuloma venereum (LGV) proctocolitis, particularly among men who have sex with men (MSM). Symptoms of this sexually transmitted infection include anal pain, ... ...

    Abstract Rectal infection with the L1, L2, and L3 serovars of Chlamydia trachomatis can cause lymphogranuloma venereum (LGV) proctocolitis, particularly among men who have sex with men (MSM). Symptoms of this sexually transmitted infection include anal pain, rectal bleeding and discharge, tenesmus, constipation, and fever. Clinicians should consider LGV when there is a history of receptive anal intercourse and symptoms of proctocolitis. A positive nucleic acid amplification test (NAAT) on a rectal sample is diagnostic. This report describes a man with HIV and chronic proctocolitis in whom the diagnosis of LGV was delayed because the clinical picture mimicked inflammatory bowel disease.
    Keywords Medicine (General) ; R5-920 ; Pathology ; RB1-214
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
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  4. Article ; Online: Sweet Syndrome precipitated by

    Thapa, Priyenka / Mohr, Kayla / Campbell, Katelynn K / Saccente, Michael

    Journal of investigative medicine high impact case reports

    2021  Volume 9, Page(s) 2324709621990771

    Abstract: Autoantibodies to interferon γ, part of the first line of defense in the human immune response, constitutes a rare form of an acquired immunodeficiency in HIV-uninfected adults that can predispose to disseminated atypical mycobacterial infection. ... ...

    Abstract Autoantibodies to interferon γ, part of the first line of defense in the human immune response, constitutes a rare form of an acquired immunodeficiency in HIV-uninfected adults that can predispose to disseminated atypical mycobacterial infection. Particularly, this has been described in people of Southeast Asian origin. In this case report, we describe a previously healthy, Laotian man who presented with skin lesions consistent with Sweet syndrome that were later found to be precipitated by disseminated atypical mycobacterial disease. Extensive immunological workup revealed the patient to have autoantibodies to interferon γ, rendering him susceptible to this infection. Our report demonstrates a complex case with a multilayered diagnosis, while inviting perspective from multiple specialties. This enigmatic case emphasizes the importance of a broad differential with special attention to demographics while demonstrating the difficulty in treating certain atypical infections that are inherently multidrug resistant.
    MeSH term(s) Adult ; Autoantibodies ; Humans ; Interferon-gamma ; Male ; Mycobacterium Infections, Nontuberculous/complications ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium abscessus ; Sweet Syndrome/diagnosis ; Sweet Syndrome/drug therapy
    Chemical Substances Autoantibodies ; Interferon-gamma (82115-62-6)
    Language English
    Publishing date 2021-02-02
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709621990771
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  5. Article: Central nervous system histoplasmosis.

    Saccente, Michael

    Current treatment options in neurology

    2008  Volume 10, Issue 3, Page(s) 161–167

    Abstract: Involvement of the central nervous system (CNS) is recognized clinically in 5% to 10% of patients with progressive disseminated histoplasmosis. The risk of developing CNS histoplasmosis is increased in individuals with impaired cellular immunity, but not ...

    Abstract Involvement of the central nervous system (CNS) is recognized clinically in 5% to 10% of patients with progressive disseminated histoplasmosis. The risk of developing CNS histoplasmosis is increased in individuals with impaired cellular immunity, but not all patients with this condition are immunocompromised. Clinical syndromes include chronic meningitis, focal parenchymal lesions of the brain or spinal cord, stroke due to infected emboli, and diffuse encephalitis. CNS histoplasmosis should be considered in any patient with one of these syndromes who has resided in an area endemic for histoplasmosis. A high index of suspicion is necessary when extraneural signs and symptoms are absent. Culture of the causative fungus, Histoplasma capsulatum, from cerebrospinal fluid, brain tissue, or other sites is the gold standard for diagnosis. In culture-negative cases, detection of H. capsulatum antigen in cerebrospinal fluid, urine, or blood is helpful diagnostically. Aggressive and prolonged antifungal therapy is indicated in all cases of CNS histoplasmosis. There are no data from prospective comparative trials upon which to base specific recommendations for treatment. Expert opinion favors an initial course of liposomal amphotericin B, followed by at least 1 year of itraconazole.
    Language English
    Publishing date 2008-06-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2057342-X
    ISSN 1534-3138 ; 1092-8480
    ISSN (online) 1534-3138
    ISSN 1092-8480
    DOI 10.1007/s11940-008-0017-x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5535: Show issues Location:
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  6. Article ; Online: Intensive care of patients with HIV infection.

    Saccente, Michael

    The New England journal of medicine

    2006  Volume 355, Issue 15, Page(s) 1619; author reply 1619–20

    MeSH term(s) Anti-Retroviral Agents/therapeutic use ; Critical Illness ; HIV Infections/drug therapy ; Humans ; Patient Compliance
    Chemical Substances Anti-Retroviral Agents
    Language English
    Publishing date 2006-10-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc062171
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  7. Article: Mycobacterium fortuitum group periprosthetic joint infection.

    Saccente, Michael

    Scandinavian journal of infectious diseases

    2006  Volume 38, Issue 8, Page(s) 737–739

    Abstract: The Mycobacterium fortuitum group of rapidly growing mycobacteria is recognized infrequently as a cause of periprosthetic joint infection. This report describes a case of periprosthetic joint infection due to a member of the M. fortuitum group where ... ...

    Abstract The Mycobacterium fortuitum group of rapidly growing mycobacteria is recognized infrequently as a cause of periprosthetic joint infection. This report describes a case of periprosthetic joint infection due to a member of the M. fortuitum group where failure to consider this pathogen caused months of diagnostic delay. Aggressive surgery and 6 months of combination antimicrobial therapy eradicated the infection.
    MeSH term(s) Adult ; Arthroplasty, Replacement, Knee ; Female ; Humans ; Joint Diseases/drug therapy ; Joint Diseases/microbiology ; Joint Diseases/surgery ; Mycobacterium fortuitum/isolation & purification ; Prosthesis-Related Infections/drug therapy ; Prosthesis-Related Infections/microbiology ; Prosthesis-Related Infections/surgery
    Language English
    Publishing date 2006
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 390956-6
    ISSN 1651-1980 ; 0036-5548
    ISSN (online) 1651-1980
    ISSN 0036-5548
    DOI 10.1080/00365540500504133
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  8. Article ; Online: Sweet Syndrome precipitated by in a Laotian Man with Autoantibodies to Interferon Gamma

    Priyenka Thapa MD / Kayla Mohr MD / Katelynn K. Campbell MD / Michael Saccente MD

    Journal of Investigative Medicine High Impact Case Reports, Vol

    2021  Volume 9

    Abstract: Autoantibodies to interferon γ, part of the first line of defense in the human immune response, constitutes a rare form of an acquired immunodeficiency in HIV-uninfected adults that can predispose to disseminated atypical mycobacterial infection. ... ...

    Abstract Autoantibodies to interferon γ, part of the first line of defense in the human immune response, constitutes a rare form of an acquired immunodeficiency in HIV-uninfected adults that can predispose to disseminated atypical mycobacterial infection. Particularly, this has been described in people of Southeast Asian origin. In this case report, we describe a previously healthy, Laotian man who presented with skin lesions consistent with Sweet syndrome that were later found to be precipitated by disseminated atypical mycobacterial disease. Extensive immunological workup revealed the patient to have autoantibodies to interferon γ, rendering him susceptible to this infection. Our report demonstrates a complex case with a multilayered diagnosis, while inviting perspective from multiple specialties. This enigmatic case emphasizes the importance of a broad differential with special attention to demographics while demonstrating the difficulty in treating certain atypical infections that are inherently multidrug resistant.
    Keywords Medicine (General) ; R5-920 ; Pathology ; RB1-214
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
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  9. Article ; Online: Clinical and laboratory update on blastomycosis.

    Saccente, Michael / Woods, Gail L

    Clinical microbiology reviews

    2010  Volume 23, Issue 2, Page(s) 367–381

    Abstract: Blastomycosis is endemic in regions of North America that border the Great Lakes and the St. Lawrence River, as well as in the Mississippi River and Ohio River basins. Men are affected more often than women and children because men are more likely to ... ...

    Abstract Blastomycosis is endemic in regions of North America that border the Great Lakes and the St. Lawrence River, as well as in the Mississippi River and Ohio River basins. Men are affected more often than women and children because men are more likely to participate in activities that put them at risk for exposure to Blastomyces dermatitidis. Human infection occurs when soil containing microfoci of mycelia is disturbed and airborne conidia are inhaled. If natural defenses in the alveoli fail to contain the infection, lymphohematogenous dissemination ensues. Normal host responses generate a characteristic pyogranulomatous reaction. The most common sites of clinical disease are the lung and skin; osseous, genitourinary, and central nervous system manifestations follow in decreasing order of frequency. Blastomycosis is one of the great mimickers in medicine; verrucous cutaneous blastomycosis resembles malignancy, and mass-like lung opacities due to B. dermatitidis often are confused with cancer. Blastomycosis may be clinically indistinguishable from tuberculosis. Diagnosis is based on culture and direct visualization of round, multinucleated yeast forms that produce daughter cells from a single broad-based bud. Although a long course of amphotericin B is usually curative, itraconazole is also highly effective and is the mainstay of therapy for most patients with blastomycosis.
    MeSH term(s) Blastomyces ; Blastomycosis/diagnosis ; Blastomycosis/therapy ; Female ; Humans ; Male
    Language English
    Publishing date 2010-04-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 645015-5
    ISSN 1098-6618 ; 0893-8512
    ISSN (online) 1098-6618
    ISSN 0893-8512
    DOI 10.1128/CMR.00056-09
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    Zs.A 2409: Show issues Location:
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  10. Article: Candida lusitaniae septic arthritis: case report and review of the literature.

    Bariola, Jeremy Ryan / Saccente, Michael

    Diagnostic microbiology and infectious disease

    2008  Volume 61, Issue 1, Page(s) 61–63

    Abstract: Candida lusitaniae is an infrequently encountered Candida species that has been associated with resistance to amphotericin B. We present a case of septic arthritis with C. lusitaniae and provide a brief review of the organism, especially in regard to ... ...

    Abstract Candida lusitaniae is an infrequently encountered Candida species that has been associated with resistance to amphotericin B. We present a case of septic arthritis with C. lusitaniae and provide a brief review of the organism, especially in regard to current information about its pattern of resistance to antifungal agents.
    MeSH term(s) Antifungal Agents/pharmacology ; Arthritis, Infectious/microbiology ; Candida/isolation & purification ; Candidiasis/complications ; Candidiasis/microbiology ; Drug Resistance, Fungal ; Humans ; Male ; Middle Aged
    Chemical Substances Antifungal Agents
    Language English
    Publishing date 2008-05
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 604920-5
    ISSN 0732-8893
    ISSN 0732-8893
    DOI 10.1016/j.diagmicrobio.2007.12.003
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