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  1. Article ; Online: Age-associated change in pyruvate metabolism investigated with hyperpolarized

    Uthayakumar, Biranavan / Soliman, Hany / Bragagnolo, Nadia D / Cappelletto, Nicole I C / Lee, Casey Y / Geraghty, Benjamin / Chen, Albert P / Perks, William J / Ma, Nathan / Heyn, Chris / Endre, Ruby / MacIntosh, Bradley J / Stanisz, Greg J / Black, Sandra E / Cunningham, Charles H

    Human brain mapping

    2023  Volume 44, Issue 10, Page(s) 4052–4063

    Abstract: In this study, ... ...

    Abstract In this study, hyperpolarized
    MeSH term(s) Humans ; Bicarbonates/metabolism ; Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Brain/metabolism ; Pyruvic Acid/metabolism ; Lactic Acid/metabolism ; Carbon Isotopes/metabolism
    Chemical Substances Bicarbonates ; Pyruvic Acid (8558G7RUTR) ; Lactic Acid (33X04XA5AT) ; Carbon Isotopes
    Language English
    Publishing date 2023-05-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1197207-5
    ISSN 1097-0193 ; 1065-9471
    ISSN (online) 1097-0193
    ISSN 1065-9471
    DOI 10.1002/hbm.26329
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4028: Show issues Location:
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  2. Article ; Online: Correlation of hyperpolarized

    Lee, Casey Y / Lau, Justin Y C / Geraghty, Benjamin J / Chen, Albert P / Gu, Yi-Ping / Cunningham, Charles H

    NMR in biomedicine

    2020  Volume 33, Issue 5, Page(s) e4269

    Abstract: Hyperpolarized (HP) ...

    Abstract Hyperpolarized (HP)
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4269
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2869: Show issues Location:
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  3. Article ; Online: Correction: The One Health High-Level Expert Panel (OHHLEP).

    Mettenleiter, Thomas C / Markotter, Wanda / Charron, Dominique F / Adisasmito, Wiku B / Almuhairi, Salama / Behravesh, Casey Barton / Bilivogui, Pépé / Bukachi, Salome A / Casas, Natalia / Becerra, Natalia Cediel / Chaudhary, Abhishek / Ciacci Zanella, Janice R / Cunningham, Andrew A / Dar, Osman / Debnath, Nitish / Dungu, Baptiste / Farag, Elmoubasher / Gao, George F / Hayman, David T S /
    Khaitsa, Margaret / Koopmans, Marion P G / Machalaba, Catherine / Mackenzie, John S / Morand, Serge / Smolenskiy, Vyacheslav / Zhou, Lei

    One health outlook

    2024  Volume 6, Issue 1, Page(s) 6

    Language English
    Publishing date 2024-03-27
    Publishing country England
    Document type Published Erratum
    ISSN 2524-4655
    ISSN (online) 2524-4655
    DOI 10.1186/s42522-024-00096-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Paradigms in oncology, old and new.

    Cunningham, C Casey

    Proceedings (Baylor University. Medical Center)

    2005  Volume 15, Issue 2, Page(s) 123–124

    Language English
    Publishing date 2005-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2002.11927825
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6987: Show issues Location:
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  5. Article: New modalities in oncology: antisense oligonucleotides.

    Cunningham, C Casey

    Proceedings (Baylor University. Medical Center)

    2005  Volume 15, Issue 2, Page(s) 125–128

    Language English
    Publishing date 2005-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2002.11927826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6987: Show issues Location:
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  6. Article: New modalities in oncology: ribozymes.

    Cunningham, C Casey

    Proceedings (Baylor University. Medical Center)

    2005  Volume 15, Issue 3, Page(s) 247–249

    Language English
    Publishing date 2005-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2703932-8
    ISSN 1525-3252 ; 0899-8280
    ISSN (online) 1525-3252
    ISSN 0899-8280
    DOI 10.1080/08998280.2002.11927847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6987: Show issues Location:
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  7. Article ; Online: State Marijuana Laws and Marijuana Use Among Sexual and Gender Minority Youth in the United States.

    Wheldon, Christopher W / Watson, Ryan J / Cunningham, Casey / Fish, Jessica N

    LGBT health

    2022  Volume 10, Issue 2, Page(s) 121–129

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Female ; Humans ; Adolescent ; United States/epidemiology ; Cannabis ; Marijuana Use/epidemiology ; Sexual and Gender Minorities ; Sexual Behavior ; Substance-Related Disorders
    Language English
    Publishing date 2022-10-13
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 2727303-9
    ISSN 2325-8306 ; 2325-8292
    ISSN (online) 2325-8306
    ISSN 2325-8292
    DOI 10.1089/lgbt.2021.0419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The impact of SBF2 on taxane-induced peripheral neuropathy.

    Cunningham, Geneva M / Shen, Fei / Wu, Xi / Cantor, Erica L / Gardner, Laura / Philips, Santosh / Jiang, Guanglong / Bales, Casey L / Tan, Zhiyong / Liu, Yunlong / Wan, Jun / Fehrenbacher, Jill C / Schneider, Bryan P

    PLoS genetics

    2022  Volume 18, Issue 1, Page(s) e1009968

    Abstract: Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose reductions or treatment discontinuation, adversely impacting survival ... ...

    Abstract Taxane-induced peripheral neuropathy (TIPN) is a devastating survivorship issue for many cancer patients. In addition to its impact on quality of life, this toxicity may lead to dose reductions or treatment discontinuation, adversely impacting survival outcomes and leading to health disparities in African Americans (AA). Our lab has previously identified deleterious mutations in SET-Binding Factor 2 (SBF2) that significantly associated with severe TIPN in AA patients. Here, we demonstrate the impact of SBF2 on taxane-induced neuronal damage using an ex vivo model of SBF2 knockdown of induced pluripotent stem cell-derived sensory neurons. Knockdown of SBF2 exacerbated paclitaxel changes to cell viability and neurite outgrowth while attenuating paclitaxel-induced sodium current inhibition. Our studies identified paclitaxel-induced expression changes specific to mature sensory neurons and revealed candidate genes involved in the exacerbation of paclitaxel-induced phenotypes accompanying SBF2 knockdown. Overall, these findings provide ex vivo support for the impact of SBF2 on the development of TIPN and shed light on the potential pathways involved.
    MeSH term(s) Black or African American/genetics ; Cell Survival/drug effects ; Disease Progression ; Female ; Gene Knockdown Techniques ; Humans ; Induced Pluripotent Stem Cells/chemistry ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/drug effects ; Paclitaxel/adverse effects ; Paclitaxel/pharmacology ; Peripheral Nervous System Diseases/chemically induced ; Peripheral Nervous System Diseases/ethnology ; Peripheral Nervous System Diseases/genetics ; Polymorphism, Single Nucleotide ; Protein Tyrosine Phosphatases, Non-Receptor/genetics ; Quality of Life ; Sensory Receptor Cells/chemistry ; Sensory Receptor Cells/cytology ; Sensory Receptor Cells/drug effects ; Sequence Analysis, RNA ; Single-Cell Analysis ; White People/genetics
    Chemical Substances Protein Tyrosine Phosphatases, Non-Receptor (EC 3.1.3.48) ; SBF2 protein, human (EC 3.1.3.48) ; Paclitaxel (P88XT4IS4D)
    Language English
    Publishing date 2022-01-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2186725-2
    ISSN 1553-7404 ; 1553-7390
    ISSN (online) 1553-7404
    ISSN 1553-7390
    DOI 10.1371/journal.pgen.1009968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The One Health High-Level Expert Panel (OHHLEP).

    Mettenleiter, Thomas C / Markotter, Wanda / Charron, Dominique F / Adisasmito, Wiku B / Almuhairi, Salama / Behravesh, Casey Barton / Bilivogui, Pépé / Bukachi, Salome A / Casas, Natalia / Becerra, Natalia Cediel / Chaudhary, Abhishek / Zanella, Janice R Ciacci / Cunningham, Andrew A / Dar, Osman / Debnath, Nitish / Dungu, Baptiste / Farag, Elmoubasher / Gao, George F / Hayman, David T S /
    Khaitsa, Margaret / Koopmans, Marion P G / Machalaba, Catherine / Mackenzie, John S / Morand, Serge / Smolenskiy, Vyacheslav / Zhou, Lei

    One health outlook

    2023  Volume 5, Issue 1, Page(s) 18

    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Letter
    ISSN 2524-4655
    ISSN (online) 2524-4655
    DOI 10.1186/s42522-023-00085-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Pilot study of responsive nucleus accumbens deep brain stimulation for loss-of-control eating.

    Shivacharan, Rajat S / Rolle, Camarin E / Barbosa, Daniel A N / Cunningham, Tricia N / Feng, Austin / Johnson, Noriah D / Safer, Debra L / Bohon, Cara / Keller, Corey / Buch, Vivek P / Parker, Jonathon J / Azagury, Dan E / Tass, Peter A / Bhati, Mahendra T / Malenka, Robert C / Lock, James D / Halpern, Casey H

    Nature medicine

    2022  Volume 28, Issue 9, Page(s) 1791–1796

    Abstract: Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens ( ... ...

    Abstract Cravings that precede loss of control (LOC) over food consumption present an opportunity for intervention in patients with the binge eating disorder (BED). In this pilot study, we used responsive deep brain stimulation (DBS) to record nucleus accumbens (NAc) electrophysiology during food cravings preceding LOC eating in two patients with BED and severe obesity (trial registration no. NCT03868670). Increased NAc low-frequency oscillations, prominent during food cravings, were used to guide DBS delivery. Over 6 months, we observed improved self-control of food intake and weight loss. These findings provide early support for restoring inhibitory control with electrophysiologically-guided NAc DBS. Further work with increased sample sizes is required to determine the scalability of this approach.
    MeSH term(s) Deep Brain Stimulation ; Eating ; Humans ; Nucleus Accumbens ; Obesity, Morbid ; Pilot Projects ; Synaptic Transmission
    Language English
    Publishing date 2022-08-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-01941-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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