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Article ; Online: Static and dynamic balance impairment and relationship with disease-related factors in patients with chronic obstructive pulmonary disease : A cross-sectional study.

Eymir, Musa / Yakut, Hazal / Özalevli, Sevgi / Alpaydın, Aylin Ö

2021 Volume 133, Issue 21-22, Page(s) 1186–1194

Abstract: Background: Disease and aging-related factors may predispose chronic obstructive pulmonary disease (COPD) patients to impaired balance, although the underlying determinants of impaired balance in COPD patients are still unknown. The purpose of this ... ...

Abstract	Background: Disease and aging-related factors may predispose chronic obstructive pulmonary disease (COPD) patients to impaired balance, although the underlying determinants of impaired balance in COPD patients are still unknown. The purpose of this study was to identify the determinants of impaired balance in COPD patients. Also, we aimed to determine which balance measures (clinical or laboratory tests) are more indicative in determining balance impairment in these patients. Methods: This cross-sectional study recruited 24 patients with moderate to severe COPD and 24 age-matched healthy subjects. Participants were evaluated regarding demographic and clinical data, previous falls history, lower limb muscle strength, exercise capacity, physical activity and balance level. Results: COPD patients exhibited significantly a longer test duration on timed up and go test, a higher sway index on the postural stability and lower directional control score on the limit of stability of Biodex balance system (all, p < 0.001) compared to healthy controls, whereas there was no difference in Berg balance scale score between groups (p > 0.05). Balance impairment of the patient group was significantly associated with nonpulmonary conditions, such as physical activity level, exercise capacity, lower limb muscle strength, and with fall history. Also, COPD patients represented significantly lower physical activity level and exercise capacity, weaker lower limb muscle strength than healthy controls (all, p < 0.001). Conclusions: Patients with moderate to severe COPD exhibit apparently important reductions in balance control that is directly associated with nonpulmonary consequences and fall history. These results may be extremely important to fall prevention and to guide the development of interventions for this population.
MeSH term(s)	Accidental Falls ; Cross-Sectional Studies ; Humans ; Muscle Strength ; Postural Balance ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology ; Time and Motion Studies
Language	English
Publishing date	2021-08-05
Publishing country	Austria
Document type	Journal Article
ZDB-ID	200462-8
ISSN	1613-7671 ; 0043-5325 ; 0300-5178
ISSN (online)	1613-7671
ISSN	0043-5325 ; 0300-5178
DOI	10.1007/s00508-021-01918-8
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Zs.A 902: Show issues

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Article: Tuberculous mastitis: A masquerading face of granulomatous mastitis.

Uçan, Eyüp Sabri / Alpaydın, Aylin Özgen / Gündüz Karayazı, Damla / Kapkaç, Murat / Takar, Burça / Zekioğlu, Osman / Balcı, Pınar / Yılmaz, Mehmet Rasih

Tuberkuloz ve toraks

2022 Volume 70, Issue 3, Page(s) 271–278

Abstract: Introduction: Tuberculosis (TB) mastitis is a rare form of granulomatous mastitis. We aimed to evaluate the clinical characteristics and prognosis of patients diagnosed with TB mastitis.: Materials and methods: A descriptive study was carried out on ... ...

Title translation	Tüberküloz mastit: Granülomatöz mastitin maskeli yüzü.
Abstract	Introduction: Tuberculosis (TB) mastitis is a rare form of granulomatous mastitis. We aimed to evaluate the clinical characteristics and prognosis of patients diagnosed with TB mastitis. Materials and methods: A descriptive study was carried out on patients who were reported to national tuberculosis control authorities as having TB mastitis between 2003 and 2021. Demographic, histopathological, and radiological data including mammography, ultrasonography (US), and magnetic resonance imaging (MRI) were reviewed. All were followed up to 24 months and prognosis was also evaluated. Result: This study identified 29 TB mastitis patients who had been diagnosed using excisional biopsies. The mean age was 33.5 ± 10.1, all were premenopausal women. The most common symptom was breast mass (n= 24, %82.8), nearly half of the patients also had ipsilateral axillary lymphadenopathy (n= 14, 48.3). One-fourth of the patients had bilateral involvement (n= 7, 24.1%), and half of the patients (n= 16, 55.2%) presented with multiple masses. One patient had co-existing pulmonary TB. Predisposing factors for TB were not identified in any of the patients. Nearly half of the patients received prior mastitis treatment. The most common radiological finding was mass in both mammography and US. All patients received anti-tuberculosis treatment of a standard regimen for six to 21 months, three patients had a relapse but were finally cured. Conclusions: TB mastitis should be suspected in young and premenopausal women presenting with a breast mass and axillary lymphadenopathy in an endemic region. Radiological findings could not identify the diagnosis. A multidisciplinary approach including bacteriology and histopathology should be performed. Anti-tuberculosis treatment can be implemented successfully.
MeSH term(s)	Adult ; Antitubercular Agents/therapeutic use ; Diagnosis, Differential ; Female ; Granulomatous Mastitis/diagnosis ; Humans ; Lymphadenopathy ; Mammography ; Tuberculosis/diagnosis ; Tuberculosis/drug therapy ; Tuberculosis/microbiology ; Young Adult
Chemical Substances	Antitubercular Agents
Language	English
Publishing date	2022-09-27
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2468802-2
ISSN	0494-1373
ISSN	0494-1373
DOI	10.5578/tt.20229706
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Zs.A 6702: Show issues

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Article ; Online: Can Some Viral Respiratory Infections Observed Before the Pandemic Announcement Be Related to SARS-CoV-2?

Özgen Alpaydın, Aylin / Appak, Özgür / Gezer, Naciye Sinem / Yiğit, Salih / Gündüz Karayazı, Damla / Kuruüzüm, Ziya / Ömeroğlu Şimşek, Gökçen / Eren Kutsoylu, Oya Özlem / Sayıner, Ayça Arzu / Sevinç, Can / Uçan, Eyüp Sabri / Uğur, Yasin Levent / Gökmen, Ali Necati / Yapar, Nur

Thoracic research and practice

2023 Volume 24, Issue 2, Page(s) 91–95

Abstract: Objective: There have been doubts that SARS-CoV-2 has been circulating before the first case was announced. The aim of this study was to evaluate the possibility of COVID-19 in some cases diagnosed to be viral respiratory tract infection in the pre- ... ...

Abstract	Objective: There have been doubts that SARS-CoV-2 has been circulating before the first case was announced. The aim of this study was to evaluate the possibility of COVID-19 in some cases diagnosed to be viral respiratory tract infection in the pre-pandemic period in our center. Material and methods: Patients who were admitted to our hospital's pulmonary diseases, infectious diseases, and intensive care clinics with the diagnosis of viral respiratory system infection within a 6-month period between October 2019 and March 12, 2020, were screened. Around 248 archived respiratory samples from these patients were analyzed for SARS-CoV-2 ribonucleic acid by real-timequantitative polymerase chain reaction. The clinical, laboratory, and radiological data of the patients were evaluated. Results: The mean age of the study group was 47.5 (18-89 years); 103 (41.5%) were female and 145 (58.4%) were male. The most common presenting symptoms were cough in 51.6% (n = 128), fever in 42.7% (n = 106), and sputum in 27.0% (n = 67). Sixty-nine percent (n = 172) of the patients were pre-diagnosed to have upper respiratory tract infection and 22.0% (n = 55) had pneumonia, one-third of the patients (n = 84, 33.8%) were followed in the service. Respiratory viruses other than SARS-CoV-2 were detected in 123 (49.6%) patients. Influenza virus (31.9%), rhinovirus (10.5%), and human metapneumovirus (6.5%) were the most common pathogens, while none of the samples were positive for SARS-CoV-2 RNA. Findings that could be significant for COVID-19 pneumonia were detected in the thorax computed tomography of 7 cases. Conclusion: The negative SARS-CoV-2 real-time-quantitative polymerase chain reaction results in the respiratory samples of the cases followed up in our hospital for viral pneumonia during the pre-pandemic period support that there was no COVID-19 among our cases during the period in question. However, if clinical suspicion arises, both SARS and non-SARS respiratory viral pathogens should be considered for differential diagnosis.
Language	English
Publishing date	2023-07-17
Publishing country	Turkey
Document type	Journal Article
ISSN	2979-9139
ISSN (online)	2979-9139
DOI	10.5152/ThoracResPract.2023.22187
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Article ; Online: Clinical and radiological diagnosis of non-SARS-CoV-2 viruses in the era of COVID-19 pandemic.

Alpaydin, Aylin O / Gezer, Naciye S / Simsek, Gokçen O / Tertemiz, Kemal C / Kutsoylu, Oya O E / Zeka, Arzu N / Guzel, Irmak / Soyturk, Mujde / Sayiner, Ayca A / Oguz, Vildan A

Journal of medical virology

2020 Volume 93, Issue 2, Page(s) 1119–1125

Abstract: Following the announcement of the first coronavirus disease 2019 (COVID-19) case on 11 March 2020 in Turkey, we aimed to report the coinfection rates, and the clinical, laboratory, radiological distinctive features of viral pneumonia caused by viruses ... ...

Abstract	Following the announcement of the first coronavirus disease 2019 (COVID-19) case on 11 March 2020 in Turkey, we aimed to report the coinfection rates, and the clinical, laboratory, radiological distinctive features of viral pneumonia caused by viruses other than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted between 18 and 31 March 2020. COVID-19 suspected cases admitted to pandemic policlinic, who had nasopharyngeal swab specimens tested for both SARS-CoV-2 and other respiratory viral pathogens, were included. Among 112 patients, SARS-CoV-2 was detected in 34 patients (30%). Among the non-SARS-CoV-2 viruses (n = 25, 22%), metapneumovirus (n = 10) was the most frequent agent. There were two coinfections with SARS-CoV-2. Sputum was less in the SARS-CoV-2 group (P = .003). The leukocyte, lymphocyte, and thrombocyte count and C-reactive protein levels were the lowest in the SARS-CoV-2 group (P < .001, P = .04, P < .001, P = .007, respectively). Peripheral involvement (80% vs 20%; P ≤ .001), pure ground-glass opacity (65% vs 33%; P = .04), apicobasal gradient (60% vs 40%; P = .08), involvement of greater than or equal to three lobes (80% vs 40%; odds ratio: 6.0; 95% confidence interval: 1.33-27.05; P = .02), and consolidation with accompanying ground-glass opacity (4% vs 33%; P = .031) were more common in SARS-CoV-2 group. Some clinical, laboratory, and radiological findings may help in the differential diagnosis of non-SARS-CoV-2 viruses from COVID-19. However, coinfections may occur, and a non-SARS-CoV-2 pathogen positivity does not exclude accompanying COVID-19.
MeSH term(s)	Adult ; Aged ; COVID-19/epidemiology ; Coinfection/diagnosis ; Coinfection/virology ; Cross-Sectional Studies ; Diagnosis, Differential ; Hospitalization ; Humans ; Middle Aged ; Nasopharynx/virology ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Sputum/virology ; Tomography, X-Ray Computed ; Turkey/epidemiology ; Virus Diseases/diagnosis ; Virus Diseases/epidemiology ; Viruses/classification ; Viruses/genetics ; Viruses/isolation & purification
Keywords	covid19
Language	English
Publishing date	2020-10-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26410
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Zs.A 1320: Show issues

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Article: Efficacy of thymoquinone in the treatment of experimental lipopolysaccharide-induced acute lung injury.

Çolak, Mustafa / Kalemci, Serdar / Alpaydın, Aylin Özgen / Karaçam, Volkan / Meteoğlu, Ibrahim / Yılmaz, Osman / Itil, Bahriye Oya

Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

2020 Volume 17, Issue 2, Page(s) 65–69

Abstract: Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are acute onset syndromes affecting the lungs, which develop for several reasons and are characterized by hypoxemia and diffuse lung infiltration. The activity of ... ...

Abstract	Introduction: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are acute onset syndromes affecting the lungs, which develop for several reasons and are characterized by hypoxemia and diffuse lung infiltration. The activity of thymoquinone (TQ) is known in acute lung injury. It is considered that it could be effective in ALI/ARDS treatment by ensuring possible COX-2 inhibition. Aim: By this study was to show the protective activity of TQ in lipopolysaccharide (LPS) induced acute lung injury.Material and methods: A total of 28 BALB/c male mice were randomized to 4 groups of 7 as the Control group, TQ group (3 mg/kg), LPS group (5 mg/kg) and TQ treatment group. TQ was administered intraperitoneally 1 hour before the intratracheal administration of LPS (5 mg/kg). The mice were sacrificed 6 hours after the LPS administration and the lungs were extracted for histopathological examination. All experimental procedures complied with the requirements of the Animal Care and Ethics Committee of Dokuz Eylul University. Results: When all the study groups were compared, significant differences were found between the groups in terms of the degrees of neutrophil migration ( Conclusions: The results of this study showed that TQ may have a protective effect against LPS-induced acute lung injury. The possible mechanism could be considered to be cyclooxygenase 2 (COX-2) inhibition.
Language	English
Publishing date	2020-07-20
Publishing country	Poland
Document type	Journal Article
ZDB-ID	2237053-5
ISSN	1897-4252 ; 1731-5530
ISSN (online)	1897-4252
ISSN	1731-5530
DOI	10.5114/kitp.2020.97259
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Article ; Online: Exposure to Fumes of a Vegetable Margarine for Frying: Respiratory Effects in an Experimental Model.

Cimrin, Arif H / Ozgen Alpaydin, Aylin / Ozbal, Seda / Toprak, Melis / Yilmaz, Osman / Uluorman, Funda / Ergur, Bekir Ugur / Gurel, Duygu / Sofuoglu, Sait C

ACS omega

2023 Volume 8, Issue 35, Page(s) 31880–31889

Abstract: Deep frying is one of the strongest emission sources into indoor air. A vegetable margarine has recently been used in commercial kitchens. This study investigated the respiratory effects of exposure to its fumes in an experimental model. A setup with ... ...

Abstract	Deep frying is one of the strongest emission sources into indoor air. A vegetable margarine has recently been used in commercial kitchens. This study investigated the respiratory effects of exposure to its fumes in an experimental model. A setup with glass chambers was constructed. A chamber housed a fryer. The fumes were transported to the other chamber where 24 Wistar albino rats were placed in four randomized groups: acute, subacute, chronic, and control for the exposure durations. PM
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.3c03340
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Article ; Online: The effect of Oxygen application with nCPAP for the prevention of desaturation during EBUS-TBNA.

Oral Tapan, Ozge / Genc, Sebahat / Tertemiz, Kemal Can / Ozgen Alpaydin, Aylin / Itil, Bahriye Oya / Iyilikci Karaoglan, Leyla

International journal of clinical practice

2021 Volume 75, Issue 5, Page(s) e14045

Abstract: Purpose: EBUS-TBNA is a frequently used diagnostic method for mediastinal/hilar lymphadenopathies and masses. This procedure is performed with intravenous sedation (IVS). During IVS, patients often develop hypoxemia and nasal oxygen delivery is ... ...

Abstract	Purpose: EBUS-TBNA is a frequently used diagnostic method for mediastinal/hilar lymphadenopathies and masses. This procedure is performed with intravenous sedation (IVS). During IVS, patients often develop hypoxemia and nasal oxygen delivery is insufficient in some patients. The aim of this study was to investigate the effect of oxygen application with nCPAP on hypoxemia during EBUS-TBNA. Methods: Patients with EBUS-TBNA indication who did not have any serious heart-lung disease were randomly divided into two groups. One group received only oxygen and the other group received nCPAP+oxygen. Patient characteristics, arterial oxygen saturations, anesthetic agents, CPAP pressures, oxygen concentrations and processing times were recorded during the procedure. Practitioner satisfaction was evaluated at the end. Results: 29 nCPAP+oxygen, 31 oxygen patients were included in the study. There were no significant differences in terms of age, sex, smoking history and presence of additional diseases in two groups. Neck circumference, BMI and STOP BANG questionnaire values were similar. Desaturation time was significantly longer in oxygen group than nCPAP+oxygen group (316±390 sec, 12±118 sec, respectively, p=0,019). Snoring was detected during the procedure in 22 patients in the oxygen group and in 11 patients in the nCPAP group (p=0,01). There were no serious complications in both groups. Practitioner satisfaction was higher in the nCPAP group but this was not statistically significant (p=0,052). Conclusion: Oxygen application by nCPAP during EBUS-TBNA under IVS, significantly reduces desaturation time. Oxygen delivery with nCPAP seems to be a better choice especially for the patients with high Mallampati index.
MeSH term(s)	Endoscopic Ultrasound-Guided Fine Needle Aspiration ; Humans ; Lung Neoplasms ; Lymph Nodes ; Mediastinum/diagnostic imaging ; Oxygen ; Retrospective Studies ; Sensitivity and Specificity
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2021-02-11
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1386246-7
ISSN	1742-1241 ; 1368-5031
ISSN (online)	1742-1241
ISSN	1368-5031
DOI	10.1111/ijcp.14045
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Ua VI Zs.301: Show issues

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Article: Clinical and radiological diagnosis of non-SARS-CoV-2 viruses in the era of COVID-19 pandemic

Alpaydin, Aylin O / Gezer, Naciye S / Simsek, Gokçen O / Tertemiz, Kemal C / Kutsoylu, Oya O E / Zeka, Arzu N / Guzel, Irmak / Soyturk, Mujde / Sayiner, Ayca A / Oguz, Vildan A

J. med. virol

Abstract	Following the announcement of the first coronavirus disease 2019 (COVID-19) case on 11 March 2020 in Turkey, we aimed to report the coinfection rates, and the clinical, laboratory, radiological distinctive features of viral pneumonia caused by viruses other than severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A cross-sectional study was conducted between 18 and 31 March 2020. COVID-19 suspected cases admitted to pandemic policlinic, who had nasopharyngeal swab specimens tested for both SARS-CoV-2 and other respiratory viral pathogens, were included. Among 112 patients, SARS-CoV-2 was detected in 34 patients (30%). Among the non-SARS-CoV-2 viruses (n = 25, 22%), metapneumovirus (n = 10) was the most frequent agent. There were two coinfections with SARS-CoV-2. Sputum was less in the SARS-CoV-2 group (P = .003). The leukocyte, lymphocyte, and thrombocyte count and C-reactive protein levels were the lowest in the SARS-CoV-2 group (P < .001, P = .04, P < .001, P = .007, respectively). Peripheral involvement (80% vs 20%; P ≤ .001), pure ground-glass opacity (65% vs 33%; P = .04), apicobasal gradient (60% vs 40%; P = .08), involvement of greater than or equal to three lobes (80% vs 40%; odds ratio: 6.0; 95% confidence interval: 1.33-27.05; P = .02), and consolidation with accompanying ground-glass opacity (4% vs 33%; P = .031) were more common in SARS-CoV-2 group. Some clinical, laboratory, and radiological findings may help in the differential diagnosis of non-SARS-CoV-2 viruses from COVID-19. However, coinfections may occur, and a non-SARS-CoV-2 pathogen positivity does not exclude accompanying COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #695183
Database	COVID19

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Article ; Online: Prevalence of Gastrointestinal Symptoms and Clinical Outcomes in Hospitalized Coronavirus Disease 2019 Patients: A Single-Center Study from Turkey.

The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology

2022 Volume 33, Issue 11, Page(s) 955–963

Abstract: Background: In patients with coronavirus disease 2019, the gastrointestinal symptoms have been reported increasingly in addition to the respiratory system symptoms. The studies show that the prevalence of gastrointestinal system symptoms and how the ... ...

Abstract	Background: In patients with coronavirus disease 2019, the gastrointestinal symptoms have been reported increasingly in addition to the respiratory system symptoms. The studies show that the prevalence of gastrointestinal system symptoms and how the gastrointestinal system contributes to the severity and prognosis of the disease is still not clear. This study aims to find the prevalence of gastrointestinal symptoms and the correlation between the gastrointestinal symptoms and the clinical results in hospitalized patients diagnosed with coronavirus disease 2019. Methods: This study retrospectively analyzes patients diagnosed with coronavirus disease 2019 and hospitalized in the pandemic unit between March 2020 and August 2020 and compares their demographic and clinical characteristics, laboratory and radiologic findings, coronavirus disease 2019 treatments received, the clinical course of the disease, and the gastrointestinal symptoms. Results: In our study, we included 322 patients diagnosed with coronavirus disease 2019 and hospitalized; 39 patients (12.1%) were admitted to the hospital with at least one gastrointestinal symptom (nausea and vomiting, diarrhea, abdominal pain, and the loss of taste). Nausea and vomiting are the most common gastrointestinal symptoms with a prevalence of 7.1%, followed by diarrhea with 2.8%, the loss of taste with 2.2%, and abdominal pain with 1.5%. The mean age and D-dimer levels of the patients showing gastrointestinal symptoms were lower than those who did not have any gastrointestinal symptoms. We did not find a significant correlation between the presence of the gastrointestinal symptoms and the severity of the disease, treatment received, risk of acute respiratory distress syndrome and septic shock, admission to the intensive care unit, the need for mechanical ventilation, the mortality rate or the length of hospitalization in the medical floor or the intensive care unit. Conclusion: In this study, we observed that 12.1% of coronavirus disease 2019 patients apply to the hospital due to gastrointestinal symptoms. Furthermore, the gastrointestinal symptoms do not seem to affect the severity and the course of the disease, it is important to identify coronavirus disease 2019 patients showing unusual symptoms such as the gastrointestinal symptoms at an early stage to protect healthcare professionals from infection risk.
MeSH term(s)	Humans ; COVID-19/epidemiology ; SARS-CoV-2 ; Prevalence ; Retrospective Studies ; Turkey/epidemiology ; Ageusia ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/diagnosis ; Diarrhea/epidemiology ; Diarrhea/etiology ; Abdominal Pain/epidemiology ; Abdominal Pain/etiology ; Vomiting ; Nausea
Language	English
Publishing date	2022-09-01
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	1340275-4
ISSN	2148-5607 ; 1300-4948
ISSN (online)	2148-5607
ISSN	1300-4948
DOI	10.5152/tjg.2022.21484
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Article ; Online: Does high-frequency chest wall oscillation therapy have any impact on the infective exacerbations of chronic obstructive pulmonary disease? A randomized controlled single-blind study.

Goktalay, Tugba / Akdemir, Selim E / Alpaydin, Aylin O / Coskun, Aysin S / Celik, Pinar / Yorgancioglu, Arzu

Clinical rehabilitation

2013 Volume 27, Issue 8, Page(s) 710–718

Abstract: ... therapy.: Main measures: Body mass index (B), forced expiratory volume in the first second (O ...

Abstract	Objective: To investigate the impact of high-frequency chest wall oscillation in chronic obstructive pulmonary disease patients with infective exacerbation. Design: Clinical randomized controlled trial. Setting: Patients received high-frequency chest wall oscillation therapy at the Department of Pulmonology. Subjects: Stage III-IV chronic obstructive pulmonary disease patients hospitalized with acute infective exacerbation who had received high-frequency chest wall oscillation therapy were studied. Interventions: Patients were randomized into two groups, which were classified as I and II. All patients have been treated with bronchodilators, antibiotics, if necessary oxygen and patient education, as part of acute chronic obstructive pulmonary disease exacerbation protocol. Group II patients received additional high-frequency chest wall oscillation therapy. Main measures: Body mass index (B), forced expiratory volume in the first second (O), modified Medical Research Council dyspnea scale (D) and 6-minute walking test (E) (BODE) index, forced expiratory volume in the first second, dyspnea, exercise capacity, oxygenation parameters and hospitalization of duration were recorded at baseline and at three-days and five-days follow-up. Results: From April 2009 to July 2011, a total of 99 patients were assessed for eligibility, 50 patients were enrolled and randomized into two groups. A total of 50 (100%) patients (25 in Group I and 25 in Group II) were followed up for five days. Application of high-frequency chest wall oscillation therapy resulted in no significant advantage in all outcomes (p > 0.05). Mean (SD) baseline BODE index value in Group I was 7.72 (1.76), in Group II was 7.72(1.89) (p = 0.55). On the fifth-day assessment, mean (SD) BODE index value in Group I was 7.24 (1.83), in group II was 6.44 (2.46) (p = 0.18). Conclusions: The application of high-frequency chest wall oscillation therapy offers no additional advantages on infective exacerbations in chronic obstructive pulmonary disease.
MeSH term(s)	Body Mass Index ; Chest Wall Oscillation/methods ; Disease Progression ; Dyspnea/classification ; Dyspnea/etiology ; Dyspnea/therapy ; Exercise Test ; Forced Expiratory Volume ; Humans ; Infection/etiology ; Infection/therapy ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Disease, Chronic Obstructive/therapy ; Turkey
Language	English
Publishing date	2013-08
Publishing country	England
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	639276-3
ISSN	1477-0873 ; 0269-2155
ISSN (online)	1477-0873
ISSN	0269-2155
DOI	10.1177/0269215513478226
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