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  1. Article ; Online: Comparison between targeted and vaccinated populations during the mpox vaccination campaign in France.

    Thy, Michael / Cosson, Guillaume / Danjou, William / Kramer, Laura / Pourcher, Valérie / Lescure, François-Xavier

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 10, Page(s) 1351–1353

    MeSH term(s) Humans ; Mpox (monkeypox) ; France ; Vaccination
    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type Letter
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.07.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patient-centered approach to the management of drug-resistant tuberculosis in France

    Yousra Kherabi / Bastien Mollo / Sandrine Gerard / François-Xavier Lescure / Christophe Rioux / Yazdan Yazdanpanah

    PLOS Global Public Health, Vol 2, Iss 4, p e

    How far off the mark are we?

    2022  Volume 0000313

    Abstract: ... tuberculosis management in Paris, France. Sixty-five DR-TB patients were hospitalized during the study period ...

    Abstract Drug-resistant tuberculosis (DR-TB) is a major public health concern worldwide. The prolonged isolation required is a source of challenges for both healthcare workers and patients, especially in high-income countries where DR-TB patients are frequently migrants with vulnerabilities. However, data on the needs of these vulnerable patients are scarce. Our objective was to identify and quantify conflict or inappropriate care situations experienced by both DR-TB patients and healthcare workers. This 10-year retrospective observational study (01/2008 to 10/2018) was conducted in a referral center for resistant tuberculosis management in Paris, France. Sixty-five DR-TB patients were hospitalized during the study period. Their demographic, clinical and social characteristics and any conflict or inappropriate care situations they experienced with healthcare workers while hospitalized were analyzed. Conflict or inappropriate care situations with healthcare workers were reported for 24 patients during their stay (36.9%). Eleven patients (16.9%) had difficulty adhering to respiratory isolation rules, 15 (23.1%) were discharged against medical advice, 9 (13.8%) were excluded from hospital for disciplinary reasons, verbal or physical violence was reported for 7 patients (10.8%), and 4 arrests (6.2%) were made by the police. Conflict situations were reported more often when there was a language barrier (70.8%, p<0.0001). More than one-third of patients with DR-TB in this referral center experienced at least one inappropriate care situation with healthcare workers. This study illustrates the urgent need to promote a patient-centered approach and to respond to the challenges of its practical implementation.
    Keywords Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Patient-centered approach to the management of drug-resistant tuberculosis in France: How far off the mark are we?

    Kherabi, Yousra / Mollo, Bastien / Gerard, Sandrine / Lescure, François-Xavier / Rioux, Christophe / Yazdanpanah, Yazdan

    PLOS global public health

    2022  Volume 2, Issue 4, Page(s) e0000313

    Abstract: ... tuberculosis management in Paris, France. Sixty-five DR-TB patients were hospitalized during the study period ...

    Abstract Drug-resistant tuberculosis (DR-TB) is a major public health concern worldwide. The prolonged isolation required is a source of challenges for both healthcare workers and patients, especially in high-income countries where DR-TB patients are frequently migrants with vulnerabilities. However, data on the needs of these vulnerable patients are scarce. Our objective was to identify and quantify conflict or inappropriate care situations experienced by both DR-TB patients and healthcare workers. This 10-year retrospective observational study (01/2008 to 10/2018) was conducted in a referral center for resistant tuberculosis management in Paris, France. Sixty-five DR-TB patients were hospitalized during the study period. Their demographic, clinical and social characteristics and any conflict or inappropriate care situations they experienced with healthcare workers while hospitalized were analyzed. Conflict or inappropriate care situations with healthcare workers were reported for 24 patients during their stay (36.9%). Eleven patients (16.9%) had difficulty adhering to respiratory isolation rules, 15 (23.1%) were discharged against medical advice, 9 (13.8%) were excluded from hospital for disciplinary reasons, verbal or physical violence was reported for 7 patients (10.8%), and 4 arrests (6.2%) were made by the police. Conflict situations were reported more often when there was a language barrier (70.8%, p<0.0001). More than one-third of patients with DR-TB in this referral center experienced at least one inappropriate care situation with healthcare workers. This study illustrates the urgent need to promote a patient-centered approach and to respond to the challenges of its practical implementation.
    Language English
    Publishing date 2022-04-20
    Publishing country United States
    Document type Journal Article
    ISSN 2767-3375
    ISSN (online) 2767-3375
    DOI 10.1371/journal.pgph.0000313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Enterococcal endocarditis management and relapses.

    Garofoli, Nina / Joly, Véronique / Le Pluart, Diane / Hobson, Claire Amaris / Beaumont, Anne-Lise / Lariven, Sylvie / Grall, Nathalie / Para, Marylou / Yazdanpanah, Yazdan / Lescure, François-Xavier / Peiffer-Smadja, Nathan / Deconinck, Laurène / Thy, Michael

    JAC-antimicrobial resistance

    2024  Volume 6, Issue 2, Page(s) dlae033

    Abstract: ... electronic device defined by the modified ESC 2015 Duke criteria in a referral centre in Paris, France ...

    Abstract Introduction: Enterococcus faecalis
    Methods: We conducted a monocentric, retrospective analysis of all patients hospitalized for EE including endocarditis or infection of cardiac implantable electronic device defined by the modified ESC 2015 Duke criteria in a referral centre in Paris, France.
    Results: Between October 2016, and September 2022, 54 patients with EE were included, mostly men (
    Conclusions: EE is a worrying disease associated with a high risk of relapse and significant mortality. Suppressive antibiotic therapy could be a key treatment to limit the occurrence of relapses.
    Language English
    Publishing date 2024-03-06
    Publishing country England
    Document type Journal Article
    ISSN 2632-1823
    ISSN (online) 2632-1823
    DOI 10.1093/jacamr/dlae033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Analysis of COVID-19 Transmission Sources in France by Self-Assessment Before and After the Partial Lockdown: Observational Study.

    Denis, Fabrice / Septans, Anne-Lise / Le Goff, Florian / Jeanneau, Stephan / Lescure, François-Xavier

    Journal of medical Internet research

    2021  Volume 23, Issue 5, Page(s) e26932

    Abstract: ... circumstances in France during the second wave of the pandemic.: Objective: This study aims to analyze ... the impact on contamination characteristics before and after the second partial lockdown in France to adapt ... about their own or a close relative's COVID-19 contamination after August 15, 2020, in France. The data ...

    Abstract Background: We developed a questionnaire on a web application for analyzing COVID-19 contamination circumstances in France during the second wave of the pandemic.
    Objective: This study aims to analyze the impact on contamination characteristics before and after the second partial lockdown in France to adapt public health restrictions to further prevent pandemic surges.
    Methods: Between December 15 and 24, 2020, after a national media campaign, users of the sourcecovid.fr web application were asked questions about their own or a close relative's COVID-19 contamination after August 15, 2020, in France. The data of the contamination's circumstances were assessed and compared before and after the second partial lockdown, which occurred on October 25, 2020, during the second wave of the pandemic and was ongoing on December 24, 2020.
    Results: As of December 24, 2020, 441,000 connections on the web application were observed. A total of 2218 questionnaires were assessable for analysis. About 61.8% (n=1309) of the participants were sure of their contamination origin, and 38.2% (n=809) thought they knew it. The median age of users was 43.0 (IQR 32-56) years, and 50.7% (n=1073) were male. The median incubation time of the assessed cohort was 4.0 (IQR 3-5) days. Private areas (family's or friend's house) were the main source of contamination (1048/2090, 50.2%), followed by work colleagues (579/2090, 27.7%). The main time of day for the contamination was the evening (339/961, 35.3%) before the lockdown and was reduced to 18.2% (86/473) after the lockdown (P<.001). The person who transmitted the virus to the user before and after the lockdown was significantly different (P<.001): a friend (382/1317, 29% vs 109/773, 14.1%), a close relative (304/1317, 23.1% vs 253/773, 32.7%), or a work colleague (315/1317, 23.9% vs 264/773, 34.2%). The main location where the virus was transmitted to the users before and after the lockdown was significantly different too (P<.001): home (278/1305, 21.3% vs 194/760, 25.5%), work (293/1305, 22.5% vs 225/760, 29.6%), collective places (430/1305, 33% vs 114/760, 15%), and care centers (58/1305, 4.4% vs 74/760, 9.7%).
    Conclusions: Modalities of transmissions significantly changed before and after the second lockdown in France. The main sources of contamination remained the private areas and with work colleagues. Work became the main location of contamination after the lockdown, whereas contaminations in collective places were strongly reduced.
    Trial registration: ClinicalTrials.gov NCT04670003; https://clinicaltrials.gov/ct2/show/NCT04670003.
    MeSH term(s) Adult ; COVID-19/epidemiology ; COVID-19/transmission ; Cohort Studies ; Communicable Disease Control/methods ; Female ; France/epidemiology ; Humans ; Male ; Middle Aged ; Pandemics ; SARS-CoV-2/isolation & purification ; Self-Assessment ; Surveys and Questionnaires
    Language English
    Publishing date 2021-05-04
    Publishing country Canada
    Document type Journal Article ; Observational Study
    ZDB-ID 2028830-X
    ISSN 1438-8871 ; 1439-4456
    ISSN (online) 1438-8871
    ISSN 1439-4456
    DOI 10.2196/26932
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Contributions and challenges of community pharmacists during the COVID-19 pandemic: a qualitative study.

    Durand, Claire / Douriez, Eric / Chappuis, Aude / Poulain, Frédérique / Yazdanpanah, Yazdan / Lariven, Sylvie / Lescure, François-Xavier / Peiffer-Smadja, Nathan

    Journal of pharmaceutical policy and practice

    2022  Volume 15, Issue 1, Page(s) 43

    Abstract: ... pharmacists in France. Participants were recruited through a professional organization of pharmacists combined ...

    Abstract Background: Healthcare services across the world have been deeply impacted by the COVID-19 pandemic. In primary care, community pharmacists have had an important role in the frontline healthcare response to the pandemic.
    Objectives: This study aimed to explore the experiences, contributions and perceived challenges of community pharmacists regarding the provision of healthcare services during the COVID-19 pandemic.
    Methods: Semi-structured qualitative interviews were conducted with community pharmacists in France. Participants were recruited through a professional organization of pharmacists combined with a snowballing technique. Interviews were transcribed and then analyzed using thematic analysis.
    Results: A total of 16 community pharmacists participated in the interviews. Study participants described providing a range of novel services in response to the pandemic on top of continuing their usual services. All participants described providing preventative services to reduce and mitigate the spread of SARS-CoV-2, such as education on hygiene and social distancing, delivery of face masks and hand sanitizer and adjusting pharmacy premises. Most respondents also described being involved in SARS-CoV-2 detection through screening and performing antigen testing in pharmacies. Participants reported being actively involved in COVID-19 vaccination by educating the general public about vaccines, facilitating their distribution to general practitioners as well as administering vaccines. Over half the respondents described rapidly changing guidelines and service users' anxiety as challenges to the provision of healthcare services during the pandemic.
    Conclusions: This study suggests that community pharmacists have significantly contributed to the response to the COVID-19 pandemic by ensuring continuity of pharmaceutical services and providing novel screening, testing and vaccination services. Their roles and responsibilities during the COVID-19 health crisis indicate that they can play an important role in the management of emerging infectious diseases.
    Language English
    Publishing date 2022-06-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2734772-2
    ISSN 2052-3211
    ISSN 2052-3211
    DOI 10.1186/s40545-022-00438-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Perceptions, current practices, and interventions of community pharmacists regarding antimicrobial stewardship: A qualitative study.

    Durand, Claire / Chappuis, Aude / Douriez, Eric / Poulain, Frédérique / Ahmad, Raheelah / Lescure, François-Xavier / Peiffer-Smadja, Nathan

    Journal of the American Pharmacists Association : JAPhA

    2022  Volume 62, Issue 4, Page(s) 1239–1248.e1

    Abstract: ... conducted with community pharmacists in France. Participants were recruited ...

    Abstract Background: Community health care accounts for the vast majority of antibiotic use in Europe. Given the threat of antimicrobial resistance (AMR), there is an urgent need to develop new antimicrobial stewardship (AMS) interventions in primary care that could involve different health care providers, including community pharmacists.
    Objectives: This study aimed to explore the perceptions, currents practices, and interventions of community pharmacists regarding AMS.
    Methods: Semistructured qualitative interviews were conducted with community pharmacists in France. Participants were recruited through a professional organization of community pharmacists combined with a snowballing technique. Interviews were audio recorded, transcribed, and analyzed using thematic analysis. The Consolidated Framework for Implementation Research was used while developing the interview guide and carrying out thematic analysis.
    Results: Sixteen community pharmacists participated. All the respondents had good awareness about antimicrobial resistance and believed that community pharmacists had an important role in tackling AMR. Some barriers to community pharmacists' participation in AMS were identified such as difficult interactions with prescribers, lack of time, and lack of access to patient medical records and diagnosis. Increased patient education, audits and feedback of antibiotic prescribing, increased point-of-care testing, and delayed prescribing were interventions suggested by the pharmacists to improve antibiotic use in primary care. Strategies cited by participants to facilitate the implementation of such interventions are increased pharmacist-general practitioner collaboration, specialized training, clinical decision support tools, and financial incentives.
    Conclusion: This study suggests that community pharmacists could play a greater role in infection management and AMS interventions. Further interprofessional collaboration is needed to optimize antibiotic prescribing and utilization in community health care.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship/methods ; Attitude of Health Personnel ; Humans ; Pharmacists ; Qualitative Research
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2118585-2
    ISSN 1544-3450 ; 1544-3191 ; 1086-5802
    ISSN (online) 1544-3450
    ISSN 1544-3191 ; 1086-5802
    DOI 10.1016/j.japh.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Severe SARS-CoV-2 infections: practical considerations and management strategy for intensivists.

    Bouadma, Lila / Lescure, Francois-Xavier / Lucet, Jean-Christophe / Yazdanpanah, Yazdan / Timsit, Jean-Francois

    Intensive care medicine

    2020  Volume 46, Issue 4, Page(s) 579–582

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections/epidemiology ; Coronavirus Infections/therapy ; Critical Care ; Decision Making ; Humans ; Intensive Care Units ; Pandemics ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/therapy ; Practice Guidelines as Topic ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-02-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-020-05967-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Adaptation and Response of a Major Parisian Referral Hospital to the COVID-19 Surge

    Fanny Chabrol / Lola Traverson / Renyou Hou / Lisa Chotard / Jean-Christophe Lucet / Nathan Peiffer-Smadja / Gisèle Bendjelloul / François-Xavier Lescure / Yazdan Yazdanpanah / Kate Zinszer / Valéry Ridde

    Health Systems & Reform, Vol 9, Iss

    A Qualitative Study

    2023  Volume 2

    Abstract: ... the first three COVID cases in France and to analyze its resilience capacities. Between March 2020 and June ...

    Abstract ABSTRACTSince the beginning of the COVID-19 pandemic, few studies have focused on crisis management of multiple services within one hospital over several waves of the pandemic. The purpose of this study was to provide an overview of the COVID-19 crisis response of a Parisian referral hospital which managed the first three COVID cases in France and to analyze its resilience capacities. Between March 2020 and June 2021, we conducted observations, semi-structured interviews, focus groups, and lessons learned workshops. Data analysis was supported by an original framework on health system resilience. Three configurations emerged from the empirical data: 1) reorganization of services and spaces; 2) management of professionals’ and patients’ contamination risk; and 3) mobilization of human resources and work adaptation. The hospital and its staff mitigated the effects of the pandemic by implementing multiple and varied strategies, which the staff perceived as having positive and/or negative consequences. We observed an unprecedented mobilization of the hospital and its staff to absorb the crisis. Often the mobilization fell on the shoulders of the professionals, adding to their exhaustion. Our study demonstrates the capacity of the hospital and its staff to absorb the COVID-19 shock by putting in place mechanisms for continuous adaptation. More time and insight will be needed to observe whether these strategies and adaptations will be sustainable over the coming months and years and to assess the overall transformative capacities of the hospital.
    Keywords COVID-19 ; emergency response capacity ; hospital ; resilience ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Type 1 interferons as a potential treatment against COVID-19.

    Sallard, Erwan / Lescure, François-Xavier / Yazdanpanah, Yazdan / Mentre, France / Peiffer-Smadja, Nathan

    Antiviral research

    2020  Volume 178, Page(s) 104791

    Abstract: Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the ... ...

    Abstract Type 1 interferons have a broad antiviral activity in vitro and are currently evaluated in a clinical trial to treat MERS-CoV. In this review, we discuss preliminary data concerning the potential activity of type 1 interferons on SARS-CoV-2, and the relevance of evaluating these molecules in clinical trials for the treatment of COVID-19.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus/isolation & purification ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/virology ; Humans ; Interferon Type I/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/virology ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Interferon Type I
    Keywords covid19
    Language English
    Publishing date 2020-04-07
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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