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  1. Article ; Online: What did bees eat? (interview met S. van der Steen)

    van der Steen, J.J.M. / Kleijn, D.

    WageningenWorld

    2010  Volume 2010, Issue 2

    Keywords Life Science
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 2210-7908
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: 'A role model is like a mosaic': reimagining URiM students' role models in medical school.

    Spaans, Isabella / de Kleijn, Renske / Seeleman, Conny / Dilaver, Gönül

    BMC medical education

    2023  Volume 23, Issue 1, Page(s) 396

    Abstract: ... on research conducted in the U.S. Second, as cognitive constructs: the participants engaged in selective ...

    Abstract Background: Role modelling is a widely acknowledged element of medical education and it is associated with a range of beneficial outcomes for medical students, such as contributing to professional identity development and a sense of belonging. However, for students who are racially and ethnically underrepresented in medicine (URiM), identification with clinical role models may not be self-evident, as they have no shared ethnic background as a basis for social comparison. This study aims to learn more about the role models of URiM students during medical school and about the added value of representative role models.
    Methods: In this qualitative study we used a concept-guided approach to explore URiM alumni's experiences with role models during medical school. We conducted semi-structured interviews with ten URiM alumni about their perception of role models, who their own role models were during medical school and why they considered these figures as role models. Sensitizing concepts guided the topic list, interview questions and finally served as deductive codes in the first round of coding.
    Results: The participants needed time to think about what a role model is and who their own role models are. Having role models was not self-evident as they had never thought about it before, and participants appeared hesitant and uncomfortable discussing representative role models. Eventually, all participants identified not one, but multiple people as their role model. These role models served different functions: role models from outside medical school, such as parents, motivated them to work hard. Clinical role models were fewer and functioned primarily as examples of professional behaviour. The participants experienced a lack of representation rather than a lack of role models.
    Conclusions: This study presents us with three ways to reimagine role models in medical education. First, as culturally embedded: having a role model is not as self-evident as it appears in existing role model literature, which is largely based on research conducted in the U.S. Second, as cognitive constructs: the participants engaged in selective imitation, where they did not have one archetypical clinical role model, but rather approach role models as a mosaic of elements from different people. Third, role models carry not only a behavioural but also a symbolical value, the latter of which is particularly important for URiM students because it relies heavier on social comparison.
    MeSH term(s) Humans ; Students, Medical/psychology ; Schools, Medical ; Ethnicity ; Education, Medical ; Social Identification
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-023-04394-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Short-term transcutaneous vagus nerve stimulation increases pupil size but does not affect EEG alpha power: A replication of Sharon et al. (2021, Journal of Neuroscience).

    Lloyd, Beth / Wurm, Franz / de Kleijn, Roy / Nieuwenhuis, Sander

    Brain stimulation

    2023  Volume 16, Issue 4, Page(s) 1001–1008

    Abstract: ... s) taVNS at the maximum level below the pain threshold, while we collected resting-state pupil-size ...

    Abstract Background: Transcutaneous auricular vagus nerve stimulation (taVNS) has been tested as a potential treatment for pharmaco-resistant epilepsy and depression. Its clinical efficacy is thought to depend on taVNS-induced activation of the locus coeruleus and other neuromodulator systems. However, unlike for invasive VNS in rodents, there is little evidence for an effect of taVNS on noradrenergic activity.
    Objective: We attempted to replicate recently published findings by Sharon et al. (2021), showing that short bursts of taVNS transiently increased pupil size and decreased EEG alpha power, two correlates of central noradrenergic activity.
    Methods: Following the original study, we used a single-blind, sham-controlled, randomized cross-over design. Human volunteers (n = 29) received short-term (3.4 s) taVNS at the maximum level below the pain threshold, while we collected resting-state pupil-size and EEG data. To analyze the data, we used scripts provided by Sharon and colleagues.
    Results: Consistent with Sharon et al. (2021), pupil dilation was significantly larger during taVNS than during sham stimulation (p = .009; Bayes factor supporting the difference = 7.45). However, we failed to replicate the effect of taVNS on EEG alpha power (p = .37); the data were four times more likely under the null hypothesis (BF
    Conclusion: Our findings support the effectiveness of short-term taVNS in inducing transient pupil dilation, a correlate of phasic noradrenergic activity. However, we failed to replicate the recent finding by Sharon et al. (2021) that taVNS attenuates EEG alpha activity. Overall, this study highlights the need for continued research on the neural mechanisms underlying taVNS efficacy and its potential as a treatment option for pharmaco-resistant conditions. It also highlights the need for direct replications of influential taVNS studies.
    MeSH term(s) Humans ; Vagus Nerve Stimulation ; Pupil/physiology ; Single-Blind Method ; Bayes Theorem ; Transcutaneous Electric Nerve Stimulation ; Vagus Nerve/physiology ; Electroencephalography
    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2023.06.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6740: Show issues Location:
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  4. Article ; Online: A virtual place of memory

    Jitte Waagen / Tijm Lanjouw / Maurice de Kleijn

    Heritage, Memory and Conflict, Vol 3, Iss , Pp 87-

    Virtual reality as a method for communicating conflicted heritage at Camp Westerbork

    2023  Volume 93

    Abstract: ... The Commander’s house at Herinneringscentrum Westerbork is a case in point and can be placed in different ... Commander’s House App’, provides a concise technical description of the actual application and presents ...

    Abstract An important goal of the project Accessing Campscapes: inclusive strategies for using European Conflicted Heritage (iC-ACCESS), has been to develop inclusive approaches for the presentation and communication of contending perspectives on Nazi and Stalinist sites (Dolghin et al. 2017). A key objective for treating these ‘heritagescapes’ has been to ‘develop state-of-the-art strategies and implement innovative tools which provide sustainable in-situ and virtual forms of investigation, presentation and representation’ (Van der Laarse 2020). A central issue which is gaining increasing attention in heritage studies and management is the dilemma of preserving and exhibiting material remnants of Wehrmacht and SS-barracks or residencies at Holocaust memorial camps which are generally framed as victimhood sites. The Commander’s house at Herinneringscentrum Westerbork is a case in point and can be placed in different perspectives on the history of the camp terrain and all related sensibilities on its meaning as an object of heritage. In order to realise an application that can accommodate these perspectives, iC-ACCESS project leader Prof. dr. R. van der Laarse contracted two laboratories specialised consecutively in 3D visualisation technologies and spatial information to cooperate on its development, the 4D Research Lab (University of Amsterdam, The Netherlands) and the SPINlab (Vrije Universiteit Amsterdam). This paper illustrates the ideas, discussions and choices related to the production of the ‘Campscapes – Westerbork Commander’s House App’, provides a concise technical description of the actual application and presents a short prospection on potential future developments.
    Keywords Social Sciences ; H
    Subject code 700
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Amsterdam University Press
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book ; Online: Lookahead Diffusion Probabilistic Models for Refining Mean Estimation

    Zhang, Guoqiang / Kenta, Niwa / Kleijn, W. Bastiaan

    2023  

    Abstract: ... that plugging in the additional connection into DDPM, DDIM, DEIS, S-PNDM, and high-order DPM-Solvers leads ...

    Abstract We propose lookahead diffusion probabilistic models (LA-DPMs) to exploit the correlation in the outputs of the deep neural networks (DNNs) over subsequent timesteps in diffusion probabilistic models (DPMs) to refine the mean estimation of the conditional Gaussian distributions in the backward process. A typical DPM first obtains an estimate of the original data sample $\boldsymbol{x}$ by feeding the most recent state $\boldsymbol{z}_i$ and index $i$ into the DNN model and then computes the mean vector of the conditional Gaussian distribution for $\boldsymbol{z}_{i-1}$. We propose to calculate a more accurate estimate for $\boldsymbol{x}$ by performing extrapolation on the two estimates of $\boldsymbol{x}$ that are obtained by feeding $(\boldsymbol{z}_{i+1},i+1)$ and $(\boldsymbol{z}_{i},i)$ into the DNN model. The extrapolation can be easily integrated into the backward process of existing DPMs by introducing an additional connection over two consecutive timesteps, and fine-tuning is not required. Extensive experiments showed that plugging in the additional connection into DDPM, DDIM, DEIS, S-PNDM, and high-order DPM-Solvers leads to a significant performance gain in terms of FID score.

    Comment: accepted by CVPR, 2023
    Keywords Computer Science - Artificial Intelligence ; Computer Science - Machine Learning
    Subject code 519
    Publishing date 2023-04-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Book: On the (S - 1, S) lost sales inventory model with priority demand classes

    Dekker, Rommert / Hill, R. M / Kleijn, Marcel J

    (Discussion paper : Tinbergen Institute ; 97,114 ; Discussion paper / Tinbergen Institute : Tinbergen Institute ; 97,114 : 4, Econometrics)

    1997  

    Author's details R. Dekker ; R. M. Hill ; M. J. Kleijn
    Series title Discussion paper : Tinbergen Institute ; 97,114
    Discussion paper / Tinbergen Institute : Tinbergen Institute ; 97,114 : 4, Econometrics
    Keywords Lagerhaltungsmodell ; Theorie
    Language English
    Size 18 S. : graph. Darst
    Document type Book
    Database ECONomics Information System

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  7. Book ; Online: On the (S-1, S) lost sales inventory model with priority demand classes

    Dekker, Rudolf / Hill, R. M / Kleijn, Marcel J

    (Discussion paper / Tinbergen Institute : 4 ; 1997,114)

    1997  

    Abstract: ... is analysed. We consider a lot-for-lot or (S-1,S) inventory model with lost sales.For each demand ...

    Author's details R. Dekker; R. M. Hill; M. J. Kleijn
    Series title Discussion paper / Tinbergen Institute : 4 ; 1997,114
    Abstract In this paper an inventory model with several demand classes, prioritised according to importance, is analysed. We consider a lot-for-lot or (S-1,S) inventory model with lost sales.For each demand class there is a critical stock level at and below which demand from that class is not satisfied from stock on hand. In this way stock is retained to meet demand from higher priority demand classes. A set of such critical levels determines the stocking policy. For Poisson demand and a generally distributed lead time we derive expressions for the service levels for each demand class and the average total cost per unit time. Efficient solution methods for obtaining optimal policies, with and withoutservice level constraints, are presented. Numerical experiments in which the solution methods are tested demonstrate that significant cost reductions can be achieved by distinguishing between demand classes.
    Keywords Inventory ; demand classes ; spare parts ; lost sales ; rationing
    Language English
    Size Online-Ressource (18 S.), graph. Darst.
    Publisher Tinbergen Inst
    Publishing place Rotterdam u.a.
    Document type Book ; Online
    Database ECONomics Information System

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  8. Article ; Online: Factors Affecting Adherence, Intake, and Perceived Palatability of Oral Nutritional Supplements: A Literature Review.

    Lester, S / Kleijn, M / Cornacchia, L / Hewson, L / Taylor, M A / Fisk, I

    The journal of nutrition, health & aging

    2022  Volume 26, Issue 7, Page(s) 663–674

    Abstract: Oral nutritional supplements (ONS) are a clinically effective and relatively inexpensive way to supplement the diet of patients with, or at risk of, undernutrition. Good adherence is a primary determinant of the effectiveness of ONS. However adherence ... ...

    Abstract Oral nutritional supplements (ONS) are a clinically effective and relatively inexpensive way to supplement the diet of patients with, or at risk of, undernutrition. Good adherence is a primary determinant of the effectiveness of ONS. However adherence can be problematic for those with the greatest clinical need, such as undernourished older adults. This review aimed to appraise the available literature for the factors (contextual, personal and product related) affecting patient adherence and perceived palatability of ONS, identify areas requiring improvement and uncover gaps in the evidence to guide the focus of future research. Contextual factors identified were healthcare staff and the timing of administration. Personal factors included sensory changes and motivation which alter experience of and desire to consume ONS. The product's sensory characteristics determined palatability and intake, but undesirable attributes, such as off-flavours, can stem from nutritional ingredients. The contribution made by aroma to older adults' experience of ONS was a comparatively under-researched area. Further research should address this evidence gap to optimise the flavour, aroma profile and palatability for undernourished older consumers, thereby optimising intake. A combined multidisciplinary effort involving strategic expansion of research, industry development and clinical practice should simultaneously address the factors identified, to provide the best approach to improve adherence.
    MeSH term(s) Administration, Oral ; Aged ; Diet ; Dietary Supplements ; Humans ; Malnutrition/prevention & control ; Nutritional Status ; Patient Compliance
    Language English
    Publishing date 2022-06-16
    Publishing country France
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2081921-3
    ISSN 1760-4788 ; 1279-7707
    ISSN (online) 1760-4788
    ISSN 1279-7707
    DOI 10.1007/s12603-022-1819-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7466: Show issues

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  9. Article ; Online: Blood biomarkers for the differentiation between central and peripheral vertigo in the emergency department: a systematic review and meta-analysis.

    Klokman, Vincent W / Koningstein, Fiona N / Dors, Job W W / Sanders, Marieke S / Koning, Sam W / de Kleijn, Dominique P V / Jie, Kim E

    Academic emergency medicine : official journal of the Society for Academic Emergency Medicine

    2024  Volume 31, Issue 4, Page(s) 371–385

    Abstract: Background/introduction: In patients with acute vestibular syndrome (AVS), differentiating between stroke and nonstroke causes is challenging in the emergency department (ED). Correct diagnosis of vertigo etiology is essential for early optimum ... ...

    Abstract Background/introduction: In patients with acute vestibular syndrome (AVS), differentiating between stroke and nonstroke causes is challenging in the emergency department (ED). Correct diagnosis of vertigo etiology is essential for early optimum treatment and disposition.
    Objectives: The aim of this systematic review and meta-analysis was to summarize the published evidence on the potential of blood biomarkers in the diagnosis and differentiation of peripheral from central causes of AVS.
    Methods: A literature search was conducted for studies published until January 1, 2023, in PubMed, Ovid Medline, and EMBASE databases analyzing biomarkers for the differentiation between central and peripheral AVS. The Quality Assessment of Diagnostic Accuracy Studies questionnaire 2 was used for quality assessment. Pooled standardized mean difference and 95% confidence intervals were calculated if a biomarker was reported in two or more studies. Heterogeneity among included studies was investigated using the I
    Results: A total of 17 studies with 859 central and 4844 peripheral causes of acute dizziness or vertigo, and analysis of 61 biomarkers were included. The general laboratory markers creatinine, blood urea nitrogen, albumin, C-reactive protein, glucose, HbA1c, leukocyte counts, and neutrophil counts and the brain-derived biomarkers copeptin, S100 calcium-binding protein β (S100β), and neuron-specific enolase (NSE) significantly differentiated central from peripheral causes of AVS.
    Conclusions: This systematic review and meta-analysis highlights the potential of generalized inflammatory markers and brain-specific blood protein markers of NSE and S100β as diagnostic biomarkers for central from peripheral differentiation in AVS. These results, as a complement to clinical characteristics, provide guidance for future large-scale diagnostic research, in this challenging ED patient population.
    MeSH term(s) Humans ; Vertigo/diagnosis ; Vertigo/etiology ; Vestibular Diseases/complications ; Stroke/diagnosis ; Biomarkers ; Emergency Service, Hospital ; Dizziness
    Chemical Substances Biomarkers
    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1329813-6
    ISSN 1553-2712 ; 1069-6563
    ISSN (online) 1553-2712
    ISSN 1069-6563
    DOI 10.1111/acem.14864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4479: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Atherosclerotic Expansive Remodeled Plaques: A Wolf in Sheep’s Clothing

    Pasterkamp, Gerard / Fitzgerald, Peter F. / de Kleijn, Dominique P.V.

    Journal of Vascular Research

    2003  Volume 39, Issue 6, Page(s) 514–523

    Abstract: ... remodeled plaques should be considered as a wolf in sheep’s clothes. Further understanding of the processes ...

    Institution Laboratory of Experimental Cardiology, University Medical Center and the Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands, and Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, Conn., USA
    Abstract Geometric arterial remodeling is an important determinant of luminal narrowing in atherosclerotic disease. Expansive remodeling retards while constrictive remodeling accelerates luminal narrowing by plaque formation. Cross-sectional as well as follow-up studies revealed that expansive remodeling is associated with adverse cardiovascular events and a vulnerable plaque phenotype. Although the relation between expansive remodeling and plaque vulnerability is associative rather than causal, expansively remodeled plaques should be considered as a wolf in sheep’s clothes. Further understanding of the processes that regulate arterial remodeling and plaque rupture may lead to new strategies to responsibly manipulate these processes for the benefit of patient outcomes.
    Keywords Plaque rupture ; Angina ; Arterial remodeling ; Atherosclerosis ; Cardiovascular diseases ; Constrictive remodeling
    Language English
    Publishing date 2003-01-17
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Research Paper
    ZDB-ID 1105259-4
    ISSN 1423-0135 ; 1018-1172
    ISSN (online) 1423-0135
    ISSN 1018-1172
    DOI 10.1159/000067204
    Database Karger publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 513: Show issues Location:
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