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  1. Article ; Online: The Digital Future Is Now.

    Cowie, Martin R / O'Connor, Christopher M

    JACC. Heart failure

    2021  Volume 10, Issue 1, Page(s) 67–69

    MeSH term(s) Forecasting ; Heart Failure ; Humans
    Language English
    Publishing date 2021-11-10
    Publishing country United States
    Document type Editorial
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2021.11.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The Digital Future of Heart Failure Care.

    Cowie, M R / McBeath, K C C / Angermann, C E

    Current heart failure reports

    2022  Volume 19, Issue 3, Page(s) 109–113

    MeSH term(s) Heart Failure/therapy ; Humans ; Patient-Centered Care
    Language English
    Publishing date 2022-04-19
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-022-00547-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Laparoscopic Cholecystectomy with Intraoperative Cholangiogram and Antegrade Biliary Stenting in Acute Gallstone Pancreatitis: A Pilot Study.

    Cowie, Jonathan / Saedon, Mahmud / Brown, Rory / Rate, Anthony

    Journal of laparoendoscopic & advanced surgical techniques. Part A

    2022  Volume 33, Issue 3, Page(s) 236–240

    Abstract: Aims: ...

    Abstract Aims:
    MeSH term(s) Humans ; Gallstones/complications ; Gallstones/surgery ; Cholecystectomy, Laparoscopic/methods ; Pilot Projects ; Retrospective Studies ; Case-Control Studies ; Cholangiography ; Cholangiopancreatography, Endoscopic Retrograde/methods ; Pancreatitis/surgery ; Pancreatitis/complications ; Choledocholithiasis/surgery ; Intraoperative Care
    Language English
    Publishing date 2022-10-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1381909-4
    ISSN 1557-9034 ; 1092-6429
    ISSN (online) 1557-9034
    ISSN 1092-6429
    DOI 10.1089/lap.2022.0227
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: SGLT2 inhibitors: mechanisms of cardiovascular benefit beyond glycaemic control.

    Cowie, Martin R / Fisher, Miles

    Nature reviews. Cardiology

    2020  Volume 17, Issue 12, Page(s) 761–772

    Abstract: Sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic therapies in patients with type 2 diabetes mellitus and are associated with improved glycaemic control as well as with reductions in body mass and blood pressure. In large ... ...

    Abstract Sodium-glucose cotransporter 2 (SGLT2) inhibitors are effective antidiabetic therapies in patients with type 2 diabetes mellitus and are associated with improved glycaemic control as well as with reductions in body mass and blood pressure. In large cardiovascular outcome trials in patients with diabetes, SGLT2 inhibitors improve cardiovascular and renal outcomes, including hospitalization for heart failure, with this benefit extending to patients without diabetes who have heart failure with reduced ejection fraction. The possible mechanisms of benefit are being extensively investigated because they are unlikely to be related to improved glycaemic control. Early natriuresis with a reduction in plasma volume, a consequent rise in haematocrit, improved vascular function, a reduction in blood pressure and changes in tissue sodium handling are all likely to have a role. Additional mechanisms of SGLT2 inhibitors that might be beneficial include a reduction in adipose tissue-mediated inflammation and pro-inflammatory cytokine production, a shift towards ketone bodies as the metabolic substrate for the heart and kidneys, reduced oxidative stress, lowered serum uric acid level, reduced glomerular hyperfiltration and albuminuria, and suppression of advanced glycation end-product signalling. Further outcome trials and mechanistic studies, including in patients with heart failure with preserved ejection fraction or non-diabetic kidney disease, might identify other possible mechanisms of benefit of SGLT2-inhibitor therapy.
    MeSH term(s) Cardiovascular Diseases/drug therapy ; Glycemic Control ; Humans ; Sodium-Glucose Transporter 2 Inhibitors/therapeutic use
    Chemical Substances Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2020-07-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2490375-9
    ISSN 1759-5010 ; 1759-5002
    ISSN (online) 1759-5010
    ISSN 1759-5002
    DOI 10.1038/s41569-020-0406-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Digital Technologies to Support Better Outcome and Experience of Care in Patients with Heart Failure.

    McBeath, K C C / Angermann, C E / Cowie, M R

    Current heart failure reports

    2022  Volume 19, Issue 3, Page(s) 75–108

    Abstract: Purpose of review: In this article, we review a range of digital technologies for possible application in heart failure patients, with a focus on lessons learned. We also discuss a future model of heart failure management, as digital technologies ... ...

    Abstract Purpose of review: In this article, we review a range of digital technologies for possible application in heart failure patients, with a focus on lessons learned. We also discuss a future model of heart failure management, as digital technologies continue to become part of standard care.
    Recent findings: Digital technologies are increasingly used by healthcare professionals and those living with heart failure to support more personalised and timely shared decision-making, earlier identification of problems, and an improved experience of care. The COVID-19 pandemic has accelerated the acceptability and implementation of a range of digital technologies, including remote monitoring and health tracking, mobile health (wearable technology and smartphone-based applications), and the use of machine learning to augment data interpretation and decision-making. Much has been learned over recent decades on the challenges and opportunities of technology development, including how best to evaluate the impact of digital health interventions on health and healthcare, the human factors involved in implementation and how best to integrate dataflows into the clinical pathway. Supporting patients with heart failure as well as healthcare professionals (both with a broad range of health and digital literacy skills) is crucial to success. Access to digital technologies and the internet remains a challenge for some patients. The aim should be to identify the right technology for the right patient at the right time, in a process of co-design and co-implementation with patients.
    MeSH term(s) COVID-19/epidemiology ; Digital Technology ; Heart Failure/therapy ; Humans ; Pandemics ; Telemedicine
    Language English
    Publishing date 2022-04-29
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2151202-4
    ISSN 1546-9549 ; 1546-9530
    ISSN (online) 1546-9549
    ISSN 1546-9530
    DOI 10.1007/s11897-022-00548-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Wearable Sensors to Monitor Physical Activity in Heart Failure Clinical Trials: State-of-the-Art Review.

    Buendia, Ruben / Karpefors, Martin / Folkvaljon, Folke / Hunter, Robert / Sillen, Henrik / Luu, Long / Docherty, Kieran / Cowie, Martin R

    Journal of cardiac failure

    2024  

    Abstract: Background: Estimation of the effects that drugs or other interventions have on patients' symptoms and functions is crucial in heart failure trials. Traditional symptoms and functions clinical outcome assessments have important limitations. Actigraphy ... ...

    Abstract Background: Estimation of the effects that drugs or other interventions have on patients' symptoms and functions is crucial in heart failure trials. Traditional symptoms and functions clinical outcome assessments have important limitations. Actigraphy may help to overcome these limitations due to its objective nature and the potential for continuous recording of data. However, actigraphy is not currently accepted as clinically relevant by key stakeholders.
    Methods and results: In this state-of-the-art study, the key aspects to consider when implementing actigraphy in heart failure trials are discussed. They include which actigraphy-derived measures should be considered, how to build endpoints using them, how to measure and analyze them, and how to handle the patients' and sites' logistics of integrating devices into trials. A comprehensive recommendation based on the current evidence is provided.
    Conclusion: Actigraphy is technically feasible in clinical trials involving heart failure, but successful implementation and use to demonstrate clinically important differences in physical functioning with drug or other interventions require careful consideration of many design choices.
    Language English
    Publishing date 2024-03-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1281194-4
    ISSN 1532-8414 ; 1071-9164
    ISSN (online) 1532-8414
    ISSN 1071-9164
    DOI 10.1016/j.cardfail.2024.01.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Temporal association of ventricular arrhythmias and respiratory events in heart failure patients with central sleep apnoea.

    Guenzler, Valentin / Arzt, Michael / Grimm, Marjorie / Ebert, Amelie / Zeman, Florian / Linz, Dominik / Woehrle, Holger / Tamisier, Renaud / Cowie, Martin / Fisser, Christoph

    Sleep medicine

    2024  Volume 118, Page(s) 59–62

    Abstract: In contrast to obstructive sleep apnoea, the peak of sympathetic tone in central sleep apnoea occurs during the hyperventilation phase. To explore the temporal association of premature ventricular complex (PVC) burden in the context of the apnoea/ ... ...

    Abstract In contrast to obstructive sleep apnoea, the peak of sympathetic tone in central sleep apnoea occurs during the hyperventilation phase. To explore the temporal association of premature ventricular complex (PVC) burden in the context of the apnoea/hypopnoea-hyperpnoea cycle, the duration of apnoea/hypopnoea was defined as 100 %. We assessed the PVC burden throughout the apnoea/hypopnoea-hyperpnoea cycle during the periods of ±150 % in 50 % increments before and after the apnoea/hypopnoea phase. In this subanalysis of 54 SERVE-HF patients, PVC burden was 32 % higher in the late hyperventilation period (50-100 % after apnoea/hypopnoea) compared to the apnoea/hypopnoea phase.
    Language English
    Publishing date 2024-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2012041-2
    ISSN 1878-5506 ; 1389-9457
    ISSN (online) 1878-5506
    ISSN 1389-9457
    DOI 10.1016/j.sleep.2024.04.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Perceived barriers and enablers influencing physical activity in heart failure: A qualitative one-to-one interview study.

    Amirova, Aliya / Lucas, Rebecca / Cowie, Martin R / Haddad, Mark

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0271743

    Abstract: In heart failure (HF), increased physical activity is associated with improved quality of life, reduced hospitalisation, and increased longevity and is an important aim of treatment. However, physical activity levels in individuals living with HF are ... ...

    Abstract In heart failure (HF), increased physical activity is associated with improved quality of life, reduced hospitalisation, and increased longevity and is an important aim of treatment. However, physical activity levels in individuals living with HF are typically extremely low. This qualitative study with one-to-one interviews systematically explores perceived clinical, environmental, and psychosocial barriers and enablers in older adults (≥70 years old) living with HF. Semi-structured interviews (N = 16) based on the Theoretical Domains Framework elicited 39 belief statements describing the barriers and enablers to physical activity. Theoretical domains containing these beliefs and corresponding constructs that were both pervasive and common were deemed most relevant. These were: concerns about physical activity (Beliefs about Consequences), self-efficacy (Beliefs about Capabilities), social support (Social Influences), major health event (Environmental Context and Resources), goal behavioural (Goal), action planning (Behavioural Regulation). This work extends the limited research on the modifiable barriers and enablers for physical activity participation by individuals living with HF. The research findings provide insights for cardiologists, HF-specialist nurses, and physiotherapists to help co-design and deliver a physical activity intervention more likely to be effective for individuals living with HF.
    MeSH term(s) Aged ; Exercise ; Heart Failure/therapy ; Humans ; Motivation ; Qualitative Research ; Quality of Life
    Language English
    Publishing date 2022-08-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0271743
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  9. Article ; Online: From left to right: an unusual presentation of Tolosa-Hunt syndrome with bilateral eye involvement.

    Cowie, Matthew / Duncan, Roderick / Alamri, Yassar

    The New Zealand medical journal

    2021  Volume 134, Issue 1544, Page(s) 175–178

    Abstract: Here we discuss a presentation of Tolosa-Hunt syndrome (THS) in a 44-year-old female with new right-eye ptosis, ophthalmoplegia and headache. Four days prior, she had almost identical ptosis and ophthalmoplegia in her left eye, which resolved. Cavernous ... ...

    Abstract Here we discuss a presentation of Tolosa-Hunt syndrome (THS) in a 44-year-old female with new right-eye ptosis, ophthalmoplegia and headache. Four days prior, she had almost identical ptosis and ophthalmoplegia in her left eye, which resolved. Cavernous sinus inflammation and symptom improvement with glucocorticoid treatment indicated THS with bilateral eye involvement, a presentation which may be undervalued by the current THS classification.
    MeSH term(s) Adult ; Blepharoptosis/etiology ; Cavernous Sinus/pathology ; Female ; Glucocorticoids/therapeutic use ; Headache/etiology ; Humans ; Magnetic Resonance Imaging ; Ophthalmoplegia/etiology ; Tolosa-Hunt Syndrome/diagnosis ; Tolosa-Hunt Syndrome/drug therapy ; Tolosa-Hunt Syndrome/physiopathology ; Treatment Outcome
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2021-10-22
    Publishing country New Zealand
    Document type Case Reports ; Letter
    ZDB-ID 390590-1
    ISSN 1175-8716 ; 0028-8446 ; 0110-7704
    ISSN (online) 1175-8716
    ISSN 0028-8446 ; 0110-7704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Sleep Disordered Breathing and Heart Failure: What Does the Future Hold?

    Cowie, Martin R / Gallagher, Angela M

    JACC. Heart failure

    2017  Volume 5, Issue 10, Page(s) 715–723

    Abstract: Most patients with heart failure (HF) have sleep-disordered breathing (SDB), with central (rather than obstructive) sleep apnea becoming the predominant form in patients with more severe disease. Cyclical apnea and hypopneas are associated with sleep ... ...

    Abstract Most patients with heart failure (HF) have sleep-disordered breathing (SDB), with central (rather than obstructive) sleep apnea becoming the predominant form in patients with more severe disease. Cyclical apnea and hypopneas are associated with sleep disturbance, hypoxemia, hemodynamic changes, and sympathetic activation. These patients have a worse prognosis than those without SDB. Mask-based therapies of positive airway pressure targeted at SDB can improve measures of sleep quality and can partially normalize the sleep and respiratory physiology. However, recent randomized trials of cardiovascular outcomes in central sleep apnea in chronic HF with reduced ejection fraction have had neutral findings or suggested the possibility of harm, likely from an increased rate of sudden death. Further randomized outcome studies are required to determine whether mask-based treatment is appropriate for patients with chronic HF with reduced ejection fraction and obstructive sleep apnea, for patients with heart failure with preserved ejection fraction, and for patients with decompensated heart failure. New therapies for sleep apnea (e.g., implantable phrenic nerve stimulators) also require robust assessment. No longer can the surrogate endpoints of improvement in respiratory and sleep metrics be taken as adequate therapeutic outcome measures in patients with HF and sleep apnea.
    MeSH term(s) Chronic Disease ; Death, Sudden, Cardiac/epidemiology ; Electric Stimulation Therapy ; Heart Failure/complications ; Heart Failure/physiopathology ; Hemodynamics ; Humans ; Hypoxia/complications ; Hypoxia/physiopathology ; Phrenic Nerve ; Positive-Pressure Respiration/methods ; Prognosis ; Severity of Illness Index ; Sleep ; Sleep Apnea Syndromes/complications ; Sleep Apnea Syndromes/physiopathology ; Sleep Apnea Syndromes/therapy ; Sleep Apnea, Central/complications ; Sleep Apnea, Central/physiopathology ; Sleep Apnea, Central/therapy ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/physiopathology ; Sleep Apnea, Obstructive/therapy ; Stroke Volume ; Sympathetic Nervous System/physiopathology ; Treatment Outcome
    Language English
    Publishing date 2017-09-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2017.06.016
    Database MEDical Literature Analysis and Retrieval System OnLINE

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