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  1. Article ; Online: Do Patient-Reported Outcome Measures Tell Us the Full Story?

    Meadows, Keith

    Clinical nursing research

    2022  Volume 31, Issue 2, Page(s) 159–162

    MeSH term(s) Humans ; Patient Reported Outcome Measures
    Language English
    Publishing date 2022-02-05
    Publishing country United States
    Document type Editorial
    ZDB-ID 1146553-0
    ISSN 1552-3799 ; 1054-7738
    ISSN (online) 1552-3799
    ISSN 1054-7738
    DOI 10.1177/10547738221078335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Over the Edge: What Can Imaging Tell Us When the Ejection Fraction Is "Supranormal"?

    Feher, Attila / Meadows, Judith

    JACC. Heart failure

    2022  Volume 10, Issue 8, Page(s) 595–597

    MeSH term(s) Echocardiography/methods ; Heart Failure/diagnostic imaging ; Humans ; Magnetic Resonance Imaging, Cine ; Predictive Value of Tests ; Stroke Volume ; Ventricular Function, Left
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2705621-1
    ISSN 2213-1787 ; 2213-1779
    ISSN (online) 2213-1787
    ISSN 2213-1779
    DOI 10.1016/j.jchf.2022.06.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Story completion (SC) - an epistemological approach to the interpretation of patient-reported outcomes?

    Meadows, Keith A / Reaney, Matt

    Expert review of pharmacoeconomics & outcomes research

    2024  Volume 24, Issue 1, Page(s) 49–56

    Abstract: ... Expert opinion: Story completion (SC) is an epistemological approach involving participants telling a story ...

    Abstract Introduction: Patient-reported outcome measures (PROMs) quantitative data are increasingly accompanied by qualitative narrative data, which does not always provide the insights required to inform healthcare.
    Areas covered: This perspective considers how story completion (SC) may be used to gain a deeper insight on people's experiences and guide interpretation of the meaning of PROM responses.
    Expert opinion: Story completion (SC) is an epistemological approach involving participants telling a story in response to a pre-determined 'stem' they have been presented with.
    MeSH term(s) Humans ; Narration ; Patient Reported Outcome Measures
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2208481-2
    ISSN 1744-8379 ; 1473-7167
    ISSN (online) 1744-8379
    ISSN 1473-7167
    DOI 10.1080/14737167.2023.2268833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Clinical aspects of platelet inhibitors and thrombus formation.

    Meadows, Telly A / Bhatt, Deepak L

    Circulation research

    2007  Volume 100, Issue 9, Page(s) 1261–1275

    Abstract: The platelet, once thought to be solely involved in clot formation, is now known to be a key mediator in various others processes such as inflammation, thrombosis, and atherosclerosis. Supported by the wealth of evidence from clinical trials ... ...

    Abstract The platelet, once thought to be solely involved in clot formation, is now known to be a key mediator in various others processes such as inflammation, thrombosis, and atherosclerosis. Supported by the wealth of evidence from clinical trials demonstrating their benefits in patient outcomes, antiplatelet agents have become paramount in the prevention and management of various diseases involving the cardiovascular, cerebrovascular, and peripheral arterial systems. Despite being among the most widely used and studied classes of medical therapies, new discoveries regarding important clinical aspects and properties of these agents continue to be made. As our understanding of platelet biology expands, more effective and safer novel therapies continue to be developed. The use of more refined agents in conjunction with a better understanding of their effects will further the ability to provide more optimized care on an individual basis.
    MeSH term(s) Aspirin/therapeutic use ; Atherosclerosis/etiology ; Atherosclerosis/prevention & control ; Blood Platelets/physiology ; Cardiovascular Diseases/prevention & control ; Dipyridamole/therapeutic use ; Drug Resistance ; Humans ; Pentanoic Acids/therapeutic use ; Platelet Adhesiveness/drug effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Glycoprotein GPIIb-IIIa Complex/antagonists & inhibitors ; Purinergic P2 Receptor Antagonists ; Pyridines/therapeutic use ; Receptor, PAR-1/antagonists & inhibitors ; Stents/adverse effects ; Tetrazoles/therapeutic use ; Thrombosis/etiology ; Thrombosis/prevention & control ; Thromboxanes/antagonists & inhibitors ; Ticlopidine/analogs & derivatives ; Ticlopidine/therapeutic use
    Chemical Substances Pentanoic Acids ; Platelet Aggregation Inhibitors ; Platelet Glycoprotein GPIIb-IIIa Complex ; Purinergic P2 Receptor Antagonists ; Pyridines ; Receptor, PAR-1 ; Tetrazoles ; Thromboxanes ; Dipyridamole (64ALC7F90C) ; clopidogrel (A74586SNO7) ; cilostazol (N7Z035406B) ; Ticlopidine (OM90ZUW7M1) ; ridogrel (QTS5QOO42O) ; Aspirin (R16CO5Y76E)
    Language English
    Publishing date 2007-05-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/01.RES.0000264509.36234.51
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Ethnic differences in cardiovascular risks and mortality in atherothrombotic disease: insights from the Reduction of Atherothrombosis for Continued Health (REACH) registry.

    Meadows, Telly A / Bhatt, Deepak L / Cannon, Christopher P / Gersh, Bernard J / Röther, Joachim / Goto, Shinya / Liau, Chiau-Suong / Wilson, Peter W F / Salette, Genevieve / Smith, Sidney C / Steg, Ph Gabriel

    Mayo Clinic proceedings

    2011  Volume 86, Issue 10, Page(s) 960–967

    Abstract: Objective: To determine whether ethnic-specific differences in the prevalence of cardiovascular risk factors and outcomes exist worldwide among individuals with stable arterial disease.: Patients and methods: From December 1, 2003, to June 30, 2004, ... ...

    Abstract Objective: To determine whether ethnic-specific differences in the prevalence of cardiovascular risk factors and outcomes exist worldwide among individuals with stable arterial disease.
    Patients and methods: From December 1, 2003, to June 30, 2004, the prospective, observational REduction of Atherothrombosis for Continued Health (REACH) Registry enrolled 49,602 out-patients with coronary artery disease, cerebrovascular disease, and/or peripheral arterial disease from 7 predefined ethnic/racial groups: white, Hispanic, East Asian, South Asian, Other Asian, black, and Other (comprising any race distinct from those specified). The baseline demographic and risk factor profiles, medication use, and 2-year cardiovascular outcomes were assessed among these groups.
    Results: The prevalence of traditional atherothrombotic risk factors varied significantly among the ethnic/racial groups. The use of medical therapies to reduce risk was comparable among all groups. At 2-year follow-up, the rate of cardiovascular death was significantly higher in blacks (6.1%) compared with all other ethnic/racial groups (3.9%; P=.01). Cardiovascular death rates were significantly lower in all 3 Asian ethnic/racial groups (overall, 2.1%) compared with the other groups (4.5%; P<.001).
    Conclusion: The REACH Registry, a large international study of individuals with atherothrombotic disease, documents the important ethnic-specific differences in cardiovascular risk factors and variations in cardiovascular mortality that currently exist worldwide.
    MeSH term(s) Adult ; Aged ; Atherosclerosis/complications ; Atherosclerosis/ethnology ; Atherosclerosis/mortality ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/ethnology ; Cardiovascular Diseases/mortality ; Female ; Humans ; Male ; Middle Aged ; Prevalence ; Prospective Studies ; Registries ; Risk Assessment ; Risk Factors ; Venous Thrombosis/complications ; Venous Thrombosis/ethnology ; Venous Thrombosis/mortality ; Venous Thrombosis/prevention & control
    Language English
    Publishing date 2011-09-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.4065/mcp.2011.0010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Multidetector computed tomographic angiography in planning of reoperative cardiothoracic surgery.

    Kamdar, Apur R / Meadows, Telly A / Roselli, Eric E / Gorodeski, Eiran Z / Curtin, Ronan J / Sabik, Joseph F / Schoenhagen, Paul / White, Richard D / Lytle, Bruce W / Flamm, Scott D / Desai, Milind Y

    The Annals of thoracic surgery

    2008  Volume 85, Issue 4, Page(s) 1239–1245

    Abstract: Background: Redo cardiothoracic surgery is associated with increased morbidity and mortality compared with primary operations. Multidetector computed tomographic angiography (MDCTA) delineates the course of previous coronary artery bypass grafts (CABG) ... ...

    Abstract Background: Redo cardiothoracic surgery is associated with increased morbidity and mortality compared with primary operations. Multidetector computed tomographic angiography (MDCTA) delineates the course of previous coronary artery bypass grafts (CABG) and proximity of mediastinal structures to the chest wall. We sought to determine if high-risk preoperative MDCTA findings were associated with greater use of preventive surgical strategies during redo cardiac surgery in patients with prior CABG.
    Methods: We studied 167 patients (mean age 69 +/- 9 years, 79% men) with prior CABG, referred for redo cardiac surgery, who underwent contrast-enhanced MDCTA to assess CABG location and mediastinal relationship to chest wall. Preoperative risk was determined. Prevalence of high-risk MDCTA findings, use of preventive surgical strategies, frequency of severe intraoperative bleeding, and postoperative mortality were recorded.
    Results: Mean risk score was high (7.5 +/- 3). High-risk MDCTA findings included proximity (<1 cm) of right ventricle/aorta to chest wall (24%) or CABG crossing midline in close proximity (<1 cm anteroposteriorly) to sternum (38%). Preventive surgical strategies included surgery cancelled (4%), nonmidline incision (8%), deep hypothermic circulatory arrest (5%), initiation of peripheral cardiopulmonary bypass (11%) and extrathoracic vascular exposure before incision (53%). These strategies were used at a higher frequency in patients with high-risk MDCTA findings versus those without (88% versus 28%, p < 0.0001). Frequency of severe bleeding, graft injuries, and 1-month mortality were 4.4%, 5%, and 2.5%, respectively.
    Conclusions: Routine use of preoperative MDCTA to detect high-risk findings has a strong association with adoption of preventive surgical strategies in high-risk patients undergoing redo cardiac surgery.
    MeSH term(s) Aged ; Cardiac Surgical Procedures/methods ; Cohort Studies ; Contrast Media/pharmacology ; Coronary Angiography/methods ; Coronary Artery Bypass/adverse effects ; Coronary Artery Bypass/methods ; Coronary Stenosis/diagnostic imaging ; Coronary Stenosis/surgery ; Female ; Follow-Up Studies ; Graft Occlusion, Vascular/diagnostic imaging ; Graft Occlusion, Vascular/etiology ; Graft Occlusion, Vascular/mortality ; Graft Occlusion, Vascular/surgery ; Humans ; Male ; Middle Aged ; Patient Care Planning/organization & administration ; Preoperative Care/methods ; Probability ; Reoperation/methods ; Retrospective Studies ; Risk Assessment ; Sensitivity and Specificity ; Survival Analysis ; Tomography, X-Ray Computed/methods ; Treatment Outcome
    Chemical Substances Contrast Media
    Language English
    Publishing date 2008-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2007.11.075
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Ethnic differences in the prevalence and treatment of cardiovascular risk factors in US outpatients with peripheral arterial disease: insights from the reduction of atherothrombosis for continued health (REACH) registry.

    Meadows, Telly A / Bhatt, Deepak L / Hirsch, Alan T / Creager, Mark A / Califf, Robert M / Ohman, E Magnus / Cannon, Christopher P / Eagle, Kim A / Alberts, Mark J / Goto, Shinya / Smith, Sidney C / Wilson, Peter W F / Watson, Karol E / Steg, P Gabriel

    American heart journal

    2009  Volume 158, Issue 6, Page(s) 1038–1045

    Abstract: Background: Prior investigations to define ethnic-related differences in the risks, medical treatment, and outcomes of patients with peripheral arterial disease (PAD) have been limited.: Methods: The impact of ethnicity on the risk factor profiles, ... ...

    Abstract Background: Prior investigations to define ethnic-related differences in the risks, medical treatment, and outcomes of patients with peripheral arterial disease (PAD) have been limited.
    Methods: The impact of ethnicity on the risk factor profiles, use of evidence-based medical therapies, and 2-year cardiovascular outcomes were investigated in 2,168 individuals (blacks n = 237, Hispanics n = 115, whites n = 1,816) from the United States with PAD from the international Reduction of Atherothrombosis for Continued Health Registry.
    Results: Blacks and Hispanics were more likely to have diabetes mellitus and hypertension, whereas whites had a higher rate of diagnosed hypercholesterolemia. Control of blood pressure and cholesterol levels differed significantly in the groups at baseline: elevated blood pressure was present in 55% of blacks versus 48% of Hispanics versus 38% of whites (P < .01), whereas 41% of blacks versus 31% of Hispanics versus 25% of whites had elevated total cholesterol (P < .01). Aspirin use (62% of blacks vs 68% of Hispanics vs 72% of whites, P < .01) and statin use (72% of blacks vs 68% of Hispanics vs 77% of whites, P = .03) also varied significantly. In this context, rates by ethnicity for cardiovascular death, myocardial infarction, or stroke seemed to be no different at 2 years, at 8.8% for the total population: 11.6% for blacks, 8.5% for whites, and 5.0% for Hispanics (P = .32). Fewer blacks (0.6%) had undergone peripheral arterial bypass surgery compared with whites (3.4%) and Hispanics (5.2%) (P = .02).
    Conclusions: Ethnic-related differences have been documented in the prevalence and treatment of several atherosclerotic risk factors known to be associated with PAD, including a variation in the use of surgical revascularization procedures.
    MeSH term(s) African Americans ; Aged ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Cardiovascular Diseases/therapy ; European Continental Ancestry Group ; Female ; Hispanic Americans ; Humans ; Male ; Outpatients ; Peripheral Vascular Diseases/complications ; Peripheral Vascular Diseases/epidemiology ; Peripheral Vascular Diseases/therapy ; Prevalence ; Registries ; Risk Factors ; United States
    Language English
    Publishing date 2009-12
    Publishing country United States
    Document type Comparative Study ; Journal Article
    ZDB-ID 80026-0
    ISSN 1097-6744 ; 0002-8703
    ISSN (online) 1097-6744
    ISSN 0002-8703
    DOI 10.1016/j.ahj.2009.09.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: So you want to do research? 2: developing the research question.

    Meadows, Keith A

    British journal of community nursing

    2003  Volume 8, Issue 9, Page(s) 397–403

    Abstract: ... to tell us very much. Developing a tightly focused research question or hypothesis defines how and ...

    Abstract The development of the research question for a study can be where a lot of research fails. Without a well-defined and specific research question or hypothesis, findings from the research are unlikely to tell us very much. Developing a tightly focused research question or hypothesis defines how and what data is collected and analysed and provides a context for the results. This article, the second in a series of six, focuses on the process of developing a research question or hypothesis from the initial idea through to the final research question, using examples to illustrate the key principles. Approaches to reviewing the literature, including hand searching and the use of electronic sources, are described together with their different strengths and weaknesses. An overview of the deductive and inductive approaches to research are described, as well as the underlying rationale of the null hypothesis and one and two-tailed tests. Finally, issues around the feasibility of the study, including cost, time and relevance, are discussed in relationship to developing the research question or hypothesis.
    MeSH term(s) Humans ; Nursing Research/methods ; Research Design
    Language English
    Publishing date 2003-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2146386-4
    ISSN 1462-4753
    ISSN 1462-4753
    DOI 10.12968/bjcn.2003.8.9.11572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Multimodality Imaging Involving Magnetic Resonance Facilitates Giant Symptomatic Myxoma Resection.

    Hur, David J / Prescher, Lindsey M / Meadows, Judith L / Pfau, Steven E / Homer, Robert J / Tellides, George / Yun, James J

    The Annals of thoracic surgery

    2018  Volume 107, Issue 1, Page(s) e15–e17

    Abstract: Myxoma, the most common adult primary cardiac tumor, can manifest with profound symptoms. The preferred treatment of symptomatic myxoma is surgical resection, which can be curative. Preoperatively, multimodality imaging provides crucial information on ... ...

    Abstract Myxoma, the most common adult primary cardiac tumor, can manifest with profound symptoms. The preferred treatment of symptomatic myxoma is surgical resection, which can be curative. Preoperatively, multimodality imaging provides crucial information on the number, size, location, and proximity of myxoma or myxomas to adjacent structures, thereby facilitating an optimal operative approach. This report presents a case of symptomatic, giant left atrial myxoma and the utility of multimodality imaging to guide surgical planning.
    MeSH term(s) Echocardiography ; Heart Neoplasms/diagnostic imaging ; Heart Neoplasms/surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multimodal Imaging ; Myxoma/diagnostic imaging ; Myxoma/surgery ; Tomography, X-Ray Computed
    Language English
    Publishing date 2018-07-02
    Publishing country Netherlands
    Document type Case Reports ; Journal Article
    ZDB-ID 211007-6
    ISSN 1552-6259 ; 0003-4975
    ISSN (online) 1552-6259
    ISSN 0003-4975
    DOI 10.1016/j.athoracsur.2018.05.083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book: The Comanche code talkers of World War II

    Meadows, William C

    2002  

    Abstract: This book tells the full story of the Comanche Code Talkers for the first time. Drawing ...

    Author's details William C. Meadows
    Abstract This book tells the full story of the Comanche Code Talkers for the first time. Drawing on interviews with all surviving members of the unit, their original training officer, and fellow soldiers, as well as military records and news accounts, the author follows the group from their recruitment and training to their active duty in World War II and on through their postwar lives up to present. He also provides the first comparison of Native American code talking programs, comparing the Comanche Code Talkers with their better-known Navajo counterparts in the Pacific and with other Native American code talking in World Wars I and II, identifying two distinct forms of Native American code talking, examining the attitudes of the American military toward Native American code talkers, and assessing the complex cultural factors that led Comanche and other Native Americans to serve their country in this way.
    MeSH term(s) World War II ; Indians, North American ; Military Personnel
    Keywords United States
    Language English
    Size xxvi, 280 pages, [13] pages of plates :, illustrations cm
    Edition 1st ed.
    Publisher University of Texas Press
    Publishing place Austin
    Document type Book
    ISBN 0292752636 ; 9780292752634 ; 0292752741 ; 9780292752740
    Database Catalogue of the US National Library of Medicine (NLM)

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