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Article: Tenascin C in Lung Diseases.

Donovan, Chantal / Bai, Xu / Chan, Yik Lung / Feng, Min / Ho, Kin-Fai / Guo, Hai / Chen, Hui / Oliver, Brian G

2023 Volume 12, Issue 2

Abstract: Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous ...

Abstract	Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous cellular processes in embryonic development and can be increased in disease, or under conditions of trauma or cell stress in adults. However, the role of TNC in lung diseases remains unclear. In this study, we investigated the expression of TNC during development, in offspring following maternal particulate matter (PM) exposure, asthma, chronic obstructive pulmonary disease (COPD) and lung cancer.
Language	English
Publishing date	2023-01-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12020199
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Tetradentate C

Kwok, Wing-Kei / Li, Lok-Kwan / Lai, Shiu-Lun / Leung, Ming-Yi / Tang, Wai Kit / Cheng, Shun-Cheung / Tang, Man-Chung / Cheung, Wai-Lung / Ko, Chi-Chiu / Chan, Mei-Yee / Yam, Vivian Wing-Wah

Journal of the American Chemical Society

2023 Volume 145, Issue 17, Page(s) 9584–9595

Abstract: A new class of thermally activated delayed fluorescence (TADF) tetradentate C ...

Abstract	A new class of thermally activated delayed fluorescence (TADF) tetradentate C
Language	English
Publishing date	2023-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.2c13820
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Article ; Online: Trialkylphosphonium Oxoborate as C(sp

Leung, Vincent Ming-Yau / Pook, Chun-Man / Chan, Tsz-Chun / Yeung, Ying-Yeung

Chemistry, an Asian journal

2024 Volume 19, Issue 4, Page(s) e202300981

Abstract: We have developed a catalytic protocol for Diels-Alder reaction using trialkylphosphonium oxoborates as oxyanion hole catalysts. The reaction can be operated under ambient conditions. Dienes could easily polymerize under acidic condition. Nonetheless, ... ...

Abstract	We have developed a catalytic protocol for Diels-Alder reaction using trialkylphosphonium oxoborates as oxyanion hole catalysts. The reaction can be operated under ambient conditions. Dienes could easily polymerize under acidic condition. Nonetheless, these acid-sensitive substrates are compatible with the catalytic protocol and the reaction scope covers a wide range of substrates.
Language	English
Publishing date	2024-01-04
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2233006-9
ISSN	1861-471X ; 1861-4728
ISSN (online)	1861-471X
ISSN	1861-4728
DOI	10.1002/asia.202300981
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Dcp2 C-terminal

He, Feng / Wu, Chan / Jacobson, Allan

eLife

2022 Volume 11

Abstract: ... elusive. Through extensive genetic analyses we reveal that Dcp2 C-terminal domain ...

Abstract	A single Dcp1-Dcp2 decapping enzyme targets diverse classes of yeast mRNAs for decapping-dependent 5' to 3' decay, but the molecular mechanisms controlling mRNA selectivity by the enzyme remain elusive. Through extensive genetic analyses we reveal that Dcp2 C-terminal domain
MeSH term(s)	DEAD-box RNA Helicases/metabolism ; Endoribonucleases/metabolism ; Nonsense Mediated mRNA Decay ; RNA Stability/genetics ; RNA, Messenger/metabolism ; RNA-Binding Proteins/metabolism ; Ribonucleoproteins/metabolism ; Saccharomyces cerevisiae/genetics ; Saccharomyces cerevisiae/metabolism ; Saccharomyces cerevisiae Proteins/genetics ; Saccharomyces cerevisiae Proteins/metabolism
Chemical Substances	PAT1 protein, S cerevisiae ; RNA, Messenger ; RNA-Binding Proteins ; Ribonucleoproteins ; Saccharomyces cerevisiae Proteins ; Scd6 protein, S cerevisiae ; mRNA decapping enzymes ; DCP2 protein, S cerevisiae (EC 3.1.-) ; Endoribonucleases (EC 3.1.-) ; DHH1 protein, S cerevisiae (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13)
Language	English
Publishing date	2022-05-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2687154-3
ISSN	2050-084X ; 2050-084X
ISSN (online)	2050-084X
ISSN	2050-084X
DOI	10.7554/eLife.74410
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Article ; Online: Tenascin C in Lung Diseases

Donovan, Chantal / Bai, Xu / Chan, Yik Lung / Feng, Min / Ho, Kin-Fai / Guo, Hai / Chen, Hui / Oliver, Brian G.

Biology (Basel). 2023 Jan. 28, v. 12, no. 2

2023

Abstract: Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous ...

Abstract	Tenascin C (TNC) is a multifunctional large extracellular matrix protein involved in numerous cellular processes in embryonic development and can be increased in disease, or under conditions of trauma or cell stress in adults. However, the role of TNC in lung diseases remains unclear. In this study, we investigated the expression of TNC during development, in offspring following maternal particulate matter (PM) exposure, asthma, chronic obstructive pulmonary disease (COPD) and lung cancer. TNC expression is increased during lung development in biopsy cells, endothelial cells, mesenchymal cells, and epithelial cells. Maternal PM exposure increased TNC and collagen deposition, which was not affected by the removal of PM exposure after pregnancy. TNC expression was also increased in basal epithelial cells and fibroblasts in patients with asthma and AT2 and endothelial cells in patients with COPD. Furthermore, there was an increase in the expression of TNC in stage II compared to stage IA lung cancer; however, overall survival analysis showed no correlation between levels of TNC and survival. In conclusion, TNC is increased during lung development, in offspring following maternal PM exposure, and in asthma, COPD, and lung cancer tissues. Therefore, targeting TNC may provide a novel therapeutic target for lung diseases.
Keywords	asthma ; biopsy ; collagen ; embryogenesis ; epithelium ; extracellular matrix ; fibroblasts ; lung neoplasms ; lungs ; particulates ; pregnancy ; progeny
Language	English
Dates of publication	2023-0128
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2661517-4
ISSN	2079-7737
ISSN	2079-7737
DOI	10.3390/biology12020199
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Identification of a novel A allele with a nucleotide deletion c.198delG in the ABO gene associated with A

Zheng, Haixiao / Peng, Chan / Wang, Min / Hong, Qinhan / Hua, Lin

Transfusion

2024 Volume 64, Issue 4, Page(s) E16–E17

MeSH term(s)	Humans ; Alleles ; Nucleotides ; Phenotype ; ABO Blood-Group System/genetics ; Genotype
Chemical Substances	Nucleotides ; ABO Blood-Group System
Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	208417-x
ISSN	1537-2995 ; 0041-1132
ISSN (online)	1537-2995
ISSN	0041-1132
DOI	10.1111/trf.17753
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Article ; Online: Reply to E.C. Dee et al.

Koczwara, Bogda / Chan, Alexandre / Jefford, Michael / Lam, Wendy W T / Taylor, Carolyn / Wakefield, Claire E / Pathy, Nirmala Bhoo / Gyawali, Bishal / Harvet, Gregory / Lou, Yan / Pramesh, C S / Takahashi, Miyako / Yu, Ke / Chan, Raymond J

JCO global oncology

2023 Volume 9, Page(s) e2300102

Language	English
Publishing date	2023-06-06
Publishing country	United States
Document type	Journal Article
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.23.00102
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Article ; Online: Predicting the risk of pulmonary infection in patients with chronic kidney failure: A-C

Deng, Wenqian / Liu, Chen / Cheng, Qianhui / Yang, Jingwen / Chen, Wenwen / Huang, Yao / Hu, Yu / Guan, Jiangan / Weng, Jie / Wang, Zhiyi / Chen, Chan

International urology and nephrology

2024

Abstract: ... and 583 individuals comprising the validation group. Three different models, namely Models A, B, and C ... Ultimately, a statistical knowledge-driven model was selected, which exhibited a C-statistic of 0.891 (0.855 ... demonstrated good calibration. Additionally, Model A displayed a satisfactory C-statistic of 0.883 (0.856-0.911 ...

Abstract	Purpose: The objective of this study is to investigate the associated risk factors of pulmonary infection in individuals diagnosed with chronic kidney disease (CKD). The primary goal is to develop a predictive model that can anticipate the likelihood of pulmonary infection during hospitalization among CKD patients. Methods: This retrospective cohort study was conducted at two prominent tertiary teaching hospitals. Three distinct models were formulated employing three different approaches: (1) the statistics-driven model, (2) the clinical knowledge-driven model, and (3) the decision tree model. The simplest and most efficient model was obtained by comparing their predictive power, stability, and practicability. Results: This study involved a total of 971 patients, with 388 individuals comprising the modeling group and 583 individuals comprising the validation group. Three different models, namely Models A, B, and C, were utilized, resulting in the identification of seven, four, and eleven predictors, respectively. Ultimately, a statistical knowledge-driven model was selected, which exhibited a C-statistic of 0.891 (0.855-0.927) and a Brier score of 0.012. Furthermore, the Hosmer-Lemeshow test indicated that the model demonstrated good calibration. Additionally, Model A displayed a satisfactory C-statistic of 0.883 (0.856-0.911) during external validation. The statistical-driven model, known as the A-C2GH2S risk score (which incorporates factors such as albumin, C2 [previous COPD history, blood calcium], random venous blood glucose, H2 [hemoglobin, high-density lipoprotein], and smoking), was utilized to determine the risk score for the incidence rate of lung infection in patients with CKD. The findings revealed a gradual increase in the occurrence of pulmonary infections, ranging from 1.84% for individuals with an A-C2GH2S Risk Score ≤ 6, to 93.96% for those with an A-C2GH2S Risk Score ≥ 18.5. Conclusion: A predictive model comprising seven predictors was developed to forecast pulmonary infection in patients with CKD. This model is characterized by its simplicity, practicality, and it also has good specificity and sensitivity after verification.
Language	English
Publishing date	2024-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	204048-7
ISSN	1573-2584 ; 0301-1623 ; 0042-1162
ISSN (online)	1573-2584
ISSN	0301-1623 ; 0042-1162
DOI	10.1007/s11255-024-03953-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Photoredox Cleavage of a C

Liao, Ke / Chan, Cho Ying / Liu, Siqi / Zhang, Xinhao / Chen, Jiean / Huang, Yong

Journal of the American Chemical Society

2023 Volume 145, Issue 22, Page(s) 12284–12292

Abstract: ... chemistry, the selective cleavage of inert C ...

Abstract	Functionalizing molecules through the selective cleavage of carbon-carbon bonds is an attractive approach in synthetic chemistry. Despite recent advances in both transition-metal catalysis and radical chemistry, the selective cleavage of inert C
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c02745
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Article ; Online: Systematic approaches to C-lignin engineering in Medicago truncatula.

Ha, Chan Man / Escamilla-Trevino, Luis / Zhuo, Chunliu / Pu, Yunqiao / Bryant, Nathan / Ragauskas, Arthur J / Xiao, Xirong / Li, Ying / Chen, Fang / Dixon, Richard A

Biotechnology for biofuels and bioproducts

2023 Volume 16, Issue 1, Page(s) 100

Abstract: Background: C-lignin is a homopolymer of caffeyl alcohol present in the seed coats of a variety ... Because of its unique chemical and physical properties, there is considerable interest in engineering C-lignin ... from a transcriptomic analysis of developing C. hassleriana seed coats to suggest strategies for engineering C-lignin ...

Abstract	Background: C-lignin is a homopolymer of caffeyl alcohol present in the seed coats of a variety of plant species including vanilla orchid, various cacti, and the ornamental plant Cleome hassleriana. Because of its unique chemical and physical properties, there is considerable interest in engineering C-lignin into the cell walls of bioenergy crops as a high-value co-product of bioprocessing. We have used information from a transcriptomic analysis of developing C. hassleriana seed coats to suggest strategies for engineering C-lignin in a heterologous system, using hairy roots of the model legume Medicago truncatula. Results: We systematically tested strategies for C-lignin engineering using a combination of gene overexpression and RNAi-mediated knockdown in the caffeic acid/5-hydroxy coniferaldehyde 3/5-O-methyltransferase (comt) mutant background, monitoring the outcomes by analysis of lignin composition and profiling of monolignol pathway metabolites. In all cases, C-lignin accumulation required strong down-regulation of caffeoyl CoA 3-O-methyltransferase (CCoAOMT) paired with loss of function of COMT. Overexpression of the Selaginella moellendorffii ferulate 5-hydroxylase (SmF5H) gene in comt mutant hairy roots resulted in lines that unexpectedly accumulated high levels of S-lignin. Conclusion: C-Lignin accumulation of up to 15% of total lignin in lines with the greatest reduction in CCoAOMT expression required the strong down-regulation of both COMT and CCoAOMT, but did not require expression of a heterologous laccase, cinnamyl alcohol dehydrogenase (CAD) or cinnamoyl CoA reductase (CCR) with preference for 3,4-dihydroxy-substituted substrates in M. truncatula hairy roots. Cell wall fractionation studies suggested that the engineered C-units are not present in a heteropolymer with the bulk of the G-lignin.
Language	English
Publishing date	2023-06-12
Publishing country	England
Document type	Journal Article
ISSN	2731-3654
ISSN (online)	2731-3654
DOI	10.1186/s13068-023-02339-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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