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Article ; Online: Endogenous retrovirus activation: potential for immunology and clinical applications.

Yu, Jundan / Qiu, Peishan / Ai, Jingwen / Liu, Bo / Han, Guan-Zhu / Zhu, Fan / Zhang, Wenhong / Cui, Jie

2024 Volume 11, Issue 4, Page(s) nwae034

Language	English
Publishing date	2024-01-25
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwae034
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Article ; Online: Anticancer activity of four trinuclear cobalt complexes bearing bis(salicylidene)-1,3-propanediamine derivatives.

Zhao, Peishan / Liu, Dongcheng / Hu, Huancheng / Qiu, Zhihui / Liang, Yuning / Chen, Zilu

Journal of inorganic biochemistry

2022 Volume 233, Page(s) 111860

Abstract: Schiff base and its complexes are being paid more and more interests for their great prospects in biological applications. We reported here four cobalt(II) complexes [ ... ...

Abstract	Schiff base and its complexes are being paid more and more interests for their great prospects in biological applications. We reported here four cobalt(II) complexes [Co
MeSH term(s)	Cobalt ; Coordination Complexes/pharmacology ; Diamines/pharmacology ; Schiff Bases/pharmacology
Chemical Substances	Coordination Complexes ; Diamines ; Schiff Bases ; Cobalt (3G0H8C9362) ; trimethylenediamine (CB3ISL56KG)
Language	English
Publishing date	2022-05-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	162843-4
ISSN	1873-3344 ; 0162-0134
ISSN (online)	1873-3344
ISSN	0162-0134
DOI	10.1016/j.jinorgbio.2022.111860
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Article ; Online: The Eph/ephrin system symphony of gut inflammation.

Qiu, Peishan / Li, Daojiang / Xiao, Cong / Xu, Fei / Chen, Xiaoyu / Chang, Ying / Liu, Lan / Zhang, Lei / Zhao, Qiu / Chen, Yuhua

Pharmacological research

2023 Volume 197, Page(s) 106976

Abstract: The extent of gut inflammation depends largely on the gut barrier's integrity and enteric neuroimmune interactions. However, the factors and molecular mechanisms that regulate inflammation-related changes in the enteric nervous system (ENS) remain ... ...

Abstract	The extent of gut inflammation depends largely on the gut barrier's integrity and enteric neuroimmune interactions. However, the factors and molecular mechanisms that regulate inflammation-related changes in the enteric nervous system (ENS) remain largely unexplored. Eph/ephrin signaling is critical for inflammatory response, neuronal activation, and synaptic plasticity in the brain, but its presence and function in the ENS have been largely unknown to date. This review discusses the critical role of Eph/ephrin in regulating gut homeostasis, inflammation, neuroimmune interactions, and pain pathways. Targeting the Eph/ephrin system offers innovative treatments for gut inflammation disorders, offering hope for enhanced patient prognosis, pain management, and overall quality of life.
MeSH term(s)	Humans ; Quality of Life ; Brain ; Ephrins ; Homeostasis ; Inflammation
Chemical Substances	Ephrins
Language	English
Publishing date	2023-10-29
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	1003347-6
ISSN	1096-1186 ; 0031-6989 ; 1043-6618
ISSN (online)	1096-1186
ISSN	0031-6989 ; 1043-6618
DOI	10.1016/j.phrs.2023.106976
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Zs.A 721: Show issues

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Article ; Online: Comprehensive analysis of the relationship between cuproptosis-related gene GCSH and prognosis, tumor microenvironment infiltration, and therapy response in endometrial cancer.

Zhao, Mengya / Nie, Haihang / Qiu, Peishan / Yu, Yali / Wang, Haizhou / Wang, Fan / Fang, Jun / Zhao, Qiu

Oncology

2023

Abstract: Background: Cuproptosis, a novel form of cell death regulated by protein lipoylation and implicated in mitochondrial metabolism. However, the impact of the cuproptosis-related gene γ-glutamylcysteine synthetase (GCSH) on endometrial cancer (EC) ... ...

Abstract	Background: Cuproptosis, a novel form of cell death regulated by protein lipoylation and implicated in mitochondrial metabolism. However, the impact of the cuproptosis-related gene γ-glutamylcysteine synthetase (GCSH) on endometrial cancer (EC) prognosis, tumor immune microenvironment, and therapeutic response remains to be further researched. Methods: The differential expression of GCSH between endometrial cancer and normal tissues was analyzed using multiple public databases. Additionally, cancer and adjacent tissues were prospectively collected from 17 EC patients, and immunohistochemical analysis was performed to further investigate GCSH expression differences. The relationship between GCSH and the prognosis and clinicopathological characteristics of EC patients was evaluated, and a nomogram was constructed to predict patient survival based on GCSH expression. Then, Gene set variation analysis (GSVA) was utilized to explore the potential biological functions of GCSH in EC. The impact of GCSH on the tumor microenvironment (TME) was estimated. Finally, the effect of GCSH on the response to immunotherapy and chemotherapeutic drugs in EC was investigated. Results: The expression of GCSH was significantly upregulated in EC. High GCSH expression was associated with poor prognosis in EC patients. Enrichment analysis showed that high GCSH was associated with immune suppression. Furthermore, high GCSH was found to be associated with a non-inflamed TME, leading to decreased infiltration levels of immune cells. Finally, it was observed that patients with high GCSH were insensitive to both immunotherapy and chemotherapeutic drugs. Conclusion: This study revealed the role of GCSH in TME, response to therapy, and clinical prognosis in EC, which provided novel insights for the therapeutic application in EC.
Language	English
Publishing date	2023-10-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	250101-6
ISSN	1423-0232 ; 0030-2414
ISSN (online)	1423-0232
ISSN	0030-2414
DOI	10.1159/000534018
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Article ; Online: Guanylate-binding proteins signature predicts favorable prognosis, immune-hot microenvironment, and immunotherapy response in hepatocellular carcinoma.

Ning, Yumei / Fang, Shilin / Fang, Jun / Lin, Kun / Nie, Haihang / Xiong, Peiling / Qiu, Peishan / Zhao, Qiu / Wang, Haizhou / Wang, Fan

Cancer medicine

2023 Volume 12, Issue 16, Page(s) 17504–17521

Abstract: Background: The role of guanylate-binding proteins (GBPs) in various cancers has been elucidated recently. However, our knowledge of the clinical relevance and biological characteristics of GBPs in hepatocellular carcinoma (HCC) remains limited.: ... ...

Abstract	Background: The role of guanylate-binding proteins (GBPs) in various cancers has been elucidated recently. However, our knowledge of the clinical relevance and biological characteristics of GBPs in hepatocellular carcinoma (HCC) remains limited. Methods: A total of 955 HCC patients were enrolled from five independent public HCC cohorts. The role of GBP molecules in HCC was preliminarily investigated, and a GBP family signature, termed GBPs-score, was constructed by principal component analysis to combine the GBP molecule values. We revealed the effects of GBP genes and GBPs-score in HCC via well-established bioinformatics methods and validated GBP1-5 experimentally in a tissue microarray (TMA) cohort. Results: GBPs molecules were closely associated with the prognosis of patients with HCC, and a high GBPs-score highly inferred a favorable survival outcome. We also revealed high GBPs-score was related to anti-tumor immunity, the immune-hot tumor microenvironment (TME), and immunotherapy response. Among the GBPs members, GBP1-5 rather than GBP6/7 may be dominant in these fields. The TMA analysis based on immunohistochemistry showed positive correlations between GBP1-5 and the immune-hot TME with abundant infiltration of CD8 Conclusions: Our integrative study revealed the genetic and immunologic characterizations of GBPs in HCC and highlighted their potential values as promising biomarkers for prognosis and immunotherapy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Carcinoma, Hepatocellular/therapy ; CD8-Positive T-Lymphocytes ; Liver Neoplasms/genetics ; Liver Neoplasms/therapy ; Prognosis ; Immunotherapy ; Tumor Microenvironment/genetics
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6347
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Article: Identification of Pharmacological Autophagy Regulators of Active Ulcerative Colitis.

Qiu, Peishan / Liu, Lan / Fang, Jun / Zhang, Meng / Wang, Haizhou / Peng, Yanan / Chen, Min / Liu, Jing / Wang, Fan / Zhao, Qiu

Frontiers in pharmacology

2021 Volume 12, Page(s) 769718

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-12-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.769718
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Article ; Online: Nickel(II)-Catalyzed Borylation of Alkenyl Methyl Ethers via C-O Bond Cleavage.

Qiu, Xiaodong / Li, Yangyang / Zhou, Li / Chen, Peishan / Li, Fan / Zhang, Yanan / Ling, Yong

Organic letters

2020 Volume 22, Issue 16, Page(s) 6424–6428

Abstract: A new protocol has been developed for the borylation of conjugated alkenyl methyl ethers using ... ...

Abstract	A new protocol has been developed for the borylation of conjugated alkenyl methyl ethers using B
Language	English
Publishing date	2020-07-31
Publishing country	United States
Document type	Journal Article
ISSN	1523-7052
ISSN (online)	1523-7052
DOI	10.1021/acs.orglett.0c02236
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Article ; Online: The liver injury and gastrointestinal symptoms in patients with Coronavirus Disease 19: A systematic review and meta-analysis.

Wang, Haizhou / Qiu, Peishan / Liu, Jing / Wang, Fan / Zhao, Qiu

Clinics and research in hepatology and gastroenterology

2020 Volume 44, Issue 5, Page(s) 653–661

Abstract: Backgrounds: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with ... ...

Abstract	Backgrounds: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. Our study aimed to evaluate the association of liver injury and gastrointestinal symptoms (GIS) with the progression of COVID-19. Methods: A comprehensive search was performed on the PubMed to identify eligible studies that summarized the liver injury and GIS in COVID-19. Results: A total of 21 studies with 3024 patients were included. Up to 53% patients had liver dysfunctions and the degree of liver damage was associated the severity of the disease. The prevalence of diarrhoea, nausea/vomiting or abdominal pain in patients with COVID-19 were 9.1%, 5.2% and 3.5%, respectively. No significant was found in the prevalence of diarrhoea (OR, 1.24; 95%CI, 0.90 to 1.72; Conclusions: The incidences of GIS in patients with COVID-19 is relatively low and are not associated with the COVID-19 progression. Gastroenterologists should pay more attention to the liver injury induced by SARS-CoV-2 during the course of infection.
MeSH term(s)	Abdominal Pain/epidemiology ; Betacoronavirus ; COVID-19 ; China/epidemiology ; Coronavirus Infections/complications ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Diarrhea/epidemiology ; Diarrhea/virology ; Gastrointestinal Diseases/epidemiology ; Gastrointestinal Diseases/virology ; Humans ; Liver Diseases/epidemiology ; Liver Diseases/virology ; Nausea/epidemiology ; Nausea/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Prevalence ; Prognosis ; SARS-CoV-2 ; Severity of Illness Index ; Symptom Assessment ; Vomiting/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-05-12
Publishing country	France
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't ; Systematic Review
ZDB-ID	2594333-9
ISSN	2210-741X ; 2210-7401
ISSN (online)	2210-741X
ISSN	2210-7401
DOI	10.1016/j.clinre.2020.04.012
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Article ; Online: Emerging glyco-risk prediction model to forecast response to immune checkpoint inhibitors in colorectal cancer.

Qiu, Peishan / Chen, Xiaoyu / Xiao, Cong / Zhang, Meng / Wang, Haizhou / Wang, Chun / Li, Daojiang / Liu, Jing / Chen, Yuhua / Liu, Lan / Zhao, Qiu

Journal of cancer research and clinical oncology

2023 Volume 149, Issue 9, Page(s) 6411–6434

Abstract: Background: Aberrant glycosylation is one of the most common post-translational modifications leading to heterogeneity in colorectal cancer (CRC). This study aims to construct a risk prediction model based on glycosyltransferase to forecast the response ...

Abstract	Background: Aberrant glycosylation is one of the most common post-translational modifications leading to heterogeneity in colorectal cancer (CRC). This study aims to construct a risk prediction model based on glycosyltransferase to forecast the response to immune checkpoint inhibitors in CRC patients. Methods: Based on the TCGA dataset and glycosyltransferase genes, the NMF algorithm and WGCNA were used to identify molecular subtypes and co-expressed genes, respectively. Lasso and multivariate COX regression were used to identify prognostic glycosyltransferase genes and construct a glyco-risk prediction model in CRC patients. Univariate and multivariate Cox regression, Kaplan-Meier, and ROC curves were applied to further verify the prognostic performance of the model in CRC patients in the training and validation sets. We compared the responsiveness of immunotherapy and chemotherapy between the two groups. In vitro experiments and clinical specimens verified the specific function of the key glycosyltransferase genes in CRC. Results: The CRC cohort was divided into two subtypes with prominent differences in survival based on the well-robust seven-gene glyco-risk prediction model (composed of ALG1L2, HAS1, PYGL, COLGALT2, B3GNT4, POFUT2, and GALNT7). The nomograms based on the risk model could predict the prognosis of CRC patients independently of other clinicopathologic characteristics. Our prediction model showed a better overall prediction performance than other models. Compared with the low-risk group, the high-risk CRC patients showed a lower immune infiltration state, but a higher TMB and a lower response to anti-PD-1, anti-PD-L1, and anti-CTLA-4 therapy. Clinical specimen validation showed an obvious difference in the expression of seven glycosyltransferase genes between the low- and high-risk groups. Significant reduction in POFUT2 expression in high-risk groups was associated with reduced N-glycans production. Conclusion: Our study constructed a robust glyco-risk prediction model that could provide direction for immunotherapy and chemotherapy in CRC patients, which could help clinicians make personalized treatment decisions.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy ; Algorithms ; Glycosyltransferases ; Colorectal Neoplasms/drug therapy ; Colorectal Neoplasms/genetics ; Prognosis
Chemical Substances	Immune Checkpoint Inhibitors ; Glycosyltransferases (EC 2.4.-)
Language	English
Publishing date	2023-02-09
Publishing country	Germany
Document type	Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-023-04626-0
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Article ; Online: CPT1A induction following epigenetic perturbation promotes MAVS palmitoylation and activation to potentiate antitumor immunity.

Zhang, Guiheng / Jiang, Peishan / Tang, Wen / Wang, Yunyi / Qiu, Fengqi / An, Jie / Zheng, Yuping / Wu, Dandan / Zhou, Jianya / Neculai, Dante / Shi, Yang / Sheng, Wanqiang

Molecular cell

2023 Volume 83, Issue 23, Page(s) 4370–4385.e9

Abstract: Targeting epigenetic regulators to potentiate anti-PD-1 immunotherapy converges on the activation of type I interferon (IFN-I) response, mimicking cellular response to viral infection, but how its strength and duration are regulated to impact combination ...

Abstract	Targeting epigenetic regulators to potentiate anti-PD-1 immunotherapy converges on the activation of type I interferon (IFN-I) response, mimicking cellular response to viral infection, but how its strength and duration are regulated to impact combination therapy efficacy remains largely unknown. Here, we show that mitochondrial CPT1A downregulation following viral infection restrains, while its induction by epigenetic perturbations sustains, a double-stranded RNA-activated IFN-I response. Mechanistically, CPT1A recruits the endoplasmic reticulum-localized ZDHHC4 to catalyze MAVS Cys79-palmitoylation, which promotes MAVS stabilization and activation by inhibiting K48- but facilitating K63-linked ubiquitination. Further elevation of CPT1A incrementally increases MAVS palmitoylation and amplifies the IFN-I response, which enhances control of viral infection and epigenetic perturbation-induced antitumor immunity. Moreover, CPT1A chemical inducers augment the therapeutic effect of combined epigenetic treatment with PD-1 blockade in refractory tumors. Our study identifies CPT1A as a stabilizer of MAVS activation, and its link to epigenetic perturbation can be exploited for cancer immunotherapy.
MeSH term(s)	Humans ; Signal Transduction ; Adaptor Proteins, Signal Transducing/genetics ; Adaptor Proteins, Signal Transducing/metabolism ; Lipoylation ; Interferon Type I ; Virus Diseases ; Epigenesis, Genetic ; Immunity, Innate
Chemical Substances	Adaptor Proteins, Signal Transducing ; Interferon Type I
Language	English
Publishing date	2023-11-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	1415236-8
ISSN	1097-4164 ; 1097-2765
ISSN (online)	1097-4164
ISSN	1097-2765
DOI	10.1016/j.molcel.2023.10.043
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