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  1. Article ; Online: Draft genome sequence including the capsule operon of a

    Okutani, Akiko / Okugawa, Shu / Fujimoto, Fumie / Ikeda, Mahoko / Tsutsumi, Takeya / Moriya, Kyoji / Maeda, Ken

    Microbiology resource announcements

    2024  Volume 13, Issue 2, Page(s) e0076623

    Abstract: ... Bacillus ... ...

    Abstract Bacillus cereus
    Language English
    Publishing date 2024-01-05
    Publishing country United States
    Document type Journal Article
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/MRA.00766-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Comparison of phylogenetic and virulence factors between

    Ikeda, Mahoko / Kobayashi, Tatsuya / Okugawa, Shu / Fujimoto, Fumie / Okada, Yuta / Tatsuno, Keita / Higurashi, Yoshimi / Tsutsumi, Takeya / Moriya, Kyoji

    Heliyon

    2023  Volume 9, Issue 11, Page(s) e21748

    Abstract: Escherichia ... ...

    Abstract Escherichia coli
    Language English
    Publishing date 2023-10-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e21748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series.

    Doi, Kent / Ikeda, Mahoko / Hayase, Naoki / Moriya, Kyoji / Morimura, Naoto

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 392

    MeSH term(s) Aged ; Amides/therapeutic use ; Benzamidines ; Coronavirus Infections/drug therapy ; Critical Illness ; Drug Therapy, Combination ; Female ; Guanidines/therapeutic use ; Humans ; Male ; Middle Aged ; Pyrazines/therapeutic use ; Treatment Outcome ; COVID-19 Drug Treatment
    Chemical Substances Amides ; Benzamidines ; Guanidines ; Pyrazines ; favipiravir (EW5GL2X7E0) ; nafamostat (Y25LQ0H97D)
    Keywords covid19
    Language English
    Publishing date 2020-07-03
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03078-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Pre-Transplant Seroprevalence, Associated Factors, and Post-Transplant Incidence of Toxoplasma gondii Infection Among Heart Transplant Recipients in Japan.

    Kanno, Yoshiaki / Okamoto, Koh / Shinohara, Takayuki / Kinoshita, Osamu / Hatano, Masaru / Ikeda, Mahoko / Harada, Sohei / Okugawa, Shu / Moriya, Kyoji / Ono, Minoru / Tsutsumi, Takeya

    Transplantation proceedings

    2024  Volume 56, Issue 1, Page(s) 148–152

    Abstract: Background: Among solid organ transplant (SOT) recipients, heart transplant (HT) recipients are at a higher risk of Toxoplasma gondii infection. As Toxoplasma seroprevalence varies by geographic location, updated local epidemiology is essential to guide ...

    Abstract Background: Among solid organ transplant (SOT) recipients, heart transplant (HT) recipients are at a higher risk of Toxoplasma gondii infection. As Toxoplasma seroprevalence varies by geographic location, updated local epidemiology is essential to guide preventive and therapeutic strategies. However, the Toxoplasma seroprevalence and incidence of post-transplant toxoplasmosis among SOT recipients in Japan are unknown.
    Methods: We performed a single-center retrospective observational study at an HT center in Tokyo, Japan. All HT recipients aged ≥18 years between 2006 and April 2019 were included. We reviewed patient charts and conducted a questionnaire survey to investigate the risk factors for infection.
    Results: Among 105 recipients included in the study, 11 (10.5%) were seropositive before transplant. Ninety-five recipients (90.5%), including all pre-transplant seropositive recipients, answered the questionnaire. The recipients who had lived in Okinawa (odds ratio [OR] 7.5 [95% CI 1.42-39.61]; P = .032) and who reported raw-meat eating habits (OR 4.64 [95% CI 1.04-23.3]; P = .021) were more likely to be seropositive. None of the patients developed symptoms of toxoplasmosis. The post-transplant incidence of other major adverse outcomes was not significantly different according to the pre-transplant serostatus.
    Conclusions: About 10% of HT recipients at an HT center in Tokyo were seropositive for Toxoplasma pre-transplant, and none developed symptomatic toxoplasmosis post-transplant on trimethoprim-sulfamethoxazole. The history of raw meat consumption was associated with seropositivity; therefore, avoiding it might be recommended for HT recipient candidates.
    MeSH term(s) Adolescent ; Adult ; Humans ; Heart Transplantation/adverse effects ; Incidence ; Japan/epidemiology ; Risk Factors ; Seroepidemiologic Studies ; Toxoplasma ; Toxoplasmosis/diagnosis ; Toxoplasmosis/epidemiology ; Toxoplasmosis/etiology ; Transplant Recipients ; Retrospective Studies
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 82046-5
    ISSN 1873-2623 ; 0041-1345
    ISSN (online) 1873-2623
    ISSN 0041-1345
    DOI 10.1016/j.transproceed.2023.11.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 835: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Genetic diversity and epidemiology of accessory gene regulator loci in

    Okada, Yuta / Okugawa, Shu / Ikeda, Mahoko / Kobayashi, Tatsuya / Saito, Ryoichi / Higurashi, Yoshimi / Moriya, Kyoji

    Access microbiology

    2020  Volume 2, Issue 7, Page(s) acmi000134

    Abstract: Quorum sensing is known to regulate bacterial virulence, and the accessory gene regulator ( ...

    Abstract Quorum sensing is known to regulate bacterial virulence, and the accessory gene regulator (
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Journal Article
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Neisseria meningitidis serogroup W135 in a traveler visiting Japan from Argentina, 2019.

    Ito, Hiroshi / Okamoto, Koh / Ariyoshi, Tsukasa / Yamamoto, Shinya / Yamashita, Marie / Kanno, Yoshiaki / Ikeda, Mahoko / Okugawa, Shu / Moriya, Kyoji

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2022  Volume 28, Issue 8, Page(s) 1180–1181

    Abstract: Invasive meningococcal disease (IMD) can occur in travelers returning from mass-gathering events or endemic regions. We present a 60-year-old Argentine traveler to Tokyo who developed IMD by Neisseria meningitidis Serogroup W135 during her stay in Japan. ...

    Abstract Invasive meningococcal disease (IMD) can occur in travelers returning from mass-gathering events or endemic regions. We present a 60-year-old Argentine traveler to Tokyo who developed IMD by Neisseria meningitidis Serogroup W135 during her stay in Japan. N. meningitidis serogroup W135 infection has become common in Argentina, whereas IMD less commonly occurs in Japan. Considering the prevalence, the patient most likely acquired the infection in Argentina, and it developed in Japan. Air travel enables passengers to reach the four corners of the world within a few days. IMD should be considered in travelers due to its potential to induce rapid clinical deterioration and transmission.
    MeSH term(s) Argentina/epidemiology ; Female ; Humans ; Japan ; Meningococcal Infections/diagnosis ; Meningococcal Infections/epidemiology ; Middle Aged ; Neisseria meningitidis ; Neisseria meningitidis, Serogroup W-135 ; Serogroup
    Language English
    Publishing date 2022-04-23
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2022.04.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Nafamostat mesylate treatment in combination with favipiravir for patients critically ill with Covid-19: a case series

    Doi, Kent / Ikeda, Mahoko / Hayase, Naoki / Moriya, Kyoji / Morimura, Naoto

    Crit Care

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #631375
    Database COVID19

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  8. Article: A Cold-Blooded Tiptoer: Nonresolving Cellulitis in an Immunocompromised Patient.

    Kitaura, Satoshi / Okamoto, Koh / Wakabayashi, Yoshitaka / Okada, Yuta / Okazaki, Aiko / Ikeda, Mahoko / Okugawa, Shu / Fujimoto, Fumie / Bujo, Chie / Minatsuki, Shun / Tsushima, Kensuke / Chikamatsu, Kinuyo / Mitarai, Satoshi / Moriya, Kyoji

    Open forum infectious diseases

    2022  Volume 9, Issue 4, Page(s) ofac074

    Abstract: Mycobacterium ... ...

    Abstract Mycobacterium haemophilum
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofac074
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  9. Article ; Online: Comparative performance and cycle threshold values of 10 nucleic acid amplification tests for SARS-CoV-2 on clinical samples.

    Miyuki Mizoguchi / Sohei Harada / Koh Okamoto / Yoshimi Higurashi / Mahoko Ikeda / Kyoji Moriya

    PLoS ONE, Vol 16, Iss 6, p e

    2021  Volume 0252757

    Abstract: Background A number of nucleic acid amplification tests (NAATs) for SARS-CoV-2 with different reagents have been approved for clinical use in Japan. These include research kits approved under emergency use authorization through simplified process to ... ...

    Abstract Background A number of nucleic acid amplification tests (NAATs) for SARS-CoV-2 with different reagents have been approved for clinical use in Japan. These include research kits approved under emergency use authorization through simplified process to stabilize the supply of the reagents. Although these research kits have been increasingly used in clinical practice, limited data is available for the diagnostic performance in clinical settings. Methods We compared sensitivity, specificity, and cycle threshold (Ct) values obtained by NAATs using 10 kits approved in Japan including eight kits those receiving emergency use authorization using 69 frozen-stored clinical samples including 23 positive samples with various Ct values and 46 negative samples. Results Viral copy number of the frozen-stored samples determined with LightMix E-gene test ranged from 0.6 to 84521.1 copies/μL. While no false-positive results were obtained by any of these tests (specificity: 100% [95% CI, 88.9%-100%]), sensitivity of the nine tests ranged from 68.2% [95% CI, 45.1%-86.1%] to 95.5% [95% CI, 77.2%-99.9%] using LightMix E-gene test as the gold standard. All tests showed positive results for all samples with ≥100 copies/μL. Significant difference of Ct values even among tests amplifying the same genetic region (N1-CDC, N2) was also observed. Conclusion Difference in the diagnostic performance was observed among NAATs approved in Japan. Regarding diagnostic kits for emerging infectious diseases, a system is needed to ensure both rapidity of reagent supply and accuracy of diagnosis. Ct values, which are sometimes regarded as a marker of infectivity, are not interchangeable when obtained by different assays.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Clinical and Microbiological Characteristics of Recurrent Escherichia coli Bacteremia.

    Kobayashi, Tatsuya / Ikeda, Mahoko / Okada, Yuta / Higurashi, Yoshimi / Okugawa, Shu / Moriya, Kyoji

    Microbiology spectrum

    2021  Volume 9, Issue 3, Page(s) e0139921

    Abstract: The causative agents of recurrent Escherichia coli bacteremia can be genetically identical or discordant, but the differences between them remain unclear. This study aimed to explore these differences, with regard to their clinical and microbiological ... ...

    Abstract The causative agents of recurrent Escherichia coli bacteremia can be genetically identical or discordant, but the differences between them remain unclear. This study aimed to explore these differences, with regard to their clinical and microbiological features. Patients were recruited from a Japanese tertiary teaching hospital based on blood culture data and the incidence of recurrent E. coli bacteremia. We compared the patients' clinical and microbiological characteristics between the two groups (those with identical or discordant E. coli bacteremia) divided by the result of enterobacterial repetitive intergenic consensus PCR. Among 70 pairs of recurrent E. coli bacteremia strains, 49 pairs (70%) were genetically identical. Patients with genetically identical or discordant E. coli bacteremia were more likely to have renal failure or neoplasms, respectively. The virulence factor (VF) scores of genetically identical E. coli strains were significantly higher than those of genetically discordant strains, with the prevalence of eight VF genes being significantly higher in genetically identical E. coli strains. No significant differences were found between the two groups regarding antimicrobial susceptibility and biofilm formation potential. This study showed that genetically identical E. coli bacteremia strains have more VF genes than genetically discordant strains in recurrent E. coli bacteremia.
    MeSH term(s) Aged ; Aged, 80 and over ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/microbiology ; Bacteremia/pathology ; Biofilms/growth & development ; Escherichia coli/drug effects ; Escherichia coli/genetics ; Escherichia coli/isolation & purification ; Escherichia coli/pathogenicity ; Escherichia coli Infections/pathology ; Female ; Humans ; Japan ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Recurrence ; Tertiary Care Centers ; Virulence/genetics ; Virulence Factors/genetics
    Chemical Substances Anti-Bacterial Agents ; Virulence Factors
    Language English
    Publishing date 2021-12-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/Spectrum.01399-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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