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Article ; Online: Factors influencing the success of cryopreserved parathyroid autotransplantation: A systematic review.

Yuan, Haoran / Zhong, Zibiao / Liu, Zhongzhong / Ye, Qifa

2023 Volume 46, Issue 9, Page(s) 3426–3431

Abstract: Permanent hypoparathyroidism is a postoperative complication of thyroid and parathyroid surgery and can be cured by cryopreserved parathyroid autotransplantation (CPAT). However, due to the lack of unified and standardized guidelines, the limited ability ...

Abstract	Permanent hypoparathyroidism is a postoperative complication of thyroid and parathyroid surgery and can be cured by cryopreserved parathyroid autotransplantation (CPAT). However, due to the lack of unified and standardized guidelines, the limited ability of the parathyroid tissue itself to withstand cryopreservation, and some yet-to-be-defined processes or technologies, the success rate of cryopreserved parathyroid autotransplantation varies between institutions; it is low for some institutions and high for others. Due to the sparsity of data, views vary on which factors most influence the success rate of cryopreserved parathyroid autotransplantation. In this review, we analyzed the following probable influencing factors: ischemic period before cryopreservation; processes of cryopreservation and thawing, including freezing medium; freezing and thawing methods; duration of cryopreservation; examination of the graft before transplantation; graft site; mass of transplanted tissue fragments; blood calcium level; and the evaluation criteria for cryopreserved parathyroid autotransplantation success. Although the effects of these factors are debatable, we hypothesized that examining them in the above-given order to determine whether they affect the success rate of cryopreserved parathyroid autotransplantation could be beneficial to maximizing the success rate. Our findings led us to conclude that cryopreserved parathyroid autotransplantation operations should be standardized. Standardized guidelines for cryopreserved parathyroid autotransplantation that include such factors as ischemic period time, freezing and thawing methods, and recipient status should be established based on a comprehensive analysis of these factors.
MeSH term(s)	Humans ; Transplantation, Autologous ; Parathyroid Glands/surgery ; Hypoparathyroidism ; Cryopreservation ; Postoperative Complications
Language	English
Publishing date	2023-04-25
Publishing country	Netherlands
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1068461-x
ISSN	0219-3108 ; 1015-9584
ISSN (online)	0219-3108
ISSN	1015-9584
DOI	10.1016/j.asjsur.2023.04.032
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Article ; Online: Corrigendum to "Biocompatible, antibacterial and anti-inflammatory zinc ion cross-linked quaternized cellulose-sodium alginate composite sponges for accelerated wound healing" [International Journal of Biological Macromolecules volume 191 (2021) 27-39/10.1016/IJBIOMAC-D-21-05321].

Xie, Hongxia / Xia, Haoyang / Huang, Lin / Zhong, Zibiao / Ye, Qifa / Zhang, Lina / Lu, Ang

International journal of biological macromolecules

2023 Volume 249, Page(s) 126046

Language	English
Publishing date	2023-08-05
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.126046
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Article ; Online: Photothermal Fibrous Chitosan/Polydopamine Sponge for Intraoperative Hemostasis and Prevention of Tumor Recurrence in Hepatocellular Carcinoma Resection

Lanxin Mu / Luhe Qi / Haitao Long / Jing Huang / Zibiao Zhong / Xiaowen Shi / Chaoji Chen / Qifa Ye

Advanced Science, Vol 11, Iss 3, Pp n/a-n/a (2024)

2024

Abstract: Abstract Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating ...

Abstract	Abstract Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating tumor cells in the bloodstream. To address this issue, a novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, which has the potential to ablate microlesions and improve the immune microenvironment simultaneously. Specifically, the integrated strategy is realized based on the fibrous chitosan/polydopamine sponge (CPDS), which is constructed from shearing‐flow‐induced oriented hybrid chitosan fibers and subsequent self‐assembly of polydopamine. The CPDS demonstrates high elasticity, excellent water absorption, and photothermal conversion performance. The results confirm the efficient hemostatic properties of the fibrous CPDS in various bleeding models. Notably, in subcutaneous and orthotopic postoperative recurrence and metastasis models of hepatocellular carcinoma, the fibrous CPDS significantly inhibits local tumor recurrence and distant metastasis. Moreover, the combination with lenvatinib can substantially enhance the antitumor effect. This comprehensive treatment strategy offers new insights into hepatectomy of liver cancer, representing a promising approach for clinical management.
Keywords	hemostasis ; immunotherapy ; lenvatinib ; liver cancer recurrence ; photothermal therapy ; Science ; Q
Subject code	610
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
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Article ; Online: Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.

Peng, Sheng / Liang, Wenjin / Liu, Zhongzhong / Ye, Shaojun / Peng, Zhiyong / Zhong, Zibiao / Ye, Qifa

Human cell

2023 Volume 37, Issue 2, Page(s) 420–434

Abstract: Hypothermic machine perfusion (HMP) has been demonstrated to be more effective in mitigating ischemia-reperfusion injury (IRI) of donation after circulatory death (DCD) organs than cold storage (CS), yet the underlying mechanism remains obscure. We aimed ...

Abstract	Hypothermic machine perfusion (HMP) has been demonstrated to be more effective in mitigating ischemia-reperfusion injury (IRI) of donation after circulatory death (DCD) organs than cold storage (CS), yet the underlying mechanism remains obscure. We aimed to propose a novel therapeutic approach to ameliorate IRI in DCD liver transplantation. Twelve clinical liver samples were randomly assigned to HMP or CS treatment and subsequent transcriptomics analysis was performed. By combining in vivo HMP models, we discovered that HMP attenuated inflammation, oxidative stress, and apoptosis in DCD liver through a SEPRINA3-mediated PI3Kδ/AKT signaling cascade. Moreover, in the hypoxia/reoxygenation (H/R) model of BRL-3A, overexpression of SERPINA3 mitigated H/R-induced apoptosis, while SERPINA3 knockdown exacerbated cell injury. Idelalisib (IDE) treatment also reversed the protective effect of SERPINA3 overexpression. Overall, our research provided new insights into therapeutic strategies and identified potential novel molecular targets for therapeutic intervention against DCD liver.
MeSH term(s)	Humans ; Proto-Oncogene Proteins c-akt/metabolism ; Liver/metabolism ; Perfusion ; Reperfusion Injury/prevention & control ; Reperfusion Injury/metabolism ; Liver Transplantation ; Serpins/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; SERPINA3 protein, human ; Serpins
Language	English
Publishing date	2023-12-22
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1149134-6
ISSN	1749-0774 ; 0914-7470
ISSN (online)	1749-0774
ISSN	0914-7470
DOI	10.1007/s13577-023-01012-3
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Article: Roles of TRAFs in Ischemia-Reperfusion Injury.

Zhou, Wei / Lin, Danni / Zhong, Zibiao / Ye, Qifa

Frontiers in cell and developmental biology

2020 Volume 8, Page(s) 586487

Abstract: Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. ... ...

Abstract	Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAF-dependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.
Keywords	covid19
Language	English
Publishing date	2020-11-05
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2737824-X
ISSN	2296-634X
ISSN	2296-634X
DOI	10.3389/fcell.2020.586487
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Article ; Online: Roles of TRAFs in Ischemia-Reperfusion Injury

Wei Zhou / Danni Lin / Zibiao Zhong / Qifa Ye

Frontiers in Cell and Developmental Biology, Vol

2020 Volume 8

Abstract	Tumor necrosis factor receptor-associated factor (TRAF) proteins are a family of signaling molecules that function downstream of multiple receptor signaling pathways, and they play a pivotal role in the regulation of intracellular biological progresses. These TRAF-dependent signaling pathways and physiological functions have been involved in the occurrence and progression of ischemia-reperfusion injury (IRI), which is a common pathophysiological process that occurs in a wide variety of clinical events, including ischemic shock, organ transplantation, and thrombolytic therapy, resulting in a poor prognosis and high mortality. IRI occurs in multiple organs, including liver, kidney, heart, lung, brain, intestine, and retina. In recent years, mounting compelling evidence has confirmed that the genetic alterations of TRAFs can cause subversive phenotype changes during IRI of those organs. In this review, based on current knowledge, we summarized and analyzed the regulatory effect of TRAFs on the IRI of various organs, providing clear direction and a firm theoretical basis for the development of treatment strategies to manipulate TRAF proteins or TRAF-dependent signaling pathways in IRI-related diseases.
Keywords	TRAFs ; ischemia-reperfusion injury ; hypoxia/reoxygenation ; inflammation ; ubiquitination ; Biology (General) ; QH301-705.5
Subject code	610
Language	English
Publishing date	2020-11-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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Article ; Online: Photothermal Fibrous Chitosan/Polydopamine Sponge for Intraoperative Hemostasis and Prevention of Tumor Recurrence in Hepatocellular Carcinoma Resection.

Mu, Lanxin / Qi, Luhe / Long, Haitao / Huang, Jing / Zhong, Zibiao / Shi, Xiaowen / Chen, Chaoji / Ye, Qifa

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2023 Volume 11, Issue 3, Page(s) e2304053

Abstract: Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating tumor ... ...

Abstract	Hepatectomy, a surgical procedure for liver cancer, is often plagued by high recurrence rates worldwide. The recurrence of liver cancer is primarily attributed to microlesions in the liver, changes in the immune microenvironment, and circulating tumor cells in the bloodstream. To address this issue, a novel intervention method that combines intraoperative hemostasis with mild photothermal therapy is proposed, which has the potential to ablate microlesions and improve the immune microenvironment simultaneously. Specifically, the integrated strategy is realized based on the fibrous chitosan/polydopamine sponge (CPDS), which is constructed from shearing-flow-induced oriented hybrid chitosan fibers and subsequent self-assembly of polydopamine. The CPDS demonstrates high elasticity, excellent water absorption, and photothermal conversion performance. The results confirm the efficient hemostatic properties of the fibrous CPDS in various bleeding models. Notably, in subcutaneous and orthotopic postoperative recurrence and metastasis models of hepatocellular carcinoma, the fibrous CPDS significantly inhibits local tumor recurrence and distant metastasis. Moreover, the combination with lenvatinib can substantially enhance the antitumor effect. This comprehensive treatment strategy offers new insights into hepatectomy of liver cancer, representing a promising approach for clinical management.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/surgery ; Liver Neoplasms/surgery ; Chitosan/pharmacology ; Neoplasm Recurrence, Local/prevention & control ; Hemostasis ; Tumor Microenvironment ; Indoles ; Polymers
Chemical Substances	polydopamine ; Chitosan (9012-76-4) ; Indoles ; Polymers
Language	English
Publishing date	2023-11-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202304053
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: High-strength, antibacterial, antioxidant, hemostatic, and biocompatible chitin/PEGDE-tannic acid hydrogels for wound healing.

Cao, Hankun / Xiang, Du / Zhou, Xin / Yue, Pengpeng / Zou, Yongkang / Zhong, Zibiao / Ma, Yongsheng / Wang, Lizhe / Wu, Shuangquan / Ye, Qifa

Carbohydrate polymers

2023 Volume 307, Page(s) 120609

Abstract: Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. ... ...

Abstract	Natural polymer hydrogels are widely used in various aspects of biomedical engineering, such as wound repair, owing to their abundance and biosafety. However, the low strength and the lack of function restricted their development and application scope. Herein, we fabricated novel multifunctional chitin/PEGDE-tannic acid (CPT) hydrogels through chemical- and physical-crosslinking strategies, using chitin as the base material, polyethylene glycol diglycidyl ether (PEGDE) and tannic acid (TA) as crosslinking agents, and 90 % ethanol as the regenerative bath. CPT hydrogels maintained a stable three-dimensional porous structure with suitable water contents and excellent biocompatibility. The mechanical properties of hydrogels were greatly improved (tensile stress up to 5.43 ± 1.14 MPa). Moreover, CPT hydrogels had good antibacterial, antioxidant, and hemostatic activities and could substantially promote wound healing in a rat model of full-thickness skin defect by regulating inflammatory responses and promoting collagen deposition and blood vessel formation. Therefore, this work provides a useful strategy to fabricate novel multifunctional CPT hydrogels with excellent mechanical, antibacterial, antioxidant, hemostatic, and biocompatible properties. CPT hydrogels could be promising candidates for wound healing.
MeSH term(s)	Rats ; Animals ; Hemostatics/pharmacology ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Hydrogels/pharmacology ; Hydrogels/chemistry ; Wound Healing/physiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/chemistry ; Chitin/pharmacology
Chemical Substances	Hemostatics ; Antioxidants ; Hydrogels ; Anti-Bacterial Agents ; Chitin (1398-61-4)
Language	English
Publishing date	2023-01-21
Publishing country	England
Document type	Journal Article
ZDB-ID	1501516-6
ISSN	1879-1344 ; 0144-8617
ISSN (online)	1879-1344
ISSN	0144-8617
DOI	10.1016/j.carbpol.2023.120609
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Article ; Online: New Drainage Management Following Liver Transplant Results in Fewer Postoperative Hospital Days.

Wang, Lizhe / Liu, Zhongzhong / Cao, Hankun / Yue, Pengpeng / Ma, Yongsheng / Zhong, Zibiao / Zhou, Xin / Hu, Zhengbin / Ye, Shaojun / Ye, Qifa

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation

2023 Volume 21, Issue 9, Page(s) 749–755

Abstract: Objectives: Drain tube management after liver transplant is controversial. A new peritoneal drainage management protocol was developed to validate clinical characteristics, such as drain characteristics, postoperative complications, duration of ... ...

Abstract	Objectives: Drain tube management after liver transplant is controversial. A new peritoneal drainage management protocol was developed to validate clinical characteristics, such as drain characteristics, postoperative complications, duration of postoperative hospital stay, changes in albumin levels, and 30-day readmission rates. Materials and methods: Data from 183 consecutive patients who underwent deceased donor liver transplant at our institution between January 2019 and June 2022 were retrospectively analyzed. A new drain management protocol was implemented on August 1, 2021, which included early removal of the drain tube when the serum albumin level was >3 g/dL and nonchylous fluid drainage was <200 mL/day. Results: When we compared the traditional and new drain management protocol groups (n = 131 vs n = 52), the new management protocol group showed a decrease in the median duration of intraperitoneal drainage. In addition, the median length of postoperative hospital stay decreased from 33 to 27 days and serum albumin levels returned to normal faster at postoperative 3 weeks. No significant differences were found in postoperative hemorrhage, hematoma, hydrops abdominis, infections, biliary complications, orin the rate ofreinterventions and 30-day rehospitalizations. Conclusions: The new management protocol was associated with fewer postoperative hospital days and faster recovery than traditional management. Our findings may aid in the development of new drain policy recommendations based on preexisting risk factors.
MeSH term(s)	Humans ; Liver Transplantation/adverse effects ; Retrospective Studies ; Time Factors ; Living Donors ; Drainage/adverse effects ; Drainage/methods ; Postoperative Complications/etiology ; Postoperative Complications/therapy ; Length of Stay ; Serum Albumin ; Hospitals
Chemical Substances	Serum Albumin
Language	English
Publishing date	2023-10-26
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2396778-X
ISSN	2146-8427 ; 1304-0855
ISSN (online)	2146-8427
ISSN	1304-0855
DOI	10.6002/ect.2023.0159
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Article ; Online: Multiple Roles of 25-Hydroxycholesterol in Lipid Metabolism, Antivirus Process, Inflammatory Response, and Cell Survival.

Cao, Qin / Liu, Zhongzhong / Xiong, Yan / Zhong, Zibiao / Ye, Qifa

Oxidative medicine and cellular longevity

2020 Volume 2020, Page(s) 8893305

Abstract: As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, ... ...

Abstract	As an essential lipid, cholesterol is of great value in keeping cell homeostasis, being the precursor of bile acid and steroid hormones, and stabilizing membrane lipid rafts. As a kind of cholesterol metabolite produced by enzymatic or radical process, oxysterols have drawn much attention in the last decades. Among which, the role of 25-hydroxycholesterol (25-HC) in cholesterol and bile acid metabolism, antivirus process, and inflammatory response has been largely disclosed. This review is aimed at revealing these functions and underlying mechanisms of 25-HC.
MeSH term(s)	Animals ; Cell Survival ; Humans ; Hydroxycholesterols/metabolism ; Inflammation/metabolism ; Inflammation/pathology ; Inflammation/virology ; Lipid Metabolism ; Membrane Microdomains/pathology ; Membrane Microdomains/virology ; Virus Diseases/metabolism ; Virus Diseases/pathology
Chemical Substances	Hydroxycholesterols ; 25-hydroxycholesterol (767JTD2N31)
Language	English
Publishing date	2020-11-19
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2455981-7
ISSN	1942-0994 ; 1942-0994
ISSN (online)	1942-0994
ISSN	1942-0994
DOI	10.1155/2020/8893305
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