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  1. Article ; Online: Mesenchymal stem cells in glioblastoma therapy and progression: How one cell does it all.

    Nowak, Blazej / Rogujski, Piotr / Janowski, Miroslaw / Lukomska, Barbara / Andrzejewska, Anna

    Biochimica et biophysica acta. Reviews on cancer

    2021  Volume 1876, Issue 1, Page(s) 188582

    Abstract: Mesenchymal stem cells (MSCs) are among the most investigated and applied somatic stem cells in experimental therapies for the regeneration of damaged tissues. Moreover, as it was recently postulated, MSCs may demonstrate anti-tumor properties. ... ...

    Abstract Mesenchymal stem cells (MSCs) are among the most investigated and applied somatic stem cells in experimental therapies for the regeneration of damaged tissues. Moreover, as it was recently postulated, MSCs may demonstrate anti-tumor properties. Glioblastoma (GBM) is a grade IV central nervous system tumor with no available effective therapy and an inevitably fatal prognosis. Experimental studies utilizing MSCs in GBM treatment resulted in numerous controversies. Native MSCs were shown to exert anti-GBM activity by controlling angiogenesis, regulating cell cycle, and inducing apoptosis. They also were used as sensitizing factors and vehicles delivering various anti-cancer compounds. On the other hand, some experiments revealed significant risks related to MSC-based therapies for GBM, such as enhancement of tumor cell proliferation, invasion, and aggressiveness. The following review elaborates on all mentioned contradictory data and provides a realistic, current clinical perspective on MSCs' potential in GBM treatment.
    Language English
    Publishing date 2021-06-16
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2918802-7
    ISSN 1879-2561 ; 0304-419X
    ISSN (online) 1879-2561
    ISSN 0304-419X
    DOI 10.1016/j.bbcan.2021.188582
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    Zs.A 7162: Show issues Location:
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  2. Article ; Online: Genetic basis of sow hyperprolificacy and litter size optimization based on a genome-wide association study.

    Nowak, Błażej / Mucha, Anna / Zatoń-Dobrowolska, Magdalena / Chrostowski, Grzegorz / Kruszyński, Wojciech

    Theriogenology

    2024  Volume 218, Page(s) 119–125

    Abstract: Over the last few decades, there has been a constant increase in sow litter size, the consequences of which include parturition duration extension, an increase in the percentage of stillborn and hypoxic piglets, and increased variation in piglet birth ... ...

    Abstract Over the last few decades, there has been a constant increase in sow litter size, the consequences of which include parturition duration extension, an increase in the percentage of stillborn and hypoxic piglets, and increased variation in piglet birth weight, which reduces their vitality. As such, it seems clear that further increasing sow fertility will generate difficulties and costs in rearing numerous litters with low birth weights. Therefore, the current study aimed to analyze the genetic background of sow hyperprolifcacy using a genome-wide association study (GWAS). The research included 144 sows in the maternal component, divided into two equal groups. The first group (control) consisted of females giving birth to the optimal number of piglets in their third and fourth litters (14-16), while the second group (cases) included those with excessive litter size (>16). The analyzed sows were genotyped using Illumina's PorcineSNP60v2 BeadChip microarray, comprising 64,232 single nucleotide polymorphisms (SNPs). Statistical analysis using R included quality control of genotyping data and GWAS analysis based on five logistic regression models (dominant, codominant, overdominant, recessive, and log-additive) with a single SNP marker as the explanatory variable. On this basis, one SNP (SIRI0000069) was identified on chromosome seven within the EFCAB11 (EF-hand calcium binding domain 11) gene that had a statistically significant effect on sow hyperprolificacy. Additionally, ten SNPs (INRA0007631, ALGA0011600, ALGA0043433, ALGA0043428, M1GA0010535 ALGA00443338, ALGA0087116, MARC0056787, ALGA0112928, and ALGA0089047) had a relationship with the analyzed feature at a level close to significance, set at 1
    MeSH term(s) Animals ; Swine/genetics ; Pregnancy ; Female ; Litter Size/genetics ; Genome-Wide Association Study/veterinary ; Reproduction/genetics ; Birth Weight ; Stillbirth/veterinary ; Lactation ; Swine Diseases
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 189232-0
    ISSN 1879-3231 ; 0093-691X
    ISSN (online) 1879-3231
    ISSN 0093-691X
    DOI 10.1016/j.theriogenology.2024.01.035
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    Zs.A 3929: Show issues Location:
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  3. Article ; Online: Mesenchymal stem cells injected into carotid artery to target focal brain injury home to perivascular space.

    Andrzejewska, Anna / Dabrowska, Sylwia / Nowak, Blazej / Walczak, Piotr / Lukomska, Barbara / Janowski, Miroslaw

    Theranostics

    2020  Volume 10, Issue 15, Page(s) 6615–6628

    Abstract: ... ...

    Abstract Rationale
    MeSH term(s) Animals ; Brain Injuries/metabolism ; Brain Injuries/pathology ; Brain Injuries/therapy ; Carotid Arteries/metabolism ; Cell Adhesion ; Cells, Cultured ; Disease Models, Animal ; Glymphatic System/metabolism ; Integrin alpha4beta1/metabolism ; Male ; Mesenchymal Stem Cell Transplantation/methods ; Mesenchymal Stem Cells/cytology ; Mesenchymal Stem Cells/metabolism ; Rats ; Rats, Wistar ; Transfection ; Vascular Cell Adhesion Molecule-1/metabolism
    Chemical Substances Integrin alpha4beta1 ; Vascular Cell Adhesion Molecule-1
    Language English
    Publishing date 2020-05-17
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592097-2
    ISSN 1838-7640 ; 1838-7640
    ISSN (online) 1838-7640
    ISSN 1838-7640
    DOI 10.7150/thno.43169
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  4. Article ; Online: Prawa własności intelektualnej jako składniki majątków małżonków w świetle art. 33 pkt 9 k.r.o.

    Błażej Bugajski / Aleksandra Nowak-Gruca

    Ruch Prawniczy, Ekonomiczny i Socjologiczny, Vol 82, Iss

    2020  Volume 3

    Abstract: Motywem podjęcia rozważań na ten temat praw własności intelektualnej jako składników majątków małżonków jest dokonujący się przewrót technologiczny, w wyniku którego zmienia się własność i struktura czynników produkcji a aktywa intelektualne zyskująi ... ...

    Abstract Motywem podjęcia rozważań na ten temat praw własności intelektualnej jako składników majątków małżonków jest dokonujący się przewrót technologiczny, w wyniku którego zmienia się własność i struktura czynników produkcji a aktywa intelektualne zyskująi będą zyskiwać na znaczeniu. W artykule przedstawiono w pierwszej kolejności kwestie terminologiczne związane z pojęciami „własność intelektualna”, „dobra niematerialne” i „prawo własności intelektualnej”. Dopiero po wyjaśnieniu tego zagadnienia omówiono podstawowe założenia konstrukcyjne majątkowych ustrojów małżeńskich i wynikające z nich zasady przyporządkowywania praw własności intelektualnej, które ustanawia Kodeks rodzinny i opiekuńczy. W uwagach końcowych zaprezentowano ocenę obowiązujących przepisów Kodeksu rodzinnego i opiekuńczego, które dotyczą prawa własności intelektualnej.
    Keywords prawo własności intelektualnej ; Kodeks rodzinny i opiekuńczy ; majątkowy ustrój małżeński ; prawa autorskie ; prawa pokrewne ; prawa własności przemysłowej ; Law ; K ; Social Sciences ; H
    Language English
    Publishing date 2020-09-01T00:00:00Z
    Publisher Adam Mickiewicz University, Poznan
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Some theoretical aspects of reprogramming the standard genetic code.

    Nowak, Kuba / Błażej, Paweł / Wnetrzak, Małgorzata / Mackiewicz, Dorota / Mackiewicz, Paweł

    Genetics

    2021  Volume 218, Issue 1

    Abstract: Reprogramming of the standard genetic code to include non-canonical amino acids (ncAAs) opens new prospects for medicine, industry, and biotechnology. There are several methods of code engineering, which allow us for storing new genetic information in ... ...

    Abstract Reprogramming of the standard genetic code to include non-canonical amino acids (ncAAs) opens new prospects for medicine, industry, and biotechnology. There are several methods of code engineering, which allow us for storing new genetic information in DNA sequences and producing proteins with new properties. Here, we provided a theoretical background for the optimal genetic code expansion, which may find application in the experimental design of the genetic code. We assumed that the expanded genetic code includes both canonical and non-canonical information stored in 64 classical codons. What is more, the new coding system is robust to point mutations and minimizes the possibility of reversion from the new to old information. In order to find such codes, we applied graph theory to analyze the properties of optimal codon sets. We presented the formal procedure in finding the optimal codes with various number of vacant codons that could be assigned to new amino acids. Finally, we discussed the optimal number of the newly incorporated ncAAs and also the optimal size of codon groups that can be assigned to ncAAs.
    MeSH term(s) Amino Acids/genetics ; Codon ; Genetic Code ; Models, Genetic ; Protein Biosynthesis ; Protein Engineering/methods ; Proteins/genetics
    Chemical Substances Amino Acids ; Codon ; Proteins
    Language English
    Publishing date 2021-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2167-2
    ISSN 1943-2631 ; 0016-6731
    ISSN (online) 1943-2631
    ISSN 0016-6731
    DOI 10.1093/genetics/iyab040
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    Zs.B 767: Show issues Location:
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  6. Article: Identification of SNP markers for canine mammary gland tumours in females based on a genome-wide association study - preliminary results.

    Mucha, Anna / Nowak, Błażej / Dzimira, Stanisław / Liszka, Bartłomiej / Zatoń-Dobrowolska, Magdalena

    Journal of veterinary research

    2023  Volume 67, Issue 3, Page(s) 427–436

    Abstract: Introduction: The development of genetic research over recent decades has enabled the discovery of new genetic markers, such as single nucleotide polymorphisms (SNPs). This, as well as the full sequencing of the dog genome, has enabled genome-wide ... ...

    Abstract Introduction: The development of genetic research over recent decades has enabled the discovery of new genetic markers, such as single nucleotide polymorphisms (SNPs). This, as well as the full sequencing of the dog genome, has enabled genome-wide association studies (GWAS) to be used in the search for genetic causes of canine mammary tumours (CMTs).
    Material and methods: Genotypic data containing 175,000 SNPs, which had been obtained using the Illumina CanineHD BeadChip microarray technique, were available for analysis in this study. The data concerned 118 bitches, including 36 animals with CMT, representing various breeds and age groups. Statistical analysis was performed in two steps: quality control of genotyping data and genome-wide association analysis based on dominant, recessive, overdominant, codominant, and log-additive models with the single SNP effects.
    Results: A total of 40 different SNPs significantly associated with CMT appearance were detected. Moreover, twelve SNPs showed statistical significance in more than one model. Of all the significant SNPs, two, namely
    Conclusion: In the group of SNPs indicated as significant in the GWAS analysis, several transpired to be localised within genes that may play an important role in CMT.
    Language English
    Publishing date 2023-09-20
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2855010-9
    ISSN 2450-8608 ; 2450-7393
    ISSN (online) 2450-8608
    ISSN 2450-7393
    DOI 10.2478/jvetres-2023-0040
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  7. Article: Cardiovascular disease, therapy and mortality of oligosymptomatic and symptomatic patients infected with SARS-CoV-2: experiences of a designated hospital in Poland

    Pawlak, Agnieszka / Drezewski, Karol / Szymanski, Piotr / Nowak, Blazej / Zaczynski, Artur / Król, Zbigniew / Wierzba, Waldemar / Gil, Robert

    Kardiol. pol

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #749386
    Database COVID19

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  8. Article: Reproduction Indicators Related to Litter Size and Reproduction Cycle Length Among Sows of Breeds Considered Maternal and Paternal Components Kept on Medium-Size Farms.

    Nowak, Błażej / Mucha, Anna / Moska, Magdalena / Kruszyński, Wojciech

    Animals : an open access journal from MDPI

    2020  Volume 10, Issue 7

    Abstract: The present research aimed to study twelve reproductive indicators related to litter size and the farrowing interval for three maternal (Polish Large White, Polish Landrace, and Yorkshire) and three paternal (Duroc, Berkshire, Hampshire) breeds, raised ... ...

    Abstract The present research aimed to study twelve reproductive indicators related to litter size and the farrowing interval for three maternal (Polish Large White, Polish Landrace, and Yorkshire) and three paternal (Duroc, Berkshire, Hampshire) breeds, raised on two farms in Poland and a farm in the United States. The study included 196 sows (45 Polish Large White, 37 Polish Landrace, 26 Berkshire, 33 Duroc, 40 Yorkshire, and 15 Hampshire), which altogether gave birth to 736 litters. The Kruskal-Wallis test was used to verify the influence of the breed on the reproductive traits, with a post-hoc procedure for pairwise comparisons implemented in the pgirmes of R. The adegenet, ade4, and factoextra packages of R were used to conduct multivariate analysis of the traits by means of principal component analysis. The breed significantly (
    Language English
    Publishing date 2020-07-09
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani10071164
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  9. Article: Clipping of a ruptured middle cerebral artery aneurysm in a patient with coronavirus disease 2019 (COVID-19): A case report.

    Kostyra, Kacper / Nowak, Błażej / Kostkiewicz, Bogusław

    Interdisciplinary neurosurgery : Advanced techniques and case management

    2020  Volume 22, Page(s) 100849

    Abstract: Aim of the study: The aim of this study is to present our suggestions for organization, personal protective equipment (PPE) use, work flow of the operating theater, and the treatment of patients with COVID-19 and co-existing neurological disease.: ... ...

    Abstract Aim of the study: The aim of this study is to present our suggestions for organization, personal protective equipment (PPE) use, work flow of the operating theater, and the treatment of patients with COVID-19 and co-existing neurological disease.
    Materials and methods: We present the case of a 70-year-old male who was transferred to our Department because of subarachnoid hemorrhage with ruptured right middle cerebral artery aneurysm and SARS CoV-2 infection. The emergency clipping of the aneurysm and hematoma evacuation was performed. According to the therapeutic committee guidelines, chloroquine was started for COVID-19 treatment.
    Results: Postoperatively, the patient is in good condition, with the Glasgow Coma Scale (GCS) score of 15, with mild, left hemiparesis, 4+/5 points on the Lovett scale, without symptoms of acute respiratory distress syndrome (ARDS). No one from the stuff was infected during the treatment.
    Conclusions: Managing patients with infectious diseases such as COVID-19 presents many challenges and risks for healthcare personnel. Our experience suggests that by following strict safety protocols of PPE use, donning and doffing, and reducing operation time, the surgery may be safe for both the healthcare personnel and the patient.
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2785532-6
    ISSN 2214-7519
    ISSN 2214-7519
    DOI 10.1016/j.inat.2020.100849
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  10. Article ; Online: Clipping of a ruptured middle cerebral artery aneurysm in a patient with coronavirus disease 2019 (COVID-19)

    Kacper Kostyra / Błażej Nowak / Bogusław Kostkiewicz

    Interdisciplinary Neurosurgery, Vol 22, Iss , Pp 100849- (2020)

    A case report

    2020  

    Abstract: Aim of the study: The aim of this study is to present our suggestions for organization, personal protective equipment (PPE) use, work flow of the operating theater, and the treatment of patients with COVID-19 and co-existing neurological disease. ... ...

    Abstract Aim of the study: The aim of this study is to present our suggestions for organization, personal protective equipment (PPE) use, work flow of the operating theater, and the treatment of patients with COVID-19 and co-existing neurological disease. Materials and methods: We present the case of a 70-year-old male who was transferred to our Department because of subarachnoid hemorrhage with ruptured right middle cerebral artery aneurysm and SARS CoV-2 infection. The emergency clipping of the aneurysm and hematoma evacuation was performed. According to the therapeutic committee guidelines, chloroquine was started for COVID-19 treatment. Results: Postoperatively, the patient is in good condition, with the Glasgow Coma Scale (GCS) score of 15, with mild, left hemiparesis, 4+/5 points on the Lovett scale, without symptoms of acute respiratory distress syndrome (ARDS). No one from the stuff was infected during the treatment. Conclusions: Managing patients with infectious diseases such as COVID-19 presents many challenges and risks for healthcare personnel. Our experience suggests that by following strict safety protocols of PPE use, donning and doffing, and reducing operation time, the surgery may be safe for both the healthcare personnel and the patient.
    Keywords Aneurysm ; COVID-19 ; SARS CoV-2 ; Surgery ; RD1-811 ; Neurology. Diseases of the nervous system ; RC346-429 ; covid19
    Subject code 610
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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