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  1. Article ; Online: Subphenotypes in critical illness: a priori biological rationale is key. Author's reply.

    Yang, Jie / Huang, Jiajie / Hong, Yucai / Zhang, Zhongheng

    Intensive care medicine

    2024  Volume 50, Issue 2, Page(s) 302–303

    MeSH term(s) Humans ; Critical Illness
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Letter
    ZDB-ID 80387-x
    ISSN 1432-1238 ; 0340-0964 ; 0342-4642 ; 0935-1701
    ISSN (online) 1432-1238
    ISSN 0340-0964 ; 0342-4642 ; 0935-1701
    DOI 10.1007/s00134-023-07316-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1089: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Application of Artificial Intelligence to Advance Individualized Diagnosis and Treatment in Emergency and Critical Care Medicine.

    Yang, Jie / Zhang, Bo / Jiang, Xiaocong / Huang, Jiajie / Hong, Yucai / Ni, Hongying / Zhang, Zhongheng

    Diagnostics (Basel, Switzerland)

    2024  Volume 14, Issue 7

    Abstract: Emergency and critical illnesses refer to severe diseases or conditions characterized by rapid changes in health that may endanger life within a short period [ ... ]. ...

    Abstract Emergency and critical illnesses refer to severe diseases or conditions characterized by rapid changes in health that may endanger life within a short period [...].
    Language English
    Publishing date 2024-03-25
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics14070687
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Corrigendum: Adiponectin modified BMSCs alleviate heart fibrosis via inhibition TGF-beta1/smad in diabetic rats.

    Meng, Ke / Cai, Huabo / Cai, Simin / Hong, Yucai / Zhang, Xiaoming

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 997572

    Abstract: This corrects the article DOI: 10.3389/fcell.2021.644160.]. ...

    Abstract [This corrects the article DOI: 10.3389/fcell.2021.644160.].
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.997572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Application of artificial intelligence in the management of patients with renal dysfunction.

    Zhang, Bo / Jiang, Xiaocong / Yang, Jie / Huang, Jiajie / Hu, Chaoming / Hong, Yucai / Ni, Hongying / Zhang, Zhongheng

    Renal failure

    2024  Volume 46, Issue 1, Page(s) 2337289

    MeSH term(s) Humans ; Artificial Intelligence ; Kidney Diseases/diagnosis ; Kidney Diseases/therapy
    Language English
    Publishing date 2024-04-03
    Publishing country England
    Document type Editorial
    ZDB-ID 632949-4
    ISSN 1525-6049 ; 0886-022X
    ISSN (online) 1525-6049
    ISSN 0886-022X
    DOI 10.1080/0886022X.2024.2337289
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1331: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Genomic surveillance indicates clonal replacement of hypervirulent

    Liu, Ning / Lou, Ningjie / Huang, Jiajie / Chen, Zhenhao / Li, Bing / Zhang, Zhongheng / Hong, Yucai / Cao, Liping / Xiao, Wei

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1375624

    Abstract: The emergence of ... ...

    Abstract The emergence of hypervirulent
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1375624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Low Quality Evidence Supporting Recommendations in the 2021 Sepsis Guideline

    Zhongheng Zhang / Lin Chen / Huabo Cai / Yucai Hong

    Intensive Care Research, Vol 2, Iss 1-2, Pp 23-

    An Indication for Precise Medicine?

    2022  Volume 25

    Keywords Medical emergencies. Critical care. Intensive care. First aid ; RC86-88.9 ; Medicine ; R
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Springer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Evaluating the Metabolic Basis of α-Gal A mRNA Therapy for Fabry Disease.

    Zhang, Zhendong / Liu, Qi / Deng, Zhiwen / Liu, Jun / Li, Shuang / Hong, Mei / Peng, Yucai

    Biology

    2024  Volume 13, Issue 2

    Abstract: mRNA injection-based protein supplementation has emerged as a feasible treatment for Fabry disease. However, whether the introduction of LNP-encapsulated mRNA results in the alteration of metabolomics in an in vivo system remains largely unknown. In the ... ...

    Abstract mRNA injection-based protein supplementation has emerged as a feasible treatment for Fabry disease. However, whether the introduction of LNP-encapsulated mRNA results in the alteration of metabolomics in an in vivo system remains largely unknown. In the present study, α-galactosidase A (α-Gal A) mRNA was generated and injected into the Fabry disease mouse model. The α-Gal A protein was successfully expressed. The level of globotriaosylsphingosine (Lyso-Gb3), a biomarker for Fabry disease, as well as pro-inflammatory cytokines such as nuclear factor kappa-B (NF-κB), interleukin 6 (IL-6), and tumor necrosis factor-α (TNF-α), were greatly decreased compared to the untreated control, indicating the therapeutic outcome of the mRNA drug. Metabolomics analysis found that the level of 20 metabolites was significantly altered in the plasma of mRNA-injected mice. These compounds are primarily enriched in the arachidonic acid metabolism, alanine, aspartate and glutamate metabolism, and glycolysis/gluconeogenesis pathways. Arachidonic acid and 5-hydroxyeicosatetraenoic acid (5-HETE), both of which are important components in the eicosanoid pathway and related to inflammation response, were significantly increased in the injected mice, possibly due to the presence of lipid nanoparticles. Moreover, mRNA can effectively alter the level of metabolites in the amino acid and energy metabolic pathways that are commonly found to be suppressed in Fabry disease. Taken together, the present study demonstrated that in addition to supplementing the deficient α-Gal A protein, the mRNA-based therapeutic agent can also affect levels of metabolites that may help in the recovery of metabolic homeostasis in the full body system.
    Language English
    Publishing date 2024-02-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology13020106
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genetic correlations and causal relationships between cardio-metabolic traits and sepsis.

    Zhang, Zhongheng / Chen, Lin / Zhang, Haoyang / Xiao, Wei / Yang, Jie / Huang, Jiajie / Hu, Qichao / Jin, Ketao / Hong, Yucai

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 5718

    Abstract: Cardio-metabolic traits have been reported to be associated with the development of sepsis. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability, or are confounded by environmental factors. We ... ...

    Abstract Cardio-metabolic traits have been reported to be associated with the development of sepsis. It is, however, unclear whether these co-morbidities reflect causal associations, shared genetic heritability, or are confounded by environmental factors. We performed three analyses to explore the relationships between cardio-metabolic traits and sepsis. Mendelian randomization (MR) study to evaluate the causal effects of multiple cardio-metabolic traits on sepsis. Global genetic correlation analysis to explore the correlations between cardio-metabolic traits and sepsis. Local genetic correlation (GC) analysis to explore shared genetic heritability between cardio-metabolic traits and sepsis. Some loci were further examined for related genes responsible for the causal relationships. Genetic associations were obtained from the UK Biobank data or published large-scale genome-wide association studies with sample sizes between 200,000 to 750,000. In MR, we found causality between BMI and sepsis (OR: 1.53 [1.4-1.67]; p < 0.001). Body mass index (BMI), which is confirmed by sensitivity analyses and multivariable MR adjusting for confounding factors. Global GC analysis showed a significant correlation between BMI and sepsis (r
    MeSH term(s) Humans ; Genome-Wide Association Study ; Diabetes Mellitus, Type 2/genetics ; Causality ; Phenotype ; Sepsis/genetics ; Mendelian Randomization Analysis
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56467-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Adiponectin Modified BMSCs Alleviate Heart Fibrosis via Inhibition TGF-beta1/Smad in Diabetic Rats.

    Meng, Ke / Cai, Huabo / Cai, Simin / Hong, Yucai / Zhang, Xiaoming

    Frontiers in cell and developmental biology

    2021  Volume 9, Page(s) 644160

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-03-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2021.644160
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Micro-Three-Coil Sensor with Dual Excitation Signals Use Asymmetric Magnetic Fields to Distinguish between Non-Ferrous Metals.

    Hong, Jiaju / Xie, Yucai / Zhang, Shuyao / Shi, Haotian / Liu, Yu / Zhang, Hongpeng / Sun, Yuqing

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 3

    Abstract: Intelligent operation and maintenance technology for vessels can ensure the safety of the entire system, especially for the development of intelligent and unmanned marine technology. The material properties of metal abrasive particles in oil could ... ...

    Abstract Intelligent operation and maintenance technology for vessels can ensure the safety of the entire system, especially for the development of intelligent and unmanned marine technology. The material properties of metal abrasive particles in oil could demonstrate the wear areas of the marine mechanical system because different components consist of different materials. However, most sensors can only roughly separate metallic contaminants into ferromagnetic and non-ferromagnetic particles but cannot differentiate them in greater detail. A micro-three-coil sensor is designed in this paper; the device applies different excitation signals to two excitation coils to differentiate materials, based on the different effects of different material particles in the asymmetric magnetic field. Therefore, a particle's material can be judged by the shape of the induction electromotive force output signal from the induction coil, while the particle size can be judged by the amplitude of the signal. Experimental results show that the material differentiation of four different types of particles can be achieved, namely, of aluminum, iron, 304 stainless steel, and carbon steel. This newly designed sensor provides a new research prospect for the realization of an inductive detection method to distinguish non-ferrous metals and a reference for the subsequent detection of metal contaminants in oil and other liquids.
    Language English
    Publishing date 2023-02-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23031637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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