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Article: Diagnosis by metagenomic next-generation sequencing of a

Yang, Aimei / Hu, Yan / Chen, Peiling / Zheng, Guilang / Hu, Xuejiao / Zhang, Jingwen / Wang, Jing / Wang, Chun / Huang, Zijian / Zhang, Yuxin / Guo, Yuxiong

Frontiers in pediatrics

2022 Volume 10, Page(s) 903617

Abstract: Background: Talaromyces marneffei: Case description: We report a case of a TM bloodstream infection, confirmed by the results of blood culture, of a child who was HIV negative and possessed a : Conclusions: HIV-negative patients ... ...

Abstract	Background: Talaromyces marneffei Case description: We report a case of a TM bloodstream infection, confirmed by the results of blood culture, of a child who was HIV negative and possessed a Conclusions: HIV-negative patients with
Language	English
Publishing date	2022-08-15
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2711999-3
ISSN	2296-2360
ISSN	2296-2360
DOI	10.3389/fped.2022.903617
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Article ; Online: Epidemiological characteristics and trends in postoperative death in children with congenital heart disease (CHD): a single-center retrospective study from 2005 to 2020.

Zheng, Guilang / Wang, Jing / Chen, Peiling / Huang, Zijian / Zhang, Lei / Yang, Aimei / Wu, Jiaxing / Chen, Chunlin / Zhang, Jingwen / Sun, Yueyu / Zhou, Chengbin / Yuan, Haiyun / Liu, Xiaobing / Cen, Jianzheng / Wen, Shusheng / Guo, Yuxiong

Journal of cardiothoracic surgery

2023 Volume 18, Issue 1, Page(s) 165

Abstract: Objectives: To analyze the epidemiological characteristics and trends in death after thoracotomy in children with congenital heart disease (CHD).: Methods: The clinical data of children with CHD aged 0-14 years who died after thoracotomy in our ... ...

Abstract	Objectives: To analyze the epidemiological characteristics and trends in death after thoracotomy in children with congenital heart disease (CHD). Methods: The clinical data of children with CHD aged 0-14 years who died after thoracotomy in our hospital from January 1, 2005, to December 31, 2020, were retrospectively collected to analyze the characteristics of and trends in postoperative death. Results: A total of 502 patients (365 males; 72.7%) died from January 1, 2005, to December 31, 2020, with an average of 31 deaths per year. For these patients, the median age was 2.0 months, the median length of hospital stay was 16.0 days, the median postoperative time to death was 5.0 days, and the median risk adjustment in congenital heart surgery-1 (RACHS-1) score was 3.0. 29.5% underwent emergency surgery, 16.9% had postoperative ECMO support, and 15.9% received postoperative blood purification treatment. In the past 16 years, the deaths of children with CHD under 1 year old accounted for 80.5% of all deaths among children with CHD aged 0-14 years, and deaths (349 cases) under 6 kg accounted for 69.5% of all deaths. Age at death, weight, and disease type were characterized by annual changes. Conclusions: The postoperative deaths of children with CHD mainly occurred in infants and toddlers who weighed less than 6.0 kg, and TGA and PA were the most lethal CHDs. The proportion of deaths has been increasing across the years among patients who are young, have a low body weight, and have complex cyanotic CHD.
MeSH term(s)	Male ; Infant ; Humans ; Retrospective Studies ; Heart Defects, Congenital/surgery ; Length of Stay ; Hospitals ; Thoracotomy
Language	English
Publishing date	2023-04-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2227224-0
ISSN	1749-8090 ; 1749-8090
ISSN (online)	1749-8090
ISSN	1749-8090
DOI	10.1186/s13019-023-02224-2
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Article: Clinical Features and Factors Associated With Sepsis-Associated Encephalopathy in Children: Retrospective Single-Center Clinical Study.

Chen, Yihao / Hu, Yan / Li, Xufeng / Chen, Peiling / Wang, Chun / Wang, Jing / Wu, Jiaxing / Sun, Yueyu / Zheng, Guilang / Lu, Yiyun / Guo, Yuxiong

Frontiers in neurology

2022 Volume 13, Page(s) 838746

Abstract: Background: Sepsis-associated encephalopathy (SAE) is a common complication in septic patients with a higher ICU and hospital mortality in adults and poorer long-term outcomes. Clinical presentation may range from mild confusion to convulsions and deep ... ...

Abstract	Background: Sepsis-associated encephalopathy (SAE) is a common complication in septic patients with a higher ICU and hospital mortality in adults and poorer long-term outcomes. Clinical presentation may range from mild confusion to convulsions and deep coma; however, little is known about SAE in children. We aimed to retrospectively analyze the data for children with sepsis, to illustrate the epidemiology, performance, and adverse outcome, and to evaluate the association between risk factors and SAE in children. Methods: All children with sepsis who were admitted to the Department of Pediatrics, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China from January 2010 to December 2020 were retrospectively analyzed. Results: A total of 210 patients with sepsis were retrospectively assigned to the SAE and non-SAE groups, of which 91 (43.33%) were diagnosed with SAE with a mortality of 6.70% (14/210). Significant differences were observed in the level of white blood platelet, platelets, international normalized ratio, prothrombin time, activated partial thromboplastin time, total protein, Ccr, UREA, blood urea nitrogen, alanine transaminase, aspartate transaminase, creatine kinase, creatine kinase isoenzymes, lactate dehydrogenase, procalcitonin, and lactic acid ( Conclusions: The incidence of SAE in children was found high and the prognosis poor. In this retrospective study, the identified patients were more susceptible to SAE, with an inflammatory storm with hypocalcemia or septic shock. The use of midazolam will increase the occurrence of SAE, whereas fentanyl will reduce the incidence of SAE, and PELOD-2 may predict the occurrence of SAE.
Language	English
Publishing date	2022-05-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2022.838746
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Article ; Online: Application of Metagenomic Next-Generation Sequencing (mNGS) Using Bronchoalveolar Lavage Fluid (BALF) in Diagnosing Pneumonia of Children.

Yang, Aimei / Chen, Chen / Hu, Yan / Zheng, Guilang / Chen, Peiling / Xie, Zhiwei / Fan, Huifeng / Sun, Yueyu / Wu, Peiqiong / Jiang, Wenhui / Wang, Chun / Zhang, Jingwen / Zhang, Dongwei / Wang, Jing / Hu, Xiaoyin / Xia, Han / Yin, Genquan / Guo, Yuxiong

Microbiology spectrum

2022 Volume 10, Issue 5, Page(s) e0148822

Abstract: Pneumonia is the leading cause of death in children; the pathogens are often difficult to diagnose. In this study, the performance of metagenomic next-generation sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) samples from 112 children with ... ...

Abstract	Pneumonia is the leading cause of death in children; the pathogens are often difficult to diagnose. In this study, the performance of metagenomic next-generation sequencing (mNGS) using bronchoalveolar lavage fluid (BALF) samples from 112 children with confirmed pneumonia has been evaluated. mNGS performed a significantly higher positive detection rate (91.07%, 95% confidence interval [CI] 83.80% to 95.40%) and coincidence rate against the final diagnosis (72.32%, 95% CI 62.93% to 80.15%) than that of conventional methods (70.54%, 95% CI 61.06% to 78.58% and 56.25%, 95% CI 46.57% to 65.50%, respectively) (
MeSH term(s)	Child ; Humans ; Bronchoalveolar Lavage Fluid ; Sensitivity and Specificity ; Metagenomics/methods ; High-Throughput Nucleotide Sequencing/methods ; Pneumonia/diagnosis ; Pneumonia/microbiology ; Bacteria/genetics ; Anti-Bacterial Agents
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.01488-22
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Article ; Online: Characteristics of in-hospital mortality of congenital heart disease (CHD) after surgical treatment in children from 2005 to 2017: a single-center experience.

Zheng, Guilang / Wu, Jiaxing / Chen, Peiling / Hu, Yan / Zhang, Huiqiong / Wang, Jing / Zeng, Hanshi / Li, Xufeng / Sun, Yueyu / Xu, Gang / Wen, Shusheng / Cen, Jianzheng / Chen, Jimei / Guo, Yuxiong / Zhuang, Jian

BMC pediatrics

2021 Volume 21, Issue 1, Page(s) 521

Abstract: Background: To evaluate trends in the in-hospital mortality rate for pediatric cardiac surgery procedures between 2005 and 2017 in our center, and to discuss the mortality characteristics of children's CHD after thoracotomy.: Methods: This ... ...

Abstract	Background: To evaluate trends in the in-hospital mortality rate for pediatric cardiac surgery procedures between 2005 and 2017 in our center, and to discuss the mortality characteristics of children's CHD after thoracotomy. Methods: This retrospective data were collected from medical records of children underwent CHD surgery between 2005 and 2017. Results: A total of 19,114 children with CHD underwent surgery and 444 children died, with the in-hospital mortality was 2.3%. Complex mixed defect CHD had the highest fatality rate (8.63%), left obstructive lesion CHD had the second highest fatality rate (4.49%), right to left shunt CHD had the third highest mortality rate (3.51%), left to right shunt CHD had the lowest mortality rate (χ2 = 520.3,P < 0.05). The neonatal period has the highest mortality rate (12.17%), followed by infant mortality (2.58%), toddler age mortality (1.16%), and preschool age mortality (0.94%), the school age and adolescent mortality rate was the lowest (χ2 = 529.3,P < 0.05). In addition, the fatality rate in boys was significantly higher than that in girls (2.77% versus 1.62%, χ2 = 26.4, P < 0.05). Conclusions: The mortality rate of CHD surgery in children decreased year by year. The younger the age and the more complicated the cyanotic heart disease, the higher the mortality rate may be.
MeSH term(s)	Adolescent ; Cardiac Surgical Procedures/adverse effects ; Child ; Child, Preschool ; Female ; Heart Defects, Congenital/surgery ; Hospital Mortality ; Humans ; Infant ; Infant, Newborn ; Male ; Retrospective Studies ; Risk Factors
Language	English
Publishing date	2021-11-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041342-7
ISSN	1471-2431 ; 1471-2431
ISSN (online)	1471-2431
ISSN	1471-2431
DOI	10.1186/s12887-021-02935-2
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Article ; Online: Clinical characteristics of acute respiratory syndrome with SARS‐CoV‐2 infection in children in South China

Zheng, Guilang / Wang, Bangqin / Zhang, Hua / Xie, Chuxing / Zhang, Yuehua / Wen, Zhihong / Guo, Qingyun / Zhu, Hong / Ye, Guojing / Liang, Jiayi / Meng, Qiong / Xie, Jingquan / Jiang, Suhua / Liu, Guojun / Gao, Wenjun / Wang, Yanhao / Guo, Yuxiong

Pediatric Pulmonology

2020 Volume 55, Issue 9, Page(s) 2419–2426

Keywords	Pediatrics, Perinatology, and Child Health ; Pulmonary and Respiratory Medicine ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24921
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Article ; Online: Experimental treatments for mitochondrial dysfunction in sepsis

Guilang Zheng / Juanjuan Lyu / Jingda Huang / Dan Xiang / Meiyan Xie / Qiyi Zeng

Journal of Research in Medical Sciences, Vol 20, Iss 2, Pp 185-

A narrative review

2015 Volume 195

Abstract: Sepsis is a systemic inflammatory response to infection. Sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. Pathogenesis is extremely complex. In recent years, cell hypoxia ... ...

Abstract	Sepsis is a systemic inflammatory response to infection. Sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. Pathogenesis is extremely complex. In recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. Sepsis damages the structure and function of mitochondria, conversely, mitochondrial dysfunction aggravated sepsis. The treatment of sepsis lacks effective specific drugs. The aim of this paper is to undertake a narrative review of the current experimental treatment for mitochondrial dysfunction in sepsis. The search was conducted in PubMed databases and Web of Science databases from 1950 to January 2014. A total of 1,090 references were retrieved by the search, of which 121 researches met all the inclusion criteria were included. Articles on the relationship between sepsis and mitochondria, and drugs used for mitochondrial dysfunction in sepsis were reviewed retrospectively. The drugs were divided into four categories: (1) Drug related to mitochondrial matrix and respiratory chain, (2) drugs of mitochondrial antioxidant and free radical scavengers, (3) drugs related to mitochondrial membrane stability, (4) hormone therapy for septic mitochondria. In animal experiments, many drugs show good results. However, clinical research lacks. In future studies, the urgent need is to develop promising drugs in clinical trials.
Keywords	Mitochondria ; mitochondrial dysfunction ; sepsis ; drug ; Medicine ; R
Subject code	610
Language	English
Publishing date	2015-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
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Article: Experimental treatments for mitochondrial dysfunction in sepsis: A narrative review.

Zheng, Guilang / Lyu, Juanjuan / Huang, Jingda / Xiang, Dan / Xie, Meiyan / Zeng, Qiyi

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences

2015 Volume 20, Issue 2, Page(s) 185–195

Abstract	Sepsis is a systemic inflammatory response to infection. Sepsis, which can lead to severe sepsis, septic shock, and multiple organ dysfunction syndrome, is an important cause of mortality. Pathogenesis is extremely complex. In recent years, cell hypoxia caused by mitochondrial dysfunction has become a hot research field. Sepsis damages the structure and function of mitochondria, conversely, mitochondrial dysfunction aggravated sepsis. The treatment of sepsis lacks effective specific drugs. The aim of this paper is to undertake a narrative review of the current experimental treatment for mitochondrial dysfunction in sepsis. The search was conducted in PubMed databases and Web of Science databases from 1950 to January 2014. A total of 1,090 references were retrieved by the search, of which 121 researches met all the inclusion criteria were included. Articles on the relationship between sepsis and mitochondria, and drugs used for mitochondrial dysfunction in sepsis were reviewed retrospectively. The drugs were divided into four categories: (1) Drug related to mitochondrial matrix and respiratory chain, (2) drugs of mitochondrial antioxidant and free radical scavengers, (3) drugs related to mitochondrial membrane stability, (4) hormone therapy for septic mitochondria. In animal experiments, many drugs show good results. However, clinical research lacks. In future studies, the urgent need is to develop promising drugs in clinical trials.
Language	English
Publishing date	2015-04-23
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	2513029-8
ISSN	1735-7136 ; 1735-1995
ISSN (online)	1735-7136
ISSN	1735-1995
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Article ; Online: Clinical characteristics of acute respiratory syndrome with SARS-CoV-2 infection in children in South China.

Pediatric pulmonology

2020 Volume 55, Issue 9, Page(s) 2419–2426

Abstract: Background: A retrospective study was conducted to summarize the clinical information of childhood infections during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic.: Methods: Children with SARS-CoV-2 infection in 11 ... ...

Abstract	Background: A retrospective study was conducted to summarize the clinical information of childhood infections during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic. Methods: Children with SARS-CoV-2 infection in 11 hospitals from three provinces of South China were included in the study. Clinical information was collected and compared with children and adults infected by SARS-CoV-2 in Wuhan. Results: In total, 52 children were enrolled, including 28 boys. The median age was 9 years (interquartile range [IQR], 4-12); 44.2% cases were of clustered occurrences, 40.4% patients had fever, 48.1% had cough, and 46.2% had a high lymphocyte count. No abnormalities were found in the liver and kidney function. Also, 82.7% of patients received antiviral therapy, but such therapy did not shorten the time to virus negativity or hospital stay (P = .082). The time to virus negativity was 12.0 days (IQR, 8.0-16.8) and hospital stay was 14.5 days (IQR, 10.3-17.9). Compared with reports in Wuhan, there were more acute upper respiratory tract infection (AURTI) and fewer pneumonia cases (P = .000). Compared with the non-ICU adult COVID-19 in Wuhan, these children's diseases were relatively mild, with fewer complications. Conclusions: Children with SARS-CoV-2 infection had a mild fever, lymphocyte elevation was more common than reduction, and antiviral treatment had no obvious effect. The overall clinical manifestations were mild, and the prognosis was good.
MeSH term(s)	Adolescent ; Adult ; Antiviral Agents/therapeutic use ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/immunology ; COVID-19 Testing ; Child ; Child, Preschool ; China/epidemiology ; Cough/diagnosis ; Cough/drug therapy ; Cough/epidemiology ; Cough/immunology ; Epidemics ; Female ; Fever/diagnosis ; Fever/drug therapy ; Fever/epidemiology ; Fever/immunology ; Humans ; Infant ; Infant, Newborn ; Length of Stay ; Lymphocyte Count ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome ; COVID-19 Drug Treatment
Chemical Substances	Antiviral Agents
Keywords	covid19
Language	English
Publishing date	2020-07-03
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	632784-9
ISSN	1099-0496 ; 8755-6863
ISSN (online)	1099-0496
ISSN	8755-6863
DOI	10.1002/ppul.24921
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Article: Identification and expression characterization of three Wnt signaling genes in pearl oyster (Pinctada fucata)

Gao, Jing / Guilang Zheng / Jian Liang / Jun Liu / Jun Xie / Liping Xie / Rongqing Zhang / Shiguo Li / Yi Yang

Comparative biochemistry and physiology. 2016 June, July, v. 196-197

2016

Abstract: The Wnt signaling pathway plays an important role in animal development and in the biomineralization process. At present, although the biomineralization mechanism in pearl oyster (Pinctada fucata) has been extensively studied, there is little research on ...

Abstract	The Wnt signaling pathway plays an important role in animal development and in the biomineralization process. At present, although the biomineralization mechanism in pearl oyster (Pinctada fucata) has been extensively studied, there is little research on the Wnt signaling pathway in pearl oyster. To understand the potential role of the Wnt signaling pathway in pearl oyster, we cloned and sequenced three genes from the Wnt signaling pathway in pearl oyster that encode the following proteins: β-catenin, Dishevelled (Dvl) and T-cell factor (TCF). Genomic structure analysis revealed that Pf-β-catenin genomic DNA contained 15 exons, Pf-Dvl genomic DNA contained 16 exons, and Pf-TCF genomic DNA contained 7 exons. Their deduced amino acid sequences all showed the highest identity with homologs in Crassostrea gigas. Yeast two-hybrid analysis verified that Pf-β-catenin interacted with Pf-TCF. These three genes were ubiquitously expressed in seven pearl oyster tissues analyzed with the highest expression in the gill and a certain amount of expression in the mantle, a tissue related to shell formation. After shell notching, the dynamic changes in expression of these three genes showed that they reached a maximum at 4days, indicating their response to shell regeneration. All three genes were constitutively expressed during five developmental stages of the pearl oyster, with high levels at the early embryonic development stage. Taken together, these results suggested that Pf-β-catenin, Pf-Dvl and Pf-TCF might participate in shell formation and early embryonic and larval development in the pearl oyster.
Keywords	amino acid sequences ; biomineralization ; Crassostrea gigas ; developmental stages ; DNA ; embryogenesis ; exons ; gene expression ; genes ; larval development ; oysters ; Pinctada fucata ; proteins ; sequence analysis ; signal transduction ; T-lymphocytes ; two hybrid system techniques
Language	English
Dates of publication	2016-06
Size	p. 92-101.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	121247-3
ISSN	1879-1107 ; 0305-0491 ; 1096-4959
ISSN (online)	1879-1107
ISSN	0305-0491 ; 1096-4959
DOI	10.1016/j.cbpb.2016.03.003
Database	NAL-Catalogue (AGRICOLA)

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