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Article: Exploring the therapeutic effect of Pen Yan Kang Fu Decoction on SPID rats based on LIF/JAK2/STAT3 signaling pathway.

Ji, Xiaoli / Hu, Quan / Yang, Chengcheng / Huang, Li / Huang, Yefang / Deng, Linwen / Song, Xiaoqing / Zhang, Yongqing / Wang, Yan

3 Biotech

2024 Volume 14, Issue 5, Page(s) 134

Abstract: ... problem in clinical research. The efficacy of Pen Yan Kang Fu Decoction (PYKFD) has been verified in long ...

Abstract	Tubal inflammation, endometritis, and uterine adhesions due to post-pelvic inflammatory disease (SPID) are important causes of infertility. Chronic endometritis (CE) belongs to SPID, which seriously affects women's reproductive health, quality of life, and family harmony, and is a hot and difficult problem in clinical research. The efficacy of Pen Yan Kang Fu Decoction (PYKFD) has been verified in long-term clinical practice for chronic endometritis infertility caused by the SPID. Numerous studies have confirmed that the LIF/JAK2/STAT3 signaling pathway is important in embryo implantation and development, and endometritis infertility is close to LIF/JAK2/STAT3. In vivo results showed that PYKFD increased endometrial receptivity, repaired uterine tissue damage, and regulates the expression of endometrial receptivity-related factors ER (estrogen receptor), PR (progesterone receptor), CD31, and integrin αvβ3, and induced the transduction of LIF/JAK2/STAT3 signaling pathway. PYKFD can also regulate the expression of IL-6. The results of in vitro experiments showed that PYKFD regulates the behavior of rat endometrial epithelial cells (REECs) involving LIF. In conclusion, PYKFD can improve endometrial receptivity and promote endometrial repair by LIF/JAK2/STAT3 signaling pathway. Supplementary information: The online version contains supplementary material available at 10.1007/s13205-024-03981-0.
Language	English
Publishing date	2024-04-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-024-03981-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)

Yan, Yu-Chen / Yan, Wen-Long / Deng, Tie-Jun / Wei, Mei-Cai

Journal of Hymenoptera Research. 2022 June 30, v. 91 p.265-308

2022

Abstract: ... Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov ... A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov ... A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new ...

Abstract	AbstractA new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
Keywords	Cimbex ; females ; new genus ; new species ; research ; China ; Cimbicinae ; distribution pattern ; Eastern Asia ; Sawflies ; Tenthredinoidea
Language	English
Dates of publication	2022-0630
Size	p. 265-308.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2477175-2
ISSN	1314-2607 ; 1070-9428
ISSN (online)	1314-2607
ISSN	1070-9428
DOI	10.3897/jhr.91.83710
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Asicimbex Yan, Deng & Wei, a new genus with eight new species and four new combinations (Hymenoptera, Cimbicidae)

Yu-Chen Yan / Wen-Long Yan / Tie-Jun Deng / Mei-Cai Wei

Journal of Hymenoptera Research, Vol 91, Iss , Pp 265-

2022 Volume 308

Abstract: ... Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus ... Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov ... A new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan ...

Abstract	A new genus and eight new species of Cimbicinae from the East Asia are described: Asicimbex Yan, Deng & Wei gen. nov., A. concavicaputus Yan & Wei sp. nov., A. dengi Yan & Wei sp. nov., A. koreanus Yan & Wei sp. nov., A. lii Yan & Wei sp. nov., A. latistriatus Yan, Deng & Wei sp. nov., A. maculotegularis Yan & Wei sp. nov., A. nanjingensis Yan & Wei sp. nov. and A. shengi Yan & Wei sp. nov. Four new combinations are proposed: A. eous (Semenov, 1935) comb. nov., A. elminus (Li & Wu, 2003) comb. nov., A. ulmusvorus (Yang, 1996) comb. nov. and A. malaisei (Gussakovskij, 1947) comb. nov., all from Agenocimbex. The 12 known species of Asicimbex are separated into two species groups. Asicimbex stands between Agenocimbex Rohwer 1910 and Cimbex Olivier 1791. The differences between Asicimbex and Cimbex, Asicimbex and Palaeocimbex are discussed in detail. Descriptions, remarks, illustrations, a key to the known species of Asicimbex and a key to genera of Cimbicinae are provided. A. malaisei is confirmed as a valid species and recorded from China for the first time, with the female described for the first time. The distribution of the genus is also briefly discussed.
Keywords	Zoology ; QL1-991
Subject code	590
Language	English
Publishing date	2022-06-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: San Huang Xiao Yan recipe modulates the HMGB1-mediated abnormal inflammatory microenvironment and ameliorates diabetic foot by activating the AMPK/Nrf2 signalling pathway.

Zhang, Zhihui / Zheng, Yihan / Chen, Nan / Xu, Chenqin / Deng, Jie / Feng, Xia / Liu, Wei / Ma, Chao / Chen, Jian / Cai, Tongkai / Xu, Yicheng / Wang, Song / Cao, Yemin / Ge, Guangbo / Jia, Chenglin / Cao, Yongbing

Phytomedicine : international journal of phytotherapy and phytopharmacology

2023 Volume 118, Page(s) 154931

Abstract: ... pathogenesis of DF. The traditional prescription San Huang Xiao Yan Recipe (SHXY) has been used in the clinical ...

Abstract	Background: Diabetic foot (DF) is one of the serious complications of diabetes and lacks of therapeutic drugs. Abnormal and chronic inflammation promoting foot infection and wound healing delay are the main pathogenesis of DF. The traditional prescription San Huang Xiao Yan Recipe (SHXY) has been used in the clinical treatment of DF for several decades as approved hospital experience prescription and showed remarkable therapeutic effect, but the mechanisms by which SHXY treats DF are still unclear. Purpose: Objectives of this study were to investigate SHXY anti-inflammatory effect on DF and explore the molecular mechanism for SHXY. Methods: We detected the effects of SHXY on DF in C57 mouse and SD rat DF models. Animal blood glucose, weight and wound area were detected every week. Serum inflammatory factors were detected by ELISA. H&E and Masson's trichrome were used to observe tissue pathology. Single-cell sequencing data reanalysis revealed the role of M1 macrophages in DF. Venn analysis showed the co-target genes between DF M1 macrophages and compound-disease network pharmacology. Western blotting was used to explored target protein expression. Meanwhile, RAW264.7 cells were treated with drug-containing serum of SHXY to further unravel the roles of target proteins during high glucose-induced inflammation in vitro. The Nrf2 inhibitor ML385 was used on RAW 264.7 cells to further explore the relationship between Nrf2, AMPK and HMGB1. The main components of SHXY were analysed by HPLC. Finally, the treatment effect of SHXY on DF were detected on rat DF model. Results: In vivo, SHXY can ameliorate inflammatory, accelerate wound healing and upregulate expression of Nrf2, AMPK and downregulate of HMGB1. Bioinformatic analysis showed that M1 macrophages were the main inflammatory cell population in DF. Moreover, the Nrf2 downstream proteins HO-1 and HMGB1 were potential DF therapeutic targets for SHXY. In vitro, we also found that SHXY increased AMPK and Nrf2 protein levels and downregulated HMGB1 expression in RAW264.7 cells. Inhibiting the expression of Nrf2 impaired the inhibition effect of SHXY on HMGB1. SHXY promoted Nrf2 translocation into the nucleus and increased the phosphorylation of Nrf2. SHXY also inhibited HMGB1 extracelluar release under high glucose. In rat DF models, SHXY also exhibited significant anti-inflammatory effect. Conclusion: The SHXY activated AMPK/Nrf2 pathway to suppress abnormal inflammation on DF via inhibiting HMGB1 expression. These findings provide novel insight into the mechanisms by which SHXY treats DF.
MeSH term(s)	Rats ; Mice ; Animals ; AMP-Activated Protein Kinases/metabolism ; NF-E2-Related Factor 2/metabolism ; Diabetic Foot ; HMGB1 Protein/metabolism ; Rats, Sprague-Dawley ; Inflammation/drug therapy ; Anti-Inflammatory Agents/therapeutic use ; Glucose/metabolism ; Lipopolysaccharides/pharmacology ; Diabetes Mellitus/drug therapy
Chemical Substances	AMP-Activated Protein Kinases (EC 2.7.11.31) ; NF-E2-Related Factor 2 ; HMGB1 Protein ; Anti-Inflammatory Agents ; Glucose (IY9XDZ35W2) ; Lipopolysaccharides
Language	English
Publishing date	2023-06-20
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1205240-1
ISSN	1618-095X ; 0944-7113
ISSN (online)	1618-095X
ISSN	0944-7113
DOI	10.1016/j.phymed.2023.154931
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Article ; Online: Analysis of Medication Rule of Primary Epilepsy Based on Xiaocheng Yan’s Clinical Experience Collection of Epilepsy

Yu Zhang / Lin Tong / Guangkun Chen / Jingpeng Deng / Lei Zhang / Hongtao Li / Pengfei Chang

Evidence-Based Complementary and Alternative Medicine, Vol

2022 Volume 2022

Abstract: Objective. To explore and analyze the medication rule of Professor Xiaocheng Yan in the treatment ... Mining and analysis of Professor Xiaocheng Yan sorted out the medical cases of primary epilepsy ... in Xiaocheng Yan’s clinical experience collection of epilepsy, extracted the traditional Chinese medicine (TCM ...

Abstract	Objective. To explore and analyze the medication rule of Professor Xiaocheng Yan in the treatment of primary epilepsy, hoping to provide reference for the clinical treatment of primary epilepsy. Methods. Mining and analysis of Professor Xiaocheng Yan sorted out the medical cases of primary epilepsy in Xiaocheng Yan’s clinical experience collection of epilepsy, extracted the traditional Chinese medicine (TCM) prescription data in the medical cases, standardized the obtained TCM prescription data, and used the data mining function integrated by the ancient and modern medical case cloud platform V2.3.5 to carry out frequency statistics, cluster analysis, association analysis, and complex network analysis on the TCM data, and the common herbs used by Professor Xiaocheng Yan in the treatment of primary epilepsy, properties and classifications of commonly used herbs, pairs of commonly used herbs, and core prescriptions were obtained. Results. A total of 39 cases, 228 medical records, and 230 prescriptions data of TCM were included. A total of 96 Chinese medicinal herbs were involved, and the total frequency of medication was 3,828. High-frequency herbs include Rhizoma Gastrodiae (Tianma) (222 times), Ramulus Uncariae cum Uncis (Gouteng) (220 times), Rhizoma Acori Tatarinowii (Shichangpu) (216 times), Rhizoma Pinelliae Praeparatum (Fabanxia) (207 times), Bombyx Batryticatus (Jiangcan) (206 times), and Periostracum Cicadae (Chantui) (181 times). The main properties and flavors of commonly used Chinese medicinal herbs were sweet, bitter, and pungent, which were mainly attributed to the four meridians of liver, lung, heart, and spleen. Commonly used couplet herbs were {Periostracum Cicadae (Chantui)} ≥ {Bombyx Batryticatus (Jiangcan)}, {Rhizoma Acori Tatarinowii (Shichangpu)} ≥{ Bombyx Batryticatus (Jiangcan)}, {Radix Bupleuri (Chaihu)} ≥ {Radix Scutellariae (Huangqin)}, {Rhizoma Gastrodiae (Tianma)} ≥ {Ramulus Uncariae cum Uncis (Gouteng)}, {Rhizoma Acori Tatarinowii (Shichangpu)} ≥ {Periostracum Cicadae (Chantui)}, ...
Keywords	Other systems of medicine ; RZ201-999
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Hepatoprotective mechanisms of Yan-gan-wan.

Yang, Melissa D / Deng, Qing-Gao / Chen, Shuang / Xiong, Shigang / Koop, Dennis / Tsukamoto, Hidekazu

Hepatology research : the official journal of the Japan Society of Hepatology

2005 Volume 32, Issue 4, Page(s) 202–212

Abstract: Background and aims: : A herbal prescription, Yan-gan-wan (YGW), has been known to offer ...

Abstract	Background and aims: : A herbal prescription, Yan-gan-wan (YGW), has been known to offer hepatoprotective effects in Asian countries for years. This study investigated its mechanisms of action. Methods: : The effects of YGW on CCl(4) induced liver damage were tested in mice and cultured hepatocytes. Microarray analysis screened genes affected by YGW. YGWs effects on the expression of cytochrome P450 (CYP) 2E1 and other isozymes were determined. YGWs effects on TNFalpha expression and NF-kappaB activation in Kupffer cells (KC), and TNFalpha promoter activity in RAW264.7 cells, were also assessed. Results: : Administration of YGW reduced the plasma ALT, centrilobular necrosis, neutrophilic infiltration, and TNFalpha mRNA in the livers of mice acutely given CCl(4). The in vivo herb treatment reduced ALT release and necrosis of isolated hepatocytes directly exposed to CCl(4). Microarray analysis demonstrated marked reductions in CYP4A10 and 4A14 by YGW but no changes in other CYP isozymes as confirmed by immunoblot analysis. The herb treatment suppressed LPS-stimulated TNFalpha release in vivo and by cultured KC. Direct addition of the aqueous herb extract suppressed NF-kappaB activation by KC and TNFalpha promoter activity in RAW cells under LPS stimulation. This activity to suppress TNFalpha expression was largely separated into gel filtration fractions with the molecular size of 102-107Da. YGW also attenuated liver fibrosis induced by chronic treatment of CCl(4) or porcine serum. Conclusions: : The protective effects of YGW on CCl(4) hepatotoxicity are due in part to inhibition of KC NF-kappaB activation and TNFalpha expression by small water soluble molecules, and may also be related to suppressed hepatic expression of CYP4A10 and 4A14 that are considered as alternative prooxidant cytochromes.
Language	English
Publishing date	2005-08-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1387041-5
ISSN	1386-6346 ; 0928-4346
ISSN	1386-6346 ; 0928-4346
DOI	10.1016/j.hepres.2005.06.004
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Zs.A 3826: Show issues

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Book: Zhong yao ping xing yao yao xing yan jiu

Deng, Jiagang

2012

Author's details	zhu bian Deng Jiagang
MeSH term(s)	Drugs, Chinese Herbal/pharmacology ; Materia Medica/analysis
Language	Chinese
Size	5, 330 p. :, ill.
Edition	Di 1 ban.
Publisher	Zhongguo Zhong yi yao chu ban she
Publishing place	Beijing
Document type	Book
ISBN	9787513208208 ; 7513208204
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Zhong yi pi ben zhi de xian dai yan jiu

Deng, Weimin

Zhongyi pi benzhi de xiandai yanjiu

2010

Author's details	zhu bian Deng Weimin, Liu Youzhang ; fu zhu bian Huang Xiaoyan, Li Jun, Song Yafang
MeSH term(s)	Spleen/physiology ; Medicine, Chinese Traditional
Language	Chinese
Size	2, 170 p. :, ill., ports. ;, 21 cm.
Edition	Di 1 ban.
Publisher	Ren min jun yi chu ban she
Publishing place	Beijing Shi
Document type	Book
ISBN	9787509135297 ; 750913529X
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Gu sheng wu xue qian yan

Deng, Hongwen

2006

Title variant	Current topics in bone biology
Author's details	zhu bian Deng Hongwen, Liu Yaozhong
MeSH term(s)	Bone and Bones/physiology
Language	Chinese
Size	ii, ii, 343 p. :, ill.
Edition	Di 1 ban.
Publisher	Gao deng jiao yu chu ban she
Publishing place	Beijing Shi
Document type	Book
ISBN	9787040182958 ; 7040182955
Database	Catalogue of the US National Library of Medicine (NLM)

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Book: Ming dai wen xue yan jiu

Shi, Tieliang / Chen, Liren / Deng, Shaoqiu

(20 shi ji zhong guo wen xue yan jiu ; 6 ; 20世纪中国文学研究 ; 6)

2001

Author's details	Shi tie liang, chen li ren, deng shao qiu
Series title	20 shi ji zhong guo wen xue yan jiu ; 6 ; 20世纪中国文学研究 ; 6
Language	Chinese
Size	2, 3, 13, 3, 717 S
Edition	Di yi ban
Publisher	Bei jing chu ban she
Publishing place	Bei jing
Document type	Book
ISBN	720004430X ; 9787200044300
Database	Former special subject collection: coastal and deep sea fishing

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