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  1. Article ; Online: Lactobacillus plantarum

    Li, Siying / Han, Xuebing / Liu, Naiyuan / Chang, Jiang / Liu, Gang / Hu, Siwang

    Frontiers in immunology

    2024  Volume 14, Page(s) 1285442

    Abstract: Introduction: Osteoporosis, one of the most common non-communicable human diseases worldwide, is one of the most prevalent disease of the adult skeleton. Glucocorticoid-induced osteoporosis(GIOP) is the foremost form of secondary osteoporosis, ... ...

    Abstract Introduction: Osteoporosis, one of the most common non-communicable human diseases worldwide, is one of the most prevalent disease of the adult skeleton. Glucocorticoid-induced osteoporosis(GIOP) is the foremost form of secondary osteoporosis, extensively researched due to its prevalence.Probiotics constitute a primary bioactive component within numerous foods, offering promise as a potential biological intervention for preventing and treating osteoporosis. This study aimed to evaluate the beneficial effects of the probiotic
    Methods: We examined the bone microstructure (Micro-CT and HE staining) and analyzed the gut microbiome and serum metabolome in rats.
    Results and discussion: The results revealed that
    MeSH term(s) Adult ; Humans ; Animals ; Rats ; Gastrointestinal Microbiome ; Glucocorticoids ; Lactobacillus plantarum ; Metabolome ; Osteoporosis ; Clostridiales
    Chemical Substances Glucocorticoids
    Language English
    Publishing date 2024-01-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1285442
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cyclodextrin-Based Polymeric Drug Delivery Systems for Cancer Therapy.

    Li, Xuebing / Liu, Junda / Qiu, Neng

    Polymers

    2023  Volume 15, Issue 6

    Abstract: Cyclodextrins (CDs) are one of the most extensively studied cyclic-oligosaccharides due to their low toxicity, good biodegradability and biocompatibility, facile chemical modification, and unique inclusion capacity. However, problems such as poor ... ...

    Abstract Cyclodextrins (CDs) are one of the most extensively studied cyclic-oligosaccharides due to their low toxicity, good biodegradability and biocompatibility, facile chemical modification, and unique inclusion capacity. However, problems such as poor pharmacokinetics, plasma membrane disruption, hemolytic effects and a lack of target specificity still exist for their applications as drug carriers. Recently, polymers have been introduced into CDs to combine the advantages of both biomaterials for the superior delivery of anticancer agents in cancer treatment. In this review, we summarize four types of CD-based polymeric carriers for the delivery of chemotherapeutics or gene agents for cancer therapy. These CD-based polymers were classified based on their structural properties. Most of the CD-based polymers were amphiphilic with the introduction of hydrophobic/hydrophilic segments and were able to form nanoassemblies. Anticancer drugs could be included in the cavity of CDs, encapsulated in the nanoparticles or conjugated on the CD-based polymers. In addition, the unique structures of CDs enable the functionalization of targeting agents and stimuli-responsive materials to realize the targeting and precise release of anticancer agents. In summary, CD-based polymers are attractive carriers for anticancer agents.
    Language English
    Publishing date 2023-03-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15061400
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  3. Article: Lactobacillus plantarum

    Ma, Yong / Fei, Yanquan / Han, Xuebing / Liu, Gang / Fang, Jun

    Frontiers in nutrition

    2022  Volume 9, Page(s) 947367

    Abstract: Metabolic disorders and intestinal flora imbalance usually accompany obesity. Due to its diverse biological activities, ...

    Abstract Metabolic disorders and intestinal flora imbalance usually accompany obesity. Due to its diverse biological activities,
    Language English
    Publishing date 2022-06-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2776676-7
    ISSN 2296-861X
    ISSN 2296-861X
    DOI 10.3389/fnut.2022.947367
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  4. Article ; Online: Mechanical properties and numerical simulation analysis on large deformation of Jiangluling Carbonaceous Shale Tunnel

    Peng Cao / Xuebing Hu / Enlong Liu / Hongyan Guo

    Frontiers in Earth Science, Vol

    2023  Volume 11

    Abstract: Taking the Jiangluling Carbonaceous Shale Tunnel as an example, this study aims to investigate the mechanism of large deformation and design construction technology of carbonaceous shale tunnels. Using theoretical analysis and comparative analysis of ... ...

    Abstract Taking the Jiangluling Carbonaceous Shale Tunnel as an example, this study aims to investigate the mechanism of large deformation and design construction technology of carbonaceous shale tunnels. Using theoretical analysis and comparative analysis of numerical simulation and field measured data, the mechanism, mechanical properties, and causes of large squeezing deformation of the Jiangluling Tunnel were analyzed. The study results are as follows: 1) Six failure modes of the support structure can be generated due to the large deformation of the surrounding rocks during the construction of Jiangluling Carbonaceous Shale Tunnel; 2) The causes of large deformation during the construction can be divided into internal and external causes; 3) The deformation degree of the surrounding rock of Jiangluling Carbonaceous Shale Tunnel increases with the burial depth in an approximately linear manner. Under deep-buried conditions, horizontal convergence is more severe than vault settlement in carbonaceous shale tunnels; 4) The deformation of the construction cavern of the Jiangluling Carbonaceous Shale Tunnel typically includes the displacement before tunnel face excavation, tunnel face deformation, and deformation behind the tunnel face. The advance displacement accounts for 30.73% of the total displacement. The influence range of advance displacement is 1-1.2D in front of the tunnel face. These results can provide a reference for the design and construction of carbonaceous shale tunnels.
    Keywords Carbonaceous Shale Tunnels ; large deformation ; mechanical properties ; numerical simulation ; tunnel construction ; Science ; Q
    Subject code 690
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Cyclodextrin-Based Polymeric Drug Delivery Systems for Cancer Therapy

    Xuebing Li / Junda Liu / Neng Qiu

    Polymers, Vol 15, Iss 1400, p

    2023  Volume 1400

    Abstract: Cyclodextrins (CDs) are one of the most extensively studied cyclic-oligosaccharides due to their low toxicity, good biodegradability and biocompatibility, facile chemical modification, and unique inclusion capacity. However, problems such as poor ... ...

    Abstract Cyclodextrins (CDs) are one of the most extensively studied cyclic-oligosaccharides due to their low toxicity, good biodegradability and biocompatibility, facile chemical modification, and unique inclusion capacity. However, problems such as poor pharmacokinetics, plasma membrane disruption, hemolytic effects and a lack of target specificity still exist for their applications as drug carriers. Recently, polymers have been introduced into CDs to combine the advantages of both biomaterials for the superior delivery of anticancer agents in cancer treatment. In this review, we summarize four types of CD-based polymeric carriers for the delivery of chemotherapeutics or gene agents for cancer therapy. These CD-based polymers were classified based on their structural properties. Most of the CD-based polymers were amphiphilic with the introduction of hydrophobic/hydrophilic segments and were able to form nanoassemblies. Anticancer drugs could be included in the cavity of CDs, encapsulated in the nanoparticles or conjugated on the CD-based polymers. In addition, the unique structures of CDs enable the functionalization of targeting agents and stimuli-responsive materials to realize the targeting and precise release of anticancer agents. In summary, CD-based polymers are attractive carriers for anticancer agents.
    Keywords cyclodextrin ; polyrotaxane ; conjugate ; polymer ; crosslink ; copolymer ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Isolation, Structural Characteristics Analysis of a

    Fan, Yijun / Xu, Erya / Ma, Jie / Li, Xuebing / Liu, Yuanyuan / Xu, Linlong / Luo, Aoxue

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 14

    Abstract: Cowpea ( ...

    Abstract Cowpea (
    MeSH term(s) Vigna ; Polysaccharides/chemistry ; Monosaccharides/analysis ; Glucose/chemistry ; Ethanol
    Chemical Substances Polysaccharides ; Monosaccharides ; Glucose (IY9XDZ35W2) ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28145566
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  7. Article ; Online: Iron(I) Complex Bearing an Open-Shell Diazenido Ligand.

    Liu, Qing / Wang, Peng / Wang, Yujian / Zou, Junjie / Leng, Xuebing / Deng, Liang

    Journal of the American Chemical Society

    2024  

    Abstract: Low-valent transition-metal diazenido species are important intermediates in transition-metal-mediated dinitrogen reduction reactions. Isolable complexes of the type unanimously feature closed-shell diazenido ligands. Those bearing open-shell diazenido ... ...

    Abstract Low-valent transition-metal diazenido species are important intermediates in transition-metal-mediated dinitrogen reduction reactions. Isolable complexes of the type unanimously feature closed-shell diazenido ligands. Those bearing open-shell diazenido ligands have remained elusive. Herein, we report the synthesis, characterization, and reactivity of a
    Language English
    Publishing date 2024-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.4c03483
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    In stock of ZB MED Bonn / Germany

    Z 4' 55/32: Show issues
    Z 7.3: Show issues

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  8. Article ; Online: Mapping and spatiotemporal dynamics of land-use and land-cover change based on the Google Earth Engine cloud platform from Landsat imagery

    Chao Chen / Xuebing Yang / Shenghui Jiang / Zhisong Liu

    Heliyon, Vol 9, Iss 9, Pp e19654- (2023)

    A case study of Zhoushan Island, China

    2023  

    Abstract: Land resources are an essential foundation for socioeconomic development. Island land resources are limited, the type changes are particularly frequent, and the environment is fragile. Therefore, large-scale, long-term, and high-accuracy land-use ... ...

    Abstract Land resources are an essential foundation for socioeconomic development. Island land resources are limited, the type changes are particularly frequent, and the environment is fragile. Therefore, large-scale, long-term, and high-accuracy land-use classification and spatiotemporal characteristic analysis are of great significance for the sustainable development of islands. Based on the advantages of remote sensing indices and principal component analysis in accurate classification, and taking Zhoushan Archipelago, China, as the study area, in this work long-term satellite remote sensing data were used to perform land-use classification and spatiotemporal characteristic analysis. The classification results showed that the land-use types could be exactly classified, with the overall accuracy and Kappa coefficient greater than 94% and 0.93, respectively. The results of the spatiotemporal characteristic analysis showed that the built-up land and forest land areas increased by 90.00 km2 and 36.83 km2, respectively, while the area of the cropland/grassland decreased by 69.77 km2. The areas of the water bodies, tidal flats, and bare land exhibited slight change trends. The spatial coverage of Zhoushan Island continuously expanded toward the coast, encroaching on nearby sea areas and tidal flats. The cropland/grassland was the most transferred-out area, at up to 108.94 km2, and built-up land was the most transferred-in areas, at up to 73.31 km2. This study provides a data basis and technical support for the scientific management of land resources.
    Keywords Zhoushan island ; Landsat ; GEE ; Land use and land cover change ; Spatio-temporal characteristics ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Subject code 910 ; 710
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Mapping and spatiotemporal dynamics of land-use and land-cover change based on the Google Earth Engine cloud platform from Landsat imagery: A case study of Zhoushan Island, China.

    Chen, Chao / Yang, Xuebing / Jiang, Shenghui / Liu, Zhisong

    Heliyon

    2023  Volume 9, Issue 9, Page(s) e19654

    Abstract: Land resources are an essential foundation for socioeconomic development. Island land resources are limited, the type changes are particularly frequent, and the environment is fragile. Therefore, large-scale, long-term, and high-accuracy land-use ... ...

    Abstract Land resources are an essential foundation for socioeconomic development. Island land resources are limited, the type changes are particularly frequent, and the environment is fragile. Therefore, large-scale, long-term, and high-accuracy land-use classification and spatiotemporal characteristic analysis are of great significance for the sustainable development of islands. Based on the advantages of remote sensing indices and principal component analysis in accurate classification, and taking Zhoushan Archipelago, China, as the study area, in this work long-term satellite remote sensing data were used to perform land-use classification and spatiotemporal characteristic analysis. The classification results showed that the land-use types could be exactly classified, with the overall accuracy and Kappa coefficient greater than 94% and 0.93, respectively. The results of the spatiotemporal characteristic analysis showed that the built-up land and forest land areas increased by 90.00 km
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e19654
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  10. Article ; Online: Improving Anti-HIV activity and pharmacokinetics of enfuvirtide (T20) by modification with oligomannose.

    Cheng, Shuihong / Xu, Mingyue / Li, Mingli / Feng, Yong / He, Lin / Liu, Tong / Ma, Liying / Li, Xuebing

    European journal of medicinal chemistry

    2024  Volume 269, Page(s) 116299

    Abstract: Dendritic cells (DCs) play a pivotal role in controlling HIV-1 infections of ... ...

    Abstract Dendritic cells (DCs) play a pivotal role in controlling HIV-1 infections of CD4
    MeSH term(s) Animals ; Rats ; Enfuvirtide/pharmacology ; Enfuvirtide/metabolism ; HIV Infections ; HIV Fusion Inhibitors/pharmacology ; HIV Fusion Inhibitors/metabolism ; Peptide Fragments/pharmacology ; Peptide Fragments/metabolism ; HIV Envelope Protein gp41/metabolism ; HIV-1
    Chemical Substances Enfuvirtide (19OWO1T3ZE) ; HIV Fusion Inhibitors ; Peptide Fragments ; HIV Envelope Protein gp41
    Language English
    Publishing date 2024-03-08
    Publishing country France
    Document type Journal Article
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116299
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 784: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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