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  1. Article: Three-dimensional model of normal human dermal tissue using serial tissue sections.

    Liu, Peng / Zhang, Tao / Huang, Yihui

    Frontiers in bioengineering and biotechnology

    2024  Volume 12, Page(s) 1347159

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2024.1347159
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: PET/CT study of dopamine transporter (DAT) binding with the triple reuptake inhibitor toludesvenlafaxine in rats and humans.

    Huang, Zhiwei / Wu, Junhao / Guan, Yihui / Wei, Yumei / Xie, Fang / Shen, Yifeng

    European journal of nuclear medicine and molecular imaging

    2024  

    Language English
    Publishing date 2024-04-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8236-3
    ISSN 1619-7089 ; 0340-6997 ; 1619-7070
    ISSN (online) 1619-7089
    ISSN 0340-6997 ; 1619-7070
    DOI 10.1007/s00259-024-06700-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Beyond

    Ni, Jiaojiao / Huang, Yihui / Li, Chaoqun / Yin, Qian / Ying, Jieer

    Molecular therapy oncolytics

    2023  Volume 31, Page(s) 100750

    Abstract: Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the ... ...

    Abstract Aerobic glycolysis is a hallmark property of cancer metabolism. Enolase is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate into phosphoenolpyruvate. In mammals, enolases exist in three isoforms, encoded by the genes
    Language English
    Publishing date 2023-11-10
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2372-7705
    ISSN 2372-7705
    DOI 10.1016/j.omto.2023.100750
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Identification of a de novo CACNA1B variant and a start-loss ADRA2B variant in paroxysmal kinesigenic dyskinesia.

    Yuan, Zhuangzhuang / Wang, Qian / Wang, Chenyu / Liu, Yuxing / Fan, Liangliang / Liu, Yihui / Huang, Hao

    Heliyon

    2024  Volume 10, Issue 7, Page(s) e28674

    Abstract: Paroxysmal kinesigenic dyskinesia (PKD) represents the most prevalent form of paroxysmal dyskinesia, characterized by recurrent and transient attacks of involuntary movements triggered by a sudden voluntary action. In this study, whole-exome sequencing ... ...

    Abstract Paroxysmal kinesigenic dyskinesia (PKD) represents the most prevalent form of paroxysmal dyskinesia, characterized by recurrent and transient attacks of involuntary movements triggered by a sudden voluntary action. In this study, whole-exome sequencing was conducted on a cohort of Chinese patients to identify causal mutations. In one young female case, a de novo
    Language English
    Publishing date 2024-03-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e28674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Application Value of Target Management Mode Based on Chronic Illness Trajectory Framework in Elderly Patients with Diabetes Mellitus and Cardiovascular Diseases.

    Zhang, Yinhong / Hu, Ping / Huang, Yihui / Fu, Chong / Dong, Zhu

    Alternative therapies in health and medicine

    2024  

    Abstract: Background: Diabetes and cardiovascular diseases represent significant global health challenges, leading to organ dysfunction and increased mortality rates. Managing these conditions is complex, especially in the elderly population. The study addresses ... ...

    Abstract Background: Diabetes and cardiovascular diseases represent significant global health challenges, leading to organ dysfunction and increased mortality rates. Managing these conditions is complex, especially in the elderly population. The study addresses this pressing issue by exploring the application of the Chronic Illness Trajectory Framework (CITF), aiming to improve self-care and quality of life in elderly patients with diabetes and cardiovascular diseases.
    Methods: A total of 127 patients with diabetes mellitus and cardiovascular diseases admitted to the hospital were enrolled between January 2020 and January 2022. According to the implementation of CITF management mode, they were divided into a control group (62 cases, non-implementation) and an observation group (65 cases, implementation). The control group was given routine intervention, while the observation group was given CITF-based target management mode for 3 months. The changes in blood glucose, blood lipid, negative emotions, self-efficacy, self-management, compliance, and quality of life before and after intervention in both groups were observed. This study was approved by the Ethics Committee of Zhujiang Hospital.
    Results: After intervention, levels of fasting plasma glucose (FPG), 2h plasma glucose (2hPG), hemoglobin A1c (HbA1c), total cholesterol (TC), triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C), scores of self-rating depression scale (SDS), self-rating anxiety scale (SAS) and Diabetes Specific Quality of Life Scale (DSQL) were decreased (P < .05), while scores of General Self-Efficacy Scale (GSES) and Scale of the Diabetes Self-Care Activities Chinese version (SDSCA), and compliance rate were increased in both groups (P < .05). The levels of FPG, 2hPG, HbA1c, TC, TG, and LDL-C, scores of SDS, SAS, and DSQL in the observation group were lower than those in the control group (P < .001), and scores of GSES and SDSCA, and compliance rate were higher than those in the control group (P < .001). These results highlight the positive role of comprehensive intervention in improving the physical and mental health of patients with diabetes and provide strong support for the application of comprehensive intervention strategies in diabetes management.
    Conclusion: CITF-based target management mode can alleviate negative emotions in patients with diabetes mellitus and cardiovascular diseases, improve self-management, self-efficacy, and compliance, effectively control blood glucose and lipids, and improve quality of life. The study conclusions highlight the importance of CITF management models in improving the management of patients with diabetes and cardiovascular disease. This comprehensive intervention helps reduce negative emotions, improve self-management and compliance, effectively control blood sugar and blood lipids, and improve quality of life. These results have important clinical implications and provide strong support for better care of patients with chronic diseases.
    Language English
    Publishing date 2024-01-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Input-output specific orchestration of aversive valence in lateral habenula during stress dynamics.

    Huang, Taida / Guo, Xiaonan / Huang, Xiaomin / Yi, Chenju / Cui, Yihui / Dong, Yiyan

    Journal of Zhejiang University. Science. B

    2024  , Page(s) 1–11

    Abstract: Stress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula ( ... ...

    Title translation 压力动态过程中负性情绪在外侧缰核的“输入-输出”特异性整合.
    Abstract Stress has been considered as a major risk factor for depressive disorders, triggering depression onset via inducing persistent dysfunctions in specialized brain regions and neural circuits. Among various regions across the brain, the lateral habenula (LHb) serves as a critical hub for processing aversive information during the dynamic process of stress accumulation, thus having been implicated in the pathogenesis of depression. LHb neurons integrate aversive valence conveyed by distinct upstream inputs, many of which selectively innervate the medial part (LHbM) or lateral part (LHbL) of LHb. LHb subregions also separately assign aversive valence via dissociable projections to the downstream targets in the midbrain which provides feedback loops. Despite these strides, the spatiotemporal dynamics of LHb-centric neural circuits remain elusive during the progression of depression-like state under stress. In this review, we attempt to describe a framework in which LHb orchestrates aversive valence via the input-output specific neuronal architecture. Notably, a physiological form of Hebbian plasticity in LHb under multiple stressors has been unveiled to incubate neuronal hyperactivity in an input-specific manner, which causally encodes chronic stress experience and drives depression onset. Collectively, the recent progress and future efforts in elucidating LHb circuits shed light on early interventions and circuit-specific antidepressant therapies.
    Language Chinese
    Publishing date 2024-04-07
    Publishing country China
    Document type Journal Article
    ZDB-ID 2247290-3
    ISSN 1862-1783 ; 1673-1581
    ISSN (online) 1862-1783
    ISSN 1673-1581
    DOI 10.1631/jzus.B2300933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Biodirected Screening and Preparation of

    Yang, Zhizhi / Wang, Changrong / Huang, Baote / Chen, Yihui / Liu, Zhiyu / Chen, Hongbin / Chen, Jicheng

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 5

    Abstract: Food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides have gained attention for their potent and safe treatment of hypertensive disorders. However, there are some limitations of conventional methods for preparing ACE-inhibitory peptides. ...

    Abstract Food-derived angiotensin-I-converting enzyme (ACE)-inhibitory peptides have gained attention for their potent and safe treatment of hypertensive disorders. However, there are some limitations of conventional methods for preparing ACE-inhibitory peptides. In this study, in silico hydrolysis, the quantitative structure-activity relationship (QSAR) model, LC-MS/MS, inhibition kinetics, and molecular docking were used to investigate the stability, hydrolyzability, in vitro activity, and inhibition mechanism of bioactive peptides during the actual hydrolysis process. Six novel ACE-inhibitory peptides were screened from the
    MeSH term(s) Angiotensin-Converting Enzyme Inhibitors/chemistry ; Molecular Docking Simulation ; Peptidyl-Dipeptidase A/metabolism ; Chromatography, Liquid ; Reproducibility of Results ; Tandem Mass Spectrometry ; Peptides/chemistry ; Angiotensins
    Chemical Substances Angiotensin-Converting Enzyme Inhibitors ; Peptidyl-Dipeptidase A (EC 3.4.15.1) ; Peptides ; Angiotensins
    Language English
    Publishing date 2024-03-03
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29051134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enhancing anammox process with granular activated carbon: A study on Microbial Extracellular Secretions (MESs).

    Guo, Hengbo / Gao, Mengjiao / Yao, Yiduo / Zou, Xin / Zhang, Yihui / Huang, Wendy / Liu, Yang

    The Science of the total environment

    2024  Volume 926, Page(s) 171980

    Abstract: Granular activated carbon (GAC), a porous carbon-based material, provides increased attachment space for functional microorganisms and enhances nitrogen removal by facilitating extracellular electron transfer in the anammox process. This study ... ...

    Abstract Granular activated carbon (GAC), a porous carbon-based material, provides increased attachment space for functional microorganisms and enhances nitrogen removal by facilitating extracellular electron transfer in the anammox process. This study investigates the effects of GAC on the biosynthesis of microbial extracellular secretions (MESs) and explores the roles of these secretions in anammox activities. Four lab-scale reactors were operated: two downstream UASB reactors (D1 and D2) receiving effluents from the upstream UASB reactors (U1: no-GAC, U2: yes-GAC). Our results indicate that MESs were enhanced with the addition of GAC. The effluent from U2 exhibited a 59.62 % higher amino acid content than that from U1. These secretions contributed to an increase in the nitrogen loading rate (NLR) in the downstream reactors. Specifically, NLR in D1 increased from 130.5 to 142.7 g N/m
    MeSH term(s) Sewage/microbiology ; Charcoal/metabolism ; Anaerobic Ammonia Oxidation ; Bioreactors/microbiology ; Bacteria/metabolism ; Anaerobiosis ; Nitrogen/metabolism ; Oxidation-Reduction
    Chemical Substances Sewage ; Charcoal (16291-96-6) ; Nitrogen (N762921K75)
    Language English
    Publishing date 2024-03-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2024.171980
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Coupling Between Human Brain Cortical Thickness and Glucose Metabolism from Regional to Connective Level: A Positron Emission Tomography/Magnetic Resonance Imaging Study.

    Huang, Qi / Yang, Yihong / Qi, Na / Guan, Yihui / Zhao, Jun / Hua, Fengchun / Ren, Shuhua / Xie, Fang

    Brain connectivity

    2024  Volume 14, Issue 2, Page(s) 122–129

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Middle Aged ; Young Adult ; Humans ; Aged ; Magnetic Resonance Imaging ; Brain/pathology ; Brain Cortical Thickness ; Brain Diseases/pathology ; Glucose/metabolism ; Positron-Emission Tomography
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2609017-X
    ISSN 2158-0022 ; 2158-0014
    ISSN (online) 2158-0022
    ISSN 2158-0014
    DOI 10.1089/brain.2023.0070
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online: MTD

    Huang, Yihui / Chen, Ningjiang

    Multi-Timestep Detector for Delayed Streaming Perception

    2023  

    Abstract: Autonomous driving systems require real-time environmental perception to ensure user safety and experience. Streaming perception is a task of reporting the current state of the world, which is used to evaluate the delay and accuracy of autonomous driving ...

    Abstract Autonomous driving systems require real-time environmental perception to ensure user safety and experience. Streaming perception is a task of reporting the current state of the world, which is used to evaluate the delay and accuracy of autonomous driving systems. In real-world applications, factors such as hardware limitations and high temperatures inevitably cause delays in autonomous driving systems, resulting in the offset between the model output and the world state. In order to solve this problem, this paper propose the Multi- Timestep Detector (MTD), an end-to-end detector which uses dynamic routing for multi-branch future prediction, giving model the ability to resist delay fluctuations. A Delay Analysis Module (DAM) is proposed to optimize the existing delay sensing method, continuously monitoring the model inference stack and calculating the delay trend. Moreover, a novel Timestep Branch Module (TBM) is constructed, which includes static flow and adaptive flow to adaptively predict specific timesteps according to the delay trend. The proposed method has been evaluated on the Argoverse-HD dataset, and the experimental results show that it has achieved state-of-the-art performance across various delay settings.

    Comment: 12 pages, accepted by PRCV 2023 (The 6th Chinese Conference on Pattern Recognition and Computer Vision)
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning ; Computer Science - Robotics
    Subject code 629
    Publishing date 2023-09-13
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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