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Article: [Neurointensive Care:Managing Intracranial Hypertension and Cerebral Herniation].

Fujiwara, Daigo / Egawa, Satoshi

2023 Volume 51, Issue 6, Page(s) 1089–1103

Abstract: In order to optimize neurological outcomes in patients presenting with elevated intracranial pressure, secondary cerebral insults during therapeutic interventions should be prevented and mitigated. Considering the absence of a singular, definitive ... ...

Abstract	In order to optimize neurological outcomes in patients presenting with elevated intracranial pressure, secondary cerebral insults during therapeutic interventions should be prevented and mitigated. Considering the absence of a singular, definitive monitoring parameter, the diverse facets of its pathophysiology-encompassing the Monroe-Kellie doctrine, brain compliance, and cerebral metabolism-should be understood. Multimodality monitoring, which incorporates physiological indicators of intracranial pressure sensors, electroencephalograms, and ultrasound, can be assessed in an integrative manner. These assessments subsequently inform surgical and intensive care strategies, often guided by structured protocols, such as a stepwise approach. This comprehensive paradigm, central to neurocritical care, may significantly enhance the neurological prognosis of patients.
MeSH term(s)	Humans ; Brain Diseases ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/etiology ; Intracranial Hypertension/therapy ; Intracranial Pressure/physiology ; Brain ; Monitoring, Physiologic/methods
Language	Japanese
Publishing date	2023-11-27
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	197053-7
ISSN	1882-1251 ; 0301-2603
ISSN (online)	1882-1251
ISSN	0301-2603
DOI	10.11477/mf.1436204855
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Zs.MO 268: Show issues

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Article ; Online: Dupilumab as a novel treatment option for prurigo nodularis.

Nakajima, Saeko / Yonekura, Satoru / Nakamizo, Satoshi / Egawa, Gyohei / Kabashima, Kenji

The Journal of allergy and clinical immunology

2023 Volume 152, Issue 4, Page(s) 870–872

MeSH term(s)	Humans ; Prurigo/drug therapy ; Antibodies, Monoclonal, Humanized/therapeutic use
Chemical Substances	dupilumab (420K487FSG) ; Antibodies, Monoclonal, Humanized
Language	English
Publishing date	2023-08-23
Publishing country	United States
Document type	Editorial
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2023.08.011
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Article ; Online: Idiopathic Intracranial Hypertension with Disproportionately Enlarged Subarachnoid Space Hydrocephalus on Imaging.

Kunugitani, Ken / Miura, Satoshi / Sawamura, Masanori / Mitani, Koki / Okawa, Masakazu / Egawa, Naohiro / Takahashi, Ryosuke

Internal medicine (Tokyo, Japan)

2023 Volume 62, Issue 20, Page(s) 3043–3046

Abstract: The pathophysiology of idiopathic intracranial hypertension (IIH) and idiopathic normal-pressure hydrocephalus (iNPH) differs in terms of cerebrospinal fluid (CSF) pressure and imaging-related characteristics. A 51-year-old man presented with optic nerve ...

Abstract	The pathophysiology of idiopathic intracranial hypertension (IIH) and idiopathic normal-pressure hydrocephalus (iNPH) differs in terms of cerebrospinal fluid (CSF) pressure and imaging-related characteristics. A 51-year-old man presented with optic nerve papillary edema, visual disturbance, bilateral abducens nerve palsy, and a wide-based gait. Imaging showed characteristic findings of IIH and disproportionately enlarged subarachnoid space hydrocephalus (DESH) - characteristic of iNPH. A CSF examination revealed marked CSF hypertension. IIH with iNPH-like imaging features (DESH) was diagnosed, and ventriculoperitoneal shunt surgery was performed. Postoperatively, the visual acuity and visual field improved. This report also describes the distinct and overlapping pathophysiological mechanisms of IIH and iNPH.
MeSH term(s)	Male ; Humans ; Middle Aged ; Pseudotumor Cerebri/complications ; Pseudotumor Cerebri/diagnostic imaging ; Pseudotumor Cerebri/surgery ; Hydrocephalus, Normal Pressure/complications ; Hydrocephalus, Normal Pressure/diagnostic imaging ; Hydrocephalus, Normal Pressure/surgery ; Ventriculoperitoneal Shunt ; Magnetic Resonance Imaging/methods ; Subarachnoid Space/diagnostic imaging ; Subarachnoid Space/surgery
Language	English
Publishing date	2023-03-08
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	32371-8
ISSN	1349-7235 ; 0021-5120 ; 0918-2918
ISSN (online)	1349-7235
ISSN	0021-5120 ; 0918-2918
DOI	10.2169/internalmedicine.1201-22
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Article ; Online: Increased ACE2 and TMPRSS2 expression in ulcerative colitis.

Hamamoto, Yuichiro / Kawamura, Michihiro / Uchida, Hiroki / Hiramatsu, Kazuhiro / Katori, Chiaki / Asai, Hinako / Egawa, Satoshi / Yoshida, Kyotaro

Pathology, research and practice

2024 Volume 254, Page(s) 155108

Abstract: Ulcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has ... ...

Abstract	Ulcerative colitis (UC) is a cryptogenic inflammatory bowel disease, and there is an urgent need to elucidate its pathogenesis. ACE2 and TMPRSS2, the entry molecules of SARS-CoV-2, are reportedly associated with the disease; however, no consensus has been reached yet. In this study, we examined the expression of ACE2 and TMPRSS2 in colon and rectal specimens of UC. We collected colorectal specimens from 60 patients (30 patients with UC and 30 controls from 2018 to 2021) and analyzed the proportion and intensity of ACE2 and TMPRSS2 using immunohistochemistry. The results revealed a significant increase in the proportion of ACE2 expression and the intensity of TMPRSS2 expression in patients with UC. ACE2 and TMPRSS2 expression in UC remained unaffected by the COVID-19 pandemic. We demonstrated that ACE2 and TMPRSS2 are likely involved in the pathogenesis of UC.
MeSH term(s)	Humans ; Angiotensin-Converting Enzyme 2 ; Colitis, Ulcerative ; Pandemics ; COVID-19 ; SARS-CoV-2 ; Serine Endopeptidases
Chemical Substances	Angiotensin-Converting Enzyme 2 (EC 3.4.17.23) ; TMPRSS2 protein, human (EC 3.4.21.-) ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2024-01-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2024.155108
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Article ; Online: A New Boron-Rhodamine-Containing Carboxylic Acid as a Sugar Chemosensor.

Komori, Yuta / Sugimoto, Shun / Sato, Toranosuke / Okawara, Honoka / Watanabe, Ryo / Takano, Yuki / Kitaoka, Satoshi / Egawa, Yuya

Sensors (Basel, Switzerland)

2023 Volume 23, Issue 3

Abstract: We propose a boron-rhodamine-containing carboxylic acid (BRhoC) substance as a new sugar chemosensor. BRhoC was obtained by the Friedel-Crafts reaction of 4-formylbenzoic acid ... ...

Abstract	We propose a boron-rhodamine-containing carboxylic acid (BRhoC) substance as a new sugar chemosensor. BRhoC was obtained by the Friedel-Crafts reaction of 4-formylbenzoic acid and
Language	English
Publishing date	2023-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s23031528
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Article ; Online: The Histological Detection of Ulcerative Colitis Using a No-Code Artificial Intelligence Model.

Hamamoto, Yuichiro / Kawamura, Michihiro / Uchida, Hiroki / Hiramatsu, Kazuhiro / Katori, Chiaki / Asai, Hinako / Shimizu, Shigeki / Egawa, Satoshi / Yoshida, Kyotaro

International journal of surgical pathology

2023 , Page(s) 10668969231204955

Abstract: Ulcerative colitis (UC) is an intractable disease that affects young adults. Histological findings are essential for its diagnosis; however, the number of diagnostic pathologists is limited. Herein, we used a no-code artificial intelligence (AI) platform ...

Abstract	Ulcerative colitis (UC) is an intractable disease that affects young adults. Histological findings are essential for its diagnosis; however, the number of diagnostic pathologists is limited. Herein, we used a no-code artificial intelligence (AI) platform "Teachable Machine" to train a model that could distinguish between histological images of UC, non-UC coloproctitis, adenocarcinoma, and control. A total of 5100 histological images for training and 900 histological images for testing were prepared by pathologists. Our model showed accuracies of 0.99, 1.00, 0.99, and 0.99, for UC, non-UC coloproctitis, adenocarcinoma, and control, respectively. This is the first report in which a no-code easy AI platform has been able to comprehensively recognize the distinctive histologic patterns of UC.
Language	English
Publishing date	2023-10-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1336393-1
ISSN	1940-2465 ; 1066-8969
ISSN (online)	1940-2465
ISSN	1066-8969
DOI	10.1177/10668969231204955
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Article: Caco-2 Cell Sheet Partially Laminated with HT29-MTX Cells as a Novel In Vitro Model of Gut Epithelium Drug Permeability.

Cheng, Yi / Watanabe, Chie / Ando, Yusuke / Kitaoka, Satoshi / Egawa, Yuya / Takashima, Tomoya / Matsumoto, Akihiro / Murakami, Masahiro

Pharmaceutics

2023 Volume 15, Issue 9

Abstract: The intestinal epithelial Caco-2 cell monolayer is a well-established in vitro model useful for predicting intestinal drug absorption in humans. Coculture models of Caco-2 and goblet-cell-like HT29-MTX cells have been developed to overcome the lack of a ... ...

Abstract	The intestinal epithelial Caco-2 cell monolayer is a well-established in vitro model useful for predicting intestinal drug absorption in humans. Coculture models of Caco-2 and goblet-cell-like HT29-MTX cells have been developed to overcome the lack of a mucus layer; however, those models are much leakier compared to the intestinal epithelium. Here, we developed a partially laminated culture model where HT29-MTX cells were superimposed onto a Caco-2 monolayer to overcome this issue. A morphological study showed that the piled HT29-MTX cells were voluntarily incorporated into the Caco-2 monolayer, and mucus production was confirmed via periodic acid-Schiff and mucin protein 2 staining. Permeability was evaluated in terms of transepithelial electrical resistance (TEER) and the apparent permeability of paracellular markers with different molecular sizes. The partially laminated model maintained the high barrier function of the Caco-2 monolayer, whose permeability appeared adjustable according to the HT29-MTX/Caco-2 cell ratio. In contrast, the coculture models showed abnormally high permeability of those markers, correlated with low TEER. Thus, the partially laminated model enabled in vitro recapitulation of effective mucosal barrier function. Consequently, this novel model may be useful as an in vitro high-throughput evaluation system for enteral mucosal permeability and mucus-penetrating efficiency of drugs and nanocarriers.
Language	English
Publishing date	2023-09-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527217-2
ISSN	1999-4923
ISSN	1999-4923
DOI	10.3390/pharmaceutics15092338
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Article ; Online: Adherence to recommended vaccination policies for pre- and post-solid organ transplantation patients: A national questionnaire survey in Japan.

Tanaka, Takeshi / Kakiuchi, Satoshi / Tashiro, Masato / Fujita, Ayumi / Ashizawa, Nobuyuki / Eguchi, Susumu / Kenmochi, Takashi / Egawa, Hiroto / Izumikawa, Koichi

Vaccine

2023 Volume 41, Issue 52, Page(s) 7682–7688

Abstract: Background: Pre-transplant vaccination is recommended for patients undergoing solid organ transplantation (SOT). While appropriate vaccination protocols are implemented at some facilities, transplantation is sometimes performed with inadequate ... ...

Abstract	Background: Pre-transplant vaccination is recommended for patients undergoing solid organ transplantation (SOT). While appropriate vaccination protocols are implemented at some facilities, transplantation is sometimes performed with inadequate preoperative vaccine management. Vaccination rates vary across facilities, but those of SOT centers in Japan have never been investigated. This study aimed to conduct a nationwide questionnaire survey to assess pre- and post-transplant vaccination policies among SOT facilities in Japan. Methods: The survey was conducted from September to November 2022. All registered (n = 221) solid organ (namely, the lungs, liver, kidneys, pancreas, heart, and small intestine) transplant facilities were asked to complete a web-based survey. Results: The survey response rate was 70.2 %. Live and inactivated vaccines were recommended at 64.9 % and 68.9 % of the responding facilities, respectively. The following vaccines were incorporated into the vaccination protocols of facilities: pneumococcal vaccine, 31.7 % (13-valent pneumococcal conjugate vaccine) and 65.4 % (23-valent pneumococcal polysaccharide vaccine); hepatitis B virus vaccine, 67.3 %; severe acute respiratory syndrome coronavirus 2 vaccine, 73.1 %; influenza vaccine, 73.1 %; and zoster vaccines, 23.1 %. The reasons for unresponsiveness to vaccinations included inadequate time before transplantation (60.3 %), cost burden (41.1 %), high number of vaccinations (21.9 %), no recognition of the need for vaccination (17.9 %), and the requirement to explain the need for vaccination (15.2 %). Conclusions: Our study revealed gaps in vaccination practices across nationwide facilities in Japan. The findings indicate the importance of promoting scheduled efficiency and encouraging the national health system to reduce vaccine costs with the support of public subsidies.
MeSH term(s)	Humans ; Japan ; Vaccination/methods ; Pneumococcal Vaccines ; Transplants ; Influenza Vaccines ; Organ Transplantation
Chemical Substances	Pneumococcal Vaccines ; Influenza Vaccines
Language	English
Publishing date	2023-11-25
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2023.11.033
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Zs.A 1930: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 458: Show issues

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Article ; Online: Alterations in choroidal vascular structures due to serum levels of vascular endothelial growth factor in patients with POEMS syndrome.

Yokouchi, Hirotaka / Nagasato, Daisuke / Mitamura, Yoshinori / Egawa, Mariko / Tabuchi, Hitoshi / Misawa, Sonoko / Kuwabara, Satoshi / Baba, Takayuki

Scientific reports

2023 Volume 13, Issue 1, Page(s) 10650

Abstract: A higher serum vascular endothelial growth factor (VEGF) level can cause choroidal thickening in the choroid of patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. We aimed to determine ... ...

Abstract	A higher serum vascular endothelial growth factor (VEGF) level can cause choroidal thickening in the choroid of patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome. We aimed to determine whether fluctuations in serum VEGF levels affect choroidal vascular structures in patients with POEMS syndrome. This retrospective observational case series examined 17 left eyes of 17 patients with POEMS syndrome. Enhanced depth imaging optical coherence tomography (EDI-OCT) images were obtained, and serum VEGF levels were measured at baseline and 6 months after transplantation with dexamethasone (n = 6), thalidomide (n = 8), or lenalidomide (n = 3). EDI-OCT images were binarized using ImageJ software, and we calculated the areas of the whole choroid and the luminal and stromal areas. Subsequently, we determined whether the choroidal vascular structure had changed significantly between baseline and 6 months after treatment. Six months after treatment, serum VEGF levels and the whole choroid, luminal, and stromal areas had decreased significantly compared to the baseline values (all, P < 0.001). The mean luminal area to the whole choroidal area ratio at 6 months after treatment was 0.70 ± 0.03, which was significantly smaller than the ratio at baseline (0.72 ± 0.03; P < 0.001). Whole choroid and luminal area fluctuations were significantly positively correlated with fluctuations in serum VEGF levels (r = 0.626, P = 0.007 and r = 0.585, P = 0.014, respectively). Choroidal thickening induced by VEGF might be caused by increases in the choroidal vessel lumen area. These results may offer insights into the pathogenesis of POEMS syndrome and the role of serum VEGF in choroidal vascular structure, which may apply to other ocular diseases.
MeSH term(s)	Humans ; POEMS Syndrome ; Vascular Endothelial Growth Factor A ; Retrospective Studies ; Choroid/diagnostic imaging ; Monoclonal Gammopathy of Undetermined Significance
Chemical Substances	Vascular Endothelial Growth Factor A
Language	English
Publishing date	2023-06-30
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-37727-4
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Article ; Online: [A case of cardiac arrest due to the appearance of Brugada-type electrocardiogram during epilepsy treatment].

Miyao, Satoru / Kubota, Yuichi / Nagino, Naoto / Egawa, Satoshi / Nakamoto, Hidetoshi / Fukuchi, Satoko / Kawamata, Takakazu

Rinsho shinkeigaku = Clinical neurology

2021 Volume 61, Issue 7, Page(s) 466–470

Abstract: The appearance of arrhythmias in epilepsy practice can lead to sudden death. This time, we experienced a case of cardiac arrest caused by lethal arrhythmia and resuscitation, and captured changes in the electrocardiogram over time from outpatient, before ...

Abstract	The appearance of arrhythmias in epilepsy practice can lead to sudden death. This time, we experienced a case of cardiac arrest caused by lethal arrhythmia and resuscitation, and captured changes in the electrocardiogram over time from outpatient, before and after sudden change, after resuscitation, to convalescent period. QT prolongation and Brugada-type waveforms were confirmed in the changes over time in the electrocardiogram. Focusing on the importance of recognizing the pharmacological and pharmacokinetic interactions with Na channel blockers and psychotropic drugs that may induce electrocardiographic changes, we emphasized the importance of electrocardiogram in epilepsy treatment.
MeSH term(s)	Electrocardiography ; Epilepsy/complications ; Epilepsy/drug therapy ; Heart Arrest/etiology ; Heart Arrest/therapy ; Humans ; Resuscitation
Language	Japanese
Publishing date	2021-06-18
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	604200-4
ISSN	1882-0654 ; 0009-918X
ISSN (online)	1882-0654
ISSN	0009-918X
DOI	10.5692/clinicalneurol.cn-001573
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Zs.MO 223: Show issues

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