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  1. Article ; Online: When cancer disguises: small-cell lung cancer masquerading as HIV-associated lymphoma in leukaemic phase.

    Kurosawa, Shuhei / Hamakawa, Yusuke / Yoshimura, Yukihiro / Hayashi, Hiroyuki / Nakazato, Tomonori / Okamoto, Hiroaki

    The Lancet. Haematology

    2024  Volume 11, Issue 2, Page(s) e168

    MeSH term(s) Humans ; Lung Neoplasms/diagnosis ; Lymphoma ; HIV Infections/complications ; HIV Infections/diagnosis
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ISSN 2352-3026
    ISSN (online) 2352-3026
    DOI 10.1016/S2352-3026(23)00369-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Left bronchial compression after an arterial switch operation with the LeCompte maneuver for transposition of the great arteries: A case report and literature review.

    Fukushima, Naoya / Maeda, Jun / Yoshimura, Yukihiro

    Journal of cardiology cases

    2023  Volume 27, Issue 4, Page(s) 168–171

    Abstract: Left bronchial compression is a rarely reported, postoperative complication of the arterial switch operation with the LeCompte maneuver for transposition of the great arteries. Postoperative neopulmonary root dilatation and the anterior-posterior, ... ...

    Abstract Left bronchial compression is a rarely reported, postoperative complication of the arterial switch operation with the LeCompte maneuver for transposition of the great arteries. Postoperative neopulmonary root dilatation and the anterior-posterior, anatomical relationship of the great vessels may cause this condition. Hypoxic pulmonary vasoconstriction may mask the condition even if the left bronchus has been severely obstructed. The apparent inconsistency between the abnormally decreased pulmonary blood flow and the absence of any irregularities in the vascular structure that might account for it suggested hypoxic pulmonary vasoconstriction to be the cause. We present herein a case of left bronchial compression presenting malacia after an arterial switch operation with the LeCompte maneuver and also present a review of seven, other, reported cases.
    Learning objectives: Left bronchial compression is a rare complication of the arterial switch operation with the LeCompte maneuver for transposition of the great arteries and is possibly caused by root dilatation and the anatomical relationship of the great vessels. Hypoxic pulmonary vasoconstriction may mask the condition.
    Language English
    Publishing date 2023-01-07
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2022.12.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protein Cryoprotectant Ability of the Aqueous Zwitterionic Solution.

    Takekiyo, Takahiro / Yamada, Shuto / Uto, Takuya / Nakayama, Masaharu / Hirata, Tetsuya / Ishizaki, Takeru / Kuroda, Kosuke / Yoshimura, Yukihiro

    The journal of physical chemistry. B

    2024  Volume 128, Issue 2, Page(s) 526–535

    Abstract: Protein cryopreservation is important for the long-term storage of unstable proteins. Recently, we found ... ...

    Abstract Protein cryopreservation is important for the long-term storage of unstable proteins. Recently, we found that
    MeSH term(s) Cryoprotective Agents/chemistry ; Freezing ; Cryopreservation/methods ; Water/chemistry ; Dimethyl Sulfoxide ; Solvents ; Proteins
    Chemical Substances Cryoprotective Agents ; Water (059QF0KO0R) ; Dimethyl Sulfoxide (YOW8V9698H) ; Solvents ; Proteins
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.3c05614
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  4. Article: Application of Mass Spectrometry Imaging for Visualizing Food Components.

    Yukihiro, Yoshimura / Zaima, Nobuhiro

    Foods (Basel, Switzerland)

    2020  Volume 9, Issue 5

    Abstract: Consuming food is essential for survival, maintaining health, and triggering positive emotions like pleasure. One of the factors that drive us toward such behavior is the presence of various compounds in foods. There are many methods to analyze these ... ...

    Abstract Consuming food is essential for survival, maintaining health, and triggering positive emotions like pleasure. One of the factors that drive us toward such behavior is the presence of various compounds in foods. There are many methods to analyze these molecules in foods; however, it is difficult to analyze the spatial distribution of these compounds using conventional techniques, such as mass spectrometry combined with high-performance liquid chromatography or gas chromatography. Mass spectrometry imaging (MSI) is a two-dimensional ionization technology that enables detection of compounds in tissue sections without extraction, purification, separation, or labeling. There are many methods for ionization of analytes, including secondary ion mass spectrometry, matrix-assisted laser desorption/ionization, and desorption electrospray ionization. Such MSI technologies can provide spatial information on the location of a specific analyte in food. The number of studies utilizing MSI technologies in food science has been increasing in the past decade. This review provides an overview of some of the recent applications of MSI in food science and related fields. In the future, MSI will become one of the most promising technologies for visualizing the distribution of food components and for identifying food-related factors by their molecular weights to improve quality, quality assurance, food safety, nutritional analysis, and to locate administered food factors.
    Language English
    Publishing date 2020-05-04
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods9050575
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Peculiar High-Pressure Phase Behavior of 1-Butyl-3-methylimidazolium Iodide.

    Takekiyo, Takahiro / Yoshimura, Yukihiro

    The journal of physical chemistry. B

    2020  Volume 124, Issue 35, Page(s) 7659–7667

    Abstract: We investigated the stability of the liquid phase of 1-butyl-3-methylimidazolium iodide (hereafter abbreviated as [ ... ...

    Abstract We investigated the stability of the liquid phase of 1-butyl-3-methylimidazolium iodide (hereafter abbreviated as [C
    Language English
    Publishing date 2020-08-19
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.0c04954
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intramural aortic course in anomalous origin of single coronary artery from the right pulmonary artery: A case report and review of the literature.

    Fukushima, Naoya / Maeda, Jun / Matsuoka, Kentaro / Yoshimura, Yukihiro

    Journal of cardiology cases

    2022  Volume 25, Issue 6, Page(s) 381–384

    Abstract: Preoperatively determining the intramural aortic course in a case of anomalous origin of single coronary artery from the right pulmonary artery is important for planning surgery, such as the unroofing technique. A thin wall separating the ascending aorta ...

    Abstract Preoperatively determining the intramural aortic course in a case of anomalous origin of single coronary artery from the right pulmonary artery is important for planning surgery, such as the unroofing technique. A thin wall separating the ascending aorta from the common coronary artery on transthoracic echocardiography and a crescent-shaped cross-section of the common coronary artery on computed tomography demonstrate an intramural aortic course of the common coronary artery. We present herein a case of anomalous origin of single coronary artery from the right pulmonary artery with an intramural aortic course and review eight other reported cases. <
    Language English
    Publishing date 2022-01-20
    Publishing country Japan
    Document type Case Reports
    ISSN 1878-5409
    ISSN (online) 1878-5409
    DOI 10.1016/j.jccase.2022.01.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Pharmacokinetics and Pharmacodynamics of Glucarpidase Rescue Treatment After High-dose Methotrexate Therapy Based on Modeling and Simulation.

    Kimura, Toshimi / Fukaya, Yutaka / Hamada, Yukihiro / Yoshimura, Kenichi / Kawamoto, Hiroshi

    Anticancer research

    2023  Volume 43, Issue 5, Page(s) 1919–1924

    Abstract: Background: Model-informed approaches are important in drug development, including for dose optimization and the collection of evidence in support of efficacy.: Materials and methods: We developed a modified Michaelis-Menten pharmacokinetics/ ... ...

    Abstract Background: Model-informed approaches are important in drug development, including for dose optimization and the collection of evidence in support of efficacy.
    Materials and methods: We developed a modified Michaelis-Menten pharmacokinetics/pharmacodynamics model and used it to conduct simulations of glucarpidase at doses between 10 and 80 U/kg rescue treatment after high-dose methotrexate therapy. We carried out a dose-finding modeling and simulation study before a phase II study of glucarpidase. Monte-Carlo simulations were conducted using the deSolve package of R software (version 4.1.2). The proportion of samples in which the plasma methotrexate concentration was less than 0.1 and 1.0 μmol/l at 70 and 120 h after methotrexate treatment was evaluated for each dosage of glucarpidase.
    Results: The proportion of samples in which the plasma methotrexate concentration was less than 0.1 μmol/l at 70 h after methotrexate treatment was 71.8% and 89.6% at 20 and 50 U/kg of glucarpidase, respectively. The proportion of samples in which the plasma methotrexate concentration was less than 0.1 μmol/l at 120 h after methotrexate treatment was 46.4% and 59.0% at 20 and 50 U/kg of glucarpidase, respectively.
    Conclusion: We determined a recommended glucarpidase dose of 50 U/kg to be ethically acceptable. A rebound in the serum concentration of methotrexate may be observed in many patients after the administration of glucarpidase, and long-term monitoring (over 144 h) of the serum methotrexate concentration may be needed after the administration of glucarpidase. Its validity was confirmed in the phase II study and glucarpidase was approved for manufacturing in Japan.
    MeSH term(s) Humans ; Methotrexate ; Antimetabolites, Antineoplastic ; gamma-Glutamyl Hydrolase/therapeutic use ; Drug Development
    Chemical Substances Methotrexate (YL5FZ2Y5U1) ; Antimetabolites, Antineoplastic ; glucarpidase (2GFP9BJD79) ; gamma-Glutamyl Hydrolase (EC 3.4.19.9)
    Language English
    Publishing date 2023-04-03
    Publishing country Greece
    Document type Clinical Trial, Phase II ; Journal Article
    ZDB-ID 604549-2
    ISSN 1791-7530 ; 0250-7005
    ISSN (online) 1791-7530
    ISSN 0250-7005
    DOI 10.21873/anticanres.16351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1642: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: High titer of antibody against the SARS-CoV-2 spike protein among patients receiving neutralizing antibody cocktail therapy with REGN-COV.

    Sasaki, Hiroaki / Miyata, Nobuyuki / Yoshimura, Yukihiro / Tachikawa, Natsuo

    Infection

    2022  Volume 50, Issue 3, Page(s) 771–774

    Abstract: Purpose: Casirivimab/imdevimab (REGN-COV), a cocktail of neutralizing antibodies against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, was shown to be an effective treatment and post- ... ...

    Abstract Purpose: Casirivimab/imdevimab (REGN-COV), a cocktail of neutralizing antibodies against the receptor-binding domain of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, was shown to be an effective treatment and post-exposure prophylaxis measure for coronavirus disease 2019 (COVID-19). We assessed the antibody titers among patients who received REGN-COV with the purpose of evaluating this therapeutic and prophylactic option from the serological point of view.
    Methods: We collected serological data of patients with COVID-19 who were treated with REGN-COV 1200 mg (casirivimab 600 mg/imdevimab 600 mg). Antibody titers were assessed within 24 h before and within 48 h after the administration of REGN-COV using ARCHITECT SARS-CoV-2 immunoglobulin (Ig)G (IgG
    Results: A total of nine patients were evaluated. IgG
    Conclusion: The high titer of IgG
    MeSH term(s) Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing/therapeutic use ; Antibodies, Viral/therapeutic use ; Drug Combinations ; Humans ; Immunoglobulin G ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Drug Treatment
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antibodies, Neutralizing ; Antibodies, Viral ; Drug Combinations ; Immunoglobulin G ; Spike Glycoprotein, Coronavirus ; casirivimab and imdevimab drug combination ; spike protein, SARS-CoV-2 ; imdevimab (2Z3DQD2JHM) ; casirivimab (J0FI6WE1QN)
    Language English
    Publishing date 2022-02-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-022-01779-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 881: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 528: Show issues

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  9. Article ; Online: Intradermal Hepatitis B Vaccination in Non-responder People Living with Human Immunodeficiency Virus in Japan.

    Yoshimura, Yukihiro / Sasaki, Hiroaki / Miyata, Nobuyuki / Tachikawa, Natsuo

    Japanese journal of infectious diseases

    2022  Volume 75, Issue 5, Page(s) 519–522

    Abstract: We performed a pilot study to assess the immunogenicity and safety of intradermal hepatitis B (HB) virus vaccines in people living with HIV (PLWH). This single-center prospective study was conducted in Yokohama, Japan. Adult PLWH with serum antibodies ... ...

    Abstract We performed a pilot study to assess the immunogenicity and safety of intradermal hepatitis B (HB) virus vaccines in people living with HIV (PLWH). This single-center prospective study was conducted in Yokohama, Japan. Adult PLWH with serum antibodies against HB surface antigen (anti-HBs) <10 mIU/mL at all time points after standard HB vaccination were included. We administered HB surface antigen (total dose of 10 μg) at 5 separate sites intradermally at baseline, one month, and 6-9 months and measured anti-HBs 1-3 months after administration. Eleven PLWH were included in this study. The mean age was 36 years, and all patients were men. At baseline, all patients were on antiretroviral therapy, and the mean CD4+ lymphocyte count was 588 /μL and plasma HIV-RNA was <20 copies/mL, except for one patient. Anti-HB levels were elevated to >10 mIU/mL in one patient after one dose, 6 patients after 2 doses, and 4 patients after 3 doses of the intradermal vaccines. Eight patients experienced grade 1 local adverse events. Additional vaccination via the intradermal route induced an anti-HBs level >10 mIU/mL in all patients, without serious adverse events.
    MeSH term(s) Adult ; Humans ; Male ; Hepatitis B/prevention & control ; Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines/administration & dosage ; Hepatitis B virus ; HIV Infections ; Japan ; Pilot Projects ; Prospective Studies ; Vaccination ; Immunogenicity, Vaccine
    Chemical Substances Hepatitis B Antibodies ; Hepatitis B Surface Antigens ; Hepatitis B Vaccines
    Language English
    Publishing date 2022-04-28
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 1478383-6
    ISSN 1884-2836 ; 1344-6304
    ISSN (online) 1884-2836
    ISSN 1344-6304
    DOI 10.7883/yoken.JJID.2021.834
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: High-Pressure Raman Study of

    Takekiyo, Takahiro / Koyama, Yoshihiro / Matsuishi, Kiyoto / Yoshimura, Yukihiro

    The journal of physical chemistry. B

    2020  Volume 124, Issue 49, Page(s) 11189–11196

    Abstract: The high-pressure (HP) phase transition and conformational change ... ...

    Abstract The high-pressure (HP) phase transition and conformational change of
    Language English
    Publishing date 2020-12-01
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5207
    ISSN (online) 1520-5207
    DOI 10.1021/acs.jpcb.0c07889
    Database MEDical Literature Analysis and Retrieval System OnLINE

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