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  1. Article ; Online: The nitric oxide-soluble guanylate cyclase-cGMP pathway in pulmonary hypertension: from PDE5 to soluble guanylate cyclase.

    Benza, Raymond L / Grünig, Ekkehard / Sandner, Peter / Stasch, Johannes-Peter / Simonneau, Gérald

    European respiratory review : an official journal of the European Respiratory Society

    2024  Volume 33, Issue 171

    Abstract: The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH). Targeted treatments include phosphodiesterase type 5 inhibitors (PDE5i) and sGC ... ...

    Abstract The nitric oxide (NO)-soluble guanylate cyclase (sGC)-cyclic guanosine monophosphate (cGMP) pathway plays a key role in the pathogenesis of pulmonary hypertension (PH). Targeted treatments include phosphodiesterase type 5 inhibitors (PDE5i) and sGC stimulators. The sGC stimulator riociguat is approved for the treatment of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). sGC stimulators have a dual mechanism of action, enhancing the sGC response to endogenous NO and directly stimulating sGC, independent of NO. This increase in cGMP production
    MeSH term(s) Humans ; Soluble Guanylyl Cyclase/metabolism ; Hypertension, Pulmonary/etiology ; Nitric Oxide/metabolism ; Signal Transduction ; Pulmonary Arterial Hypertension ; Cyclic GMP/metabolism ; Guanylate Cyclase/metabolism
    Chemical Substances Soluble Guanylyl Cyclase (EC 4.6.1.2) ; Nitric Oxide (31C4KY9ESH) ; Cyclic GMP (H2D2X058MU) ; Guanylate Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1077620-5
    ISSN 1600-0617 ; 0905-9180
    ISSN (online) 1600-0617
    ISSN 0905-9180
    DOI 10.1183/16000617.0183-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Pulmonary vascular disorders

    Humbert, Marc / Souza, Rogerio / Simonneau, Gérald

    45 tables

    (Progress in respiratory research, ; 41)

    2012  

    Author's details vol. ed. Marc Humbert ; Rogerio Souza ; Gérald Simonneau
    Series title Progress in respiratory research, ; 41
    Progress in respiratory research
    Collection Progress in respiratory research
    Keywords Hypertension, Pulmonary ; Vascular Diseases ; Lunge ; Gefäßkrankheit
    Subject Angiologische Krankheit ; Angiopathie ; Blutgefäßkrankheit ; Gefäßerkrankung ; Blutgefäß ; Vaskulopathie ; Gefäßkrankheiten ; Pulmo
    Language English
    Size IX, 289 S. : Ill., graph. Darst.
    Publisher Karger
    Publishing place Basel u.a.
    Publishing country Switzerland
    Document type Book
    Note Includes bibliographical references and indexes
    HBZ-ID HT017218455
    ISBN 978-3-8055-9914-6 ; 9783805599153 ; 3-8055-9914-5 ; 3805599153
    Database Catalogue ZB MED Medicine, Health

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  3. Article: Chronic thromboembolic pulmonary hypertension: the magic of pathophysiology.

    Simonneau, Gérald / Dorfmüller, Peter / Guignabert, Christophe / Mercier, Olaf / Humbert, Marc

    Annals of cardiothoracic surgery

    2022  Volume 11, Issue 2, Page(s) 106–119

    Abstract: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and underdiagnosed complication of acute pulmonary embolism (APE). CTEPH is a common cause of pulmonary hypertension (PH) with distinct management strategy including pulmonary endarterectomy, ...

    Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare and underdiagnosed complication of acute pulmonary embolism (APE). CTEPH is a common cause of pulmonary hypertension (PH) with distinct management strategy including pulmonary endarterectomy, balloon pulmonary angioplasty, long-term anticoagulation and PH drugs targeting endothelial cell dysfunction. Initially, PH in chronic thromboembolic pulmonary disease (CTEPD) was thought to be due exclusively to the intravascular obstruction of pulmonary arteries by unresolved fibrotic clots. However, it is now well accepted that pulmonary vascular remodelling can include significant pulmonary microvasculopathy, which plays a role in the development of CTEPH. The histological description and clinical consequences of CTEPH microvasculopathy are now better understood. These lesions may involve not only small muscular pulmonary arteries <500 µm, but also pulmonary capillaries and veins. In addition, enlargement and proliferation of systemic bronchial arteries as well as anastomoses between the systemic and pulmonary circulations contribute to the development of microvasculopathy. In this review, we discuss the recent advances in the understanding of the pathophysiology of CTEPH.
    Language English
    Publishing date 2022-03-19
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 2713627-9
    ISSN 2304-1021 ; 2225-319X
    ISSN (online) 2304-1021
    ISSN 2225-319X
    DOI 10.21037/acs-2021-pte-10
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  4. Article: The revised definition of pulmonary hypertension: exploring the impact on patient management.

    Simonneau, Gérald / Hoeper, Marius M

    European heart journal supplements : journal of the European Society of Cardiology

    2019  Volume 21, Issue Suppl K, Page(s) K4–K8

    Abstract: At the 6th World Symposium on Pulmonary Hypertension (PH), it was proposed that the mean pulmonary arterial pressure (mPAP) threshold used to define PH should be lowered from ≥25 mmHg to >20 mmHg. The rationale for this change is that the ≥25 mmHg ... ...

    Abstract At the 6th World Symposium on Pulmonary Hypertension (PH), it was proposed that the mean pulmonary arterial pressure (mPAP) threshold used to define PH should be lowered from ≥25 mmHg to >20 mmHg. The rationale for this change is that the ≥25 mmHg threshold is arbitrary, whereas the revised threshold is based on scientific evidence. For the definition of all forms of pre-capillary PH, the inclusion of a pulmonary vascular resistance (PVR) ≥3 Wood Units was also proposed, placing greater emphasis on an elevated PVR to identify pulmonary vascular disease. Here, we discuss the possible impact of the revised definition of PH on future clinical management. This change may facilitate earlier PH detection, particularly in at-risk patient groups that are already undergoing screening programmes, e.g. those with systemic sclerosis or mutations associated with PH. As an mPAP above the upper limit of normal (>20 mmHg) but <25 mmHg is associated with increased risk of morbidity and mortality compared with a normal mPAP, early identification of patients in this group is important to enable close monitoring and timely treatment initiation once clinically indicated. Treatments currently approved for PH are not necessarily suitable for patients with an mPAP 21-24 mmHg, as the management of this group has not been widely examined. The revised definition may facilitate inclusion of these patients in prospective trials, allowing the evaluation of appropriate management strategies.
    Language English
    Publishing date 2019-12-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1463769-8
    ISSN 1554-2815 ; 1520-765X
    ISSN (online) 1554-2815
    ISSN 1520-765X
    DOI 10.1093/eurheartj/suz211
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  5. Article ; Online: Evaluation of the incidence of rare diseases: difficulties and uncertainties, the example of chronic thromboembolic pulmonary hypertension.

    Simonneau, Gérald / Hoeper, Marius M

    The European respiratory journal

    2017  Volume 49, Issue 2

    MeSH term(s) Humans ; Hypertension, Pulmonary ; Incidence ; Pulmonary Embolism ; Rare Diseases
    Language English
    Publishing date 2017
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02522-2016
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  6. Article ; Online: Amphetamine Derivatives and the Risk of Pulmonary Arterial Hypertension. A New Chapter of the Story.

    Simonneau, Gérald / Humbert, Marc

    American journal of respiratory and critical care medicine

    2017  Volume 197, Issue 6, Page(s) 704–706

    MeSH term(s) Amphetamine ; Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary ; Methamphetamine
    Chemical Substances Methamphetamine (44RAL3456C) ; Amphetamine (CK833KGX7E)
    Language English
    Publishing date 2017-10-17
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201709-1962ED
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  7. Article ; Online: Reply to Frachon: Amphetamine Derivatives and the Risk of Pulmonary Arterial Hypertension: A Missing Chapter of the Story?

    Simonneau, Gérald / Humbert, Marc

    American journal of respiratory and critical care medicine

    2017  Volume 197, Issue 10, Page(s) 1364–1365

    MeSH term(s) Amphetamine ; Familial Primary Pulmonary Hypertension ; Humans ; Hypertension, Pulmonary ; Methamphetamine
    Chemical Substances Methamphetamine (44RAL3456C) ; Amphetamine (CK833KGX7E)
    Language English
    Publishing date 2017-12-22
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201712-2483LE
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  8. Article ; Online: Introduction. L'hypertension artérielle pulmonaire (HTAP).

    Simonneau, Gérald

    Presse medicale (Paris, France : 1983)

    2010  Volume 39 Suppl 1, Page(s) 1S1–2

    Title translation Introduction. Pulmonary arterial hypertension.
    MeSH term(s) Antihypertensive Agents/pharmacology ; Antihypertensive Agents/therapeutic use ; Drug Therapy, Combination ; Endothelin Receptor Antagonists ; France/epidemiology ; Health Planning/organization & administration ; Humans ; Hypertension, Pulmonary/drug therapy ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/physiopathology ; Phosphodiesterase Inhibitors/therapeutic use ; Prevalence ; Prognosis ; Prostaglandins/therapeutic use ; Rare Diseases ; Survival Rate
    Chemical Substances Antihypertensive Agents ; Endothelin Receptor Antagonists ; Phosphodiesterase Inhibitors ; Prostaglandins
    Language French
    Publishing date 2010-06
    Publishing country France
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 120943-7
    ISSN 2213-0276 ; 0032-7867 ; 0755-4982 ; 0301-1518
    ISSN (online) 2213-0276
    ISSN 0032-7867 ; 0755-4982 ; 0301-1518
    DOI 10.1016/S0755-4982(10)70001-4
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  9. Book: Embolie pulmonaire et thrombose veineuse profonde

    Artigas, Antonio / Simonneau, Gérald

    (Collection d'anesthésiologie et réanimation ; 19)

    1990  

    Author's details sous la direction de G. Simonneau ... Avec la collaboration de A. Artigas
    Series title Collection d'anesthésiologie et réanimation ; 19
    Collection
    Keywords Pulmonary Embolism ; Thrombophlebitis
    Size IX, 204 S. : Ill., graph. Darst.
    Publisher Masson
    Publishing place Paris u.a.
    Publishing country France
    Document type Book
    HBZ-ID HT003725108
    ISBN 2-225-82100-3 ; 978-2-225-82100-4
    Database Catalogue ZB MED Medicine, Health

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    1991 A 1054 order for loan Magazin

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  10. Article ; Online: Characteristics and outcomes of patients developing pulmonary hypertension associated with proteasome inhibitors.

    Grynblat, Julien / Khouri, Charles / Hlavaty, Alex / Jais, Xavier / Savale, Laurent / Camille Chaumais, Marie / Kularatne, Mithum / Jevnikar, Mitja / Boucly, Athénaïs / Antigny, Fabrice / Perros, Frédéric / Simonneau, Gérald / Sitbon, Olivier / Humbert, Marc / Montani, David

    The European respiratory journal

    2024  

    Abstract: Rationale: Pulmonary arterial hypertension (PAH) has been described in patients treated with proteasome inhibitors (PI).: Objectives: To evaluate the association between PI and PAH.: Methods: Characteristics of incident PAH cases previously ... ...

    Abstract Rationale: Pulmonary arterial hypertension (PAH) has been described in patients treated with proteasome inhibitors (PI).
    Objectives: To evaluate the association between PI and PAH.
    Methods: Characteristics of incident PAH cases previously treated with Carfilzomib or Bortezomib were analyzed from the French PH Registry and the VIGIAPATH program from 2004 to 2023, concurrently with a pharmacovigilance disproportionality analysis using the WHO's global database, and a meta-analysis of randomized controlled trials.
    Results: Eleven incident cases of PI associated PAH were identified (6 with Carfilzomib and 5 with Bortezomib) with a female: male ratio of 2.7:1, a median age of 61 years, and a median delay between PI first exposure and PAH of 6 months. Four patients died (2 from right heart failure, 1 from respiratory distress, and 1 from an unknown cause). At diagnosis, 6 were in NYHA-Fc III/IV with severe hemodynamic impairment (median mean pulmonary artery pressure of 39 mmHg, cardiac index 2.45 L/min·m
    Conclusion: PI may induce PAH in patients undergoing treatment, with Carfilzomib emitting a stronger signal than Bortezomib, and these patients should be monitored closely.
    Language English
    Publishing date 2024-05-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.02158-2023
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