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  1. Article ; Online: Recent advances in "sickle and niche" research - Tribute to Dr. Paul S Frenette.

    Torres, Lidiane S / Asada, Noboru / Weiss, Mitchell J / Trumpp, Andreas / Suda, Toshio / Scadden, David T / Ito, Keisuke

    Stem cell reports

    2022  Volume 17, Issue 7, Page(s) 1509–1535

    Abstract: ... career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining ...

    Abstract In this retrospective, we review the two research topics that formed the basis of the outstanding career of Dr. Paul S. Frenette. In the first part, we focus on sickle cell disease (SCD). The defining feature of SCD is polymerization of the deoxygenated mutant hemoglobin, which leads to a vicious cycle of hemolysis and vaso-occlusion. We survey important discoveries in SCD pathophysiology that have led to recent advances in treatment of SCD. The second part focuses on the hematopoietic stem cell (HSC) niche, the complex microenvironment within the bone marrow that controls HSC function and homeostasis. We detail the cells that constitute this niche, and the factors that these cells use to exert control over hematopoiesis. Here, we trace the scientific paths of Dr. Frenette, highlight key aspects of his research, and identify his most important scientific contributions in both fields.
    MeSH term(s) Anemia, Sickle Cell/therapy ; Bone Marrow/metabolism ; Hematopoiesis ; Humans ; Retrospective Studies ; Stem Cell Niche
    Language English
    Publishing date 2022-07-10
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2720528-9
    ISSN 2213-6711 ; 2213-6711
    ISSN (online) 2213-6711
    ISSN 2213-6711
    DOI 10.1016/j.stemcr.2022.06.004
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  2. Article: Blutspende in Deutschland – Paul Oskar Morawitz

    Weiß, Johannes

    Zeitschrift für Gastroenterologie

    2015  Volume 53, Issue 09, Page(s) 1067–1067

    Language German
    Publishing date 2015-09-01
    Publisher © Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/s-0034-1397950
    Database Thieme publisher's database

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  3. Article ; Online: Hypoalbuminemia predicts acute stroke mortality: Paul Coverdell Georgia Stroke Registry.

    Famakin, Bolanle / Weiss, Paul / Hertzberg, Vicki / McClellan, William / Presley, Rodney / Krompf, Kerrie / Karp, Herbert / Frankel, Michael R

    Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association

    2010  Volume 19, Issue 1, Page(s) 17–22

    Abstract: ... in 34 hospitals in the state of Georgia participating in the Paul Coverdell Georgia Stroke Registry ...

    Abstract Background: Mortality remains unacceptably high among patients hospitalized for acute stroke. Additional knowledge about factors that contribute to mortality after stroke is important for instituting therapies to lower mortality. We sought to determine the factors that predict mortality in patients hospitalized for acute stroke.
    Methods: In all, 1477 consecutively admitted patients with acute stroke in 34 hospitals in the state of Georgia participating in the Paul Coverdell Georgia Stroke Registry during a 3-month period (December 1, 2001-February 28, 2002) were identified by retrospective chart review using primary or secondary International Classification of Diseases, Ninth Revision codes. Of patients, 31% were black, 65% were white, and 58% were women. We determined inhospital mortality after admission for acute stroke in this representative group of patients.
    Results: There were 154 (10%) inhospital deaths among the 1477 patients admitted with acute stroke. Univariate analysis showed that mortality was associated with older age (P = .0008), stroke type (P = .0051), Glasgow Coma Scale score less than 9 (P < .0001), decreased serum albumin (P = .0001), elevated creatinine (P = .0067), and elevated blood glucose (P = .0063). In the multivariate analysis, independent risk factors for mortality after acute stroke included older age (P = .004), stroke type (P = .0007), Glasgow Coma Scale score less than 9 (P < .0001), and decreased serum albumin (P = .0003). There was no relationship between race and inhospital mortality (P = .9041). In addition, there was no association between independent predictors and race.
    Conclusion: In addition to previously recognized predictors of inhospital mortality, we found hypoalbuminemia to be an independent predictor of mortality in a biracial cohort of patients with acute stroke.
    MeSH term(s) African Americans ; Age Factors ; Aged ; European Continental Ancestry Group ; Female ; Georgia/epidemiology ; Glasgow Coma Scale ; Hospital Mortality ; Hospitalization ; Humans ; Hypoalbuminemia/ethnology ; Hypoalbuminemia/mortality ; Logistic Models ; Male ; Multivariate Analysis ; Predictive Value of Tests ; Registries ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Stroke/ethnology ; Stroke/mortality
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 1131675-5
    ISSN 1532-8511 ; 1052-3057
    ISSN (online) 1532-8511
    ISSN 1052-3057
    DOI 10.1016/j.jstrokecerebrovasdis.2009.01.015
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  4. Article: The Paul Coverdell National Acute Stroke Registry: initial results from four prototypes.

    Reeves, Mathew J / Broderick, Joseph P / Frankel, Michael / LaBresh, Kenneth A / Schwamm, Lee / Moomaw, Charles J / Weiss, Paul / Katzan, Irene / Arora, Shalini / Heinrich, John P / Hickenbottom, Susan / Karp, Herbert / Malarcher, Ann / Mensah, George

    American journal of preventive medicine

    2006  Volume 31, Issue 6 Suppl 2, Page(s) S202–9

    Abstract: Background: This paper summarizes the experiences of the Paul Coverdell National Acute Stroke ...

    Abstract Background: This paper summarizes the experiences of the Paul Coverdell National Acute Stroke Registry first four prototype registries in Georgia (GA), Massachusetts (MA), Michigan (MI), and Ohio (OH), and includes information on their sampling design, case ascertainment, and data collection methods, as well as some key findings.
    Methods: Using a combination of different sampling methods, each prototype obtained a representative statewide sample of hospitals. Acute stroke admissions were identified through prospective (MA, MI) or retrospective (GA, OH) methods. A common set of case definitions and data elements were used by each registry. Weighted site-specific frequencies and 95% confidence intervals were generated for each outcome. A summary estimate, representing a weighted average of the four site-specific estimates, was also calculated.
    Results: Of the total 6867 admissions, 1487 (21.6%) were from the GA registry, 1206 (17.6%) from MA, 2566 (37.4%) from MI, and 1608 (23.4%) from the OH prototype. Just less than 60% of admissions were ischemic strokes (site-specific estimates ranged from 52% to 70%), with transient ischemic attack (18.5%) and intracerebral hemorrhage (8.8%) making up most of the remainder. Twenty-one percent of patients admitted were younger than 60 years of age, and 55.3% were women. The proportion of black subjects varied from 7.1% (MI) to 30.6% (GA). Twenty-three percent of admissions arrived at the emergency department within 3 hours of onset. Overall 4.5% of ischemic stroke admissions were treated with recombinant tissue plasminogen activator; site-specific treatment rates were 3.0% (GA), 3.2% (OH), 3.4% (MI), and 8.5% (MA). Only a small minority of treated patients (range, 10.8% [OH] to 19.6% [MI]) received recombinant tissue plasminogen activator within the recommended 1 hour door-to-needle time. A minority of eligible subjects were screened for dysphagia (45.4%), underwent lipid testing (33.6%), or received smoking-cessation counseling (21.4%). In contrast, compliance with antithrombotic treatments at discharge was high (91.5%).
    Conclusions: A minority of acute stroke patients are treated according to established guidelines. Quality improvement interventions, targeted primarily at the healthcare systems level, are needed to improve acute stroke care in the United States.
    MeSH term(s) Acute Disease ; Adolescent ; Adult ; Aged ; Aged, 80 and over ; Benchmarking ; Data Collection ; Female ; Georgia ; Humans ; Male ; Massachusetts ; Medical Audit ; Michigan ; Middle Aged ; Ohio ; Outcome and Process Assessment (Health Care) ; Program Evaluation ; Registries ; Stroke/complications ; Stroke/diagnosis ; Stroke/drug therapy ; Stroke/prevention & control ; United States
    Language English
    Publishing date 2006-12
    Publishing country Netherlands
    Document type Evaluation Studies ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 632646-8
    ISSN 1873-2607 ; 0749-3797
    ISSN (online) 1873-2607
    ISSN 0749-3797
    DOI 10.1016/j.amepre.2006.08.007
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  5. Book ; Online: Critical exponents for the cloud-crystal phase transition of charged particles in a Paul Trap

    Weiss, D. K. / Nam, Y. S. / Blümel, R.

    2015  

    Abstract: It is well known that charged particles stored in a Paul trap, one of the most versatile tools ... crystallization of nonneutral plasmas in Paul traps and mini storage rings, we conjecture that our results are ...

    Abstract It is well known that charged particles stored in a Paul trap, one of the most versatile tools in atomic and molecular physics, may undergo a phase transition from a disordered cloud state to a geometrically well-ordered crystalline state (the Wigner crystal). In this paper we show that the average lifetime $\bar\tau_m$ of the metastable cloud state preceding the cloud $\rightarrow$ crystal phase transition follows a powerlaw, $\bar\tau_m \sim (\gamma-\gamma_c)^{-\beta}$, $\gamma>\gamma_c$, where $\gamma_c$ is the critical value of the damping constant $\gamma$ at which the cloud $\rightarrow$ crystal phase transition occurs. The critical exponent $\beta$ depends on the trap control parameter $q$, but is independent of the number of particles $N$ stored in the trap and the trap control parameter $a$, which determines the shape (oblate, prolate, or spherical) of the cloud. For $q=0.15,0.20$, and $0.25$, we find $\beta=1.20\pm 0.03$, $\beta=1.61\pm 0.09$, and $\beta=2.38\pm 0.12$, respectively. In addition we find that for given $a$ and $q$, the critical value $\gamma_c$ of the damping scales approximately like $\gamma_c=C \ln [ \ln (N)] + D$ as a function of $N$, where $C$ and $D$ are constants. Beyond their relevance for Wigner crystallization of nonneutral plasmas in Paul traps and mini storage rings, we conjecture that our results are also of relevance for the field of crystalline beams.

    Comment: 4 pages, 3 figures
    Keywords Physics - Computational Physics ; Physics - Atomic and Molecular Clusters
    Subject code 612
    Publishing date 2015-12-08
    Publishing country us
    Document type Book ; Online
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  6. Article ; Online: Acute stroke care in the US: results from 4 pilot prototypes of the Paul Coverdell National Acute Stroke Registry.

    Reeves, Mathew J / Arora, Shalini / Broderick, Joseph P / Frankel, Michael / Heinrich, John P / Hickenbottom, Susan / Karp, Herbert / LaBresh, Kenneth A / Malarcher, Ann / Mensah, G / Moomaw, Charles J / Schwamm, Lee / Weiss, Paul

    Stroke

    2005  Volume 36, Issue 6, Page(s) 1232–1240

    Abstract: Background and purpose: The Paul Coverdell National Acute Stroke Registry is being developed ...

    Abstract Background and purpose: The Paul Coverdell National Acute Stroke Registry is being developed to improve the quality of acute stroke care. This article describes key features of acute stroke care from 4 prototype registries in Georgia (Ga), Massachusetts (Mass), Michigan (Mich), and Ohio.
    Methods: Each prototype developed its own sampling scheme to obtain a representative sample of hospitals. Acute stroke admissions were identified using prospective (Mass, Mich) or retrospective (Ga, Ohio) methods. All prototypes used a common set of case definitions and data elements. Weighted site-specific frequencies were generated for each outcome.
    Results: A total of 6867 admissions from 98 hospitals were included; the majority were ischemic strokes (range, 52% to 70%) with transient ischemic attack and intracerebral hemorrhage comprising the bulk of the remainder. Between 19% and 26% of admissions were younger than age 60 years, and between 52% and 58% were female. Black subjects varied from 7.1% (Mich) to 30.6% (Ga). Between 20% and 25% of admissions arrived at the emergency department within 3 hours of onset. Treatment with recombinant tissue plasminogen activator (rtPA) was administered to between 3.0% (Ga) and 8.5% (Mass) of ischemic stroke admissions. Of 118 subjects treated with intravenous rtPA, <20% received it within 60 minutes of arrival. Compliance with secondary prevention practices was poorest for smoking cessation counseling and best for antithrombotics.
    Conclusions: A minority of acute stroke patients are treated according to established guidelines. Quality improvement interventions, targeted primarily at the health care systems level, are needed to improve acute stroke care in the United States.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Brain Ischemia/pathology ; Cerebral Hemorrhage/therapy ; Female ; Fibrinolytic Agents/administration & dosage ; Fibrinolytic Agents/therapeutic use ; Georgia ; Hospital Records ; Humans ; Infusions, Intravenous ; Ischemic Attack, Transient/therapy ; Male ; Massachusetts ; Michigan ; Middle Aged ; Ohio ; Pilot Projects ; Prospective Studies ; Quality Control ; Recombinant Proteins/therapeutic use ; Registries ; Retrospective Studies ; Stroke/epidemiology ; Stroke/prevention & control ; Stroke/therapy ; Thrombolytic Therapy/methods ; Time Factors ; Tissue Plasminogen Activator/administration & dosage ; Tissue Plasminogen Activator/therapeutic use ; Treatment Outcome ; United States
    Chemical Substances Fibrinolytic Agents ; Recombinant Proteins ; Tissue Plasminogen Activator (EC 3.4.21.68)
    Language English
    Publishing date 2005-06
    Publishing country United States
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/01.STR.0000165902.18021.5b
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  7. Book ; Online ; E-Book: Social work education and the grand challenges

    Maiden, R. Paul / Weiss, Eugenia L.

    approaches to curricula and field education

    2023  

    Abstract: The Grand Challenges for Social Work (GCSW) provides an agenda for society, and for the social work profession. The 13 GCSW have been codified by the American Academy of Social Work and Social Welfare and are emerging as a significant underpinning in the ...

    Author's details edited by R. Paul Maiden and Eugenia L. Weiss
    Abstract The Grand Challenges for Social Work (GCSW) provides an agenda for society, and for the social work profession. The 13 GCSW have been codified by the American Academy of Social Work and Social Welfare and are emerging as a significant underpinning in the education of undergraduate and graduate social work students throughout the USA. This volume serves as a guide as to how this can best be achieved in alignment with the 2022 Educational Policy and Accreditation Standards (EPAS) from the Council of Social Work Education. Divided into four parts: Individual and Family Well-Being Stronger Social Fabric A Just Society The Grand Challenges in the Field Each chapter introduces a Grand Challenge, situates it within the curricula, and provides teaching practices in one of the targeted domains as well as learning objectives, class exercises, and discussions. By showing how to facilitate class discussion, manage difficult conversations, and address diversity, equity, and inclusion as part of teaching the topic, this book will be of interest to all faculty teaching at both undergraduate and graduate levels. It should be noted that there are additional supplementary chapters beyond the 13 GCSW that provide further context for the reader.
    Keywords Social service ; Social work education
    Subject code 361.3/2
    Language English
    Size 1 online resource (459 pages)
    Publisher Routledge
    Publishing place Abingdon, Oxon ; New York, NY
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 1-00-330826-0 ; 1-000-86181-3 ; 1-003-30826-0 ; 1-000-86180-5 ; 1-03-231144-4 ; 1-03-231075-8 ; 978-1-00-330826-3 ; 978-1-000-86181-5 ; 978-1-003-30826-3 ; 978-1-000-86180-8 ; 978-1-03-231144-9 ; 978-1-03-231075-6
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Book ; Thesis: Einfluss der Mannheimer Referenztafel auf die Reliabilität des SES-CD

    Weiss, Tobias / Belle, Sebastian

    2021  

    Institution Universität Heidelberg
    Author's details vorgelegt von Tobias Weiss ; Referent: Priv.-Doz. med. Belle
    Language German
    Size 65 Seiten, Diagramme, Illustrationen, 30 cm
    Publishing place Heidelberg
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Ruprecht-Karls-Universität Heidelberg, 2021
    HBZ-ID HT021221577
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2022 E 158 order for loan Magazin

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  9. Article: Spot-scanning proton therapy for malignant soft tissue tumors in childhood: First experiences at the Paul Scherrer Institute.

    Timmermann, Beate / Schuck, Andreas / Niggli, Felix / Weiss, Markus / Lomax, Antony Jonathan / Pedroni, Eros / Coray, Adolf / Jermann, Martin / Rutz, Hans Peter / Goitein, Gudrun

    International journal of radiation oncology, biology, physics

    2007  Volume 67, Issue 2, Page(s) 497–504

    Abstract: ... at the Paul Scherrer Institute, and in 3 children the PT was intensity-modulated (IMPT).: Results: After ...

    Abstract Purpose: Radiotherapy plays a major role in the treatment strategy of childhood sarcomas. Consequences of treatment are likely to affect the survivor's quality of life significantly. We investigated the feasibility of spot-scanning proton therapy (PT) for soft tissue tumors in childhood.
    Methods and materials: Sixteen children with soft tissue sarcomas were included. Median age at PT was 3.3 years. In 10 children the tumor histology was embryonal rhabdomyosarcoma. All tumors were located in the head or neck, parameningeal, or paraspinal, or pelvic region. In the majority of children, the tumor was initially unresectable (Intergroup Rhabdomyosarcoma Study [IRS] Group III in 75%). In 50% of children the tumors exceeded 5 cm. Fourteen children had chemotherapy before and during PT. Median total dose of radiotherapy was 50 cobalt Gray equivalent (CGE). All 16 children were treated with spot-scanning proton therapy at the Paul Scherrer Institute, and in 3 children the PT was intensity-modulated (IMPT).
    Results: After median follow-up of 1.5 years, local control was achieved in 12 children. Four children failed locally, 1 at the border of the radiation field and 3 within the field. All 4 children died of tumor recurrence. All 4 showed unfavorable characteristic either of site or histopathology of the tumor. Acute toxicity was low, with Grade 3 or 4 side effects according to Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer (RTOG/EORTC) criteria occurring in the bone marrow only.
    Conclusions: Proton therapy was feasible and well tolerated. Early local control rates are comparable to those being achieved after conventional radiotherapy. For investigations on late effect, longer follow-up is needed.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Feasibility Studies ; Female ; Head and Neck Neoplasms/drug therapy ; Head and Neck Neoplasms/mortality ; Head and Neck Neoplasms/radiotherapy ; Humans ; Infant ; Male ; Meningeal Neoplasms/drug therapy ; Meningeal Neoplasms/mortality ; Meningeal Neoplasms/radiotherapy ; Protons/therapeutic use ; Quality of Life ; Radiation Injuries/pathology ; Rhabdomyosarcoma, Embryonal/drug therapy ; Rhabdomyosarcoma, Embryonal/mortality ; Rhabdomyosarcoma, Embryonal/radiotherapy ; Sarcoma/drug therapy ; Sarcoma/mortality ; Sarcoma/radiotherapy ; Spinal Neoplasms/drug therapy ; Spinal Neoplasms/mortality ; Spinal Neoplasms/radiotherapy ; Survivors
    Chemical Substances Protons
    Language English
    Publishing date 2007-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2006.08.053
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  10. Article: Thirty-five years with Freud. In honour of the hundredth anniversary of Paul Federn, M.D.,

    Federn, E / Urbach, A / Meng, H / Weiss, E

    Journal of the history of the behavioral sciences

    2001  Volume 8, Page(s) 1–55

    MeSH term(s) Austria ; History, Modern 1601- ; Psychiatry/history
    Language English
    Publishing date 2001-09-11
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 6868-8
    ISSN 1520-6696 ; 0022-5061
    ISSN (online) 1520-6696
    ISSN 0022-5061
    DOI 10.1002/1520-6696(197201)8:1+<3::aid-jhbs2300080502>3.0.co;2-n
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