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Article ; Online: Hands-on versus hands-off techniques for the prevention of perineal trauma during vaginal delivery: a systematic review and meta-analysis of randomized controlled trials.

Pierce-Williams, Rebecca A M / Saccone, Gabriele / Berghella, Vincenzo

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians

2019 Volume 34, Issue 6, Page(s) 993–1001

Abstract: Background: Perineal trauma at the time of vaginal delivery is common, and when the anal sphincter is included, these injuries can be associated with additional morbidity including incontinence, pelvic pain, and sexual dysfunction.: Objective: The ... ...

Abstract	Background: Perineal trauma at the time of vaginal delivery is common, and when the anal sphincter is included, these injuries can be associated with additional morbidity including incontinence, pelvic pain, and sexual dysfunction. Objective: The aim of this systematic review with meta-analysis was to evaluate whether a hands-on technique during vaginal delivery results in less incidence of perineal trauma than a hands-off technique. Methods: Electronic databases were searched from their inception until June 2018. No restrictions for language or geographic location were applied. The reference lists of identified articles were examined to identify studies not captured by electronic searches. Randomized controlled trials comparing a hands-on technique of perineal support during vaginal delivery (i.e. intervention group) with a hands-off technique (i.e. control group) were included in the meta-analysis. Hands-on was defined as involving one hand on the fetal head, applying pressure to control expulsion, with the other hand applying pressure on the maternal perineum. The primary outcome was severe perineal trauma, defined as either third- or fourth-degree lacerations. The meta-analysis was performed using the random effects model of DerSimonian and Laird, to produce summary treatment effects in terms of relative risk (RR) with 95% confidence interval (CI). Results: Five trials, including 7287 women, were analyzed. All studies included singleton gestations with cephalic presentation at term undergoing spontaneous vaginal delivery. Women randomized to the hands-on technique had similar incidence of severe perineal trauma (1.5 versus 1.3%; RR 2.00, 95% CI 0.56-7.15). There was no significant between-group difference in the incidence of intact perineum, first-, second- and fourth-degree laceration. Hands-on technique was associated with increased risk of third-degree lacerations (2.6 versus 0.7%; RR 3.41, 95% CI 1.39-8.37) and of episiotomy (13.6 versus 9.8%, RR 1.59, 95% CI 1.14-2.22) compared to the hands-off technique. Conclusions: Hands-on technique during spontaneous vaginal delivery of singleton gestations results in similar incidence of several perineal traumas compared to a hands-off technique. The incidence of third-degree lacerations and of episiotomy increases with the hands-on technique. Key Message A hands-on technique during vaginal delivery results in similar incidence of severe lacerations compared to hands-off.
MeSH term(s)	Delivery, Obstetric ; Episiotomy/adverse effects ; Female ; Humans ; Lacerations/epidemiology ; Lacerations/etiology ; Lacerations/prevention & control ; Obstetric Labor Complications/epidemiology ; Obstetric Labor Complications/etiology ; Obstetric Labor Complications/prevention & control ; Perineum/injuries ; Pregnancy ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2019-06-03
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	2077261-0
ISSN	1476-4954 ; 1057-0802 ; 1476-7058
ISSN (online)	1476-4954
ISSN	1057-0802 ; 1476-7058
DOI	10.1080/14767058.2019.1619686
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Article ; Online: Postpartum Hemorrhage in Patients with Type 1 von Willebrand Disease: A Systematic Review.

Pierce-Williams, Rebecca A M / Makhamreh, Mona M / Blakey-Cheung, Sophia / Gao, Zimeng / Al-Kouatly, Huda B

Seminars in thrombosis and hemostasis

2021 Volume 48, Issue 2, Page(s) 219–228

Abstract: Type 1 von Willebrand disease (VWD) is the most common subtype of VWD, comprising 75% of VWD patients. We provide a systematic review of type 1 VWD in pregnancy. Our objective was to evaluate the rate of postpartum hemorrhage (PPH) in patients with known ...

Abstract	Type 1 von Willebrand disease (VWD) is the most common subtype of VWD, comprising 75% of VWD patients. We provide a systematic review of type 1 VWD in pregnancy. Our objective was to evaluate the rate of postpartum hemorrhage (PPH) in patients with known type 1 VWD. The primary outcome was rate of PPH. Primary PPH was defined as a cumulative blood loss ≥1,000 mL, or blood loss accompanied by signs and symptoms of hypovolemia within 24 hours postpartum or requiring blood products. Secondary PPH was defined as significant bleeding 24 hours to 12 weeks postpartum. Relevant articles published in English pertaining to VWD and pregnancy were identified without any time or study limitations. Seven articles (
MeSH term(s)	Female ; Humans ; Postpartum Hemorrhage/etiology ; Pregnancy ; von Willebrand Disease, Type 1 ; von Willebrand Diseases/complications ; von Willebrand Diseases/diagnosis ; von Willebrand Factor
Chemical Substances	von Willebrand Factor
Language	English
Publishing date	2021-11-08
Publishing country	United States
Document type	Journal Article ; Systematic Review
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0041-1736572
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Article: Postpartum Hemorrhage in Patients with Type 1 von Willebrand Disease: A Systematic Review

Pierce-Williams, Rebecca A.M. / Makhamreh, Mona M. / Blakey-Cheung, Sophia / Gao, Zimeng / Al-Kouatly, Huda B.

Seminars in Thrombosis and Hemostasis

(Editorial Compilation XI)

2021 Volume 48, Issue 02, Page(s) 219–228

Series title	Editorial Compilation XI
Abstract	Type 1 von Willebrand disease (VWD) is the most common subtype of VWD, comprising 75% of VWD patients. We provide a systematic review of type 1 VWD in pregnancy. Our objective was to evaluate the rate of postpartum hemorrhage (PPH) in patients with known type 1 VWD. The primary outcome was rate of PPH. Primary PPH was defined as a cumulative blood loss ≥1,000 mL, or blood loss accompanied by signs and symptoms of hypovolemia within 24 hours postpartum or requiring blood products. Secondary PPH was defined as significant bleeding 24 hours to 12 weeks postpartum. Relevant articles published in English pertaining to VWD and pregnancy were identified without any time or study limitations. Seven articles ( n = 144 pregnancies) met inclusion criteria. The rate of primary PPH was 4/144 (2.8%). The secondary PPH rate was reported in four studies, and occurred in 7/48 pregnancies (14.6%), ranging from 2 to 19 days postpartum. In conclusion, according to this systematic review, the frequency of primary PPH in pregnancies with known type 1 VWD is 2.8%. This is similar to the overall PPH rates of 3% reported in the literature. Although the sample size was small, secondary PPH occurred in almost 15% of pregnancies, while in the overall obstetrical population this occurs in approximately 1% of cases. Patients with known type 1 VWD may not be at increased risk of primary PPH, though they appear to bear increased risk of secondary PPH.
Keywords	von Willebrand disease ; type 1 VWD ; postpartum hemorrhage ; pregnancy
Language	English
Publishing date	2021-11-08
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	196901-8
ISSN	1098-9064 ; 0094-6176
ISSN (online)	1098-9064
ISSN	0094-6176
DOI	10.1055/s-0041-1736572
Database	Thieme publisher's database

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Article ; Online: Intravenous fluid rate for reduction of cesarean delivery rate in nulliparous women: a systematic review and meta-analysis.

Ehsanipoor, Robert M / Saccone, Gabriele / Seligman, Neil S / Pierce-Williams, Rebecca A M / Ciardulli, Andrea / Berghella, Vincenzo

Acta obstetricia et gynecologica Scandinavica

2017 Volume 96, Issue 7, Page(s) 804–811

Abstract: Introduction: The National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, and Society for Maternal-Fetal Medicine have emphasized the need to promote vaginal delivery and have offered ... ...

Abstract	Introduction: The National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, and Society for Maternal-Fetal Medicine have emphasized the need to promote vaginal delivery and have offered recommendations to safely prevent primary cesarean delivery. However, there has been limited discussion regarding management of intravenous fluids and other aspects of labor management that may influence mode of delivery. Therefore the aim of our study was to determine whether an intravenous fluid rate of 250 vs. 125 mL/h is associated with a difference in cesarean delivery rate. Material and methods: Searches were performed in MEDLINE, OVID, Scopus, ClinicalTrials.gov, the PROSPERO International Prospective Register of Systematic Reviews, Embase, Web of Science, and the Cochrane Library for randomized controlled trials. We included all randomized controlled trials comparing intravenous fluid rates of 250 vs. 125 mL/h in nulliparous women in spontaneous labor at term with singleton pregnancies at ≥36 weeks. Studies were included regardless of the type of intravenous fluids used and regardless of whether oral intake was restricted during labor. Studies including multiparous women or women whose labor was induced were excluded. The primary outcome was the incidence of cesarean delivery. We planned to assess a subgroup analysis according to type of fluids used and according to restriction of oral fluid intake. Results: Seven trials including 1215 nulliparous women in spontaneous labor at term were analyzed; 593 (48.8%) in the 250 mL/h group, and 622 (51.2%) in the 125 mL/h group. Five studies used lactated Ringer's solution, one used normal saline in dextrose water, and in one study it was unclear which intravenous fluid was used. Women who received intravenous fluids at 250 mL/h had a significantly lower incidence of cesarean delivery for any indication (12.5 vs. 18.1%; RR 0.70, 95% CI 0.53-0.92; seven studies, 1215 participants; I Conclusions: Our findings provide evidence that the duration of labor in low-risk nulliparous women may be shortened by a policy of intravenous fluids at a rate of 250 mL/h rather than 125 mL/h. A rate of 250 mL/h seems to be associated with a reduction in the incidence of cesarean delivery compared to 125 mL/h. The number needed to treat to prevent one cesarean delivery is 18 women. Our data support increased hydration among nulliparous women in labor when oral intake is restricted. Further study is needed regarding risks and benefits of increased hydration among women with unrestricted oral intake, those undergoing induction of labor, and those with medical comorbidities.
MeSH term(s)	Cesarean Section/utilization ; Female ; Humans ; Infusions, Intravenous ; Isotonic Solutions/administration & dosage ; Labor, Obstetric/physiology ; Parity ; Pregnancy
Chemical Substances	Isotonic Solutions
Language	English
Publishing date	2017-07
Publishing country	United States
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	80019-3
ISSN	1600-0412 ; 0001-6349
ISSN (online)	1600-0412
ISSN	0001-6349
DOI	10.1111/aogs.13121
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Article ; Online: Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study.

Pierce-Williams, Rebecca A M / Burd, Julia / Felder, Laura / Khoury, Rasha / Bernstein, Peter S / Avila, Karina / Penfield, Christina A / Roman, Ashley S / DeBolt, Chelsea A / Stone, Joanne L / Bianco, Angela / Kern-Goldberger, Adina R / Hirshberg, Adi / Srinivas, Sindhu K / Jayakumaran, Jenani S / Brandt, Justin S / Anastasio, Hannah / Birsner, Meredith / O'Brien, Devon S /

Sedev, Harish M / Dolin, Cara D / Schnettler, William T / Suhag, Anju / Ahluwalia, Shabani / Navathe, Reshama S / Khalifeh, Adeeb / Anderson, Kathryn / Berghella, Vincenzo

American journal of obstetrics & gynecology MFM

2020 Volume 2, Issue 3, Page(s) 100134

Abstract: ... had cardiac disease, and the mean body mass index was 34 kg/m: Conclusion: In pregnant women ...

Abstract	Background: The coronavirus disease 2019 pandemic has had an impact on healthcare systems around the world with 3 million people contracting the disease and 208,000 cases resulting in death as of this writing. Information regarding coronavirus infection in pregnancy is still limited. Objective: This study aimed to describe the clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnant women with positive laboratory testing for severe acute respiratory syndrome coronavirus 2. Study design: This is a cohort study of pregnant women with severe or critical coronavirus disease 2019 hospitalized at 12 US institutions between March 5, 2020, and April 20, 2020. Severe disease was defined according to published criteria as patient-reported dyspnea, respiratory rate >30 per minute, blood oxygen saturation ≤93% on room air, ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen <300 mm Hg, or lung infiltrates >50% within 24-48 hours on chest imaging. Critical disease was defined as respiratory failure, septic shock, or multiple organ dysfunction or failure. Women were excluded from the study if they had presumed coronavirus disease 2019, but laboratory testing was negative. The primary outcome was median duration from hospital admission to discharge. Secondary outcomes included need for supplemental oxygen, intubation, cardiomyopathy, cardiac arrest, death, and timing of delivery. The clinical courses are described by the median disease day on which these outcomes occurred after the onset of symptoms. Treatment and neonatal outcomes are also reported. Results: Of 64 hospitalized pregnant women with coronavirus disease 2019, 44 (69%) had severe disease, and 20 (31%) had critical disease. The following preexisting comorbidities were observed: 25% had a pulmonary condition, 17% had cardiac disease, and the mean body mass index was 34 kg/m Conclusion: In pregnant women with severe or critical coronavirus disease 2019, admission into the hospital typically occurred about 7 days after symptom onset, and the duration of hospitalization was 6 days (6 [severe group] vs 12 [critical group]). Women with critical disease had a high rate of acute respiratory distress syndrome, and there was 1 case of cardiac arrest, but there were no cases of cardiomyopathy or maternal mortality. Hospitalization of pregnant women with severe or critical coronavirus disease 2019 resulted in delivery during the clinical course of the disease in 50% of this cohort, usually in the third trimester. There were no perinatal deaths in this cohort.
MeSH term(s)	Adult ; COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/therapy ; Cesarean Section/methods ; Cesarean Section/statistics & numerical data ; Cohort Studies ; Critical Illness/epidemiology ; Critical Illness/therapy ; Female ; Hospitalization/statistics & numerical data ; Humans ; Infant, Newborn ; Infectious Disease Transmission, Vertical/prevention & control ; Infectious Disease Transmission, Vertical/statistics & numerical data ; Maternal Mortality ; Pregnancy ; Pregnancy Complications, Infectious/epidemiology ; Pregnancy Complications, Infectious/physiopathology ; Pregnancy Complications, Infectious/therapy ; Pregnancy Complications, Infectious/virology ; Pregnancy Outcome/epidemiology ; Premature Birth/epidemiology ; SARS-CoV-2/isolation & purification ; Severity of Illness Index ; United States/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-05-08
Publishing country	United States
Document type	Journal Article
ISSN	2589-9333
ISSN (online)	2589-9333
DOI	10.1016/j.ajogmf.2020.100134
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Article: Clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnancies: a United States cohort study

Brien, Devon S / Sedev, Harish M / Dolin, Cara D / Schnettler, William T / Suhag, Anju / Ahluwalia, Shabani / Navathe, Reshama S / Khalifeh, Adeeb / Anderson, Kathryn / Berghella, Vincenzo

Am J Obstet Gynecol MFM

Abstract: Background: The coronavirus disease 2019 pandemic has had an impact on healthcare systems around the world with 3 million people contracting the disease and 208,000 cases resulting in death as of this writing. Information regarding coronavirus infection ... ...

Abstract	Background: The coronavirus disease 2019 pandemic has had an impact on healthcare systems around the world with 3 million people contracting the disease and 208,000 cases resulting in death as of this writing. Information regarding coronavirus infection in pregnancy is still limited. Objective: This study aimed to describe the clinical course of severe and critical coronavirus disease 2019 in hospitalized pregnant women with positive laboratory testing for severe acute respiratory syndrome coronavirus 2. Study Design: This is a cohort study of pregnant women with severe or critical coronavirus disease 2019 hospitalized at 12 US institutions between March 5, 2020, and April 20, 2020. Severe disease was defined according to published criteria as patient-reported dyspnea, respiratory rate >30 per minute, blood oxygen saturation ≤93% on room air, ratio of partial pressure of arterial oxygen to the fraction of inspired oxygen <300 mm Hg, or lung infiltrates >50% within 24-48 hours on chest imaging. Critical disease was defined as respiratory failure, septic shock, or multiple organ dysfunction or failure. Women were excluded from the study if they had presumed coronavirus disease 2019, but laboratory testing was negative. The primary outcome was median duration from hospital admission to discharge. Secondary outcomes included need for supplemental oxygen, intubation, cardiomyopathy, cardiac arrest, death, and timing of delivery. The clinical courses are described by the median disease day on which these outcomes occurred after the onset of symptoms. Treatment and neonatal outcomes are also reported. Results: Of 64 hospitalized pregnant women with coronavirus disease 2019, 44 (69%) had severe disease, and 20 (31%) had critical disease. The following preexisting comorbidities were observed: 25% had a pulmonary condition, 17% had cardiac disease, and the mean body mass index was 34 kg/m2. Gestational age was at a mean of 29±6 weeks at symptom onset and a mean of 30±6 weeks at hospital admission, with a median disease day 7 since first symptoms. Most women (81%) were treated with hydroxychloroquine; 7% of women with severe disease and 65% of women with critical disease received remdesivir. All women with critical disease received either prophylactic or therapeutic anticoagulation during their admission. The median duration of hospital stay was 6 days (6 days [severe group] and 10.5 days [critical group]; P=.01). Intubation was usually performed around day 9 on patients who required it, and peak respiratory support for women with severe disease was performed on day 8. In women with critical disease, prone positioning was required in 20% of cases, the rate of acute respiratory distress syndrome was 70%, and reintubation was necessary in 20%. There was 1 case of maternal cardiac arrest, but there were no cases of cardiomyopathy or maternal death. Thirty-two of 64 (50%) women with coronavirus disease 2019 in this cohort delivered during their hospitalization (34% [severe group] and 85% [critical group]). Furthermore, 15 of 17 (88%) pregnant women with critical coronavirus disease 2019 delivered preterm during their disease course, with 16 of 17 (94%) pregnant women giving birth through cesarean delivery; overall, 15 of 20 (75%) women with critical disease delivered preterm. There were no stillbirths or neonatal deaths or cases of vertical transmission. Conclusion: In pregnant women with severe or critical coronavirus disease 2019, admission into the hospital typically occurred about 7 days after symptom onset, and the duration of hospitalization was 6 days (6 [severe group] vs 12 [critical group]). Women with critical disease had a high rate of acute respiratory distress syndrome, and there was 1 case of cardiac arrest, but there were no cases of cardiomyopathy or maternal mortality. Hospitalization of pregnant women with severe or critical coronavirus disease 2019 resulted in delivery during the clinical course of the disease in 50% of this cohort, usually in the third trimester. There were no perinatal deaths in this cohort.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #701218
Database	COVID19

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Article ; Online: Mindfulness-Based Stress Reduction for Our Time: A Curriculum that is up to the Task.

Crane, Rebecca S / Callen-Davies, Robert / Francis, Aesha / Francis, Dean / Gibbs, Pauline / Mulligan, Beth / O'Neill, Bridgette / Pierce Williams, Nana Korantemah / Waupoose, Michael / Vallejo, Zayda

Global advances in integrative medicine and health

2023 Volume 12, Page(s) 27536130231162604

Abstract: There is current heightened public consciousness of the intersecting challenges of social and racial injustice, other forms of inequity, and the climate and biodiversity crisis. We examine how these current realities influence how we engage as ... ...

Abstract	There is current heightened public consciousness of the intersecting challenges of social and racial injustice, other forms of inequity, and the climate and biodiversity crisis. We examine how these current realities influence how we engage as Mindfulness-Based Stress Reduction (MBSR) and Mindfulness-Based Program (MBP) teachers and researchers. Although Kabat-Zinn developed MBSR as a vehicle to enable engagement with both the individual and the collective drivers of distress and flourishing, predominant research and practice trends within the MBP field have prioritised individual wellbeing, and have not been accessible to the full societal demographic. Furthermore, there is increasing recognition that the systemic social inequities that influence access to public services have not been addressed in the MBP field. In response, there is now an increasing trend exploring how MBP participation can influence 'bigger than self' concerns, with research, practice and theory suggesting that the inner personal transformation that mindfulness practice enables, supports individuals to compassionately reconnect to self, other and the natural world in ways that foster prosocial behaviour change, and enables awareness building of personal bias and conditioning. In this paper we present perspectives on ways of both retaining fidelity to the existing MBSR program, and simultaneously embracing anti-oppression teaching methods and content, and an inclusive recognition of the micro, meso and macro causes and conditions that drive distress and flourishing. We are a group of racially diverse MBP teachers and trainers from both sides of the Atlantic, who are engaged in training initiatives with people from Black, Latinex, Indigenous, Asian, and People of Color communities.
Language	English
Publishing date	2023-04-06
Publishing country	United States
Document type	Journal Article
ISSN	2753-6130
ISSN (online)	2753-6130
DOI	10.1177/27536130231162604
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Article ; Online: The Changing Epidemiology of Candidemia in the United States: Injection Drug Use as an Increasingly Common Risk Factor-Active Surveillance in Selected Sites, United States, 2014-2017.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2019 Volume 71, Issue 7, Page(s) 1732–1737

Abstract: Background: Injection drug use (IDU) is a known, but infrequent risk factor on candidemia; however, the opioid epidemic and increases in IDU may be changing the epidemiology of candidemia.: Methods: Active population-based surveillance for candidemia ...

Abstract	Background: Injection drug use (IDU) is a known, but infrequent risk factor on candidemia; however, the opioid epidemic and increases in IDU may be changing the epidemiology of candidemia. Methods: Active population-based surveillance for candidemia was conducted in selected US counties. Cases of candidemia were categorized as IDU cases if IDU was indicated in the medical records in the 12 months prior to the date of initial culture. Results: During 2017, 1191 candidemia cases were identified in patients aged >12 years (incidence: 6.9 per 100 000 population); 128 (10.7%) had IDU history, and this proportion was especially high (34.6%) in patients with candidemia aged 19-44. Patients with candidemia and IDU history were younger than those without (median age, 35 vs 63 years; P < .001). Candidemia cases involving recent IDU were less likely to have typical risk factors including malignancy (7.0% vs 29.4%; relative risk [RR], 0.2 [95% confidence interval {CI}, .1-.5]), abdominal surgery (3.9% vs 17.5%; RR, 0.2 [95% CI, .09-.5]), and total parenteral nutrition (3.9% vs 22.5%; RR, 0.2 [95% CI, .07-.4]). Candidemia cases with IDU occurred more commonly in smokers (68.8% vs 18.5%; RR, 3.7 [95% CI, 3.1-4.4]), those with hepatitis C (54.7% vs 6.4%; RR, 8.5 [95% CI, 6.5-11.3]), and in people who were homeless (13.3% vs 0.8%; RR, 15.7 [95% CI, 7.1-34.5]). Conclusions: Clinicians should consider injection drug use as a risk factor in patients with candidemia who lack typical candidemia risk factors, especially in those with who are 19-44 years of age and have community-associated candidemia.
MeSH term(s)	Adult ; Candidemia/epidemiology ; Child ; Humans ; Pharmaceutical Preparations ; Risk Factors ; Substance Abuse, Intravenous/complications ; Substance Abuse, Intravenous/epidemiology ; United States/epidemiology ; Watchful Waiting ; Young Adult
Chemical Substances	Pharmaceutical Preparations
Language	English
Publishing date	2019-11-01
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciz1061
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Article ; Online: Accuracy of in vivo multimodal optical imaging for detection of oral neoplasia.

Pierce, Mark C / Schwarz, Richard A / Bhattar, Vijayashree S / Mondrik, Sharon / Williams, Michelle D / Lee, J Jack / Richards-Kortum, Rebecca / Gillenwater, Ann M

Cancer prevention research (Philadelphia, Pa.)

2012 Volume 5, Issue 6, Page(s) 801–809

Abstract: If detected early, oral cancer is eminently curable. However, survival rates for oral cancer patients remain low, largely due to late-stage diagnosis and subsequent difficulty of treatment. To improve clinicians' ability to detect early disease and to ... ...

Abstract	If detected early, oral cancer is eminently curable. However, survival rates for oral cancer patients remain low, largely due to late-stage diagnosis and subsequent difficulty of treatment. To improve clinicians' ability to detect early disease and to treat advanced cancers, we developed a multimodal optical imaging system (MMIS) to evaluate tissue in situ, at macroscopic and microscopic scales. The MMIS was used to measure 100 anatomic sites in 30 patients, correctly classifying 98% of pathologically confirmed normal tissue sites, and 95% of sites graded as moderate dysplasia, severe dysplasia, or cancer. When used alone, MMIS classification accuracy was 35% for sites determined by pathology as mild dysplasia. However, MMIS measurements correlated with expression of candidate molecular markers in 87% of sites with mild dysplasia. These findings support the ability of noninvasive multimodal optical imaging to accurately identify neoplastic tissue and premalignant lesions. This in turn may have considerable impact on detection and treatment of patients with oral cancer and other epithelial malignancies.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Diagnostic Imaging ; Female ; Fiber Optic Technology ; Fluorescence ; Humans ; Middle Aged ; Mouth Mucosa/pathology ; Mouth Neoplasms/diagnosis ; Precancerous Conditions/diagnosis ; Sensitivity and Specificity
Language	English
Publishing date	2012-05-02
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2434717-6
ISSN	1940-6215 ; 1940-6207
ISSN (online)	1940-6215
ISSN	1940-6207
DOI	10.1158/1940-6207.CAPR-11-0555
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Article ; Online: The global spectrum of plant form and function: enhanced species-level trait dataset.

Díaz, Sandra / Kattge, Jens / Cornelissen, Johannes H C / Wright, Ian J / Lavorel, Sandra / Dray, Stéphane / Reu, Björn / Kleyer, Michael / Wirth, Christian / Prentice, I Colin / Garnier, Eric / Bönisch, Gerhard / Westoby, Mark / Poorter, Hendrik / Reich, Peter B / Moles, Angela T / Dickie, John / Zanne, Amy E / Chave, Jérôme /

Wright, S Joseph / Sheremetiev, Serge N / Jactel, Hervé / Baraloto, Christopher / Cerabolini, Bruno E L / Pierce, Simon / Shipley, Bill / Casanoves, Fernando / Joswig, Julia S / Günther, Angela / Falczuk, Valeria / Rüger, Nadja / Mahecha, Miguel D / Gorné, Lucas D / Amiaud, Bernard / Atkin, Owen K / Bahn, Michael / Baldocchi, Dennis / Beckmann, Michael / Blonder, Benjamin / Bond, William / Bond-Lamberty, Ben / Brown, Kerry / Burrascano, Sabina / Byun, Chaeho / Campetella, Giandiego / Cavender-Bares, Jeannine / Chapin, F Stuart / Choat, Brendan / Coomes, David Anthony / Cornwell, William K / Craine, Joseph / Craven, Dylan / Dainese, Matteo / de Araujo, Alessandro Carioca / de Vries, Franciska T / Domingues, Tomas Ferreira / Enquist, Brian J / Fagúndez, Jaime / Fang, Jingyun / Fernández-Méndez, Fernando / Fernandez-Piedade, Maria T / Ford, Henry / Forey, Estelle / Freschet, Gregoire T / Gachet, Sophie / Gallagher, Rachael / Green, Walton / Guerin, Greg R / Gutiérrez, Alvaro G / Harrison, Sandy P / Hattingh, Wesley Neil / He, Tianhua / Hickler, Thomas / Higgins, Steven I / Higuchi, Pedro / Ilic, Jugo / Jackson, Robert B / Jalili, Adel / Jansen, Steven / Koike, Fumito / König, Christian / Kraft, Nathan / Kramer, Koen / Kreft, Holger / Kühn, Ingolf / Kurokawa, Hiroko / Lamb, Eric G / Laughlin, Daniel C / Leishman, Michelle / Lewis, Simon / Louault, Frédérique / Malhado, Ana C M / Manning, Peter / Meir, Patrick / Mencuccini, Maurizio / Messier, Julie / Miller, Regis / Minden, Vanessa / Molofsky, Jane / Montgomery, Rebecca / Montserrat-Martí, Gabriel / Moretti, Marco / Müller, Sandra / Niinemets, Ülo / Ogaya, Romà / Öllerer, Kinga / Onipchenko, Vladimir / Onoda, Yusuke / Ozinga, Wim A / Pausas, Juli G / Peco, Begoña / Penuelas, Josep / Pillar, Valério D / Pladevall, Clara / Römermann, Christine / Sack, Lawren / Salinas, Norma / Sandel, Brody / Sardans, Jordi / Schamp, Brandon / Scherer-Lorenzen, Michael / Schulze, Ernst-Detlef / Schweingruber, Fritz / Shiodera, Satomi / Sosinski, Ênio / Soudzilovskaia, Nadejda / Spasojevic, Marko J / Swaine, Emily / Swenson, Nathan / Tautenhahn, Susanne / Thompson, Ken / Totte, Alexia / Urrutia-Jalabert, Rocío / Valladares, Fernando / van Bodegom, Peter / Vasseur, François / Verheyen, Kris / Vile, Denis / Violle, Cyrille / von Holle, Betsy / Weigelt, Patrick / Weiher, Evan / Wiemann, Michael C / Williams, Mathew / Wright, Justin / Zotz, Gerhard

Scientific data

2022 Volume 9, Issue 1, Page(s) 755

Abstract: Here we provide the 'Global Spectrum of Plant Form and Function Dataset', containing species mean values for six vascular plant traits. Together, these traits -plant height, stem specific density, leaf area, leaf mass per area, leaf nitrogen content per ... ...

Abstract	Here we provide the 'Global Spectrum of Plant Form and Function Dataset', containing species mean values for six vascular plant traits. Together, these traits -plant height, stem specific density, leaf area, leaf mass per area, leaf nitrogen content per dry mass, and diaspore (seed or spore) mass - define the primary axes of variation in plant form and function. The dataset is based on ca. 1 million trait records received via the TRY database (representing ca. 2,500 original publications) and additional unpublished data. It provides 92,159 species mean values for the six traits, covering 46,047 species. The data are complemented by higher-level taxonomic classification and six categorical traits (woodiness, growth form, succulence, adaptation to terrestrial or aquatic habitats, nutrition type and leaf type). Data quality management is based on a probabilistic approach combined with comprehensive validation against expert knowledge and external information. Intense data acquisition and thorough quality control produced the largest and, to our knowledge, most accurate compilation of empirically observed vascular plant species mean traits to date.
Language	English
Publishing date	2022-12-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-022-01774-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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