LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 310

Search options

  1. Article ; Online: A Scoping Review of the Clinical Pharmacokinetics of Bedaquiline.

    Wilby, Kyle J

    Clinical pharmacokinetics

    2022  Volume 61, Issue 4, Page(s) 481–488

    Abstract: Tuberculosis continues to be a major infectious disease burden worldwide. Increasing drug resistance to first-line agents is making treatment more difficult. Bedaquiline is an orally administered drug active against Mycobacterium tuberculosis and is ... ...

    Abstract Tuberculosis continues to be a major infectious disease burden worldwide. Increasing drug resistance to first-line agents is making treatment more difficult. Bedaquiline is an orally administered drug active against Mycobacterium tuberculosis and is indicated for patients with confirmed multi-drug-resistant tuberculosis. This review aims to identify published literature reporting on the pharmacokinetics of bedaquiline, with a focus on key factors and drug interactions that may affect its use. Findings identified multiple areas for future study. First, exposure-response relationships should be further developed to determine the best ways to monitor both efficacy and safety. Second, dosing may be optimized through greater understanding of specific factors that may influence observed concentrations, including patient demographics and comorbidities. Finally, firm guidance for co-administration of bedaquiline with other drugs known to induce or inhibit cytochrome P450 enzymes is urgently required.
    MeSH term(s) Antitubercular Agents ; Diarylquinolines/pharmacology ; Diarylquinolines/therapeutic use ; Humans ; Mycobacterium tuberculosis ; Tuberculosis, Multidrug-Resistant/drug therapy
    Chemical Substances Antitubercular Agents ; Diarylquinolines ; bedaquiline (78846I289Y)
    Language English
    Publishing date 2022-01-27
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 197627-8
    ISSN 1179-1926 ; 0312-5963
    ISSN (online) 1179-1926
    ISSN 0312-5963
    DOI 10.1007/s40262-022-01107-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1246: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Rethinking standardization: A call for new approaches to competency-based assessment.

    Wilby, Kyle J

    Currents in pharmacy teaching & learning

    2019  Volume 11, Issue 4, Page(s) 428–429

    MeSH term(s) Clinical Competence ; Humans ; Reference Standards ; Students
    Language English
    Publishing date 2019-02-26
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2019.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: What's been trending with OSCEs in pharmacy education over the last 20 years? A bibliometric review and content analysis.

    Lim, Angelina S / Ling, Yeap Li / Wilby, Kyle J / Mak, Vivienne

    Currents in pharmacy teaching & learning

    2024  Volume 16, Issue 3, Page(s) 212–220

    Abstract: Background: Objective structured clinical examinations (OSCEs) remain an integral part of pharmacy education. This study aimed to characterize key researchers, areas, and themes in pharmacy education OSCEs using a bibliometric review with content ... ...

    Abstract Background: Objective structured clinical examinations (OSCEs) remain an integral part of pharmacy education. This study aimed to characterize key researchers, areas, and themes in pharmacy education OSCEs using a bibliometric review with content analysis.
    Methods: A bibliometric review was conducted on literature from over 23 years from January 2000 to May 2023. Articles focusing on any type of OSCE research in pharmacy education in both undergraduate and postgraduate sectors were included. Articles were excluded if they were not original articles or not published in English. A summative content analysis was also conducted to identify key topics.
    Results: A total of 192 articles were included in the analysis. There were 242 institutions that contributed to the OSCE literature in pharmacy education, with the leading country being Canada. Most OSCE research came from developed countries and were descriptive studies based on single institution data. The top themes emerging from content analysis were student perceptions on OSCE station styles (n = 98), staff perception (n = 19), grade assessment of OSCEs (n = 145), interprofessional education (n = 11), standardized patients (n = 12), and rubric development and standard setting (n = 8).
    Implications: There has been a growth in virtual OSCEs, interprofessional OSCEs, and artificial intelligence OSCEs. Communication rubrics and minimizing assessor variability are still trending research areas. There is scope to conduct more research on evaluating specific types of OSCEs, when best to hold an OSCE, and comparing OSCEs to other assessments.
    MeSH term(s) Humans ; Artificial Intelligence ; Clinical Competence ; Educational Measurement ; Education, Pharmacy ; Bibliometrics
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2515217-8
    ISSN 1877-1300 ; 1877-1297
    ISSN (online) 1877-1300
    ISSN 1877-1297
    DOI 10.1016/j.cptl.2023.12.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Polarization vision in terrestrial hermit crabs.

    How, Martin J / Robertson, Alasdair / Smithers, Samuel P / Wilby, David

    Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology

    2023  Volume 209, Issue 6, Page(s) 899–905

    Abstract: Polarization vision is used by a wide range of animals for navigating, orienting, and detecting objects or areas of interest. Shallow marine and semi-terrestrial crustaceans are particularly well known for their abilities to detect predator-like or ... ...

    Abstract Polarization vision is used by a wide range of animals for navigating, orienting, and detecting objects or areas of interest. Shallow marine and semi-terrestrial crustaceans are particularly well known for their abilities to detect predator-like or conspecific-like objects based on their polarization properties. On land, some terrestrial invertebrates use polarization vision for detecting suitable habitats, oviposition sites or conspecifics, but examples of threat detection in the polarization domain are less well known. To test whether this also applies to crustaceans that have evolved to occupy terrestrial habitats, we determined the sensitivity of two species of land and one species of marine hermit crab to predator-like visual stimuli varying in the degree of polarization. All three species showed an ability to detect these cues based on polarization contrasts alone. One terrestrial species, Coenobita rugosus, showed an increased sensitivity to objects with a higher degree of polarization than the background. This is the inverse of most animals studied to date, suggesting that the ecological drivers for polarization vision may be different in the terrestrial environment.
    MeSH term(s) Female ; Animals ; Anomura/physiology ; Ecosystem
    Language English
    Publishing date 2023-04-12
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 120907-3
    ISSN 1432-1351 ; 0302-9824 ; 0373-0859 ; 0340-7594
    ISSN (online) 1432-1351
    ISSN 0302-9824 ; 0373-0859 ; 0340-7594
    DOI 10.1007/s00359-023-01631-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.170: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: A Narrative Review of Continuing Professional Development Needs for Pharmacists with Respect to Pre-exposure Prophylaxis (PrEP) for Human Immunodeficiency Virus (HIV).

    Wilby, Kyle J / Smith, Alesha J

    Pharmacy (Basel, Switzerland)

    2020  Volume 8, Issue 2

    Abstract: Pre-exposure prophylaxis (PrEP) for the human immunodeficiency virus (HIV) is rapidly increasing in use worldwide, with many countries now publicly funding use for high risk populations. Pharmacists, as front-line care providers, must have the necessary ... ...

    Abstract Pre-exposure prophylaxis (PrEP) for the human immunodeficiency virus (HIV) is rapidly increasing in use worldwide, with many countries now publicly funding use for high risk populations. Pharmacists, as front-line care providers, must have the necessary knowledge, skills and attitudes to effectively provide care to PrEP patients. The aim of this review was to identify priority areas and key gaps for continuing professional development (CPD) needs relating to PrEP for practicing pharmacists. An electronic search of PubMed, EMBASE, International Pharmaceutical Abstracts and CPD-related journals was supplemented with a manual search of references to identify articles describing pharmacists' knowledge, perceptions and experience with PrEP. A total of eight articles were identified across four countries. Pharmacists were consistently found to lack knowledge and awareness of PrEP, express low confidence/comfort with patient care practices, report a lack of experience and/or intentions to provide patient care, but overall had positive perceptions of PrEP therapy. Older pharmacists with more experience commonly reported greater knowledge gaps than recently trained pharmacists. CPD should therefore aim to increase pharmacists' baseline knowledge and awareness of PrEP and treatment guidelines, as well as be directed towards older pharmacists with more experience.
    Language English
    Publishing date 2020-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2737194-3
    ISSN 2226-4787 ; 2226-4787
    ISSN (online) 2226-4787
    ISSN 2226-4787
    DOI 10.3390/pharmacy8020084
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: Health services for sexually transmitted infections: Where are we at in New Zealand? A narrative literature review.

    Smith, Alesha J / Wilby, Kyle J

    Journal of primary health care

    2020  Volume 12, Issue 4, Page(s) 335–344

    Abstract: INTRODUCTION Sexually transmitted infection (STI) rates continue to rise in New Zealand. To effectively prevent, test and diagnose STIs in a timely manner to limit their health effects, health services must be appropriate and accessible for all. AIM The ... ...

    Abstract INTRODUCTION Sexually transmitted infection (STI) rates continue to rise in New Zealand. To effectively prevent, test and diagnose STIs in a timely manner to limit their health effects, health services must be appropriate and accessible for all. AIM The aim of this review was to identify and collate the existing literature and identify gaps in research relating to STI health service delivery in New Zealand. METHODS A critical narrative literature review was conducted. A keyword search of PubMed (2010 to October 2020), EMBASE (2010 to October 2020) and Google Scholar (2010 to October 2020) was conducted. The electronic search was supplemented with manual screening of references from identified articles. Eligible studies reported on STI service delivery in New Zealand. Articles not meeting these criteria were excluded. Articles solely reporting on the human papillomavirus vaccine or condom use statistics or perceptions were also excluded. Data extracted included study year, authors, aim, methods and outcome results. RESULTS A total of 179 articles were identified, including 16 that met study inclusion criteria. Nine studies focused on STI testing, five on health-seeking behaviours and two had other foci. The results reflected substantial gaps in the funding and delivery of best-practice STI management across all New Zealand. DISCUSSION New strategies are needed to improve access to low-cost or free services for sexual health care in general and clinic-wide systems implemented to enable routine delivery of advice about STI prevention and testing by clinicians to patients.
    MeSH term(s) Age Factors ; Health Services Accessibility ; Humans ; New Zealand/epidemiology ; Patient Acceptance of Health Care ; Primary Health Care ; Reproductive Health Services/organization & administration ; Safe Sex ; Sex Factors ; Sexual Behavior ; Sexual Health ; Sexually Transmitted Diseases/diagnosis ; Sexually Transmitted Diseases/epidemiology ; Sexually Transmitted Diseases/prevention & control ; Sexually Transmitted Diseases/therapy ; Socioeconomic Factors
    Language English
    Publishing date 2020-12-19
    Publishing country Australia
    Document type Journal Article ; Systematic Review
    ZDB-ID 2572943-3
    ISSN 1172-6156 ; 1172-6156
    ISSN (online) 1172-6156
    ISSN 1172-6156
    DOI 10.1071/HC20039
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Development of a cancer-themed escape room learning activity for undergraduate pharmacy students.

    Wilby, Kyle John / Kremer, Lisa J

    The International journal of pharmacy practice

    2020  Volume 28, Issue 5, Page(s) 541–543

    Abstract: Objectives: The aim of this study was to evaluate the feasibility of a cancer-themed escape room as a learning activity for pharmacy students.: Methods: A cancer-themed escape room was developed with four activities linked to patient assessment, ... ...

    Abstract Objectives: The aim of this study was to evaluate the feasibility of a cancer-themed escape room as a learning activity for pharmacy students.
    Methods: A cancer-themed escape room was developed with four activities linked to patient assessment, communication, therapeutics and calculations. Twenty-six groups of six students challenged the escape room. Outcomes included student performance measures and resources required. A SWOC (strengths, weaknesses, opportunities, and challenges) analysis was also conducted.
    Results: A total of 20 student groups (77%) successfully escaped. The average escape time was 22 min. The SWOC analysis identified strengths of student engagement, opportunities for expansion, weaknesses related to student preparation, and some logistical challenges.
    Conclusion: A cancer-themed escape room is a viable learning tool for pharmacy students.
    MeSH term(s) Education, Pharmacy/methods ; Feasibility Studies ; Games, Experimental ; Humans ; Neoplasms/drug therapy ; New Zealand ; Problem-Based Learning ; Students, Pharmacy/psychology
    Language English
    Publishing date 2020-04-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1087040-4
    ISSN 2042-7174 ; 0961-7671
    ISSN (online) 2042-7174
    ISSN 0961-7671
    DOI 10.1111/ijpp.12622
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 3320: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Safety of Single-Dose Oral Cefixime, Intramuscular Ceftriaxone, or Intramuscular Gentamicin for the Treatment of Gonorrhea: A Systematic Review and Meta-analysis.

    Dresser, Jacob / Wilby, Kyle John

    The Annals of pharmacotherapy

    2020  Volume 55, Issue 7, Page(s) 914–920

    Abstract: Objective: To compare the incidence and types of adverse effects between 3 recommended treatment options for gonorrhea and to compare the incidence of injection site pain between single-dose intramuscular ceftriaxone and gentamicin.: Data sources: A ... ...

    Abstract Objective: To compare the incidence and types of adverse effects between 3 recommended treatment options for gonorrhea and to compare the incidence of injection site pain between single-dose intramuscular ceftriaxone and gentamicin.
    Data sources: A keyword search of MEDLINE (1966 to September 2020), EMBASE (1947 to September 2020), and International Pharmaceutical Abstracts (1970 to September 2020) was conducted. The electronic search was supplemented with manual screening of references.
    Study selection and data extraction: Comparator studies reporting adverse effect outcomes of treatment with cefixime, ceftriaxone, or gentamicin for gonorrhea in humans were included. Data extracted included study year, authors, aim, setting, population, dosing protocols, and outcome results.
    Data synthesis: A total of 298 articles were identified, of which 6 met inclusion criteria. Two randomized controlled trials compared ceftriaxone and gentamicin. Four randomized controlled trials compared cefixime and ceftriaxone. No differences were noted for the occurrence of at least 1 adverse effect between gentamicin and ceftriaxone (odds ratio [OR] = 0.81; 95% CI = 0.56-1.18) or between cefixime and ceftriaxone (OR = 1.11; 95% CI = 0.21-5.93). Injection site pain (ceftriaxone and gentamicin) and other adverse effects (all drugs) were common but occurred at similar rates between groups.
    Relevance to patient care and clinical practice: Results of this review show a lack of signal for safety concerns with gentamicin-based regimens for the treatment of gonorrhea. Future research should investigate patient acceptability, especially for intramuscular injections.
    Conclusions: The use of single-dose cefixime, ceftriaxone, and gentamicin-based regimens for treatment of gonorrhea appears to be safe and acceptable for use in practice.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Cefixime/adverse effects ; Ceftriaxone/adverse effects ; Gentamicins/adverse effects ; Gonorrhea/drug therapy ; Gonorrhea/epidemiology ; Humans ; Injections, Intramuscular
    Chemical Substances Anti-Bacterial Agents ; Gentamicins ; Ceftriaxone (75J73V1629) ; Cefixime (97I1C92E55)
    Language English
    Publishing date 2020-10-10
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 1101370-9
    ISSN 1542-6270 ; 1060-0280
    ISSN (online) 1542-6270
    ISSN 1060-0280
    DOI 10.1177/1060028020966333
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 900: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Lumbar radicular pain.

    Soar, H / Comer, C / Wilby, M J / Baranidharan, G

    BJA education

    2022  Volume 22, Issue 9, Page(s) 343–349

    Language English
    Publishing date 2022-08-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2888911-3
    ISSN 2058-5357 ; 2058-5349
    ISSN (online) 2058-5357
    ISSN 2058-5349
    DOI 10.1016/j.bjae.2022.05.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6459: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Correction: Investigating pharmacy students' therapeutic decision-making with respect to antimicrobial stewardship cases.

    Nasr, Ziad G / Alhaj Moustafa, Diala / Dahmani, Sara / Wilby, Kyle J

    BMC medical education

    2022  Volume 22, Issue 1, Page(s) 511

    Language English
    Publishing date 2022-06-29
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2044473-4
    ISSN 1472-6920 ; 1472-6920
    ISSN (online) 1472-6920
    ISSN 1472-6920
    DOI 10.1186/s12909-022-03584-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top