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Article ; Online: Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review.

Jomah, Shahamah / Asdaq, Syed Mohammed Basheeruddin / Al-Yamani, Mohammed Jaber

2020 Volume 13, Issue 9, Page(s) 1187–1195

Abstract: The unprecedented challenge faced by mankind due to emergence of coronavirus 2019 (COVID-19) pandemic has obligated researchers across the globe to develop effective medicine for prevention and treatment of this deadly infection. The aim of this review ... ...

Abstract	The unprecedented challenge faced by mankind due to emergence of coronavirus 2019 (COVID-19) pandemic has obligated researchers across the globe to develop effective medicine for prevention and treatment of this deadly infection. The aim of this review is to compile recently published research articles on anti-COVID 19 management with their benefits and risk to facilitate decision making of the practitioners and policy makers. Unfortunately, clinical outcomes reported for antivirals are not consistent. Initial favorable reports on lopinavir/ritonavir contradicted by recent studies. Ostalmovir has conflicting reports. Short term therapy of remdesivir claimed to be beneficial. Favipiravir demonstrated good recovery in some of the cases of COVID-19. Umifenovir (Arbidol) was associated with reduction in mortality in few studies. Overall, until now, U.S. Food and Drug administration issued only emergency use authorization to remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease.
MeSH term(s)	Adenosine Monophosphate/analogs & derivatives ; Adenosine Monophosphate/therapeutic use ; Alanine/analogs & derivatives ; Alanine/therapeutic use ; Amides/therapeutic use ; Antiviral Agents/therapeutic use ; Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Drug Combinations ; Humans ; Indoles/therapeutic use ; Lopinavir/therapeutic use ; Pandemics ; Pneumonia, Viral/drug therapy ; Pyrazines/therapeutic use ; Ritonavir/therapeutic use ; SARS-CoV-2
Chemical Substances	Amides ; Antiviral Agents ; Drug Combinations ; Indoles ; Pyrazines ; lopinavir-ritonavir drug combination ; Lopinavir (2494G1JF75) ; remdesivir (3QKI37EEHE) ; Adenosine Monophosphate (415SHH325A) ; umifenovir (93M09WW4RU) ; favipiravir (EW5GL2X7E0) ; Ritonavir (O3J8G9O825) ; Alanine (OF5P57N2ZX)
Keywords	covid19
Language	English
Publishing date	2020-08-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2467587-8
ISSN	1876-035X ; 1876-0341
ISSN (online)	1876-035X
ISSN	1876-0341
DOI	10.1016/j.jiph.2020.07.013
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Clinical efficacy of antivirals against novel coronavirus (COVID-19)

Shahamah Jomah / Syed Mohammed Basheeruddin Asdaq / Mohammed Jaber Al-Yamani

Journal of Infection and Public Health, Vol 13, Iss 9, Pp 1187-

A review

2020 Volume 1195

Abstract	The unprecedented challenge faced by mankind due to emergence of coronavirus 2019 (COVID-19) pandemic has obligated researchers across the globe to develop effective medicine for prevention and treatment of this deadly infection. The aim of this review is to compile recently published research articles on anti-COVID 19 management with their benefits and risk to facilitate decision making of the practitioners and policy makers. Unfortunately, clinical outcomes reported for antivirals are not consistent. Initial favorable reports on lopinavir/ritonavir contradicted by recent studies. Ostalmovir has conflicting reports. Short term therapy of remdesivir claimed to be beneficial. Favipiravir demonstrated good recovery in some of the cases of COVID-19. Umifenovir (Arbidol) was associated with reduction in mortality in few studies. Overall, until now, U.S. Food and Drug administration issued only emergency use authorization to remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease.
Keywords	COVID-19 ; Remdesivir ; lopinavir/ritonavir ; Favipiravir ; Umifenovir ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270 ; covid19
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Clinical efficacy of antivirals against novel coronavirus (COVID-19)

Jomah, Shahamah / Asdaq, Syed Mohammed Basheeruddin / Al-Yamani, Mohammed Jaber

Journal of Infection and Public Health

A review

2020 Volume 13, Issue 9, Page(s) 1187–1195

Keywords	Public Health, Environmental and Occupational Health ; Infectious Diseases ; General Medicine ; covid19
Language	English
Publisher	Elsevier BV
Publishing country	us
Document type	Article ; Online
ISSN	1876-0341
DOI	10.1016/j.jiph.2020.07.013
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Nigella sativa

Imran, Mohd / Khan, Shah Alam / Abida / Alshammari, Mohammed Kanan / Alkhaldi, Saif M / Alshammari, Fayez Nafea / Kamal, Mehnaz / Alam, Ozair / Asdaq, Syed Mohammed Basheeruddin / Alzahrani, A Khuzaim / Jomah, Shahamah

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 9

Abstract: COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. ...

Abstract	COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants.
MeSH term(s)	COVID-19/drug therapy ; Humans ; Inventions ; Nigella sativa/chemistry ; Plants, Medicinal ; Quality of Life ; SARS-CoV-2
Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27092750
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Article: Clinical efficacy of antivirals against novel coronavirus (COVID-19): A review

Jomah, Shahamah / Asdaq, Syed Mohammed Basheeruddin / Al-Yamani, Mohammed Jaber

J Infect Public Health

Abstract	The unprecedented challenge faced by mankind due to emergence of coronavirus 2019 (COVID-19) pandemic has obligated researchers across the globe to develop effective medicine for prevention and treatment of this deadly infection. The aim of this review is to compile recently published research articles on anti-COVID 19 management with their benefits and risk to facilitate decision making of the practitioners and policy makers. Unfortunately, clinical outcomes reported for antivirals are not consistent. Initial favorable reports on lopinavir/ritonavir contradicted by recent studies. Ostalmovir has conflicting reports. Short term therapy of remdesivir claimed to be beneficial. Favipiravir demonstrated good recovery in some of the cases of COVID-19. Umifenovir (Arbidol) was associated with reduction in mortality in few studies. Overall, until now, U.S. Food and Drug administration issued only emergency use authorization to remdesivir for the treatment of suspected or laboratory-confirmed COVID-19 in adults and children hospitalized with severe disease.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #692147
Database	COVID19

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Article: Insight into the Advances in Clinical Trials of SARS-CoV-2 Vaccines.

Basheeruddin Asdaq, Syed Mohammed / Jomah, Shahamah / Rabbani, Syed Imam / Alamri, Ali Musharraf / Salem Alshammari, Salman Khalaf / Duwaidi, Badr Sami / Alshammari, Majed Sadun / Alamri, Abdulhakeem S / Alsanie, Walaa F / Alhomrani, Majid / Sreeharsha, Nagaraja / Imran, Mohd

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

2022 Volume 2022, Page(s) 6913772

Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has thrown a challenge to the scientific community. Several interventions to stop or limit the spread of infection have failed, and every time the virus emerges, it becomes more contagious and ... ...

Abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has thrown a challenge to the scientific community. Several interventions to stop or limit the spread of infection have failed, and every time the virus emerges, it becomes more contagious and more deadly. Vaccinating a significant proportion of the population is one of the established methods to achieve herd immunity. More than 100 COVID-19 vaccines have been designed and tested against the virus. The development of a new vaccine takes years of testing, but due to the pandemic, healthcare authorities have given emergency use authorization for a few vaccines. Among them are BioNTech and Moderna vaccines (mRNA based); ChAdOx1, Gam-COVID-Vac, Janssen vaccines (vector-based); CoronaVac, COVAXIN (virus inactivated); and EpiVacCorona vaccine (viral peptide). Mixtures of vaccines are also being tested to evaluate their efficacy against mutant strains of SARS-CoV-2. All these vaccines in clinical trials have shown robust production of neutralizing antibodies sufficient to prevent infection. Some of the vaccinated people reported serious complications. However, no definitive relationship could be established between vaccination administration and the occurrence of these complications. None of the COVID-19 vaccines approved to date have been found to be effective against all of the SARS-CoV-2 variants.
Language	English
Publishing date	2022-02-09
Publishing country	Egypt
Document type	Journal Article ; Review
ZDB-ID	1057056-1
ISSN	1712-9532 ; 1180-2332
ISSN	1712-9532 ; 1180-2332
DOI	10.1155/2022/6913772
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Article ; Online: Nigella sativa L. and COVID-19

Mohd Imran / Shah Alam Khan / Abida / Mohammed Kanan Alshammari / Saif M. Alkhaldi / Fayez Nafea Alshammari / Mehnaz Kamal / Ozair Alam / Syed Mohammed Basheeruddin Asdaq / A. Khuzaim Alzahrani / Shahamah Jomah

Molecules, Vol 27, Iss 2750, p

A Glance at The Anti-COVID-19 Chemical Constituents, Clinical Trials, Inventions, and Patent Literature

2022 Volume 2750

Abstract	COVID-19 has had an impact on human quality of life and economics. Scientists have been identifying remedies for its prevention and treatment from all possible sources, including plants. Nigella sativa L. (NS) is an important medicinal plant of Islamic value. This review highlights the anti-COVID-19 potential, clinical trials, inventions, and patent literature related to NS and its major chemical constituents, like thymoquinone. The literature was collected from different databases, including Pubmed, Espacenet, and Patentscope. The literature supports the efficacy of NS, NS oil (NSO), and its chemical constituents against COVID-19. The clinical data imply that NS and NSO can prevent and treat COVID-19 patients with a faster recovery rate. Several inventions comprising NS and NSO have been claimed in patent applications to prevent/treat COVID-19. The patent literature cites NS as an immunomodulator, antioxidant, anti-inflammatory, a source of anti-SARS-CoV-2 compounds, and a plant having protective effects on the lungs. The available facts indicate that NS, NSO, and its various compositions have all the attributes to be used as a promising remedy to prevent, manage, and treat COVID-19 among high-risk people as well as for the therapy of COVID-19 patients of all age groups as a monotherapy or a combination therapy. Many compositions of NS in combination with countless medicinal herbs and medicines are still unexplored. Accordingly, the authors foresee a bright scope in developing NS-based anti-COVID-19 composition for clinical use in the future.
Keywords	Nigella sativa L ; black seed ; SARS-CoV-2 ; COVID-19 ; clinical trial ; invention ; Organic chemistry ; QD241-441
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Insights into the Uses of Traditional Plants for Diabetes Nephropathy: A Review.

Shahin D H, Haleema / Sultana, Rokeya / Farooq, Juveriya / Taj, Tahreen / Khaiser, Umaima Farheen / Alanazi, Nader Sulaiman Ayyt / Alshammari, Mohammed Kanan / Alshammari, Mohammad Nazal / Alsubaie, Firas Hamdan / Asdaq, Syed Mohammed Basheeruddin / Alotaibi, Abdulmueen A / Alamir, Abdulrhman Ahmed / Imran, Mohd / Jomah, Shahamah

Current issues in molecular biology

2022 Volume 44, Issue 7, Page(s) 2887–2902

Abstract: Diabetic nephropathy (DN) is a serious kidney illness characterized by proteinuria, glomerular enlargement, reduced glomerular filtration, and renal fibrosis. DN is the most common cause of end-stage kidney disease, accounting for nearly one-third of all ...

Abstract	Diabetic nephropathy (DN) is a serious kidney illness characterized by proteinuria, glomerular enlargement, reduced glomerular filtration, and renal fibrosis. DN is the most common cause of end-stage kidney disease, accounting for nearly one-third of all cases of diabetes worldwide. Hyperglycemia is a major factor in the onset and progression of diabetic nephropathy. Many contemporary medicines are derived from plants since they have therapeutic properties and are relatively free of adverse effects. Glycosides, alkaloids, terpenoids, and flavonoids are among the few chemical compounds found in plants that are utilized to treat diabetic nephropathy. The purpose of this review was to consolidate information on the clinical and pharmacological evidence supporting the use of a variety of medicinal plants to treat diabetic nephropathy.
Language	English
Publishing date	2022-06-29
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2000024-8
ISSN	1467-3045 ; 1467-3037
ISSN (online)	1467-3045
ISSN	1467-3037
DOI	10.3390/cimb44070199
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Article ; Online: The Impact of Recombinant Human Erythropoietin Administration in Critically ill COVID-19 Patients: A Multicenter Cohort Study.

Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis

2023 Volume 29, Page(s) 10760296231218216

Abstract: The use of erythropoietin-stimulating agents (ESAs) as adjunctive therapy in critically ill patients with COVID-19 may have a potential benefit. This study aims to evaluate the effect of ESAs on the clinical outcomes of critically ill COVID-19 patients. ... ...

Abstract	The use of erythropoietin-stimulating agents (ESAs) as adjunctive therapy in critically ill patients with COVID-19 may have a potential benefit. This study aims to evaluate the effect of ESAs on the clinical outcomes of critically ill COVID-19 patients. A multicenter, retrospective cohort study was conducted from 01-03-2020 to 31-07-2021. We included adult patients who were ≥ 18 years old with a confirmed diagnosis of COVID-19 infection and admitted to intensive care units (ICUs). Patients were categorized depending on ESAs administration during their ICU stay. The primary endpoint was the length of stay; other endpoints were considered secondary. After propensity score matching (1:3), the overall included patients were 120. Among those, 30 patients received ESAs. A longer duration of ICU and hospital stay was observed in the ESA group (beta coefficient: 0.64; 95% CI: 0.31-0.97;
MeSH term(s)	Adult ; Humans ; Adolescent ; COVID-19 ; Retrospective Studies ; Critical Illness ; Erythropoietin/therapeutic use ; Length of Stay ; Intensive Care Units
Chemical Substances	Erythropoietin (11096-26-7)
Language	English
Publishing date	2023-12-11
Publishing country	United States
Document type	Multicenter Study ; Journal Article
ZDB-ID	1237357-6
ISSN	1938-2723 ; 1076-0296
ISSN (online)	1938-2723
ISSN	1076-0296
DOI	10.1177/10760296231218216
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Article ; Online: Thiazole: A Versatile Standalone Moiety Contributing to the Development of Various Drugs and Biologically Active Agents.

Arshad, Mohammed F / Alam, Aftab / Alshammari, Abdullah Ayed / Alhazza, Mohammed Bader / Alzimam, Ibrahim Mohammed / Alam, Md Anish / Mustafa, Gulam / Ansari, Md Salahuddin / Alotaibi, Abdulelah M / Alotaibi, Abdullah A / Kumar, Suresh / Asdaq, Syed Mohammed Basheeruddin / Imran, Mohd / Deb, Pran Kishore / Venugopala, Katharigatta N / Jomah, Shahamah

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 13

Abstract: For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) electrons are free to move from one bond to other bonds rendering ... ...

Abstract	For many decades, the thiazole moiety has been an important heterocycle in the world of chemistry. The thiazole ring consists of sulfur and nitrogen in such a fashion that the pi (π) electrons are free to move from one bond to other bonds rendering aromatic ring properties. On account of its aromaticity, the ring has many reactive positions where donor-acceptor, nucleophilic, oxidation reactions, etc., may take place. Molecules containing a thiazole ring, when entering physiological systems, behave unpredictably and reset the system differently. These molecules may activate/stop the biochemical pathways and enzymes or stimulate/block the receptors in the biological systems. Therefore, medicinal chemists have been focusing their efforts on thiazole-bearing compounds in order to develop novel therapeutic agents for a variety of pathological conditions. This review attempts to inform the readers on three major classes of thiazole-bearing molecules: Thiazoles as treatment drugs, thiazoles in clinical trials, and thiazoles in preclinical and developmental stages. A compilation of preclinical and developmental thiazole-bearing molecules is presented, focusing on their brief synthetic description and preclinical studies relating to structure-based activity analysis. The authors expect that the current review may succeed in drawing the attention of medicinal chemists to finding new leads, which may later be translated into new drugs.
MeSH term(s)	Thiazoles/chemistry
Chemical Substances	Thiazoles
Language	English
Publishing date	2022-06-21
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27133994
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