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  1. Article ; Online: B-cell responses to ITP treatments.

    Crickx, Etienne / Mahévas, Matthieu

    British journal of haematology

    2023  Volume 204, Issue 2, Page(s) 397–398

    Abstract: Deficiency in regulatory B cells has been suggested in immune thrombocytopenia. In this study, Stimpson et al. emphasize the importance of considering the treatments received for immunological analyses. Commentary on: Stimpson et al. Systemic ... ...

    Abstract Deficiency in regulatory B cells has been suggested in immune thrombocytopenia. In this study, Stimpson et al. emphasize the importance of considering the treatments received for immunological analyses. Commentary on: Stimpson et al. Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia. Br J Haematol 2024;204:644-648.
    MeSH term(s) Humans ; Purpura, Thrombocytopenic, Idiopathic ; Thrombocytopenia ; B-Lymphocytes ; Immunosuppression Therapy ; Flow Cytometry
    Language English
    Publishing date 2023-12-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: B cells and antibodies in refractory immune thrombocytopenia.

    Roeser, Anaïs / Lazarus, Alan H / Mahévas, Matthieu

    British journal of haematology

    2023  Volume 203, Issue 1, Page(s) 43–53

    Abstract: Immune thrombocytopenia (ITP) is an acquired bleeding disorder mediated by pathogenic autoantibodies secreted by plasma cells (PCs) in many patients. In refractory ITP patients, the persistence of splenic and bone marrow autoreactive long-lived PCs ( ... ...

    Abstract Immune thrombocytopenia (ITP) is an acquired bleeding disorder mediated by pathogenic autoantibodies secreted by plasma cells (PCs) in many patients. In refractory ITP patients, the persistence of splenic and bone marrow autoreactive long-lived PCs (LLPCs) may explain primary failure of rituximab and splenectomy respectively. The reactivation of autoreactive memory B cells generating new autoreactive PCs contributes to relapses after initial response to rituximab. Emerging strategies targeting B cells and PCs aim to prevent the settlement of splenic LLPCs with the combination of anti-BAFF and rituximab, to deplete autoreactive PCs with anti-CD38 antibodies, and to induce deeper B-cell depletion in tissues with novel anti-CD20 monoclonal antibodies and anti-CD19 therapies. Alternative strategies, focused on controlling autoantibody mediated effects, have also been developed, including SYK and BTK inhibitors, complement inhibitors, FcRn blockers and inhibitors of platelet desialylation.
    MeSH term(s) Humans ; Rituximab/therapeutic use ; Rituximab/pharmacology ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Purpura, Thrombocytopenic, Idiopathic/pathology ; B-Lymphocytes ; Plasma Cells/pathology ; Autoantibodies
    Chemical Substances Rituximab (4F4X42SYQ6) ; Autoantibodies
    Language English
    Publishing date 2023-04-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.18773
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  3. Article ; Online: Older Adults and Immune Thrombocytopenia: Considerations for the Clinician.

    Crickx, Etienne / Mahévas, Matthieu / Michel, Marc / Godeau, Bertrand

    Clinical interventions in aging

    2023  Volume 18, Page(s) 115–130

    Abstract: Many epidemiological studies have shown that the incidence of immune thrombocytopenia (ITP) increases after age 60 years and peaks in patients over age 80 years. Therefore, ITP is a concern for physicians taking care of older patients, especially ... ...

    Abstract Many epidemiological studies have shown that the incidence of immune thrombocytopenia (ITP) increases after age 60 years and peaks in patients over age 80 years. Therefore, ITP is a concern for physicians taking care of older patients, especially regarding its diagnosis and management. The diagnostic work-up should exclude other causes of thrombocytopenia and secondary ITP, including myelodysplastic syndrome and drug-induced ITP. The treatment decision is influenced by an increased risk of bleeding, infectious diseases and thrombosis in this population and should take into account comorbidities and concomitant medications such as anticoagulant drugs. First-line treatment is based on short corticosteroids courses and intravenous immunoglobulin, which should be reserved for patients with more severe bleeding complications, with their higher risk of toxic effects as compared with younger patients. Second-line treatment should be tailored to the patient's history, comorbidities and preferences. Preferred second-line treatments are thrombopoietin receptor agonists for most groups and guidelines given their good efficacy/tolerance ratio, but the thrombotic risk is increased in older people. Other second-line options that can be good alternatives depending on the clinical context include rituximab, dapsone, fostamatinib or immunosuppressive drugs. Splenectomy is less often performed but remains an option for fit patients with chronic refractory disease. Emerging treatments such as Syk or Bruton tyrosine kinase inhibitors and FcRn antagonists are becoming available for ITP and may modify the treatment algorithm in the near future. The aim of this review is to describe the particularities of the diagnosis and treatment of ITP in older people, including the response and tolerance to the currently available drugs. We also discuss some situations related to co-morbidities that can frequently lead to adapt the management strategy in older patients.
    MeSH term(s) Aged ; Aged, 80 and over ; Humans ; Glucocorticoids/therapeutic use ; Immunoglobulins, Intravenous/therapeutic use ; Purpura, Thrombocytopenic, Idiopathic/diagnosis ; Purpura, Thrombocytopenic, Idiopathic/epidemiology ; Purpura, Thrombocytopenic, Idiopathic/therapy ; Rituximab/therapeutic use ; Thrombocytopenia/diagnosis ; Thrombocytopenia/drug therapy
    Chemical Substances Glucocorticoids ; Immunoglobulins, Intravenous ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2023-01-26
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2364924-0
    ISSN 1178-1998 ; 1176-9092
    ISSN (online) 1178-1998
    ISSN 1176-9092
    DOI 10.2147/CIA.S369574
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  4. Article ; Online: Le déficit en interférons de type I n’affecte pas la réponse immunitaire humorale au vaccin contre le SARS-CoV-2.

    Sokal, Aurélien / Bastard, Paul / Casanova, Jean-Laurent / Weill, Jean-Claude / Chappert, Pascal / Mahévas, Matthieu

    Medecine sciences : M/S

    2024  Volume 40, Issue 1, Page(s) 99–101

    Title translation Type I interferon deficiency does not impair humoral immune response to SARS-CoV-2 vaccination.
    MeSH term(s) Humans ; Immunity, Humoral ; COVID-19 Vaccines ; SARS-CoV-2 ; COVID-19/prevention & control ; Vaccination ; Antibodies, Viral
    Chemical Substances COVID-19 Vaccines ; Antibodies, Viral
    Language French
    Publishing date 2024-02-01
    Publishing country France
    Document type Journal Article
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2023182
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  5. Article ; Online: Jadassohn-Dössekker's atypical tuberous myxedema: Report of three cases and review of literature.

    Stammler, Romain / Bessis, Didier / Meunier, Laurent / Limal, Nicolas / Guillaud, Constance / Mahévas, Matthieu / Bagot, Martine / Charvet, Estelle / Cassius, Charles / Battistella, Maxime / Bouaziz, Jean-David / Mahévas, Thibault

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2023  

    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Letter
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.19029
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    Zs.MO 413: Show issues

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  6. Article ; Online: Mémoire immunitaire contre le SARS-CoV-2 - Des anticorps contre l’infection initiale et des lymphocytes B à mémoire contre les infections futures.

    Reynaud, Claude-Agnès / Weill, Jean-Claude / Chappert, Pascal / Mahévas, Matthieu

    Medecine sciences : M/S

    2021  Volume 37, Issue 8-9, Page(s) 722–725

    Title translation Immune memory against SARS-CoV-2: Antibodies against the initial infection and memory B cells for the future ones.
    MeSH term(s) Antibodies, Neutralizing/metabolism ; Antibodies, Viral/metabolism ; Antigenic Variation/genetics ; B-Lymphocytes/immunology ; B-Lymphocytes/physiology ; COVID-19/immunology ; COVID-19/prevention & control ; COVID-19/virology ; COVID-19 Vaccines/immunology ; COVID-19 Vaccines/therapeutic use ; Humans ; Immune Evasion/genetics ; Immunologic Memory/physiology ; SARS-CoV-2/genetics ; SARS-CoV-2/immunology ; Vaccination
    Chemical Substances Antibodies, Neutralizing ; Antibodies, Viral ; COVID-19 Vaccines
    Language French
    Publishing date 2021-08-04
    Publishing country France
    Document type News ; Research Support, Non-U.S. Gov't
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2021122
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  7. Article ; Online: Hepatic Sarcoidosis: Current Concepts and Treatments.

    Rossi, Geoffrey / Ziol, Marianne / Roulot, Dominique / Valeyre, Dominique / Mahévas, Matthieu

    Seminars in respiratory and critical care medicine

    2020  Volume 41, Issue 5, Page(s) 652–658

    Abstract: Hepatic sarcoidosis is a relatively common manifestation of extrapulmonary sarcoidosis. It occurs in 20 to 30% of cases and is rarely severe. However, a cluster of patients may develop severe complications such as cirrhosis and portal hypertension. In ... ...

    Abstract Hepatic sarcoidosis is a relatively common manifestation of extrapulmonary sarcoidosis. It occurs in 20 to 30% of cases and is rarely severe. However, a cluster of patients may develop severe complications such as cirrhosis and portal hypertension. In this review, we describe the current knowledge of clinical, biological, pathological, and radiological features of liver involvement in sarcoidosis and discuss essential clues for management and treatment.
    Language English
    Publishing date 2020-08-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0040-1713799
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  8. Article ; Online: Anti-CD20-mediated B-cell depletion in autoimmune diseases: successes, failures and future perspectives.

    Crickx, Etienne / Weill, Jean-Claude / Reynaud, Claude-Agnès / Mahévas, Matthieu

    Kidney international

    2020  Volume 97, Issue 5, Page(s) 885–893

    Abstract: B-cell depletion with anti-CD20 monoclonal antibodies is widely used for the treatment of autoimmune diseases. This review will discuss mechanisms contributing to success or failure of B-cell depletion therapy in antibody-mediated autoimmune diseases. It ...

    Abstract B-cell depletion with anti-CD20 monoclonal antibodies is widely used for the treatment of autoimmune diseases. This review will discuss mechanisms contributing to success or failure of B-cell depletion therapy in antibody-mediated autoimmune diseases. It will also explain how key information about disease pathogeny can be provided by the different outcomes observed after B-cell depletion therapy. These findings provide the basis for future innovative therapeutic strategies aiming at an optimized B cell and/or plasma cell depletion to increase long-term disease remission.
    MeSH term(s) Antibodies, Monoclonal/therapeutic use ; Antigens, CD20 ; Autoimmune Diseases/therapy ; B-Lymphocytes ; Humans ; Lupus Erythematosus, Systemic ; Lymphocyte Depletion ; Rituximab/therapeutic use
    Chemical Substances Antibodies, Monoclonal ; Antigens, CD20 ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2020-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2019.12.025
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  9. Article ; Online: Immune Thrombocytopenia: Recent Advances in Pathogenesis and Treatments.

    Audia, Sylvain / Mahévas, Matthieu / Nivet, Martin / Ouandji, Sethi / Ciudad, Marion / Bonnotte, Bernard

    HemaSphere

    2021  Volume 5, Issue 6, Page(s) e574

    Abstract: Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production. Although the primary triggering factors of ITP remain unknown, a loss of immune tolerance-mostly ... ...

    Abstract Immune thrombocytopenia (ITP) is a rare autoimmune disease due to both a peripheral destruction of platelets and an inappropriate bone marrow production. Although the primary triggering factors of ITP remain unknown, a loss of immune tolerance-mostly represented by a regulatory T-cell defect-allows T follicular helper cells to stimulate autoreactive splenic B cells that differentiate into antiplatelet antibody-producing plasma cells. Glycoprotein IIb/IIIa is the main target of antiplatelet antibodies leading to platelet phagocytosis by splenic macrophages, through interactions with Fc gamma receptors (FcγRs) and complement receptors. This allows macrophages to activate autoreactive T cells by their antigen-presenting functions. Moreover, the activation of the classical complement pathway participates to platelet opsonization and also to their destruction by complement-dependent cytotoxicity. Platelet destruction is also mediated by a FcγR-independent pathway, involving platelet desialylation that favors their binding to the Ashwell-Morell receptor and their clearance in the liver. Cytotoxic T cells also contribute to ITP pathogenesis by mediating cytotoxicity against megakaryocytes and peripheral platelets. The deficient megakaryopoiesis resulting from both the humoral and the cytotoxic immune responses is sustained by inappropriate levels of thrombopoietin, the major growth factor of megakaryocytes. The better understanding of ITP pathogenesis has provided important therapeutic advances. B cell-targeting therapies and thrombopoietin-receptor agonists (TPO-RAs) have been used for years. New emerging therapeutic strategies that inhibit FcγR signaling, the neonatal Fc receptor or the classical complement pathway, will deeply modify the management of ITP in the near future.
    Language English
    Publishing date 2021-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000574
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  10. Article ; Online: Platelet count threshold for hemorrhage in patients with immune thrombocytopenia treated with antiplatelet agents.

    Ollier, Natasha / Piel-Julian, Marie-Léa / Mahévas, Matthieu / Viallard, Jean-François / Comont, Thibault / Chèze, Stéphane / Audia, Sylvain / Ebbo, Mikaël / Terriou, Louis / Lega, Jean-Christophe / Jeandel, Pierre-Yves / Bonnotte, Bernard / Michel, Marc / Lapeyre-Mestre, Maryse / Godeau, Bertrand / Moulis, Guillaume

    Blood

    2023  Volume 142, Issue 12, Page(s) 1099–1101

    MeSH term(s) Humans ; Platelet Count ; Platelet Aggregation Inhibitors/adverse effects ; Purpura, Thrombocytopenic, Idiopathic/drug therapy ; Thrombocytopenia ; Hemorrhage/chemically induced
    Chemical Substances Platelet Aggregation Inhibitors
    Language English
    Publishing date 2023-01-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023020311
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