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  1. Article ; Online: Mitochondria as the Essence of Yang Qi in the Human Body.

    Luo, Junjie / Shen, Shiwei / Xia, Jingjing / Wang, Jiucun / Gu, Zhenglong

    Phenomics (Cham, Switzerland)

    2022  Volume 2, Issue 5, Page(s) 336–348

    Abstract: The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many similarities ... This article discusses the similarities in various aspects between mitochondria and Yang Qi, including body ... temperature, aging, newborns, circadian rhythm, immunity, and meridian. It is well-known that Yang Qi is vital ...

    Abstract The concept of Yang Qi in Traditional Chinese Medicine (TCM) has many similarities with mitochondria in modern medicine. Both are indispensable to human beings and closely related to life and death. This article discusses the similarities in various aspects between mitochondria and Yang Qi, including body temperature, aging, newborns, circadian rhythm, immunity, and meridian. It is well-known that Yang Qi is vital for human health. Interestingly, decreased mitochondrial function is thought to be key to the development of various diseases. Here, we further explain diseases induced by Yang Qi deficiency, such as cancer, chronic fatigue syndrome, sleep disorder, senile dementia, and metabolic diseases, from the perspective of mitochondrial function. We aim to establish similarities and connections between two important concepts, and hope our essay can stimulate further discussion and investigation on unifying important concepts in western medicine and alternative medicine, especially TCM, and provide unique holistic insights into understanding human health.
    Language English
    Publishing date 2022-06-16
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2730-5848
    ISSN (online) 2730-5848
    DOI 10.1007/s43657-022-00060-3
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  2. Article: [Serum metabolomics of chronic obstructive pulmonary disease with lung-Qi deficiency syndrome].

    Duan, Fei / Li, Man-Man / Li, Wei-Xia / Tang, Jin-Fa / Wang, Zhi-Wan

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2022  Volume 47, Issue 8, Page(s) 2251–2256

    Abstract: ... with lung-Qi deficiency syndrome by non-targeted metabolomics and explored the biological basis ... of this syndrome. Blood samples of 96 COPD patients with lung-Qi deficiency syndrome(COPD with lung-Qi deficiency ... carried out by using Progenesis QI and Simca-P. Metabolic pathways were constructed ...

    Abstract The present study analyzed the potential biomarkers of chronic obstructive pulmonary disease(COPD) with lung-Qi deficiency syndrome by non-targeted metabolomics and explored the biological basis of this syndrome. Blood samples of 96 COPD patients with lung-Qi deficiency syndrome(COPD with lung-Qi deficiency syndrome group) and 106 healthy people(healthy control group) were collected, and the metabolic profiles of both groups were analyzed by ultra-high performance liquid chromatography-quadrupole-time-of-flight mass spectrometry(UPLC-Q-TOF-MS). Multivariate statistical analysis and differential metabolite screening were carried out by using Progenesis QI and Simca-P. Metabolic pathways were constructed through the MetaboAnalyst. Seven potential biomarkers, such as L-cystathionine, protoporphyrinogen Ⅸ, and citalopram aldehyde, were identified. Compared with the results in the healthy control group, the content of citalopram aldehyde, N1-methyl-2-pyridone-5-carboxamide, and 11β,17β-dihydroxy-4-androsten-3-one was significantly up-regulated, while that of the other four compounds such as L-cystathionine, dihydrotestosterone, protoporphyrinogen Ⅸ, and D-urobilinogen was down-regulated. These potential biomarkers involved six metabolic pathways, including cysteine and methionine metabolism, porphyrin and chlorophyll metabolism, drug metabolism of cytochrome P450, steroid hormone biosynthesis, glycine, serine, and threonine metabolism, and nicotinate and nicotinamide meta-bolism. This study is expected to provide a certain scientific basis for the research on traditional Chinese medicine syndrome of COPD with lung-Qi deficiency syndrome from the molecular biology level.
    MeSH term(s) Aldehydes ; Biomarkers ; Chromatography, High Pressure Liquid ; Citalopram ; Cystathionine ; Humans ; Lung ; Metabolomics/methods ; Pulmonary Disease, Chronic Obstructive
    Chemical Substances Aldehydes ; Biomarkers ; Citalopram (0DHU5B8D6V) ; Cystathionine (375YFJ481O)
    Language Chinese
    Publishing date 2022-03-05
    Publishing country China
    Document type Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20211203.501
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  3. Article: Network Pharmacology-Based Identification of Key Pharmacological Mechanism of Shen-qi-di-huang Decoction Acting on Uremia.

    Zhang, Xiaowen / Chen, Xiao-Fei / Chen, Wen-Jia / Ding, Haibo / Zhang, Bao-Xia

    Alternative therapies in health and medicine

    2023  Volume 30, Issue 1, Page(s) 44–50

    Abstract: ... qi-di-huang decoction's efficacy in treating uremia. We identified a total of 927 differentially ... herbal medicines such as Renshen, Huangqi, shudihuang, Shanyao, Fuling, Mudanpi, and Shanzhuyu in Shen-qi-di-huang ... in Shen-qi-di-huang decoction. We then constructed a protein-protein interaction (PPI) network of 15 ...

    Abstract This study employs network pharmacology to uncover the pharmacological mechanisms underlying Shen-qi-di-huang decoction's efficacy in treating uremia. We identified a total of 927 differentially expressed genes (DEGs) through differential expression analysis and the Traditional Chinese Medicine Systems Pharmacology (TCMSP) database and analysis platform, of which 607 were downregulated and 320 were upregulated. We also obtained the effective biological components and related target gene information of Chinese herbal medicines such as Renshen, Huangqi, shudihuang, Shanyao, Fuling, Mudanpi, and Shanzhuyu in Shen-qi-di-huang decoction and constructed a regulatory relationship network between molecular components and target genes in Shen-qi-di-huang decoction. We then constructed a protein-protein interaction (PPI) network of 15 targeted genes (RXRA, ND6, CYP1B1, SLPI, CDKN1A, RB1, HIF1A, MYC, HSPB1, IFNGR1, NQO1, IRF1, RASA1, PSMG1 and MAP2K4) using the STRING database and visualized the PPI network using the software Cytoscape. In addition, we revealed the key molecular functions of uremia through Gene Ontology (GO) enrichment analysis, mainly including neuron apoptotic process, cellular response to oxidative stress, regulation of neuron apoptotic process, neuron projection cytoplasm, RNA polymerase II transcription regulator complex, plasma membrane bounded cell projection cytoplasm, NADH and NADPH dehydrogenase (quinone) activity, protein kinase inhibitor and ubiquitin protein ligase binding, etc. Finally, we identified important biological pathways in uremia through Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, which mainly concentrated in Kaposi sarcoma-associated, small cell lung cancer, Gastric cancer, Hepatitis B and C, Hepatocellular carcinoma, Thyroid cancer, Bladder cancer, MAPK signaling pathway, ErbB signaling pathway, Th17 cell differentiation, HIF-1 signaling pathway, Thyroid hormone signaling pathway and Cell cycle, etc. Using integrated bioinformatical analysis, we elucidated key pharmacological mechanisms based on targeted genes, which was enable early identification of patients with uremia and would contribute to early clinical diagnosis and treatment of patients.
    MeSH term(s) Humans ; Network Pharmacology ; Signal Transduction ; Apoptosis ; Carcinoma, Hepatocellular ; Liver Neoplasms ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Medicine, Chinese Traditional ; p120 GTPase Activating Protein
    Chemical Substances Drugs, Chinese Herbal ; RASA1 protein, human ; p120 GTPase Activating Protein
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1225073-9
    ISSN 1078-6791
    ISSN 1078-6791
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4504: Show issues Location:
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  4. Article ; Online: Integrating Network Pharmacology and Component Analysis to Study the Potential Mechanisms of Qi-Fu-Yin Decoction in Treating Alzheimer's Disease.

    Lei, Xia / Xu, Hongdan / Wang, Yan / Gao, Hainan / Zhao, Deping / Zhang, Jinfeng / Zhu, Ziyue / Zuo, Kun / Liu, Ying / Li, Xiaoliang / Zhang, Ning

    Drug design, development and therapy

    2023  Volume 17, Page(s) 2841–2858

    Abstract: Purpose: To elucidate the potential mechanisms of QFY for the treatment of Alzheimer's Disease (AD), and explore the effective substances of QFY.: Materials and methods: UPLC-LTQ-Orbitrap-MS was used to identify the chemical constituents of the serum ...

    Abstract Purpose: To elucidate the potential mechanisms of QFY for the treatment of Alzheimer's Disease (AD), and explore the effective substances of QFY.
    Materials and methods: UPLC-LTQ-Orbitrap-MS was used to identify the chemical constituents of the serum samples and the cerebrospinal fluid samples of rats after QFY administration. Network pharmacology was used to predict potential targets and pathways of QFY against AD. The AD mice model was established by subcutaneous injection of D-gal for 8 consecutive weeks. New object recognition (NOR) and Morris water maze test (MWM) were used to evaluate the learning and memory abilities of mice. Moreover, the levels of TNF-α, IL-1β, and IL-18 in the brain hippocampus of mice were determined by ELISA. The expression of Bax, Bcl-2, Caspase-1, PSD95, SYP, ICAM-1 and MCP-1 proteins in the hippocampus was detected by Western blotting. Furthermore, qRT-PCR was used to detect the gene expressions of PSD95, SYP, M1 and M2 polarization markers of microglia, including iNOS, CD16, ARG-1, and IL-10 in the hippocampus.
    Results: A total of 51 prototype compounds were detected in rat serum and 15 prototype components were identified in rat cerebrospinal fluid. Behavioral experiments revealed that QFY significantly increased the recognition index, decreased the escape latency, increased the platform crossing times and increased the residence time in the target quadrant. QFY also could alleviate the ultrastructural pathological changes in the hippocampus of AD mice. Meanwhile, QFY treatment suppressed the expression of inflammatory factors, such as TNF-α, IL-1β, and IL-18. QFY improved the synaptic plasticity of the hippocampus in D-gal model mice by significantly increasing the expression of proteins and mRNAs of PSD95 and SYP.
    Conclusion: QFY could effectively improve the learning and memory impairment of D-gal-induced AD mice by inhibiting the excessive activation of microglia, enhancing the expression of M2 microglia, inhibiting the increase of inflammatory factors, cell adhesion factors and chemokines, anti-apoptosis, and improving synaptic plasticity.
    MeSH term(s) Mice ; Rats ; Animals ; Tumor Necrosis Factor-alpha ; Alzheimer Disease/drug therapy ; Interleukin-18 ; Network Pharmacology
    Chemical Substances Tumor Necrosis Factor-alpha ; qi-fu-yin ; Interleukin-18
    Language English
    Publishing date 2023-09-14
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2451346-5
    ISSN 1177-8881 ; 1177-8881
    ISSN (online) 1177-8881
    ISSN 1177-8881
    DOI 10.2147/DDDT.S402624
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  5. Article ; Online: Yi-Qi-Jian-Pi formula ameliorates immune function in acute-on-chronic liver failure by upregulating autophagy and mitochondrial biogenesis in CD8

    Tang, Li / Wang, Xi / Zhao, Rong / Chen, Xiaomei / Wang, Feixia / Xia, Siwei / Xiao, Qian / Zhao, Qiang / Yang, Shiyan / Tan, Shanzhong

    Journal of ethnopharmacology

    2023  Volume 308, Page(s) 116276

    Abstract: ... contributes to poor prognosis. The Yi-Qi-Jian-Pi formula (YQJPF) may improve T lymphocyte immune function ...

    Abstract Ethnopharmacological relevance: A key event in the pathogenesis of acute-on-chronic liver failure (ACLF) is the imbalance in the systemic immune response; immunosuppression in patients with ACLF contributes to poor prognosis. The Yi-Qi-Jian-Pi formula (YQJPF) may improve T lymphocyte immune function in patients with ACLF.
    Aim of the study: To investigate the immune mechanism of YQJPF in vivo and in vitro.
    Materials and methods: An ACLF rat model was established by injection of CCl
    Results: YQJPF improved the peripheral blood lymphocyte count and proportion of CD8
    Conclusions: Our results suggest that YQJPF could improve immune function in a rat model of ACLF, possibly via affecting the homeostasis of lymphatic mitochondria in CD8
    MeSH term(s) Rats ; Animals ; Acute-On-Chronic Liver Failure/pathology ; Organelle Biogenesis ; CD8-Positive T-Lymphocytes ; Autophagy ; Immunity
    Language English
    Publishing date 2023-02-17
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116276
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  6. Article ; Online: Qi Wei anti-burn Tincture remodels liver metabolic pathways and treats burn wounds efficiently.

    Wang, Shuai / Zhou, Hui / Cui, Weiqi / Zhang, Junwei / Wu, Deqiao / Zhang, Nan / Xu, Xia

    Journal of burn care & research : official publication of the American Burn Association

    2022  

    Abstract: This work aims to elucidate the molecular mechanism of Qi Wei anti-burn Tincture (QW ... Qi Wei anti-burn Tincture treatment did promote the healing of the burn wounds on Kunming mice ... that Qi Wei anti-burn Tincture reprogramed the above metabolic processes in the liver. Furthermore ...

    Abstract This work aims to elucidate the molecular mechanism of Qi Wei anti-burn Tincture (QW) on wound healing in burnt mice using metabolomics and molecular biology techniques. A scald model was first established in Kunming mice. After treatment, biochemical indicators for liver function and burnt skin tissues were then evaluated via biochemical detection and HE staining respectively. Liver tissues were further analyzed for differential metabolites, inflammatory factors, and mRNA levels of cytokines using metabolomics and molecular biology techniques. Involved metabolic pathways were also identified using software. Qi Wei anti-burn Tincture treatment did promote the healing of the burn wounds on Kunming mice with a downregulation of ALP, ALT, AST to normal levels. In mouse liver tissue, the contents of glutamine, aspartic acid, succinic acid and citrulline were significantly reduced, while the contents of 5-hydroxyproline, taurine, hypotaurine and glutamic acid significantly increased. These major differential compounds are involved in the arginine metabolic pathway, nitrogen excretion, and the metabolism of taurine and hypotaurine, suggesting that Qi Wei anti-burn Tincture reprogramed the above metabolic processes in the liver. Furthermore, the application of Qi Wei anti-burn Tincture increased the expression of TGF-β1 and FGF-2, and reduced the levels of TNF-α, IL-1β, IL-6 and reactive oxygen species in the liver of mice induced by burn injury. This study found that Qi Wei anti-burn Tincture treatment promoted metabolic pathway remodeling in liver, which might be a potential mechanism for Qi Wei anti-burn Tincture to treat burn wounds.
    Language English
    Publishing date 2022-11-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2224246-6
    ISSN 1559-0488 ; 1559-047X
    ISSN (online) 1559-0488
    ISSN 1559-047X
    DOI 10.1093/jbcr/irac175
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  7. Article: Huangqi-Honghua Combination Prevents Cerebral Infarction with Qi Deficiency and Blood Stasis Syndrome in Rats by the Autophagy Pathway.

    Chen, Yue / Lei, Lu / Wang, Kai / Liang, Ruimin / Qiao, Yi / Feng, Zhijun / Zhang, Juanli / Bai, Min / Chen, Haixia / Zhao, Jiaxin / Xiong, Xingzhao / Cao, Jinyi / Shen, Xia / Yang, Zhifu

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9496926

    Abstract: Background: Cerebral ischemia/reperfusion injury (CI/RI) contributes to the process of autophagy. Huangqi-Honghua combination (HQ-HH) is a traditional Chinese medicine (TCM) combination that has been widely used in the treatment of cerebrovascular ... ...

    Abstract Background: Cerebral ischemia/reperfusion injury (CI/RI) contributes to the process of autophagy. Huangqi-Honghua combination (HQ-HH) is a traditional Chinese medicine (TCM) combination that has been widely used in the treatment of cerebrovascular diseases in China. The role of autophagy in HQ-HH-mediated treatment of CI/RI is unclear.
    Methods: Sprague-Dawley (SD) rats were used to establish the middle cerebral artery occlusion (MCAO) with QDBS syndrome model and evaluate the function of HQ-HH in protecting against CI/RI.
    Results: HQ-HH significantly improved the neuronal pathology and reduced infarct volume, neurological deficits, and whole blood viscosity in rats with CI/RI. Western blot results showed that the expression of autophagy marker proteins LC3II/LC3I and Beclin1 in the HQ-HH group was significantly lower than that in the model group, while the expression of p62 was significantly higher in the HQ-HH group as compared with the model group. There were no significant differences in PI3K, Akt, and mTOR levels between the HQ-HH group and the model group; however, p-PI3K, p-Akt, and p-mTOR were significantly upregulated. In addition, HQ-HH also changed the composition and function of intestinal flora in MCAO + QDBS model rats.
    Conclusion: HQ-HH protects from CI/RI, and its underlying mechanism may involve the activation of the PI3K-Akt-mTOR signaling pathway, relating to the changes in the composition of intestinal flora.
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9496926
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  8. Article: [Effect of Huai Qi Huang on asthma in rats and the mechanism research].

    Lu, Na / Bai, Yan / Zhao, Chen / Tian, Li / Wan, Xia / Jin, Run-Ming

    Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics

    2020  Volume 22, Issue 2, Page(s) 171–176

    Abstract: Objective: To study the role and mechanism of action of Huai Qi Huang (HQH) in the rat model ...

    Abstract Objective: To study the role and mechanism of action of Huai Qi Huang (HQH) in the rat model of asthma.
    Methods: Forty Sprague-Dawley rats were randomly divided into a control group, an asthma model group, a budesonide group, and an HQH group, with 10 rats in each group. A rat model of asthma was established by ovalbumin sensitization and challenge. The budesonide group was given budesonide aerosol 2 mg before each challenge. The HQH group was given HQH 4 g/kg dissolved in water by gavage before each challenge. Hematoxylin and eosin staining was used to observe the pathological changes of lung tissues. The percentage of eosinophils in bronchoalveolar lavage fluid (BALF) was measured. Enzyme-linked immunosorbent assay was used to determine the levels of interleukin-3 (IL-3), interleukin-4 (IL-4), interleukin-5 (IL-5), interleukin-10 (IL-10), interferon gamma (INF-γ), and immunoglobulin E (IgE) in BALF. Flow cytometry was used to determine T-helper type 1 (Th1)/T-helper type 2 (Th2) ratio in peripheral blood and the spleen. RT-PCR and Western blot were used to measure the mRNA and protein expression of T-bet and GATA-3 in lung tissue.
    Results: Compared with the control group, the asthma model group showed significant increases in the degree of airway inflammation, the percentage of eosinophils in BALF, and the levels of IL-3, IL-4, IL-5 and IgE in BALF (P<0.05), however, the asthma model group showed significant reductions in the levels of IL-10 and INF-γ in BALF (P<0.05). The asthma model group had significantly lower percentage of Th1 cells but significantly higher percentage of Th2 cells in peripheral blood and the spleen compared with the control group (P<0.05). The mRNA and protein expression of T-bet in lung tissue was significantly lower, but the mRNA and protein expression of GATA-3 in lung tissue was significantly higher in the asthma group than those in the control group (P<0.05). Both HQH and budesonide significantly improved airway inflammation and the above markers in asthmatic rats (P<0.05), with comparable effects between them. However, there were still significant differences in these indices between the control group and the HQH or budesonide group (P<0.05).
    Conclusions: HQH can reduce the airway inflammation of asthmatic rats and alleviate the symptoms of asthma, possibly by regulating the levels of related cytokines and Th1/Th2 ratio through the T-bet/GATA-3 pathway.
    MeSH term(s) Animals ; Asthma ; Bronchoalveolar Lavage Fluid ; Drugs, Chinese Herbal ; Lung ; Mice, Inbred BALB C ; Rats ; Rats, Sprague-Dawley ; Th2 Cells
    Chemical Substances Drugs, Chinese Herbal ; huai qi huang
    Language Chinese
    Publishing date 2020-02-12
    Publishing country China
    Document type Journal Article
    ISSN 1008-8830
    ISSN 1008-8830
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  9. Article: Fang-Ji-Huang-Qi-Tang Attenuates Degeneration of Early-Stage KOA Mice Related to Promoting Joint Lymphatic Drainage Function.

    Han, Haihui / Ma, Yinghui / Wang, Xiaoyun / Yun, Ruisheng / Lu, Sheng / Xia, Mengxiong / Wang, Yongjun / Shi, Qi / Zhai, Weitao / Liang, Qianqian / Xu, Hao

    Evidence-based complementary and alternative medicine : eCAM

    2020  Volume 2020, Page(s) 3471681

    Abstract: ... whether Fang-Ji-Huang-Qi-Tang (FJHQT) decoction improved the joint structure of OA or delayed the process ...

    Abstract Osteoarthritis (OA) is a chronic degenerative joint disease characterized by the breakdown of articular cartilage, subchondral bone remodeling, and inflammation of the synovium. In this study, we investigated whether Fang-Ji-Huang-Qi-Tang (FJHQT) decoction improved the joint structure of OA or delayed the process of knee joint degeneration in OA mice by promoting lymphatic drain function. The mice were randomly divided into four groups, the sham group, the PBS group, the FJHQT-treated group, and the Mobic-treated group. The mice in each group were tested for lymphatic draining function at 4, 6, 8, and 10 weeks postsurgery (WPS), then sacrificed (
    Language English
    Publishing date 2020-03-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2020/3471681
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  10. Article ; Online: UPLC-Q-TOF-MS/MS Combined with Network Pharmacology, Molecular Docking, and Animal Verification Reveals the Mechanism of Insomnia Treatment by Shen Qi Wu Wei Zi capsules.

    Bai, Fengyun / Wang, Jie / Xia, Ning / Sun, Ying / Xie, Yundong / Zhao, Chongbo / Sun, Jing / Zhang, Xiaofei

    Combinatorial chemistry & high throughput screening

    2023  

    Abstract: Background: Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat insomnia ... the mechanism underlying the therapeutic effects of the Shen Qi Wu Wei Zi capsules on insomnia.: Methods ...

    Abstract Background: Shen Qi Wu Wei Zi capsules (SQWWZ) are often used to treat insomnia; however, the potential therapeutic mechanism is still unclear.
    Objective: This study aimed to investigate the mechanism underlying the therapeutic effects of the Shen Qi Wu Wei Zi capsules on insomnia.
    Methods: The components of SQWWZ were identified using the UPLC-Q-TOF-MS/MS technique in conjunction with relevant literature. Insomnia-related targets were searched in the GeneCards and DisGeNET databases, and the intersection targets were obtained using a Venn diagram. A component-target-insomnia network diagram was constructed using Cytoscape 3.7.2 software. Core targets underwent GO and KEGG enrichment analyses. Molecular docking techniques were employed to verify the key proteins involved in the pathway and their corresponding compounds. Insomnia was induced in SD rats through the intraperitoneal injection of pchlorophenylalanine (DL-4-chlorophenylalanine, PCPA). The rats were treated orally with SQWWZ, and the serum levels of 5-HT and GABA in each group were determined using ELISA. Histological analysis of hippocampal tissue sections from the rats was performed using HE staining.
    Results: Using UPLC-Q-TOF-MS/MS and reviewing relevant literature, we identified 49 components of SQWWZ. Additionally, we obtained 1,043 drug targets and 367 insomnia-related targets. Among these, 82 targets were found to be common to both drug and insomnia targets. Following drug administration, rats in the treatment group exhibited a significant increase in the serum levels of 5-HT and GABA. Moreover, histological analysis using HE staining revealed neatly arranged hippocampal neuronal cells in the treated rats.
    Conclusion: The active components of SQWWZ had good inhibition of insomnia. This study provides a reference and guidance for the in-depth study of SQWWZ for the treatment of insomnia.
    Language English
    Publishing date 2023-12-27
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/0113862073275553231202153259
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    ab Jg. 2022: Lesesaal (EG)

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