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  1. Article ; Online: Patient Stratification for Oral Transitional Therapy in Bacterial Endocarditis.

    Russell, Clark D

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue 3, Page(s) 494–495

    MeSH term(s) Humans ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/drug therapy ; Endocarditis/diagnosis ; Endocarditis/drug therapy ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-03-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad194
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    Zs.A 1505: Show issues Location:
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  2. Article ; Online: Exploiting an early immunological window of opportunity in COVID-19.

    Russell, Clark D

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 8, Page(s) 811–812

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2021-05-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00225-3
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  3. Article ; Online: Eligibility of patients with Staphylococcus aureus bacteraemia for early oral switch.

    Cooper, George / Dolby, Heather W / Berry, Karla / Russell, Clark D

    The Lancet. Infectious diseases

    2024  Volume 24, Issue 4, Page(s) e209–e210

    MeSH term(s) Humans ; Staphylococcal Infections/drug therapy ; Bacteremia/drug therapy ; Staphylococcus aureus ; Methicillin-Resistant Staphylococcus aureus ; Anti-Bacterial Agents/therapeutic use
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Letter
    ZDB-ID 2061641-7
    ISSN 1474-4457 ; 1473-3099
    ISSN (online) 1474-4457
    ISSN 1473-3099
    DOI 10.1016/S1473-3099(24)00065-3
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    Zs.A 5743: Show issues Location:
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  4. Article ; Online: Comorbidities, multimorbidity and COVID-19.

    Russell, Clark D / Lone, Nazir I / Baillie, J Kenneth

    Nature medicine

    2023  Volume 29, Issue 2, Page(s) 334–343

    Abstract: The influence of comorbidities on COVID-19 outcomes has been recognized since the earliest days of the pandemic. But establishing causality and determining underlying mechanisms and clinical implications has been challenging-owing to the multitude of ... ...

    Abstract The influence of comorbidities on COVID-19 outcomes has been recognized since the earliest days of the pandemic. But establishing causality and determining underlying mechanisms and clinical implications has been challenging-owing to the multitude of confounding factors and patient variability. Several distinct pathological mechanisms, not active in every patient, determine health outcomes in the three different phases of COVID-19-from the initial viral replication phase to inflammatory lung injury and post-acute sequelae. Specific comorbidities (and overall multimorbidity) can either exacerbate these pathological mechanisms or reduce the patient's tolerance to organ injury. In this Review, we consider the impact of specific comorbidities, and overall multimorbidity, on the three mechanistically distinct phases of COVID-19, and we discuss the utility of host genetics as a route to causal inference by eliminating many sources of confounding. Continued research into the mechanisms of disease-state interactions will be crucial to inform stratification of therapeutic approaches and improve outcomes for patients.
    MeSH term(s) Humans ; COVID-19 ; Multimorbidity ; Comorbidity
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1220066-9
    ISSN 1546-170X ; 1078-8956
    ISSN (online) 1546-170X
    ISSN 1078-8956
    DOI 10.1038/s41591-022-02156-9
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    Zs.MG 39: Show issues

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  5. Article ; Online: Pulmonary Illness Related to E-Cigarette Use.

    Russell, Clark D / Cevik, Muge

    The New England journal of medicine

    2019  Volume 382, Issue 4, Page(s) 385–386

    MeSH term(s) Electronic Nicotine Delivery Systems ; Illinois ; Lung ; Vaping ; Wisconsin
    Language English
    Publishing date 2019-11-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1915111
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  6. Article ; Online: Does autonomous macrophage-driven inflammation promote alveolar damage in COVID-19?

    Dockrell, David H / Russell, Clark D / McHugh, Brian / Fraser, Rupsha

    The European respiratory journal

    2022  Volume 60, Issue 6

    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Angiotensin-Converting Enzyme 2 ; Permissiveness ; Lung ; Inflammation ; Macrophages
    Chemical Substances Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
    Language English
    Publishing date 2022-12-01
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 639359-7
    ISSN 1399-3003 ; 0903-1936
    ISSN (online) 1399-3003
    ISSN 0903-1936
    DOI 10.1183/13993003.01521-2022
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    Zs.A 2322: Show issues Location:
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    Zs.MO 292: Show issues

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  7. Article ; Online: Increase of Severe Pulmonary Infections in Adults Caused by M1

    Davies, Peter J B / Russell, Clark D / Morgan, Anna-Rose / Taori, Surabhi K / Lindsay, Diane / Ure, Roisin / Brown, Derek / Smith, Andrew

    Emerging infectious diseases

    2023  Volume 29, Issue 8, Page(s) 1638–1642

    Abstract: We characterized the epidemiology, host-pathogen characteristics, and outcomes of severe adult pulmonary Streptococcus pyogenes infections that coincided with a high community caseload in central Scotland, UK. The pulmonary infections had high illness ... ...

    Abstract We characterized the epidemiology, host-pathogen characteristics, and outcomes of severe adult pulmonary Streptococcus pyogenes infections that coincided with a high community caseload in central Scotland, UK. The pulmonary infections had high illness and death rates and were associated with socioeconomic deprivation, influenza A co-infection, and the M1
    MeSH term(s) Adult ; Humans ; Streptococcus pyogenes ; Streptococcal Infections/epidemiology ; Scotland/epidemiology ; Pneumonia ; Influenza, Human
    Language English
    Publishing date 2023-06-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid2908.230569
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    Zs.A 4778: Show issues Location:
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  8. Article ; Online: Clinical evidence does not support corticosteroid treatment for 2019-nCoV lung injury.

    Russell, Clark D / Millar, Jonathan E / Baillie, J Kenneth

    Lancet (London, England)

    2020  Volume 395, Issue 10223, Page(s) 473–475

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/drug therapy ; Evidence-Based Medicine/methods ; Glucocorticoids/adverse effects ; Glucocorticoids/therapeutic use ; Humans ; Pneumonia, Viral/drug therapy ; SARS-CoV-2 ; COVID-19 Drug Treatment
    Chemical Substances Glucocorticoids
    Keywords covid19
    Language English
    Publishing date 2020-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30317-2
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  9. Article: A Survey of Orthopedic Surgical Management of Pressure Ulcer-Related Pelvic Osteomyelitis.

    Russell, Clark D / Tsang, Shao-Ting Jerry / Dudareva, Maria / R W Simpson, Alasdair Hamish / Sutherland, Rebecca K / McNally, Martin A

    Open forum infectious diseases

    2023  Volume 10, Issue 6, Page(s) ofad291

    Abstract: Pressure-ulcer related pelvic osteomyelitis is managed with little high-quality evidence. We undertook an international survey of orthopedic surgical management, covering diagnostic parameters, multidisciplinary input, and surgical approaches ( ... ...

    Abstract Pressure-ulcer related pelvic osteomyelitis is managed with little high-quality evidence. We undertook an international survey of orthopedic surgical management, covering diagnostic parameters, multidisciplinary input, and surgical approaches (indications, timing, wound closure, and adjunctive therapies). This identified areas of consensus and disagreement, representing a starting point for future discussion and research.
    Language English
    Publishing date 2023-05-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2757767-3
    ISSN 2328-8957
    ISSN 2328-8957
    DOI 10.1093/ofid/ofad291
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  10. Article ; Online: Risk factors and outcomes for cholangitis after hepatic resection.

    Mangieri, Christopher W / Strode, Matthew A / Moaven, Omeed / Valenzuela, Cristian D / Erali, Richard A / Howerton, Russell / Shen, Perry / Clark, Clancy J

    Langenbeck's archives of surgery

    2023  Volume 408, Issue 1, Page(s) 236

    Abstract: Introduction: There is a paucity in the literature in regard to the incidence, risk factors, and outcomes for post-operative cholangitis following hepatic resection.: Methods: Retrospective review of the ACS NSQIP main and targeted hepatectomy ... ...

    Abstract Introduction: There is a paucity in the literature in regard to the incidence, risk factors, and outcomes for post-operative cholangitis following hepatic resection.
    Methods: Retrospective review of the ACS NSQIP main and targeted hepatectomy registries for 2012-2016.
    Results: A total of 11,243 cases met the selection criteria. The incidence of post-operative cholangitis was 0.64% (151 cases). Multivariate analysis identified several risk factors associated with the development of post-operative cholangitis, stratified out by pre-operative and operative factors. The most significant risk factors were biliary anastomosis and pre-operative biliary stenting with odds ratios (OR) of 32.39 (95% CI 22.91-45.79, P value < 0.0001) and 18.32 (95% CI 10.51-31.94, P value < 0.0001) respectively. Cholangitis was significantly associated with post-operative bile leaks, liver failure, renal failure, organ space infections, sepsis/septic shock, need for reoperation, longer length of stay, increased readmission rates, and death.
    Conclusion: Largest analysis of post-operative cholangitis following hepatic resection. While a rare occurrence, it is associated with significantly increased risk for severe morbidity and mortality. The most significant risk factors were biliary anastomosis and stenting.
    MeSH term(s) Humans ; Liver/surgery ; Cholangitis/epidemiology ; Cholangitis/etiology ; Cholangitis/surgery ; Risk Factors ; Hepatectomy/adverse effects ; Biliary Tract Diseases/surgery ; Retrospective Studies ; Postoperative Complications/epidemiology ; Postoperative Complications/etiology ; Postoperative Complications/surgery
    Language English
    Publishing date 2023-06-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1423681-3
    ISSN 1435-2451 ; 1435-2443
    ISSN (online) 1435-2451
    ISSN 1435-2443
    DOI 10.1007/s00423-023-02769-9
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