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  1. Article: Betriebliche Gesundheitsförderung

    Lehr, Dirk / Boß, Leif

    (In: Ebert, David Daniel; Baumeister, Harald (Ed.), Digitale Gesundheitsinterventionen. Anwendungen in Therapie und Prävention (S. 385-419). Berlin, Heidelberg: Springer)

    2023  

    Abstract: Digitalisierung verändert die berufliche Arbeit grundlegend, und sie beginnt ebenso, die Art und Weise zu verändern, wie Prävention und betriebliche Gesundheitsförderung gestaltet werden. Zu den vielen Facetten der Digitalisierung gehört, dass sie in der ...

    Title translation Workplace health promotion (DeepL)
    Series title In: Ebert, David Daniel; Baumeister, Harald (Ed.), Digitale Gesundheitsinterventionen. Anwendungen in Therapie und Prävention (S. 385-419). Berlin, Heidelberg: Springer
    Abstract Digitalisierung verändert die berufliche Arbeit grundlegend, und sie beginnt ebenso, die Art und Weise zu verändern, wie Prävention und betriebliche Gesundheitsförderung gestaltet werden. Zu den vielen Facetten der Digitalisierung gehört, dass sie in der Arbeitswelt eine Quelle von Stress sein kann und gleichzeitig die Entwicklung neuer Angebote der Stressprävention und der Gesundheitsförderung ermöglicht. In diesem Beitrag wird schwerpunktmäßig die psychische Gesundheit thematisiert, jedoch auch auf weitere Aspekte von Gesundheit eingegangen. (c) Springer-Verlag GmbH Deutschland
    Keywords Arbeitsbedingungen ; Beruflicher Stress ; Digital Interventions ; Digitale Interventionen ; Electronic Health Services ; Elektronische Gesundheitsdienste ; Gesundheit am Arbeitsplatz ; Gesundheitsförderung ; Health Promotion ; Mobile Gesundheitsangebote ; Mobile Health ; Occupational Health ; Occupational Stress ; Prevention ; Prävention ; Stress Management ; Stressverarbeitung ; Training ; Working Conditions
    Language German
    Document type Article
    DOI 10.1007/978-3-662-65816-1_23
    Database PSYNDEX

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  2. Article ; Online: Deontic technology perceptions

    Matthew B. Perrigino / Benjamin B. Dunford / R. Wayne Boss / Matt Troup / David S. Boss

    Journal of Humanities and Applied Social Sciences, Vol 5, Iss 2, Pp 103-

    a complementary view to instrumental perspectives on technology acceptance and use

    2023  Volume 119

    Abstract: Purpose – For decades, organizational research has primarily considered instrumental technology perceptions (ITP) – emphasizing how technology impacts the personal interests of end users themselves – to understand technology acceptance. The authors offer ...

    Abstract Purpose – For decades, organizational research has primarily considered instrumental technology perceptions (ITP) – emphasizing how technology impacts the personal interests of end users themselves – to understand technology acceptance. The authors offer a complementary paradigm by introducing deontic technology perceptions (DTP), defined as the degree to which individuals believe that the technology they use is beneficial to other individuals beyond themselves (e.g. beneficial to customers). Design/methodology/approach – The authors collected quantitative survey-based data from three different hospitals located in the United States. On the basis of conservation of resources theory, the authors investigated whether both DTP and ITP were associated with improved work-related well-being. Findings – Two pilot studies (n = 161 and n = 311 nurses) substantiated our DTP conceptualization. Our primary study (n = 346 nurses) found support for the association between DTP and improved work-related well-being. Evidence for the relationship between ITP and work-related well-being was mixed and the authors did not find a statistically significant interaction between DTP and ITP. Originality/value – The authors build on decades of research on technology acceptance by complementing it with our deontic perspective. Our work demonstrates that technology users pay attention and react meaningfully to how their use of technology impacts not only themselves but also external parties like patients, customers and members of the general public.
    Keywords Technology acceptance ; Conservation of resources theory ; Technology use ; Deontic ; Social sciences (General) ; H1-99
    Subject code 303
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Emerald Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Early Recognition and Management of Rare Kidney Stone Disorders.

    Goldstein, Boss / Goldfarb, David S

    Urologic nursing

    2017  Volume 37, Issue 2, Page(s) 81–9, 102

    Abstract: Kidney stones, especially those that present in childhood/adolescence, may be due to rare inherited disorders such as cystinuria. Early recognition and prompt treatment can help reduce or even prevent the serious long-term complications of these rare ... ...

    Abstract Kidney stones, especially those that present in childhood/adolescence, may be due to rare inherited disorders such as cystinuria. Early recognition and prompt treatment can help reduce or even prevent the serious long-term complications of these rare stone disorders.
    MeSH term(s) Adenine Phosphoribosyltransferase/deficiency ; Cystinuria/complications ; Cystinuria/diagnosis ; Cystinuria/therapy ; Dent Disease/complications ; Dent Disease/diagnosis ; Dent Disease/therapy ; Early Diagnosis ; Early Medical Intervention ; Humans ; Hyperoxaluria, Primary/complications ; Hyperoxaluria, Primary/diagnosis ; Hyperoxaluria, Primary/therapy ; Kidney Calculi/etiology ; Metabolism, Inborn Errors/complications ; Metabolism, Inborn Errors/diagnosis ; Metabolism, Inborn Errors/therapy ; Rare Diseases ; Urolithiasis/complications ; Urolithiasis/diagnosis ; Urolithiasis/therapy
    Chemical Substances Adenine Phosphoribosyltransferase (EC 2.4.2.7)
    Language English
    Publishing date 2017-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645149-4
    ISSN 2168-4626 ; 1053-816X ; 0882-9594
    ISSN (online) 2168-4626
    ISSN 1053-816X ; 0882-9594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Intratracheal cobinamide (vitamin B

    Park, Seungyong / Mukai, David / Lee, Jangweon / Burney, Tanya / Boss, Gerry / Haouzi, Phillipe / Lee, Jane Annabelle / Kim, Mark Thomas / Fox, Alexis Makenna / Philipopoulos, George / Brenner, Matthew

    Clinical toxicology (Philadelphia, Pa.)

    2024  Volume 62, Issue 2, Page(s) 94–100

    Abstract: Background: Hydrogen sulfide is a highly toxic, flammable, and colorless gas. Hydrogen sulfide has been identified as a potential terrorist chemical threat agent in mass-casualty events. Our previous studies showed that cobinamide, a vitamin B: ... ...

    Abstract Background: Hydrogen sulfide is a highly toxic, flammable, and colorless gas. Hydrogen sulfide has been identified as a potential terrorist chemical threat agent in mass-casualty events. Our previous studies showed that cobinamide, a vitamin B
    Methods: A total of 53 pathogen-free New Zealand White rabbits were used for this study. Four groups were compared: (i) received no saline solution or drug intratracheally (
    Results: The mean (± standard deviation) weight for all animals (
    Discussion: The ability to use intratracheal cobinamide as an antidote to hydrogen sulfide poisoning is a novel approach to mass-casualty care. The major limitations of this study are that it was conducted in a single species at a single inhaled hydrogen sulfide concentration. Repeated investigations in other species and at varying levels of hydrogen sulfide exposure will be needed before any definitive recommendations can be made.
    Conclusions: We demonstrated that intratracheal cobinamide and fast saline drip improved survival for hydrogen sulfide gas inhalation in rabbit models. Although further study is required, our results suggest that intratracheal administration of cobinamide and fast saline may be useful in hydrogen sulfide mass-casualty events.
    MeSH term(s) Rabbits ; Animals ; Vitamin B 12 ; Hydrogen Sulfide ; Cobamides ; Saline Solution ; Vitamins
    Chemical Substances cobinamide (13497-85-3) ; Vitamin B 12 (P6YC3EG204) ; Hydrogen Sulfide (YY9FVM7NSN) ; Cobamides ; Saline Solution ; Vitamins
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 204476-6
    ISSN 1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
    ISSN (online) 1556-9519
    ISSN 0009-9309 ; 0731-3810 ; 1556-3650
    DOI 10.1080/15563650.2024.2314155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Work-family culture within hospitals: An interdepartmental analysis of employee engagement and retention.

    Perrigino, Matthew B / Dunford, Benjamin B / Troup, Matt / Boss, R Wayne / Boss, David S

    Health care management review

    2017  Volume 44, Issue 4, Page(s) 296–305

    Abstract: Background: Helping employees balance their work and family needs is increasingly pivotal for attracting, engaging, and retaining key talent in health care. Yet, emerging theory and anecdotal evidence suggest that, within organizations, there is ... ...

    Abstract Background: Helping employees balance their work and family needs is increasingly pivotal for attracting, engaging, and retaining key talent in health care. Yet, emerging theory and anecdotal evidence suggest that, within organizations, there is considerable variation between departments or units regarding how employees' lives outside work are supported. Despite top management's efforts to develop a unified organizational work-family culture, departments have a tendency to take on their own culture, norms, and traditions such that some are more supportive than others.
    Purpose: We investigate whether more positive work-family cultures improve functioning within hospital departments.
    Methodology/approach: We surveyed 680 hospital employees nested within 60 departments at a hospital located in the southeastern United States.
    Results: Departments with a more (vs. less) positive work-family culture tend to have higher levels of (a) employee engagement, (b) pride in their organization, (c) confidence in management and leadership, and (d) intention to remain with the organization. Our analyses were robust when splitting the sample between clinical (e.g., nurses and physicians) and nonclinical (e.g., office, clerical, and support services) roles.
    Conclusion: Our study sheds further light on the importance of a positive work-family culture within hospitals. The key to instilling a positive, organization-wide work-family culture may be through a department-by-department focus.
    Practice implications: Benefits of positive work-family cultures within departments can extend beyond job-related attitudes and can potentially enhance recruitment strategies, improve a hospital's external image to the public, and lead to improvements in patient care and more positive patient experiences.
    MeSH term(s) Female ; Humans ; Male ; Organizational Culture ; Personnel Loyalty ; Personnel, Hospital ; Surveys and Questionnaires ; Work Engagement ; Work Schedule Tolerance
    Language English
    Publishing date 2017-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 430366-0
    ISSN 1550-5030 ; 0361-6274
    ISSN (online) 1550-5030
    ISSN 0361-6274
    DOI 10.1097/HMR.0000000000000190
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a single-institution retrospective dosimetric analysis of organs at risk doses.

    Wolf, Jule / Stoller, Sabine / Lübke, Jördis / Rothe, Thomas / Serpa, Marco / Scholber, Jutta / Zamboglou, Constantinos / Gkika, Eleni / Baltas, Dimos / Juhasz-Böss, Ingolf / Verma, Vivek / Krug, David / Grosu, Anca-Ligia / Nicolay, Nils H / Sprave, Tanja

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2022  Volume 199, Issue 4, Page(s) 379–388

    Abstract: Background: Radiotherapy can induce cardiac injury in left-sided breast cancer cases. Cardiac-sparing irradiation using the deep inspiration breath-hold (DIBH) technique can achieve substantial dose reduction to vulnerable cardiac substructures compared ...

    Abstract Background: Radiotherapy can induce cardiac injury in left-sided breast cancer cases. Cardiac-sparing irradiation using the deep inspiration breath-hold (DIBH) technique can achieve substantial dose reduction to vulnerable cardiac substructures compared with free breathing (FB). This study evaluated the dosimetric differences between both techniques at a single institution.
    Methods: From 2017 to 2019, 130 patients with left-sided breast cancer underwent breast-conserving surgery (BCS; n = 121, 93.1%) or mastectomy (ME; n = 9, 6.9%) along with axillary lymph node staging (n = 105, 80.8%), followed by adjuvant irradiation in DIBH technique; adjuvant systemic therapy was included if applicable. 106 (81.5%) patients received conventional and 24 (18.5%) hypofractionated irradiation. Additionally, 12 patients received regional nodal irradiation. Computed tomography (CT) scans in FB and DIBH position were performed for all patients. Intrafractional 3D position monitoring of the patient surface in deep inspiration and breath gating was performed using Sentinel and Catalyst HD 3D surface scanning systems (C-RAD, Catalyst, C‑RAD AB, Uppsala, Sweden). Individual coaching and determination of breathing amplitude during the radiation planning CT was performed. Three-dimensional treatment planning was performed using standard tangential treatment portals (6 or 18 MV). The delineation of cardiac structures and both lungs was done in both the FB and the DIBH scan.
    Results: All dosimetric parameters for cardiac structures were significantly reduced (p < 0.01 for all). The mean heart dose (Dmean) in the DIBH group was 1.3 Gy (range 0.5-3.6) vs. 2.2 Gy (range 0.9-8.8) in the FB group (p < 0.001). The Dmean for the left ventricle (LV) in DIBH was 1.5 Gy (range 0.6-4.5), as compared to 2.8 Gy (1.1-9.5) with FB (p < 0.001). The parameters for LV (V10 Gy, V15 Gy, V20 Gy, V23 Gy, V25 Gy, V30 Gy) were reduced by about 100% (p < 0.001). The LAD Dmean in the DIBH group was 4.1 Gy (range 1.2-33.3) and 14.3 Gy (range 2.4-37.5) in the FB group (p < 0.001). The median values for LAD such as V15 Gy, V20 Gy, V25 Gy, V30 Gy, and V40 Gy decreased by roughly 100% (p < 0.001). An increasing volume of left lung in the DIBH position resulted in dose sparing of cardiac structures.
    Conclusion: For all ascertained dosimetric parameters, a significant dose reduction could be achieved in DIBH technique.
    MeSH term(s) Humans ; Female ; Organs at Risk/radiation effects ; Breast Neoplasms/radiotherapy ; Radiotherapy Dosage ; Unilateral Breast Neoplasms/radiotherapy ; Unilateral Breast Neoplasms/surgery ; Retrospective Studies ; Radiotherapy Planning, Computer-Assisted/methods ; Breath Holding ; Mastectomy ; Heart/diagnostic imaging ; Heart/radiation effects
    Language English
    Publishing date 2022-09-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-022-01998-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Incidental irradiation of the regional lymph nodes during deep inspiration breath-hold radiation therapy in left-sided breast cancer patients: a dosimetric analysis.

    Wolf, Jule / Kurz, Steffen / Rothe, Thomas / Serpa, Marco / Scholber, Jutta / Erbes, Thalia / Gkika, Eleni / Baltas, Dimos / Verma, Vivek / Krug, David / Juhasz-Böss, Ingolf / Grosu, Anca-Ligia / Nicolay, Nils H / Sprave, Tanja

    BMC cancer

    2022  Volume 22, Issue 1, Page(s) 682

    Abstract: Background: Radiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of heart and lung doses in left-sided breast cancer cases. The anatomical organ movement in deep ... ...

    Abstract Background: Radiotherapy using the deep inspiration breath-hold (DIBH) technique compared with free breathing (FB) can achieve substantial reduction of heart and lung doses in left-sided breast cancer cases. The anatomical organ movement in deep inspiration also cause unintended exposure of locoregional lymph nodes to the irradiation field.
    Methods: From 2017-2020, 148 patients with left-sided breast cancer underwent breast conserving surgery (BCS) or mastectomy (ME) with axillary lymph node staging, followed by adjuvant irradiation in DIBH technique. Neoadjuvant or adjuvant systemic therapy was administered depending on hormone receptor and HER2-status. CT scans in FB and DIBH position with individual coaching and determination of the breathing amplitude during the radiation planning CT were performed for all patients. Intrafractional 3D position monitoring of the patient surface in deep inspiration and gating was performed using Sentinel and Catalyst HD 3D surface scanning systems (C-RAD, Catalyst, C-RAD AB, Uppsala, Sweden). Three-dimensional treatment planning was performed using standard tangential treatment portals (6 or 18 MV). The delineation of ipsilateral locoregional lymph nodes was done on the FB and the DIBH CT-scan according to the RTOG recommendations.
    Results: The mean doses (D
    Conclusions: The DIBH technique may result in changes in the incidental dose exposure of regional lymph node areas.
    MeSH term(s) Breast Neoplasms/radiotherapy ; Breath Holding ; Female ; Heart ; Humans ; Lymph Nodes/diagnostic imaging ; Lymph Nodes/radiation effects ; Mastectomy ; Organs at Risk/radiation effects ; Radiation Injuries ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Unilateral Breast Neoplasms/radiotherapy ; Unilateral Breast Neoplasms/surgery
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041352-X
    ISSN 1471-2407 ; 1471-2407
    ISSN (online) 1471-2407
    ISSN 1471-2407
    DOI 10.1186/s12885-022-09784-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Impact of Alternate

    Partridge, Savannah C / Steingrimsson, Jon / Newitt, David C / Gibbs, Jessica E / Marques, Helga S / Bolan, Patrick J / Boss, Michael A / Chenevert, Thomas L / Rosen, Mark A / Hylton, Nola M

    Tomography (Ann Arbor, Mich.)

    2022  Volume 8, Issue 2, Page(s) 701–717

    Abstract: ... MRI (b = 0/100/600/800 s/mm2) at multiple timepoints during neoadjuvant chemotherapy treatment and ... predictive (AUCs = 0.75−0.78 versus AUC = 0.76), p < 0.05. Using two b-values (0/600 or 0/800 s/mm2) did not ... metrics ADCfast (b ≤ 100 s/mm2), ADCslow (b ≥ 100 s/mm2), and fp did not improve predictive performance ...

    Abstract In diffusion-weighted MRI (DW-MRI), choice of b-value influences apparent diffusion coefficient (ADC) values by probing different aspects of the tissue microenvironment. As a secondary analysis of the multicenter ECOG-ACRIN A6698 trial, the purpose of this study was to investigate the impact of alternate b-value combinations on the performance and repeatability of tumor ADC as a predictive marker of breast cancer treatment response. The final analysis included 210 women who underwent standardized 4-b-value DW-MRI (b = 0/100/600/800 s/mm2) at multiple timepoints during neoadjuvant chemotherapy treatment and a subset (n = 71) who underwent test−retest scans. Centralized tumor ADC and perfusion fraction (fp) measures were performed using variable b-value combinations. Prediction of pathologic complete response (pCR) based on the mid-treatment/12-week percent change in each metric was estimated by area under the receiver operating characteristic curve (AUC). Repeatability was estimated by within-subject coefficient of variation (wCV). Results show that two-b-value ADC calculations provided non-inferior predictive value to four-b-value ADC calculations overall (AUCs = 0.60−0.61 versus AUC = 0.60) and for HR+/HER2− cancers where ADC was most predictive (AUCs = 0.75−0.78 versus AUC = 0.76), p < 0.05. Using two b-values (0/600 or 0/800 s/mm2) did not reduce ADC repeatability over the four-b-value calculation (wCVs = 4.9−5.2% versus 5.4%). The alternate metrics ADCfast (b ≤ 100 s/mm2), ADCslow (b ≥ 100 s/mm2), and fp did not improve predictive performance (AUCs = 0.54−0.60, p = 0.08−0.81), and ADCfast and fp demonstrated the lowest repeatability (wCVs = 6.71% and 12.4%, respectively). In conclusion, breast tumor ADC calculated using a simple two-b-value approach can provide comparable predictive value and repeatability to full four-b-value measurements as a marker of treatment response.
    MeSH term(s) Benchmarking ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/pathology ; Diffusion Magnetic Resonance Imaging/methods ; Female ; Humans ; Neoadjuvant Therapy/methods ; ROC Curve ; Tumor Microenvironment
    Language English
    Publishing date 2022-03-04
    Publishing country Switzerland
    Document type Journal Article ; Multicenter Study ; Research Support, N.I.H., Extramural
    ISSN 2379-139X
    ISSN (online) 2379-139X
    DOI 10.3390/tomography8020058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Lagrangian-Eulerian statistics of mesoscale ocean chlorophyll from Bio-Argo floats and satellites

    McKee, Darren Craig / Doney, Scott C. / Penna, Alice / Boss, Emmanuel S. / Gaube, Peter / Behrenfeld, Michael J. / Glover, David M.

    eISSN: 1726-4189

    2022  

    Abstract: Phytoplankton form the base of marine food webs and play an important role in carbon cycling, making it important to quantify rates of biomass accumulation and loss. Since phytoplankton drift with ocean currents, rates should be evaluated in a Lagrangian ...

    Abstract Phytoplankton form the base of marine food webs and play an important role in carbon cycling, making it important to quantify rates of biomass accumulation and loss. Since phytoplankton drift with ocean currents, rates should be evaluated in a Lagrangian as opposed to Eulerian framework. In this study, we quantify the Lagrangian (from Bio-Argo floats and surface drifters with satellite ocean colour) and Eulerian (from satellite ocean colour and altimetry) statistics of mesoscale chlorophyll and velocity by computing decorrelation time and length scales and relate the frames by scaling the material derivative of chlorophyll. Because floats profile vertically and are not perfect Lagrangian observers, we quantify the mean distance between float and surface geostrophic trajectories over the time spanned by three consecutive profiles (Quasi-Planktonic Index; QPI) to assess how their sampling is a function of their deviations from surface motion. Lagrangian-Eulerian statistics of chlorophyll are sensitive to the filtering used to compute anomalies. Chlorophyll anomalies about a 31-day time filter reveal approximate equivalence of Lagrangian and Eulerian tendencies, suggesting they are driven by ocean-colour-pixel-scale processes and sources or sinks. Chlorophyll anomalies about a seasonal cycle have Eulerian scales similar to those of velocity, suggesting mesoscale stirring helps set distributions of biological properties, and ratios of Lagrangian to Eulerian timescales depend on observer speed relative to an evolution speed of the chlorophyll fields in a manner similar to earlier theoretical results for velocity scales. By lagging surface chlorophyll patches, floats underestimate the Lagrangian tendency and advective terms, and the Eulerian tendency primarily sets timescales; however, since the QPI increases with profiling interval, frequent profiling can generate more accurate time series of phytoplankton accumulation.
    Subject code 551
    Language English
    Publishing date 2022-05-10
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A three-armed randomised controlled trial investigating the comparative impact of guidance on the efficacy of a web-based stress management intervention and health impairing and promoting mechanisms of prevention

    Patricia Nixon / Leif Boß / Elena Heber / David Daniel Ebert / Dirk Lehr

    BMC Public Health, Vol 21, Iss 1, Pp 1-

    2021  Volume 18

    Abstract: ... compared to SH. The SMI’s impact on depression was mediated by perceived stress: a1b1 = − 0.77, ... ...

    Abstract Abstract Background Web-based stress management interventions (SMI) fit increasingly digital lifestyles, reduce barriers of uptake and are easily scalable. SMIs might lower levels of stress in employees and thereby contribute to the prevention of depressive symptomatology. Different guidance formats can impact the efficacy of SMIs, with higher intensity assumed to result in larger effects. However, head-to-head comparisons of guidance formats are rare. This is the first trial to examine the impact of adherence-focused guidance compared to self-help on the efficacy of an occupational SMI compared to a wait list control condition. Additionally, it will be investigated if the SMI enfolds its impact on preventing depressive symptomatology by different pathways through reducing health impairing and increasing promoting factors. Methods A three-armed randomised controlled trial (RCT) on an occupational SMI was conducted. 404 employees with elevated levels of perceived stress (PSS-10 ≥ 22) were randomly assigned to: adherence-focused guidance (AFG), self-help (SH) or a wait list control group (WLC). The primary outcome was perceived stress (PSS-10). Secondary outcomes included health- and work-related measures. A parallel mediation analysis with stress and resilience as mediators for the effect on depression (CES-D) was carried out. Data collection took place at baseline (T1), after 7 weeks (T2) and 6 months (T3). Results The SMI was effective for all groups on the primary and secondary outcomes. For stress, analyses of covariance (ANCOVA) revealed significant group effects at T2 (F2,400 = 36.08, P < .001) and T3 (F2,400 = 37.04, P < .001) with large effect sizes for AFG (T2: d = 0.83; T3: d = 0.85) and SH (T2: d = 0.88; T3: d = 0.91) compared to WLC. No significant group differences were found for the efficacy between AFG and SH on the outcomes. Adherence in terms of completed modules was significantly higher for AFG compared to SH. The SMI’s impact on depression was mediated by perceived stress: a1b1 = − 0.77, ...
    Keywords Web-based ; Occupational health ; Stress management ; Randomised controlled trial ; Public aspects of medicine ; RA1-1270
    Subject code 150
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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