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Article: Changes in coagulation factor XIII activity during resuscitation for hemorrhagic shock.

Yamada, Yusuke / Abe, Tomohiro / Tanohata, Rina / Ochiai, Hidenobu

2024 Volume 19, Issue 2, Page(s) 76–82

Abstract: Objective: Little is known about the coagulation activity of factor XIII (FXIII) during resuscitation for hemorrhagic shock and the effects of plasma transfusions. We performed a single-center observational study to evaluate the changes in FXIII ... ...

Abstract	Objective: Little is known about the coagulation activity of factor XIII (FXIII) during resuscitation for hemorrhagic shock and the effects of plasma transfusions. We performed a single-center observational study to evaluate the changes in FXIII activity during resuscitation for hemorrhagic shock. Patient and methods: Twenty-three adult patients with hemorrhagic shock were enrolled in this study. Blood samples were drawn upon arrival (T1), at the time of hemostasis completion (T2), and on day 2 (T3). Baseline and changes in FXIII activity and the proportion of patients with adequate levels of FXIII activity (FXIII activity >70%) were evaluated. The effects of plasma transfusion on these parameters were also investigated. Results: At T1, the median (interquartile range) FXIII activity was 53% (47-85%), which did not increase (T1 vs. T3: 53% [47-85%] vs. 63% [52-70%], Conclusion: FXIII activity is low during the early phase of a hemorrhagic shock. Even with plasma transfusion, FXIII levels were not adequately maintained throughout resuscitation.
Language	English
Publishing date	2024-04-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768933-5
ISSN	1880-4888 ; 1880-487X
ISSN (online)	1880-4888
ISSN	1880-487X
DOI	10.2185/jrm.2023-028
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Should an emergency physician be a "surgeon" in a rural area? A case of blunt cardiac rupture successfully treated by an emergency physician.

Kubo, Keisuke / Abe, Tomohiro / Nagoshi, Hideki / Ochiai, Hidenobu

Journal of rural medicine : JRM

2024 Volume 19, Issue 2, Page(s) 114–118

Abstract: Objective: Blunt cardiac rupture is a life-threatening injury that requires surgical repair by cardiovascular or trauma surgeons. We report a case of blunt cardiac rupture in a rural area in which emergency physicians performed emergency department ... ...

Abstract	Objective: Blunt cardiac rupture is a life-threatening injury that requires surgical repair by cardiovascular or trauma surgeons. We report a case of blunt cardiac rupture in a rural area in which emergency physicians performed emergency department thoracotomy and surgical repair to save the patient's life. Patient and methods: This case involved an 18-year-old female who was injured in a traffic accident and underwent emergency thoracotomy and surgical repair. Results: The patient's left thorax was deformed, and sonographic assessment revealed pericardial effusion. She experienced cardiopulmonary arrest 13 min after hospital arrival. An emergency physician performed an emergency department thoracotomy. The clots were removed from the surface of the left ventricle, followed by wound compression to control bleeding from the ruptured left ventricular wall. After the recovery of spontaneous circulation, the emergency physician sutured the ruptured heart. The patient survived with good neurological function. Conclusion: In rural areas, blunt cardiac rupture may require emergency department thoracotomy and cardiac repair by emergency physicians. The establishment of educational systems that include continuous education on trauma surgical procedures and consensus guidelines is needed to assist rural emergency physicians in performing surgical procedures.
Language	English
Publishing date	2024-04-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768933-5
ISSN	1880-4888 ; 1880-487X
ISSN (online)	1880-4888
ISSN	1880-487X
DOI	10.2185/jrm.2023-009
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Article: Nicardipine versus nitroglycerin for hypertensive acute heart failure syndrome: a single-center observational study.

Koroki, Takatoshi / Abe, Tomohiro / Ochiai, Hidenobu

Journal of rural medicine : JRM

2022 Volume 17, Issue 1, Page(s) 33–39

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2022-01-12
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768933-5
ISSN	1880-4888 ; 1880-487X
ISSN (online)	1880-4888
ISSN	1880-487X
DOI	10.2185/jrm.2021-045
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Article ; Online: A pediatric case of multiple trauma with impending cardiac arrest due to hemorrhagic shock successfully treated with resuscitative thoracotomy: A case report.

Hojo, Kento / Abe, Tomohiro / Saito, Katsutoshi / Sasaki, Akira / Ochiai, Hidenobu

Acute medicine & surgery

2023 Volume 10, Issue 1, Page(s) e867

Abstract: Background: The effectiveness of resuscitative thoracotomy (RT) in pediatric patients with multiple trauma is limited. We present a pediatric case of multiple trauma successfully treated with RT.: Case presentation: A 9-year-old boy was injured after ...

Abstract	Background: The effectiveness of resuscitative thoracotomy (RT) in pediatric patients with multiple trauma is limited. We present a pediatric case of multiple trauma successfully treated with RT. Case presentation: A 9-year-old boy was injured after falling down stairs. On arrival, his blood pressure was unmeasurable, and the carotid artery pulse was barely palpable. Sonographic assessment indicated intra-abdominal hemorrhage. RT and aortic cross-clamping were performed, and he received a blood transfusion, after which his circulatory status recovered. Laparotomy indicated an inferior mesenteric vein injury that was sutured. Ten hours after arrival, an acute epidural hematoma was observed and treated with an emergency craniotomy. The patient's condition remained stable and he was discharged on the 101st day. Conclusion: RT may save the life of patients with multiple trauma, even pediatric patients, if performed in a timely manner, based on the diagnosis of hemorrhagic shock, along with rapid transfusion and hemostatic intervention.
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Case Reports
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.867
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Article ; Online: Cardiac Tamponade Due to Intrapericardial Hernia Mimicking ST-Segment Elevation Myocardial Infarction.

Abe, Tomohiro / Kijima, Hiroaki / Ohuchida, Jiro / Hisashi, Yosuke / Tachioka, Shuji / Iwatani, Kenshi / Sadohara, Keisuke / Ameda, Tatsunori / Ochiai, Hidenobu

JACC. Case reports

2024 Volume 29, Issue 11, Page(s) 102348

Abstract: Intrapericardial hernia is a diaphragmatic hernia that extremely rarely causes cardiac tamponade. We present a case of a cardiac tamponade caused by an intrapericardial hernia in a 78-year-old male patient with a history of coronary artery bypass ... ...

Abstract	Intrapericardial hernia is a diaphragmatic hernia that extremely rarely causes cardiac tamponade. We present a case of a cardiac tamponade caused by an intrapericardial hernia in a 78-year-old male patient with a history of coronary artery bypass grafting, mimicking ST-segment elevation myocardial infarction, which was successfully treated by emergent laparotomy.
Language	English
Publishing date	2024-04-20
Publishing country	Netherlands
Document type	Case Reports
ISSN	2666-0849
ISSN (online)	2666-0849
DOI	10.1016/j.jaccas.2024.102348
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Article: A case of acute cerebral infarction with a favorable prognosis after rt-PA administration by a general physician with telestroke support.

Ochiai, Hidenobu / Kanemaru, Katsuhiro / Matsuda, Shuntaro / Ohta, Hajime

Journal of rural medicine : JRM

2021 Volume 16, Issue 2, Page(s) 119–122

Abstract: Objective: ...

Abstract	Objective:
Language	English
Publishing date	2021-04-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2768933-5
ISSN	1880-4888 ; 1880-487X
ISSN (online)	1880-4888
ISSN	1880-487X
DOI	10.2185/jrm.2020-048
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Article ; Online: Severe Traumatic Brain Injury in a Patient with von Willebrand Disease Type 2A Successfully Treated with Factor VIII/von Willebrand Factor Concentrates: A Case Report.

Koroki, Takatoshi / Abe, Tomohiro / Kamimura, Sachiyo / Ochiai, Hidenobu

The American journal of case reports

2022 Volume 23, Page(s) e936690

Abstract: BACKGROUND von Willebrand disease (VWD) is characterized by a bleeding tendency due to abnormalities in von Willebrand factor (VWF). Severe traumatic brain injury (TBI) can induce secondary coagulopathy and hemostatic disorders. We herein present a rare ... ...

Abstract	BACKGROUND von Willebrand disease (VWD) is characterized by a bleeding tendency due to abnormalities in von Willebrand factor (VWF). Severe traumatic brain injury (TBI) can induce secondary coagulopathy and hemostatic disorders. We herein present a rare case of multiple trauma, including severe TBI, in a patient with VWD who was successfully treated with repeated factor VIII/VWF transfusion in addition to standard critical care. CASE REPORT A 22-year-old man with type 2A VWD sustained head and lower limb injuries in a traffic accident and was comatose. Computed tomography indicated multiple trauma, including severe TBI (left-sided traumatic epidural hematoma, left-sided traumatic subdural hematoma, traumatic subarachnoid hemorrhage, skull fracture, and skull base fracture). The patient underwent emergency craniotomy for hematoma removal, external decompression, and intracranial pressure monitoring along with massive transfusion and repeated perioperative transfusion of factor VIII/VWF concentrates according to the level of bleeding. He recovered consciousness and eventually survived without neurological deficits. CONCLUSIONS Multiple trauma including TBI in patients with VWD is a critical condition. The active transfusion of factor VIII/VWF is essential for controlling hemorrhage early and in the perioperative period.
MeSH term(s)	Adult ; Brain Injuries, Traumatic/complications ; Brain Injuries, Traumatic/therapy ; Deamino Arginine Vasopressin ; Factor VIII/therapeutic use ; Hematoma/complications ; Hemorrhage/etiology ; Humans ; Male ; Multiple Trauma/complications ; Young Adult ; von Willebrand Diseases/complications ; von Willebrand Diseases/therapy ; von Willebrand Factor
Chemical Substances	von Willebrand Factor ; Factor VIII (9001-27-8) ; Deamino Arginine Vasopressin (ENR1LLB0FP)
Language	English
Publishing date	2022-08-30
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.936690
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Article ; Online: Thrombotic Microangiopathy Secondary to Systemic Sclerosis with Severe Complement Activation Not Responsive to Eculizumab: A Case Report.

Nakamura, Masahiko / Abe, Tomohiro / Ochiai, Hidenobu

The American journal of case reports

2022 Volume 23, Page(s) e936116

Abstract: BACKGROUND Secondary thrombotic microangiopathies (TMAs) are induced by several underlying conditions and most are resolved by treating the underlying disease. Eculizumab, a human monoclonal antibody, blocks the final stages of the complement system. ... ...

Abstract	BACKGROUND Secondary thrombotic microangiopathies (TMAs) are induced by several underlying conditions and most are resolved by treating the underlying disease. Eculizumab, a human monoclonal antibody, blocks the final stages of the complement system. Several studies have shown that complement C5 monoclonal antibodies are effective in treating secondary TMA. Systemic sclerosis (SSc) is one of the most common causes of secondary TMA, and early diagnosis is important because TMA secondary to SSc has a poor prognosis. We report a case of TMA secondary to SSc that did not respond to eculizumab, despite the presence of severe complement activation. CASE REPORT A 61-year-old previously healthy man was admitted for acute renal failure and thrombocytopenia. TMA was suspected because hemolytic anemia, thrombocytopenia, and organ damage were detected. Based on the physical findings, we suspected SSc as the underlying cause. All tests for specific antibodies, including Scl-70, were negative, and C5b-9 levels were markedly elevated (11 041 ng/mL). We initiated plasma exchange on day 3, followed by eculizumab therapy, but with limited improvement. SSc with secondary TMA was identified upon further testing. After completion of the plasma exchange, the platelet count was maintained above 30 000/μL. Creatinine levels gradually decreased, and the patient was weaned off dialysis. Steroid treatment for SSc was continued, and the patient was eventually discharged. CONCLUSIONS A case of SSc-TMA was ineffectively treated with eculizumab, despite abnormal activation of the complement system. Continuous monitoring and investigation are required, and discontinuation of eculizumab should be determined according to the final diagnosis.
MeSH term(s)	Antibodies, Monoclonal, Humanized ; Complement Activation ; Complement Inactivating Agents/therapeutic use ; Humans ; Male ; Middle Aged ; Renal Dialysis/adverse effects ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/drug therapy ; Thrombotic Microangiopathies/diagnosis ; Thrombotic Microangiopathies/drug therapy ; Thrombotic Microangiopathies/etiology
Chemical Substances	Antibodies, Monoclonal, Humanized ; Complement Inactivating Agents ; eculizumab (A3ULP0F556)
Language	English
Publishing date	2022-06-07
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.936116
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Article ; Online: Venous Thoracic Outlet Syndrome with an Upper Extremity Deep Vein Thrombosis Caused by a Dislocated Clavicle Fracture: A Case Report.

Miyake, Yoshihiro / Abe, Tomohiro / Suekane, Akira / Goan, Atsushi / Ameda, Tatsunori / Ochiai, Hidenobu

The American journal of case reports

2023 Volume 24, Page(s) e939250

Abstract: BACKGROUND Clavicle fractures are a relatively common injury, and are not problematic when occurring alone. Venous thoracic outlet syndrome (TOS) is generally caused by compression of the subclavian vein between the first rib and oblique muscles, and is ... ...

Abstract	BACKGROUND Clavicle fractures are a relatively common injury, and are not problematic when occurring alone. Venous thoracic outlet syndrome (TOS) is generally caused by compression of the subclavian vein between the first rib and oblique muscles, and is often complicated by the presence of upper extremities deep vein thrombosis (UEDVT). Herein, we present a case of venous TOS complicated with UEDVT due to a dislocated clavicle fracture. CASE REPORT A 29-year-old man was injured in a motorcycle accident. The patient's right clavicle was fractured, and the distal part of the fracture had dislocated into his right thorax. Contrast-enhanced computed tomography showed an obstruction of the subclavian vein by the dislocated clavicle and thrombus on the distal side of the obstruction. Anticoagulant therapy was not indicated because of other injuries, such as traumatic subarachnoid hemorrhage. No vena cava filter was placed in the superior vena cava owing to the relatively low volume of the thrombus. Alternatively, intermittent pneumatic compression to the right forearm was initiated. On day 6, surgical reduction of the clavicle was performed. The thrombus remained after the reduction. The patient received anticoagulation therapy with heparin followed by oral anticoagulants. The patient was discharged without any complications of UEDVT or bleeding. CONCLUSIONS Venous TOS with UEDVT caused by trauma is rare. Anticoagulation therapy, pneumatic limb compression, and vena cava filter placement should be considered according to the degree of the obstruction and other associated injuries.
MeSH term(s)	Male ; Humans ; Adult ; Clavicle ; Upper Extremity Deep Vein Thrombosis/diagnostic imaging ; Upper Extremity Deep Vein Thrombosis/etiology ; Vena Cava, Superior ; Fractures, Bone/complications ; Anticoagulants/therapeutic use
Chemical Substances	Anticoagulants
Language	English
Publishing date	2023-07-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.939250
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Article ; Online: Successful Treatment of Sepsis-Induced Cardiomyopathy with Intra-Aortic Balloon Pumping: A Case Report and Literature Review.

Kuroki, Takuya / Abe, Tomohiro / Kawana, Ryo / Koroki, Takatoshi / Kubo, Keisuke / Ochiai, Hidenobu

The American journal of case reports

2023 Volume 24, Page(s) e941098

Abstract: BACKGROUND Sepsis-induced cardiomyopathy is cardiac dysfunction in sepsis that sometimes results in reduced cardiac output. Inotropic agents are recommended in patients with sepsis and cardiac dysfunction. Here, we present a case of sepsis-induced ... ...

Abstract	BACKGROUND Sepsis-induced cardiomyopathy is cardiac dysfunction in sepsis that sometimes results in reduced cardiac output. Inotropic agents are recommended in patients with sepsis and cardiac dysfunction. Here, we present a case of sepsis-induced cardiomyopathy that was resistant to inotropes and was successfully treated with intra-aortic balloon pumping (IABP). We also reviewed the literature on similar cases of sepsis-induced cardiomyopathy treated with IABP. CASE REPORT A 40-year-old woman with fever and hypotension was admitted to a university hospital. Laboratory test results showed elevated inflammatory markers and cardiac markers, such as creatinine kinase-MB and troponin T. Echocardiography revealed severe left ventricular hypokinesis, and cardiac monitoring revealed a low cardiac output. The patient received antimicrobials, vasopressors, and dobutamine; however, her circulatory status did not respond to these treatments. IABP was introduced 7 h after admission and dramatically increased her blood pressure and cardiac output, resulting in the reduction of vasopressor and dobutamine doses. The patient survived without any IABP-related complications. The literature review of 11 cases of sepsis-induced cardiomyopathy treated with IABP shows consistent results with the presented case in terms of positive effects of IABP on circulatory status and cardiac function, resulting in a reduction of inotropes. CONCLUSIONS Some sepsis-induced cardiomyopathy cases with reduced left ventricular function may not respond to inotropes. IABP would be a treatment option for these patients because of its positive effects on cardiac and circulatory functions.
MeSH term(s)	Female ; Humans ; Adult ; Intra-Aortic Balloon Pumping/methods ; Dobutamine ; Cardiomyopathies/etiology ; Cardiomyopathies/therapy ; Heart Diseases/etiology ; Sepsis/complications ; Sepsis/therapy
Chemical Substances	Dobutamine (3S12J47372)
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2517183-5
ISSN	1941-5923 ; 1941-5923
ISSN (online)	1941-5923
ISSN	1941-5923
DOI	10.12659/AJCR.941098
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