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Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway.

Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

2023 Volume 318, Issue Pt B, Page(s) 117020

Abstract: Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis ( ... ...

Abstract	Ethnopharmacological relevance: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). Materials and methods: Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected. Results: WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. Conclusion: WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
MeSH term(s)	Rats ; Animals ; NF-kappa B/metabolism ; Tumor Necrosis Factor-alpha/metabolism ; Methylnitronitrosoguanidine ; Pepsin A/metabolism ; Inflammation/pathology ; Precancerous Conditions/drug therapy ; Hyperplasia/pathology ; Stomach Neoplasms/pathology ; Metaplasia/metabolism ; Metaplasia/pathology ; Gastric Mucosa/pathology
Chemical Substances	NF-kappa B ; Tumor Necrosis Factor-alpha ; Methylnitronitrosoguanidine (12H3O2UGSF) ; Pepsin A (EC 3.4.23.1)
Language	English
Publishing date	2023-08-09
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117020
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Article ; Online: Phenylethanoid glycosides of Callicarpa kwangtungensis Chun exert cardioprotective effect by weakening Na

Sun, Jing / Chen, Lei / Jiang, Pan / Duan, Bingjing / Wang, Ruyi / Xu, Jian / Liu, Wenyuan / Xu, Yunhui / Xie, Zijian / Feng, Feng / Qu, Wei

Journal of ethnopharmacology

2020 Volume 258, Page(s) 112881

Abstract: Ethnopharmacological relevance: Callicarpa kwangtungensis Chun (C. kwangtungensis) is a very ...

Abstract	Ethnopharmacological relevance: Callicarpa kwangtungensis Chun (C. kwangtungensis) is a very famous herbal medicine with the function of promoting blood circulation and removing blood stasis which is beneficial for cardiovascular disease (CVD). Phenylethanoid glycosides (PGs) are the major class of active ingredients in C. kwangtungensis and present significant anti-oxidative and anti-inflammatory property related to apoptosis. Therefore, this study aimed to investigate the effects of total phenylethanoid glycosides of C. kwangtungensis (CK-PGs) on isoproterenol (ISO) induced myocardial ischemic injury (MI) and the mechanisms related to the apoptosis mediated by oxidative damage and inflammation. Methods: The myocardial ischemia animal model was established as subcutaneous injecting ISO. Echocardiography and biomarkers were employed to determine the degree of myocardial damage. Histopathological changes were observed by hematoxylin and eosin test. The TUNEL staining and activity of caspase-3 were measured to detect the level of apoptosis which is medicated by the oxidative damage detected by the level of MDA, GSH and ROS tested with the kit and the inflammation reflected by TNF-α. The activity of Na Results: CK-PGs showed cardioprotective effect against ISO-induced myocardial ischemic injury evidenced by improving heart function and lowering myocardial injury markers. CK-PGs could inhibit the level of apoptosis as shown by the decrease of the TUNEL-positive cells, the activity of caspase-3 and increase of the expression of Bax. CK-PGs also reduced oxidative stress and inflammation to suppress apoptosis by decreasing the level of ROS, MDA, and increasing GSH activity and lowering the level of TNF-α. In addition, CK-PGs exerted the protection by increasing the activity and the expression of NKA. Meanwhile, Na Conclusions: CK-PGs could protect cardiomyocytes from myocardial injury through suppressing Na
MeSH term(s)	Animals ; Apoptosis/drug effects ; Callicarpa/chemistry ; Cardiotonic Agents/isolation & purification ; Cardiotonic Agents/pharmacology ; Disease Models, Animal ; Glycosides/isolation & purification ; Glycosides/pharmacology ; Inflammation/drug therapy ; Inflammation/pathology ; MAP Kinase Signaling System/drug effects ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/pathology ; Oxidative Stress/drug effects ; Rats ; Rats, Sprague-Dawley ; Sodium-Potassium-Exchanging ATPase/metabolism ; src-Family Kinases/metabolism
Chemical Substances	Cardiotonic Agents ; Glycosides ; src-Family Kinases (EC 2.7.10.2) ; Sodium-Potassium-Exchanging ATPase (EC 7.2.2.13)
Language	English
Publishing date	2020-04-18
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.112881
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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Wei-fu-chun tablet halted gastric intestinal metaplasia and dysplasia associated with inflammation by regulating the NF-κB pathway

Xie, Dong / Wu, Chao / Wang, Dan / Nisma Lena, Bahaji Azami / Liu, Ningning / Ye, Guan / Sun, Mingyu

Journal of Ethnopharmacology. 2023 Aug. 09, p.117020-

2023 , Page(s) 117020–

Abstract: Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous ... ...

Abstract	Chi006Eese herbal medicine Weifuchun Tablets (WFC) approved by the State Food and Drug Administration in 1982 has been widely used in treating a variety of chronic stomach disorders including Chronic atrophic gastritis (CAG) and Gastric precancerous lesions in China clinically. This study aimed to investigate the efficacy and potential mechanism of WFC in treating Gastric intestinal metaplasia (GIM) and Gastric dysplasia (GDys). Rat GIM and GDys established by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) combined with hot paste, ethanol injury, and intermittent fasting were intervened by WFC. Body weight, histopathology, pH of gastric acid, pepsin activity, intestinal metaplasia index and inflammation were detected. Rat bone marrow derived macrophages (BMDMs) pretreated with WFC were stimulated by LPS. Inflammatory factors and the nuclear factor-kappa B (NF-κB) pathway were assessed. GES-1 cells pretreated by WFC were stimulated by MNNG and TNF-α, intestinal metaplasia index, the NF-κB pathway and interaction between P65 and CDX2 were detected. WFC improved rat body weight, histopathology, pH value of gastric acid, activity of gastric pepsin, intestinal metaplasia (CDX2), inflammation (IL-1β, IL-6 and TNF-α), macrophage aggregation (CD68) in gastric mucosa in rat GIM and GDys. WFC inhibited inflammation (IL-1β and TNF-α) by inactivating the NF-κB pathway. WFC reduced the expression of CDX2 by inhibiting the binding of CDX2 promoter TSS upstream region with p65. WFC blocked GIM and GDys associated with inflammation by regulating the NF-κB pathway.
Keywords	Food and Drug Administration ; body weight ; bone marrow ; ethanol ; fasting ; gastric acid ; gastric mucosa ; gastritis ; herbal medicines ; histopathology ; inflammation ; interleukin-6 ; intestines ; macrophages ; metaplasia ; pH ; pepsin ; rats ; traditional medicine ; transcription factor NF-kappa B ; China ; Wei-fu-chun tablet ; Gastric intestinal metaplasia ; Gastric dysplasia ; NF-κB pathway
Language	English
Dates of publication	2023-0809
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.117020
Database	NAL-Catalogue (AGRICOLA)

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Article: Effect of microbial fermentation on the sensory characteristics and chemical compositions of Chinese sweet tea (Lithocarpus litseifolius (Hance) Chun)

Huang, Weimin / Zhang, Changyi / Gu, Zepeng / Li, Cheng / Fang, Zhengfeng / Zeng, Zhen / Zhang, Zhiqing / Hu, Bin / Chen, Hong / Wu, Wenjuan / Wang, Tiqiang / Lan, Xiguo / Liu, Yuntao

Food bioscience. 2022 Apr., v. 46

2022

Abstract: Sweet tea, which has hundreds of years of use among in Chinese folk, is a traditional herbal tea with pleasant sweetness, bitterness and astringency. In the current study, we used traditional microbial fermentation to improve sensory characteristics of ... ...

Abstract	Sweet tea, which has hundreds of years of use among in Chinese folk, is a traditional herbal tea with pleasant sweetness, bitterness and astringency. In the current study, we used traditional microbial fermentation to improve sensory characteristics of sweet tea, especially for the reduction of bitterness and astringency. The dynamic changes of non-volatile, volatile compounds and microbial community were investigated during microbial fermentation. The contents of polyphenols, flavonoids, soluble sugar, soluble protein, catechins and dihydrochalcones decreased significantly while the tea pigments, free amino acids and gallic acid content inversely increased during microbial fermentation. A total of 61 volatile compounds were identified and quantified in sweet tea, of which 20 key compounds were identified as odor active compounds (OAV), including 3 aldehydes, 1 ketone, 4 alcohols, 9 esters, 4 alkenes and 3 other compounds. In addition, eight fungi and four bacteria were considered as core microorganisms, such as Aspergillus, Alternaria, Cladosporium, Epicoccum, Itersonilia, Penicillium, Periconia, Wallemia, Aureimonas, Enterobacter, Klebsiella and Stenotrophomonas, which were significantly correlated with non-volatile compounds and flavor compounds. These results provided theoretical guidance for processing of fermented sweet tea.
Keywords	Alternaria ; Aspergillus ; Cladosporium ; Enterobacter ; Epicoccum ; Klebsiella ; Lithocarpus ; Penicillium ; Periconia ; Stenotrophomonas ; Wallemia ; alkenes ; astringency ; bitterness ; fermentation ; flavanols ; gallic acid ; herbal tea ; microbial communities ; odors ; polyphenols ; sugars ; sweetness
Language	English
Dates of publication	2022-04
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2212-4292
DOI	10.1016/j.fbio.2022.101567
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Article ; Online: Phytochemicals and bioactive analysis of different sweet tea (Lithocarpus litseifolius [Hance] Chun) varieties.

Wang, Mengke / Liu, Xing / Zhang, Zejie / Yu, Jiawen / Liu, Jiajia / Wu, Yiqiang

Journal of food biochemistry

2020 Volume 45, Issue 3, Page(s) e13183

Abstract: ... Lithocarpus litseifolius (Hance) Chun (L. litseifolius) cultivars. Processed by UPLC-MS/MS and untargeted ...

Abstract	This paper aims to investigate the constituent phytochemicals and biological activities of six Lithocarpus litseifolius (Hance) Chun (L. litseifolius) cultivars. Processed by UPLC-MS/MS and untargeted metabolomics analysis software (MS-DIAL and MS-FINDER), components of different L. litseifolius cultivars were analyzed qualitatively and quantitatively. By conducting a comprehensive analysis of spectra, MS/MS fragmentation, and retention time, 40 compounds (including 6 phenolic glycosides and 34 flavonoids) were identified rapidly and accurately. Moreover, the total phenolic content (TPC), total flavonoid content (TFC), antioxidant, antimicrobial effects, and pheochromocytoma (PC12) cell viability of different L. litseifolius varieties were evaluated. Purple small leaf (PSL) was found to be the most superior variety with the highest antioxidant activities (8.27, 10.09, and 10.80 mg TE/g for DPPH, ABTS, and FRAP assays, respectively), broad-spectrum antimicrobial activity, and lowest cell cytotoxicity. The results showed that these bioactivities were closely related to phytochemicals among the six cultivars. PRACTICAL APPLICATIONS: L. litseifolius is well known as an important folk drink in the Southern China folklore for its specific efficacy in preventing diabetes. However, there is still a paucity of information on L. litseifolius, as other active components and bioactivities of it remain to be investigated. The wide range of flavonoids discovered in L. litseifolius provides abundant natural health-promoting agents for further applications in medicine and functional food.
MeSH term(s)	China ; Chromatography, Liquid ; Phytochemicals/pharmacology ; Tandem Mass Spectrometry ; Tea
Chemical Substances	Phytochemicals ; Tea
Language	English
Publishing date	2020-03-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	433846-7
ISSN	1745-4514 ; 0145-8884
ISSN (online)	1745-4514
ISSN	0145-8884
DOI	10.1111/jfbc.13183
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effect of different drying techniques on structural characteristics and bioactivities of polysaccharides extracted from (Lithocarpus litseifolius [Hance] Chun) sweet tea leaves

Kwok, Woon / Fu, Meng-Xi / Zhao, Yun-Xuan / Wu, Ding-Tao / Liu, Hong-Yan / Li, Hua-Bin / Ayyash, Mutamed / Gan, Ren-You

Food Measure. 2022 Oct., v. 16, no. 5 p.4050-4063

2022

Abstract: Sweet tea is made from the leaves of Lithocarpus litseifolius (Hance) Chun, which is an herbal tea ...

Abstract	Sweet tea is made from the leaves of Lithocarpus litseifolius (Hance) Chun, which is an herbal tea widely consumed in Chinese folk. In this study, five drying techniques were applied to dry sweet tea leaves, and the structural characteristics, antioxidant activities, α-glucosidase inhibitory activities, and antiglycation activities of sweet tea polysaccharides (STPs) were systematically evaluated. The extraction yields of STPs ranged from 2.37 to 4.09%, and STPs prepared by hot-air drying had the highest extraction yield. The five polysaccharides exhibited the same constituent monosaccharides, similar preliminary structural characteristics, different molecular weights (Mw), and different molar ratios of constituent monosaccharides. Critically, five STPs solutions exhibited non-Newtonian behavior, and STPs obtained by hot-air drying had the highest Mw and apparent viscosity. Compared with other drying technologies, relatively high total phenolic content was measured in the STPs obtained by freeze-drying (31.32 ± 1.77 mg GAE/g) and hot-air drying (29.13 ± 1.36 mg GAE/g). Furthermore, five STPs exhibited excellent biological properties, including antioxidant activities, α-glucosidase inhibitory activities, and antiglycation activities. Ultimately, the heat map analysis found that the bioactivities of STPs were related to their high Mw and high content of total phenolic. All results suggested that STPs, especially polysaccharides prepared by hot-air drying and freeze-drying, had good development prospects and application values as functional ingredients for the antidiabetic functional food development.
Keywords	Lithocarpus ; antioxidants ; freeze drying ; functional foods ; heat ; herbal tea ; polysaccharides ; viscosity
Language	English
Dates of publication	2022-10
Size	p. 4050-4063.
Publishing place	Springer US
Document type	Article ; Online
ZDB-ID	2754612-3
ISSN	2193-4134 ; 2193-4126
ISSN (online)	2193-4134
ISSN	2193-4126
DOI	10.1007/s11694-022-01510-2
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Article: Screening and process optimization of ultrasound-assisted extraction of main antioxidants from sweet tea (Lithocarpus litseifolius [Hance] Chun)

Liu, Yi / Liu, Hong-Yan / Xia, Yu / Guo, Huan / He, Xiao-Qin / Li, Hang / Wu, Ding-Tao / Geng, Fang / Lin, Fang-Jun / Li, Hua-Bin / Zhuang, Qi-Guo / Gan, Ren-You

Food bioscience. 2021 Oct., v. 43

2021

Abstract: Sweet tea (Lithocarpus litseifolius [Hance] Chun) is an herbal tea with multiple health benefits ...

Abstract	Sweet tea (Lithocarpus litseifolius [Hance] Chun) is an herbal tea with multiple health benefits due to its main bioactive compounds. In this work, the DPPH-spiking test based on high-performance liquid chromatography (DPPH-spiking HPLC) was applied to precisely screen antioxidants from sweet tea. Three main antioxidants, including isoquercitrin, phloridzin, and trilobatin, were screened out from sweet tea. Furthermore, their antioxidant capacities were verified by the DPPH radical scavenging assay, and found their antioxidant capacities in the order of isoquercitrin > trilobatin > phloridzin. Ultrasonic-assisted extraction (UAE) was applied to optimize and extract the screened antioxidants, and the optimal extraction conditions were ethanol concentration of 69.0%, sample-to-liquid ratio of 18.0 w/v, extraction time of 18.4 min, extraction temperature of 25 °C, and ultrasonic power of 450 W, yielding 17.1 ± 1.26 mg/g isoquercitrin, 34.8 ± 1.49 mg/g phloridzin, and 163 ± 1.73 mg/g trilobatin. The antioxidant capacities of the extracts based on UAE (11.5 ± 0.04 mg ascorbic acid equivalent/g DW) was much higher than the extracts based on maceration extraction (7.9 mg ± 0.02 ascorbic acid equivalent/g DW). Moreover, it was found that trilobatin, isoquercitrin, and phloridzin accounted for 30.9%, 24.9%, and 5.33% of the total antioxidant capacities of the extracts under the optimal extraction conditions, respectively. Therefore, DPPH-spiking HPLC analysis combined with UAE is an effective method for the screening and extracting of the antioxidants in sweet tea, which should have potential applications in the development of functional foods.
Keywords	Lithocarpus ; antioxidants ; ascorbic acid ; ethanol ; herbal tea ; high performance liquid chromatography ; isoquercitrin ; maceration ; phloridzin ; temperature ; ultrasonic treatment ; ultrasonics
Language	English
Dates of publication	2021-10
Publishing place	Elsevier Ltd
Document type	Article
ISSN	2212-4292
DOI	10.1016/j.fbio.2021.101277
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Article: Phenylethanoid Glycosides From Callicarpa kwangtungensis Chun Attenuate TNF-α-Induced Cell Damage by Inhibiting NF-κB Pathway and Enhancing Nrf2 Pathway in A549 Cells.

Zheng, Jing-Na / Zhuo, Jian-Yi / Nie, Juan / Liu, Yan-Lu / Chen, Bao-Yi / Wu, Ai-Zhi / Li, Yu-Cui

Frontiers in pharmacology

2021 Volume 12, Page(s) 693983

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-07-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.693983
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Article: The chemical, sensory, and volatile characteristics of instant sweet tea (Lithocarpus litseifolius [Hance] Chun) using electronic nose and GC-MS-based metabolomics analysis

Liu, Hong-Yan / Liu, Yi / Li, Ming-Yue / Mai, Ying-Hui / Guo, Huan / Wadood, Syed Abdul / Raza, Ali / Wang, Yu / Zhang, Jia-Yu / Li, Hua-Bin / Gan, Ren-You

Lebensmittel-Wissenschaft + Technologie. 2022 June 15, v. 163

2022

Abstract: ... volatile profiles of sweet tea. Young leaves of Lithocarpus litseifolius [Hance] Chun were extracted and ...

Abstract	This study aims to investigate the effect of instant tea processing on the chemical, sensory, and volatile profiles of sweet tea. Young leaves of Lithocarpus litseifolius [Hance] Chun were extracted and dried with freeze-drying and spray-drying, respectively. The contents of proteins, polysaccharides, total phenolics, total flavonoids, and free amino acids in instant teas were found to be higher than those in sweet tea. A total of 268 volatiles were identified by HS-SPME-GC-MS, and 88 compounds showed significant differences among different samples, and most of volatile compounds showed lower concentrations in instant tea powder than sweet tea powder. Nine aroma attributes were evaluated through descriptive sensory analysis. Sweet tea had a higher intensity of woody, green, floral, fruity, and sweet descriptor, while the instant sweet teas demonstrated the higher intensity of caramel-like attribute. Our study emphasized the nutritive value of instant sweet tea, while the aroma needs to be improved further.
Keywords	Lithocarpus ; electronic nose ; flavonoids ; freeze drying ; metabolomics ; nutritive value ; odors ; phenolic compounds ; polysaccharides ; sensory evaluation ; spray drying ; tea
Language	English
Dates of publication	2022-0615
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2022.113518
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Article ; Online: Isolation, identification and activities of natural antioxidants from Callicarpa kwangtungensis Chun.

Cai, Hao / Xie, Zhiyong / Liu, Guanghui / Sun, Xiuman / Peng, Guangtian / Lin, Baoqin / Liao, Qiongfeng

PloS one

2014 Volume 9, Issue 3, Page(s) e93000

Abstract: ... kwangtungensis Chun (CK) is a common remedy in traditional Chinese medicine and possesses diverse ...

Abstract	Reactive oxygen species leads to some diseases associated with oxidative stress. Callicarpa kwangtungensis Chun (CK) is a common remedy in traditional Chinese medicine and possesses diverse biological activities involving antioxidant properties; its main compounds phenylethanoid glycosides (PG) and flavonoids are always reported as antioxidants. In order to develop CK as a safe and activated antioxidant, our investigation was performed to validate antioxidant properties and assess which types of compounds (similar polarity or similar structure), even which compounds, played the role of antioxidants. The extracted compounds of CK were analyzed qualitatively and quantitatively by HPLC-DAD-ESI-Trap MS and UV for their contents and antioxidant activities. The correlations between antioxidant activities and known contents were respectively counted and a semi-quantitative experiment was designed to screen antioxidant compounds of CK with HPLC-UV. The n-butanol fraction (BF) showed the highest total phenolic and flavonoid contents (TPC, TFC), and three PG (forsythiaside B, poliumoside and acteoside) contents. BF showed the significantly best (P<0.05) activities in most assays. There were significant correlations (P<0.05) between DPPH•, ABTS(+)•, •O2(-) scavenging, Cu(2+)-chelating, anti-lipidperoxidation activities and TPC. BF also has significant antioxidant activities on CCl4-induced acute liver injury Mice and TBHP-reduced HepG2 cells. Nine PG (forsythiaside B, poliumoside, acteoside, alyssonoside, brandioside and their derivatives) and one flavone (rhamnazin) were screened out as antioxidants. BF in CK contained abundant polyphenolic, which reflected some definite antioxidant properties. The antioxidant compounds consisted at the least of nine PG and one flavone.
MeSH term(s)	Animals ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Callicarpa/chemistry ; Chemical and Drug Induced Liver Injury/metabolism ; Cytoprotection/drug effects ; Free Radicals/chemistry ; Glycosides/analysis ; Hep G2 Cells ; Humans ; Male ; Mice ; Oxidative Stress/drug effects ; Phenols/analysis ; Plant Extracts/chemistry ; Plant Extracts/isolation & purification ; Plant Extracts/pharmacology
Chemical Substances	Antioxidants ; Free Radicals ; Glycosides ; Phenols ; Plant Extracts
Language	English
Publishing date	2014-03-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0093000
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