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Article: Spondyloarthritiden im Kindes- und Jugendalter

Yıldız, Mehmet / Haşlak, Fatih / Adroviç, Amra

2023 Volume 44, Issue 172, Page(s) 4

Language	German
Document type	Article
ZDB-ID	2119820-2
ISSN	1861-2105
Database	Current Contents Medicine

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Article ; Online: Type I Interferonopathies in Childhood.

Haşlak, Fatih / Kılıç Könte, Elif / Aslan, Esma / Şahin, Sezgin / Kasapçopur, Özgür

Balkan medical journal

2023 Volume 40, Issue 3, Page(s) 165–174

Abstract: Type 1 interferonopathy is a novel context reflecting a group of inborn disorders sharing common pathway disturbances. This group of diseases is characterized by autoimmunity and autoinflammation caused by an upregulation of type 1 interferons (IFN)s due ...

Abstract	Type 1 interferonopathy is a novel context reflecting a group of inborn disorders sharing common pathway disturbances. This group of diseases is characterized by autoimmunity and autoinflammation caused by an upregulation of type 1 interferons (IFN)s due to certain genetic mutations. Several features are common in most of the diseases in this group, such as vasculitic skin changes, including chilblains, panniculitis, interstitial lung disease, basal ganglion calcifications, neuromotor impairments, epilepsy, stroke, and recurrent fever. Family history and consanguineous marriage are also common. IFN signature is a useful diagnostic tool and is positive in almost all patients with type 1 interferonopathies. Although IFN signature is a sensitive test, its specificity is relatively low. It can also be positive in viral infections and several connective tissue diseases. Therefore, next-generation sequence methods, whole exome sequencing (WES) in particular, are required for the ultimate diagnosis. The optimal treatment regime is still under debate due to a lack of clinical trials. Although high-dose steroids, anti-IL-1 and anti-IL-6 treatments, and reverse transcriptase inhibitors are used, JAK inhibitors are highly promising. Additionally, monoclonal antibodies against IFN-alpha and interferon-α receptor (IFNAR) are currently underway.
MeSH term(s)	Humans ; Mutation
Language	English
Publishing date	2023-05-16
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2023.2023-4-78
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A cursed goodbye kiss from severe acute respiratory syndrome-coronavirus-2 to its pediatric hosts: multisystem inflammatory syndrome in children.

Haslak, Fatih / Gunalp, Aybuke / Kasapcopur, Ozgur

Current opinion in rheumatology

2022 Volume 35, Issue 1, Page(s) 6–16

Abstract: Purpose of review: We aimed to summarize a novel disease called multisystem inflammatory syndrome in children (MIS-C), which develops several weeks after a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) illness.: Recent findings: Given ... ...

Abstract	Purpose of review: We aimed to summarize a novel disease called multisystem inflammatory syndrome in children (MIS-C), which develops several weeks after a severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) illness. Recent findings: Given the rarity of the disease, the question of why a minority of children develop MIS-C is not known. Certain intrinsic susceptibility factors in the host have been described. In addition to hyperinflammation induced by the innate and acquired immune cells, evidence of molecular mimicry was presented for the disease pathogenesis. As there is an increasing number of infected individuals and mass vaccination schedules, concerns regarding the usefulness of the existing diagnostic criteria sets raised. Summary: Although children are likely to have a milder COVID-19 course compared with adults, MIS-C as a postinfectious and life-threatening complication was reported in the pediatric age. After 2 years of the disease definition, optimal treatment regimes, effective preventive measures, and long-term outcomes are still debated.
MeSH term(s)	Child ; Humans ; SARS-CoV-2 ; COVID-19/diagnosis ; Systemic Inflammatory Response Syndrome
Language	English
Publishing date	2022-09-12
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	1045317-9
ISSN	1531-6963 ; 1040-8711
ISSN (online)	1531-6963
ISSN	1040-8711
DOI	10.1097/BOR.0000000000000910
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Childhood Rheumatic Diseases and COVID-19 Pandemic: An Intriguing Linkage and a New Horizon

Haşlak, Fatih / Yıldız, Mehmet / Adrovic, Amra / Barut, Kenan / Kasapçopur, Özgür

Balkan medical journal

2020 Volume 37, Issue 4, Page(s) 184–188

Abstract: As it is known, we are all in a pandemic situation due to a novel coronavirus, officially named “Severe Acute Respiratory Syndrome Coronavirus 2” and the disease caused by the virus named “Coronavirus disease-2019”. The virus seems to has propensity to ... ...

Abstract	As it is known, we are all in a pandemic situation due to a novel coronavirus, officially named “Severe Acute Respiratory Syndrome Coronavirus 2” and the disease caused by the virus named “Coronavirus disease-2019”. The virus seems to has propensity to infect older male individuals with underlying disease. The clinical features were on a large scale that varies from being an asymptomatic carrier to acute respiratory distress syndrome and multiorgan dysfunction. Fever, dry cough and fatigue are the most common symptoms. Not only, the disease seems to be rare and have a milder course in pediatric age but also respiratory failure, multiorgan dysfunction, and death are extremely rare. Although several comorbidities such as hypertension, diabetes and cardiovascular diseases are defined as a risk factor for developing the acute respiratory syndrome and need for intensive care; immune-compromised situations such as rheumatic disease which require immunosuppressive treatment strikingly are not found to be a risk factor for more severe disease course. However, there is a lack of data regarding the effects of “Coronavirus disease-2019” on pediatric patients with rheumatic diseases. Additionally, there are three controversial circumstances that patients with rheumatic diseases are believed to be more likely to have viral infections like “Severe Acute Respiratory Syndrome Coronavirus 2”, on the other hand, antirheumatic drugs may have a protective and therapeutic role in Coronavirus disease-2019 and children are more unlikely to have serious disease course. Therefore, we aimed to have a contributor role for explaining this conundrum and present a bird’s eye view regarding this equivocal issue in this review.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Humans ; Pandemics/prevention & control ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Rheumatic Diseases/complications ; Rheumatic Diseases/drug therapy ; SARS-CoV-2 ; COVID-19 Drug Treatment
Keywords	covid19
Language	English
Publishing date	2020-04-08
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2020.2020.4.43
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Autoinflammatory Diseases in Childhood

Yıldız, Mehmet / Haşlak, Fatih / Adrovic, Amra / Barut, Kenan / Kasapçopur, Özgür

Balkan medical journal

2020 Volume 37, Issue 5, Page(s) 236–246

Abstract: Autoinflammatory diseases are characterized by recurrent fevers and clinical findings of impaired natural immunity and can involve various organ systems. The concept of autoinflammatory disease emerged after the definition of familial Mediterranean fever ...

Abstract	Autoinflammatory diseases are characterized by recurrent fevers and clinical findings of impaired natural immunity and can involve various organ systems. The concept of autoinflammatory disease emerged after the definition of familial Mediterranean fever and tumor necrosis factor receptor-associated periodic syndrome. This new disease group was considered to differ from the standard concept of autoimmune diseases, which is relatively better known in terms of basic features, such as defects in innate immunity and the absence of antibodies. A better understanding has been achieved regarding the genetic and pathogenetic mechanisms of this relatively new disease group over the past 20 years since they were first diagnosed, which have led to some changes in the concept of autoinflammatory diseases. The recent definition classifies autoinflammatory disease to be a wide range of diseases with different clinical features, mainly accompanied by changes in innate immune and rarely in humoral immunity. The spectrum of autoinflammatory diseases is rapidly expanding owing to recent developments in molecular sciences and genetics. This review article discusses the clinical features, classification criteria, treatment options, and long-term prognosis of periodic fever, aphthous stomatitis, pharyngitis, adenitis syndrome, and other common autoinflammatory diseases in the light of current literature.
MeSH term(s)	Diagnosis, Differential ; Familial Mediterranean Fever/diagnosis ; Familial Mediterranean Fever/physiopathology ; Fever/diagnosis ; Fever/physiopathology ; Hereditary Autoinflammatory Diseases/diagnosis ; Hereditary Autoinflammatory Diseases/physiopathology ; Hereditary Autoinflammatory Diseases/therapy ; Humans
Language	English
Publishing date	2020-04-27
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2612982-6
ISSN	2146-3131 ; 2146-3131
ISSN (online)	2146-3131
ISSN	2146-3131
DOI	10.4274/balkanmedj.galenos.2020.2020.4.82
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Juvenile spondyloartropathies.

Yıldız, Mehmet / Haşlak, Fatih / Adroviç, Amra / Şahin, Sezgin / Barut, Kenan / Kasapçopur, Özgür

European journal of rheumatology

2021 Volume 9, Issue 1, Page(s) 42–49

Abstract: Juvenile spondyloarthropathies (JSpA) are defined as a heterogeneous group of diseases that start before the age of 16, which is associated with peripheral joint (especially large joints of the lower limbs) and axial skeletal (spine and sacroiliac joint) ...

Abstract	Juvenile spondyloarthropathies (JSpA) are defined as a heterogeneous group of diseases that start before the age of 16, which is associated with peripheral joint (especially large joints of the lower limbs) and axial skeletal (spine and sacroiliac joint) involvement, enthesitis, and human leukocyte antigen (HLA) B27 positivity. Juvenile spondyloarthropathies mainly cover juvenile ankylosing spondylitis (JAS), psoriatic arthritis, reactive arthritis, inflammatory bowel disease-associated arthritis, seronegative enthesopathy, arthropathy syndrome (SEA), and enthesitis-associated arthritis. Symptoms associated with spondyloarthropathies are enthesitis, inflammatory low back pain, dactylitis, nail changes, psoriasis, acute anterior uveitis, and inflammatory bowel disease-related symptoms. In JSpA, axial involvement is rarely seen in the early stages of the disease, in contrast to adult patients with ankylosing spondylitis (AS). The disease usually begins as asymmetric oligoarthritis of lower extremities in children, and axial skeletal involvement can occur in the course of the disease. Although the debate on the classification of juvenile spondyloarthropathies continues due to its initial nonspecific findings and the heterogeneity of the disease phenotype, the International League of Associations Rheumatology (ILAR) classification criteria are the most commonly used pediatric criteria. In that set of criteria, patients with JSpA are mainly classified under enthesitis-related arthritis or psoriatic arthritis group. Since juvenile spondyloarthropathies can cause severe loss of function and long-term sequelae, the main goal in treatment should be suppression of inflammation as early as possible and prevent sequelae.
Language	English
Publishing date	2021-06-10
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2873727-1
ISSN	2148-4279 ; 2147-9720
ISSN (online)	2148-4279
ISSN	2147-9720
DOI	10.5152/eurjrheum.2021.20235
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Article ; Online: The impact of COVID-19 on clinical course and treatment among patients with juvenile systemic sclerosis.

Adrovic, Amra / Yıldız, Mehmet / Haşlak, Fatih / Şahin, Sezgin / Köker, Oya / Günalp, Aybüke / Barut, Kenan / Kasapçopur, Özgür

Archives of rheumatology

2022 Volume 38, Issue 2, Page(s) 267–273

Abstract: Objectives: This study aimed to explore the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic among patients with juvenile systemic sclerosis (JSS).: Patients and methods: Twenty-seven patients (22 females, 5 males; ... ...

Abstract	Objectives: This study aimed to explore the influence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic among patients with juvenile systemic sclerosis (JSS). Patients and methods: Twenty-seven patients (22 females, 5 males; mean age: 20 years; range, 17 to 22 years) diagnosed with JSS and followed up at the department of pediatric rheumatology were included in the cross-sectional study. A web-based survey was performed by focusing on patients' complaints, accessibility to health care, and compliance with routine treatment from January 1, 2021, to January 10, 2021. Results: Five (18.5%) patients had deterioration of the disease, while six (22.2%) patients reported irregular usage of their routine scleroderma treatment during the last six months. Nine (33.3%) patients had missed their routine clinic control since the proclamation of the SARS-CoV-2 pandemic. Seven (25.9%) patients had household contact with coronavirus disease 2019 (COVID-19). Four (14.8%) patients were diagnosed with COVID-19, and only one (3.7%) was hospitalized. Nine patients were under biological treatment (tocilizumab); however, only one of them was diagnosed with COVID-19. Conclusion: The COVID-19 pandemic has not significantly disrupted the medical care of JSS patients. Telemedicine could be an acceptable option for JSS patients disenabled to come to the hospital.
Language	English
Publishing date	2022-11-04
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	3012972-2
ISSN	2618-6500 ; 2148-5046
ISSN (online)	2618-6500
ISSN	2148-5046
DOI	10.46497/ArchRheumatol.2023.9636
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Article ; Online: A case of juvenile systemic sclerosis and congenital pulmonary airway malformation related mucinous adenocarcinoma of the lung: paraneoplastic syndrome or just a coincidence?

Aliyeva, Ayten / Adrovic, Amra / Ocak, Süheyla / Batur, Şebnem / Yıldız, Mehmet / Haşlak, Fatih / Köker, Oya / Şahin, Sezgin / Barut, Kenan / Kasapçopur, Özgür

The Turkish journal of pediatrics

2022 Volume 64, Issue 2, Page(s) 394–399

Abstract: Background: Juvenile systemic sclerosis (JSS) is an extremely rarely seen auto-immune disease characterized by the increased fibrosis of skin and internal organs. Congenital pulmonary airway malformation (CPAM) is a developmental disorder of the lung, ... ...

Abstract	Background: Juvenile systemic sclerosis (JSS) is an extremely rarely seen auto-immune disease characterized by the increased fibrosis of skin and internal organs. Congenital pulmonary airway malformation (CPAM) is a developmental disorder of the lung, characterized by atypical cell hyperplasia which creates the ground for lung adenocarcinoma. In general, CPAM is diagnosed in early childhood, due to recurrent respiratory symptoms including cough, hemoptysis and respiratory infections. Although rare, there are some sporadic asymptomatic cases of CPAM that have been reported. We present a case with a coincidental presence of two rare diseases: JSS and CPAM. Case: An adolescent female patient was admitted to hospital due to clinical signs of JSS. During the followup, the patient had been diagnosed with cystic adenoid malformation of the lung complicated by mucinous adenocarcinoma. The patient was previously healthy with an unremarkable history, including lack of respiratory symptoms. Left inferior lobectomy was performed. Considering the small size of malignant loci, the total resection of the tumor and absence of any sign for metastasis disease, adjuvant therapy was not scheduled. We haven`t found a pediatric case of CPAM associated adenocarcinoma of the lung presented by signs of JSS in the literature. In this case, the clinical signs of JSS possibly represent part of the paraneoplastic syndrome related to adenocarcinoma of the lung. Conclusions: Internal organ involvement, including respiratory system, should not be omitted even in asymptomatic patients with JSS. Auto-antibody negativity represents a clue for the possible underlying condition. Further studies with a higher number of patients would reveal more relevant data.
MeSH term(s)	Adenocarcinoma/complications ; Adenocarcinoma, Mucinous/complications ; Adenocarcinoma, Mucinous/diagnosis ; Adenocarcinoma, Mucinous/pathology ; Adolescent ; Child ; Child, Preschool ; Cystic Adenomatoid Malformation of Lung, Congenital/complications ; Cystic Adenomatoid Malformation of Lung, Congenital/diagnosis ; Cystic Adenomatoid Malformation of Lung, Congenital/pathology ; Female ; Humans ; Lung/pathology ; Lung Neoplasms/complications ; Lung Neoplasms/diagnosis ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/etiology ; Scleroderma, Localized ; Scleroderma, Systemic/complications
Language	English
Publishing date	2022-05-21
Publishing country	Turkey
Document type	Case Reports
ZDB-ID	123487-0
ISSN	2791-6421 ; 0041-4301
ISSN (online)	2791-6421
ISSN	0041-4301
DOI	10.24953/turkjped.2020.2997
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pediatric Takayasu Arteritis: A Review of the Literature.

Haslak, Fatih / Yildiz, Mehmet / Sahin, Sezgin / Adrovic, Amra / Barut, Kenan / Kasapcopur, Ozgur

Current pediatric reviews

2022 Volume 18, Issue 4, Page(s) 243–250

Abstract: Takayasu arteritis (TA) is the third most common vasculitis of childhood and is extremely rare. It is mainly characterized by chronic, autoimmune, and granulomatous inflammation of the aorta and its major branches. Women under 40 years of age are mostly ... ...

Abstract	Takayasu arteritis (TA) is the third most common vasculitis of childhood and is extremely rare. It is mainly characterized by chronic, autoimmune, and granulomatous inflammation of the aorta and its major branches. Women under 40 years of age are mostly affected. It occurs for the first time in childhood in about 30% of affected individuals. Initially, it presents nonspecific constitutional findings. Since there is no specific laboratory finding, diagnosis is challenging. The gold standard imaging method for diagnosis is conventional angiography. Delay in diagnosis can cause devastating consequences. Therefore, in cases presenting with nonspecific findings, with hypertension and high acute phase reactants, the diagnosis should be suspected and confirmed with appropriate imaging method, and treatment should be started immediately. Immunosuppressive agents are the mainstay of the treatment. Biological agents are successful in refractory cases, and endovascular revascularization methods are used in the treatment of complications.
MeSH term(s)	Biological Factors ; Child ; Endovascular Procedures ; Female ; Humans ; Immunosuppressive Agents ; Takayasu Arteritis
Chemical Substances	Biological Factors ; Immunosuppressive Agents
Language	English
Publishing date	2022-03-04
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ISSN	1875-6336
ISSN (online)	1875-6336
DOI	10.2174/1573396318666220304205518
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Article: Non-Rheumatic Chronic Comorbidities in Children with Juvenile Idiopathic Arthritis.

Haşlak, Fatih / Guliyeva, Vafa / Hotaman, Büşra / Duman, Çisem / Yıldız, Mehmet / Günalp, Aybüke / Aslan, Esma / Kılıç Könte, Elif / Aliyeva, Ayten / Adrovic, Amra / Şahin, Sezgin / Barut, Kenan / Kasapçopur, Özgür

Turkish archives of pediatrics

2023 Volume 58, Issue 2, Page(s) 212–219

Abstract: Objective: Juvenile idiopathic arthritis is a heterogeneous group of disorders and is the most common rheumatic condition in childhood. There are scarce data regarding all comorbidities in juvenile idiopathic arthritis patients.: Materials and methods! ...

Abstract	Objective: Juvenile idiopathic arthritis is a heterogeneous group of disorders and is the most common rheumatic condition in childhood. There are scarce data regarding all comorbidities in juvenile idiopathic arthritis patients. Materials and methods: We aimed to identify the non-rheumatic comorbidities in our juvenile idiopathic arthritis patients. Data were obtained cross-sectionally from the medical records and the face-to-face interviews for 6 consecutive months. Those with more than 1 rheumatic disease were excluded, and conditions that were highly related to the disease, such as uveitis, were not taken into account. Results: The study included 459 patients with female dominance (62.1%, n = 285). The median age of the patients was 12.87 (1.53-20.95) years. One hundred fifty patients (32.7%) had at least 1 comorbidity (5 patients had 3 comorbidities, and 24 patients had 2 comorbidities). The most common 3 non-rheumatic accompanying medical conditions in our patients were allergic rhinitis (n = 37, 8.1%), attention-deficit hyperactivity disorder (n = 35, 7.6%), and atopic dermatitis (n = 28, 6.1%). None of our patients with systemic JIA had any autoimmune disease. All the patients with primary immune deficiencies had anti-nuclear antibody positivity. Conclusion: Almost one-third of our patients had at least one comorbidity. This finding might be very helpful to us in planning our multi-disciplinary approach to our patients.
Language	English
Publishing date	2023-03-01
Publishing country	Turkey
Document type	Journal Article
ISSN	2757-6256
ISSN	2757-6256
DOI	10.5152/TurkArchPediatr.2023.22303
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