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Article ; Online: Effect of prevalence of alcohol consumption and tobacco use in Mexican municipalities on early childhood development.

Prado-Galbarro, Francisco-Javier / Sanchez-Piedra, Carlos / Martínez-Núñez, Juan-Manuel

2023 Volume 39, Issue 12, Page(s) e00112422

Abstract: One of the most critical time periods in childhood is from birth to five years of age. Children exposed to alcohol and/or tobacco via family members and neighborhood are at risk for childhood developmental delays. This study evaluated the association of ... ...

Abstract	One of the most critical time periods in childhood is from birth to five years of age. Children exposed to alcohol and/or tobacco via family members and neighborhood are at risk for childhood developmental delays. This study evaluated the association of early childhood development with the prevalence of alcohol consumption and tobacco use in Mexican municipalities. This is a cross-sectional study. Early childhood development information from 2,345 children aged from 36 to 59 months was obtained from the 2015 Mexican National Survey of Boys, Girls, and Women (ENIM). Data on alcohol consumption and tobacco use come from the 2016 Mexican National Survey on Drugs, Alcohol, and Tobacco Consumption (ENCODAT). Multilevel logistic models were fitted to evaluate the association of the prevalence of alcohol consumption and tobacco use with the inadequacy of early childhood development. Children living in municipalities with high prevalence of alcohol consumption (OR = 13.410; 95%CI: 2.986; 60.240) and tobacco use (OR = 15.080; 95%CI: 2.040; 111.400) were less likely to be developmentally on track regarding early childhood development after adjustment for individual variables related to the child's development and other environmental variables at municipal level. Childhood exposure to alcohol and tobacco in the neighborhood may directly contribute to inadequate early childhood development. These findings suggest that there is an urgent need to develop effective interventions aimed at reducing alcohol consumption and tobacco use in municipalities to ensure adequate early childhood development.
MeSH term(s)	Male ; Child ; Humans ; Child, Preschool ; Female ; Cities ; Prevalence ; Cross-Sectional Studies ; Brazil ; Alcohol Drinking/epidemiology ; Tobacco Use/epidemiology ; Ethanol
Chemical Substances	Ethanol (3K9958V90M)
Language	English
Publishing date	2023-12-11
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311XEN112422
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Article ; Online: The reality of Rheumatology in Spain and its autonomous communities before the pandemic.

Sánchez-Piedra, Carlos / Álvaro-Gracia, José María / Bustabad-Reyes, Sagrario / Díaz-González, Federico

Reumatologia clinica

2022 Volume 18, Issue 8, Page(s) 486–489

Abstract: Objectives: To determine the number of rheumatologists per 100,000 inhabitants working in public or private centres in Spain as a whole, and by Autonomous Community and their distribution by age and sex.: Material and method: Cross-sectional study ... ...

Abstract	Objectives: To determine the number of rheumatologists per 100,000 inhabitants working in public or private centres in Spain as a whole, and by Autonomous Community and their distribution by age and sex. Material and method: Cross-sectional study based on the information contained in the database of the Spanish Society of Rheumatology. Quality control was performed by contact (e-mail and telephone call) with the heads of the clinical services of each of the hospitals (public and private). The information analysed was the age, sex and place of work of active rheumatologists in February 2020. The rates of rheumatologists per 100,000 inhabitants were calculated from population data from the National Institute of Statistics. Results: The rate of rheumatology specialists per 100,000 inhabitants in Spain was estimated at 2.17. The percentage of women was 59.7%, with a higher female/male ratio at younger ages. The lowest proportion of specialists per 100,000 inhabitants was in the community of Valencia (1.6), and the highest in Cantabria (3.2). Conclusions: Variations were found in the rate of rheumatologists per 100,000 inhabitants among the Autonomous Communities. The distribution by age and sex showed a tendency towards female rheumatologists, especially in the younger age strata.
MeSH term(s)	Cross-Sectional Studies ; Female ; Humans ; Male ; Pandemics ; Rheumatologists ; Rheumatology ; Spain/epidemiology
Language	English
Publishing date	2022-04-30
Publishing country	Spain
Document type	Case Reports
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reumae.2021.07.006
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Article ; Online: Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry.

Valero, Marta / Sánchez-Piedra, Carlos / Freire, Mercedes / Colazo, María / Busquets, Noemí / Meriño-Ibarra, Erardo / Rodríguez-Lozano, Carlos / Manrique, Sara / Campos, Cristina / Sánchez-Alonso, Fernando / Castrejón, Isabel

Arthritis research & therapy

2023 Volume 25, Issue 1, Page(s) 86

Abstract: Background: The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthritis in remission.: Methods: ... ...

Abstract	Background: The objectives of this study were to assess the discontinuation of biologic therapy in patients who achieve remission and identify predictors of discontinuation of biologics in patients with inflammatory arthritis in remission. Methods: An observational retrospective study from the BIOBADASER registry comprising adult patients diagnosed with rheumatoid arthritis (RA), ankylosing spondylitis (AS), or psoriatic arthritis (PsA) and receiving 1 or 2 biological disease-modifying drugs (bDMARDs) between October 1999 and April 2021. Patients were followed yearly after initiation of therapy or until discontinuation of treatment. Reasons for discontinuation were collected. Patients who discontinued bDMARDs because of remission as defined by the attending clinician were studied. Predictors of discontinuation were explored using multivariable regression models. Results: The study population comprised 3,366 patients taking 1 or 2 bDMARDs. Biologics were discontinued owing to remission by 80 patients (2.4%): 30 with RA (1.7%), 18 with AS (2.4%), and 32 with PsA (3.9%). The factors associated with a higher probability of discontinuation on remission were shorter disease duration (OR: 0.95; 95% CI: 0.91-0.99), no concomitant use of classic DMARDs (OR: 0.56; 95% CI: 0.34-0.92), and shorter usage of the previous bDMARD (before the decision to discontinue biological therapy) (OR: 1.01; 95% CI: 1.01-1.02); in contrast, smoking status (OR: 2.48; 95% CI: 1.21-5.08) was associated with a lower probability. In patients with RA, positive ACPA was associated with a lower probability of discontinuation (OR: 0.11; 95% CI: 0.02-0.53). Conclusions: Discontinuation of bDMARDs in patients who achieve remission is uncommon in routine clinical care. Smoking and positive ACPA in RA patients were associated with a lower probability of treatment discontinuation because of clinical remission.
MeSH term(s)	Adult ; Humans ; Biological Products/therapeutic use ; Retrospective Studies ; Arthritis, Psoriatic/drug therapy ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/diagnosis ; Biological Factors/therapeutic use ; Spondylitis, Ankylosing/drug therapy ; Registries ; Treatment Outcome
Chemical Substances	Biological Products ; Antirheumatic Agents ; Biological Factors
Language	English
Publishing date	2023-05-22
Publishing country	England
Document type	Observational Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-023-03045-3
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Article ; Online: Impact of environmental and individual factors on COVID-19 mortality in children and adolescents in Mexico: An observational study.

Sanchez-Piedra, Carlos / Gamiño-Arroyo, Ana-Estela / Cruz-Cruz, Copytzy / Prado-Galbarro, Francisco-Javier

Lancet Regional Health. Americas

2022 Volume 8, Page(s) 100184

Abstract: Background: During the Covid-19 pandemic, children and adolescents faced poverty, potentially dying from preventable causes, or missing out essential vaccines. The aim of this study was to assess potential environmental and individual factors associated ...

Abstract	Background: During the Covid-19 pandemic, children and adolescents faced poverty, potentially dying from preventable causes, or missing out essential vaccines. The aim of this study was to assess potential environmental and individual factors associated to COVID-19 mortality in children and adolescents in Mexico. Methods: This cross-sectional study analysed the official data of 131,001 children under 10 years of age and adolescents between 10 and 19 years of age with COVID-19 disease, in Mexico. Participants were diagnosticated between March 2020 and June 13, 2021. The environmental variables such as malnutrition, vaccination coverage and social lag index were evaluated at the state level. Multilevel models were fitted to evaluate the association between environmental and individual factors and COVID-19 mortality. Findings: A total of 773 (0.6%) children and adolescents died due to COVID-19. Younger age (OR = 0.878, 95%CI: 0.869-0.888), diabetes (OR = 3.898, 95%CI: 2.596-5.851), immunosuppression (OR = 5.410, 95%CI: 4.088-7.158), obesity (OR = 1.876, 95%CI: 1.397-2.521), hypertension (OR = 1.906, 95%CI: 1.239-2.932), cardiovascular disease (OR = 2.288, 95%CI: 1.482-3.531), and chronic kidney disease (OR = 13.250, 95%CI: 9.066-19.350) were associated with mortality. COVID-19 mortality was directly associated with social lag index and malnutrition (OR Interpretation: Malnutrition, social lag index and population density are key factors to understand COVID-19 mortality in children and adolescents. Also, age and pre-existing comorbidities were also associated with worse COVID-19 prognosis. Funding: No funding was secured for this study.
Language	English
Publishing date	2022-01-20
Publishing country	England
Document type	Journal Article
ISSN	2667-193X
ISSN (online)	2667-193X
DOI	10.1016/j.lana.2022.100184
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Article ; Online: Safety and effectiveness of bDMARDs during pregnancy in patients with rheumatic diseases: Real-world data from the BIOBADASER registry.

Membrive-Jiménez, Cristina / Sánchez-Piedra, Carlos / Martínez-González, Olga / García-González, Javier / Expósito-Pérez, Lorena / Bohórquez-Heras, Cristina / Campos-Fernández, Cristina / Sanchez-Alonso, Fernando / Cáliz-Cáliz, Rafael / Castrejón-Fernández, Isabel

Reumatologia clinica

2023 Volume 19, Issue 9, Page(s) 500–506

Abstract: Introduction: Inflammatory rheumatic diseases usually affect women of childbearing age treated with biologic drugs. However, there is a lack of literature on the efficacy and toxicity of biologic disease-modifying drugs during pregnancy. The aim of this ...

Abstract	Introduction: Inflammatory rheumatic diseases usually affect women of childbearing age treated with biologic drugs. However, there is a lack of literature on the efficacy and toxicity of biologic disease-modifying drugs during pregnancy. The aim of this study was to determine the presence of pregnant patients treated with bDMARDs in a real-world dataset and to examine the impact of pregnancy and lactation on the evolution of rheumatic disease in a registry of Spanish patients. Method: This was a multicentre prospective study with a real-world setting. Information was obtained from BIOBADASER registry. Patients included are women who got pregnant until November 2020 from 19 rheumatology units. We conducted proportions, means, and standard deviations (SD) to describe the study population and the use of treatments. T-test and Chi-square test were applied to assess differences between groups. Result: Ninety cases of pregnancy were registered (n=68 full-term pregnancies; n=22 spontaneous miscarriages). Most of the cases discontinued bDMARDs during pregnancy (78.9%) but 13 cases continued treatment during pregnancy, mainly using certolizumab pegol. These cases were obtaining better management of rheumatic disease, although the differences were not statistically significant [DAS28-CRP, 2.9 (SD: 1.6) vs. 2.0 (1.2), p=.255; DAS28-ESR, 2.2 (1.0) vs. 1.7 (.5), p=.266]. No serious adverse events were reported during pregnancy and lactation. Conclusion: Being pregnant is still an uncommon condition in patients with rheumatic diseases and using bDMARDs. Our results show that rheumatic disease tended to progress better during pregnancy in patients who continued to take bDMARDs.
MeSH term(s)	Pregnancy ; Humans ; Female ; Male ; Prospective Studies ; Rheumatic Diseases/drug therapy ; Registries ; Rheumatology ; Biological Products
Chemical Substances	Biological Products
Language	English
Publishing date	2023-11-07
Publishing country	Spain
Document type	Journal Article
ISSN	2173-5743
ISSN (online)	2173-5743
DOI	10.1016/j.reumae.2023.02.005
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Article ; Online: Effect of prevalence of alcohol consumption and tobacco use in Mexican municipalities on early childhood development

Francisco-Javier Prado-Galbarro / Carlos Sanchez-Piedra / Juan-Manuel Martínez-Núñez

Cadernos de Saúde Pública, Vol 39, Iss

2023 Volume 12

Abstract: Abstract: One of the most critical time periods in childhood is from birth to five years of age. Children exposed to alcohol and/or tobacco via family members and neighborhood are at risk for childhood developmental delays. This study evaluated the ... ...

Abstract	Abstract: One of the most critical time periods in childhood is from birth to five years of age. Children exposed to alcohol and/or tobacco via family members and neighborhood are at risk for childhood developmental delays. This study evaluated the association of early childhood development with the prevalence of alcohol consumption and tobacco use in Mexican municipalities. This is a cross-sectional study. Early childhood development information from 2,345 children aged from 36 to 59 months was obtained from the 2015 Mexican National Survey of Boys, Girls, and Women (ENIM). Data on alcohol consumption and tobacco use come from the 2016 Mexican National Survey on Drugs, Alcohol, and Tobacco Consumption (ENCODAT). Multilevel logistic models were fitted to evaluate the association of the prevalence of alcohol consumption and tobacco use with the inadequacy of early childhood development. Children living in municipalities with high prevalence of alcohol consumption (OR = 13.410; 95%CI: 2.986; 60.240) and tobacco use (OR = 15.080; 95%CI: 2.040; 111.400) were less likely to be developmentally on track regarding early childhood development after adjustment for individual variables related to the child’s development and other environmental variables at municipal level. Childhood exposure to alcohol and tobacco in the neighborhood may directly contribute to inadequate early childhood development. These findings suggest that there is an urgent need to develop effective interventions aimed at reducing alcohol consumption and tobacco use in municipalities to ensure adequate early childhood development.
Keywords	Child Development ; Child Welfare ; Alcohol Consumption ; Tobacco Use ; Neighborhood ; Medicine ; R ; Public aspects of medicine ; RA1-1270
Subject code	310
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Escola Nacional de Saúde Pública, Fundação Oswaldo Cruz
Document type	Article ; Online
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Article ; Online: Associated factors to non-medical and medical use of psychoactive medication among Mexican adolescents and adults in a national household survey.

Cruz-Cruz, Copytzy / Bustos-Gamiño, Marycarmen / Villatoro-Velázquez, Jorge / Henson, Rosie Mae / Prado-Galbarro, Francisco-Javier / Sanchez-Piedra, Carlos / López-Pérez, Lorena / Gutiérrez-López, María de Lourdes / Amador-Buenabad, Nancy / Astudillo-García, Claudia Iveth

Journal of the American Pharmacists Association : JAPhA

2024 , Page(s) 102056

Abstract: Background: Non-medical use of psychoactive medication is a public health problem. Studies in other contexts indicate that individual sociodemographic characteristics are associated with non-medical use, but these associations have not been assessed in ... ...

Abstract	Background: Non-medical use of psychoactive medication is a public health problem. Studies in other contexts indicate that individual sociodemographic characteristics are associated with non-medical use, but these associations have not been assessed in the Mexican context. Objectives: To estimate the prevalence non-medical and medical use of psychoactive medication among Mexican adolescents and adults' medication users and to estimate the associations between sociodemographic characteristics and non-medical use of psychoactive medication, using data from a nationally representative sample. Methods: Secondary analysis of data collected from the National Survey of Drug, Alcohol, and Tobacco Consumption (ENCODAT) 2016 to 2017. The analytical sample included people aged 12 to 65 years. The sample was stratified into two age categories: adolescents (12-17 years) and adults (18-65 years). Sub-analyses were performed to describe prevalence of use and non-medical use of psychoactive medication at the state-level. Descriptive statistics and multinomial logistic regression models were used to estimate associations between sociodemographic characteristics and medical, non-medical, and non-use of psychoactive medication in adolescents and adults. Results: Among Mexican medication users in 2016, the national prevalence of non-medical use of psychoactive drugs was 19.6%; 22.2% among adolescents and 19.4% among adults. States adjacent to the US-Mexico border reported the highest levels of non-medical use of psychoactive medication. Illicit drug consumption was associated with non-medical use. Sociodemographic characteristics associated with non-medical use varied between adolescents and adults. Conclusions: There is a high proportion of non-medical use of psychoactive drugs among Mexican medication users, especially among young people. Understanding factors associated with the misuse of psychoactive medications in Mexico can inform policy for prevention and treatment.
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2118585-2
ISSN	1544-3450 ; 1544-3191 ; 1086-5802
ISSN (online)	1544-3450
ISSN	1544-3191 ; 1086-5802
DOI	10.1016/j.japh.2024.102056
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Article ; Online: Correction: Factors associated with discontinuation of biologics in patients with inflammatory arthritis in remission: data from the BIOBADASER registry.

Valero, Marta / Sanchez-Piedra, Carlos / Freire, Mercedes / Colazo, Maria / Busquets, Noemi / Merino-Ibarra, Erardo / Rodriguez-Lozano, Carlos / Manrique, Sara / Campos, Cristina / Sanchez-Alonso, Fernando / Castrejon, Isabel

Arthritis research & therapy

2023 Volume 25, Issue 1, Page(s) 210

Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Published Erratum
ZDB-ID	2107602-9
ISSN	1478-6362 ; 1478-6354
ISSN (online)	1478-6362
ISSN	1478-6354
DOI	10.1186/s13075-023-03194-5
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Zs.A 5490: Show issues

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Article ; Online: Prevalence of gout in the adult general population in Spain: Estimating the proportion of undiagnosed cases.

Quilis, Neus / Sivera, Francisca / Seoane-Mato, Daniel / Pérez-Ruiz, Fernando / Sánchez-Piedra, Carlos / Díaz-González, Federico / Bustabad-Reyes, Sagrario

Joint bone spine

2021 Volume 89, Issue 1, Page(s) 105257

Abstract: Objective: To estimate the prevalence of gout in Spain.: Methods: Cross-sectional, population-based study of people aged 20 years or older. First, randomly selected individuals were contacted by telephone and rheumatic disease screening ... ...

Abstract	Objective: To estimate the prevalence of gout in Spain. Methods: Cross-sectional, population-based study of people aged 20 years or older. First, randomly selected individuals were contacted by telephone and rheumatic disease screening questionnaires were conducted. If the first screening was positive, medical records were then reviewed and/or a phone questionnaire was conducted by a rheumatologist, followed by an appointment if necessary. Newly diagnosed cases had to fulfil the ACR/EULAR 2015 criteria. To calculate the prevalence and its 95% CI, the sample design was taken into account and weighing was calculated according to age, sex and geographic origin. Results: In all, 4916 individuals were included, 1361 had a positive screening result for gout (59 of them reported a prior diagnosis). Of these, 51 were classified as missing and 95 were classified as gout cases. An additional case was detected through a positive screening for fibromyalgia and Sjögren's syndrome, although a previous gout diagnosis was confirmed by a review of the medical records. Of the 96 gout cases, 31 (32%) were de novo diagnoses. The estimated weighted prevalence of gout was 2.4% (95% CI 1.95-2.95), with a higher prevalence in men (4.55% [95%CI 3.65-5.65]) than women (0.38% [95%CI 0.19-0.76]). Conclusion: EPISER2016 is the first population-based study to estimate the prevalence of gout in Spain. Undiagnosed patients accounted for a substantial proportion of cases, highlighting the need for population-approaches when estimating the prevalence of infra-diagnosed diseases. Reliable national approaches are key to obtaining accurate estimates of diseases to better aid healthcare and workforce planning.
MeSH term(s)	Adult ; Cross-Sectional Studies ; Female ; Gout/diagnosis ; Gout/epidemiology ; Humans ; Male ; Prevalence ; Rheumatologists ; Spain/epidemiology ; Young Adult
Language	English
Publishing date	2021-07-26
Publishing country	France
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/j.jbspin.2021.105257
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Article: Effects of air pollution and climatology on COVID-19 mortality in Spain.

Sanchez-Piedra, Carlos / Cruz-Cruz, Copytzy / Gamiño-Arroyo, Ana-Estela / Prado-Galbarro, Francisco-Javier

Air quality, atmosphere, & health

2021 Volume 14, Issue 11, Page(s) 1869–1875

Abstract: The health, economic, and social impact of COVID-19 has been significant across the world. Our objective was to evaluate the association between air pollution (through NO: Supplementary information: The online version contains supplementary material ... ...

Abstract	The health, economic, and social impact of COVID-19 has been significant across the world. Our objective was to evaluate the association between air pollution (through NO Supplementary information: The online version contains supplementary material available at 10.1007/s11869-021-01062-2.
Language	English
Publishing date	2021-07-26
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2424084-9
ISSN	1873-9326 ; 1873-9318
ISSN (online)	1873-9326
ISSN	1873-9318
DOI	10.1007/s11869-021-01062-2
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