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Article ; Online: Local protection bubbles: an interpretation of the slowdown in the spread of coronavirus in the city of São Paulo, Brazil, in July 2020.

Pinto, Jose Paulo Guedes / Magalhães, Patrícia Camargo / Figueiredo, Gerusa Maria / Alves, Domingos / Angel, Diana Maritza Segura

Cadernos de saude publica

2023 Volume 39, Issue 11, Page(s) e00109522

Abstract: After four months of fighting the pandemic, the city of São Paulo, Brazil, entered a phase ... the pandemic dynamics in the city of São Paulo, we developed a multi-agent simulation model. Surprisingly ... socioeconomic development, as well as the infrastructure of the city of São Paulo. ...

Abstract	After four months of fighting the pandemic, the city of São Paulo, Brazil, entered a phase of relaxed social distancing measures in July 2020. Simultaneously, there was a decline in the social distancing rate and a reduction in the number of cases, fatalities, and hospital bed occupancy. To understand the pandemic dynamics in the city of São Paulo, we developed a multi-agent simulation model. Surprisingly, the counter-intuitive results of the model followed the city's reality. We argue that this phenomenon could be attributed to local bubbles of protection that emerged in the absence of contagion networks. These bubbles reduced the transmission rate of the virus, causing short and temporary reductions in the epidemic curve - but manifested as an unstable equilibrium. Our hypothesis aligns with the virus spread dynamics observed thus far, without the need for ad hoc assumptions regarding the natural thresholds of collective immunity or the heterogeneity of the population's transmission rate, which may lead to erroneous predictions. Our model was designed to be user-friendly and does not require any scientific or programming expertise to generate outcomes on virus transmission in a given location. Furthermore, as an input to start our simulation model, we developed the COVID-19 Protection Index as an alternative to the Human Development Index, which measures a given territory vulnerability to the coronavirus and includes characteristics of the health system and socioeconomic development, as well as the infrastructure of the city of São Paulo.
MeSH term(s)	Humans ; Brazil/epidemiology ; Cities/epidemiology ; COVID-19
Language	English
Publishing date	2023-12-15
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1115730-6
ISSN	1678-4464 ; 0102-311X
ISSN (online)	1678-4464
ISSN	0102-311X
DOI	10.1590/0102-311XEN109522
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Article ; Online: Association between the Consumption of Ultra-Processed Foods and Asthma in Adults from Ribeirão Preto, São Paulo, Brazil.

Serra, Hellen Cristina Oliveira Amorim / Rudakoff, Lívia Carolina Sobrinho / Muniz, Alessandra Karla Oliveira Amorim / Magalhães, Elma Izze da Silva / Bragança, Maylla Luanna Barbosa Martins / Silva, Antônio Augusto Moura da / Vianna, Elcio Dos Santos Oliveira / Bettiol, Heloisa / Barbieri, Marco Antonio

Nutrients

2023 Volume 15, Issue 14

Abstract: Background: Ultra-processed Food (UPF) consumption can play a role in the pathogenesis and progression of asthma. The aim of this study was to evaluate the association between the consumption of UPF and asthma.: Methods: This cross-sectional study ... ...

Abstract	Background: Ultra-processed Food (UPF) consumption can play a role in the pathogenesis and progression of asthma. The aim of this study was to evaluate the association between the consumption of UPF and asthma. Methods: This cross-sectional study included 1857 adults aged 23-25 years from the Ribeirão Preto-SP birth cohort (1978/1979). The exposure variable was the consumption of UPF (expressed as their percentage contribution to energy intake-% total caloric value [%TCV] and their percentage contribution to the amount of food ingested-%grams), which was assessed with a food frequency questionnaire. Asthma was the outcome and was defined based on a positive methacholine challenge test and the presence of wheezing, chest tightness, or shortness of breath over the last 12 months. Poisson regression with robust variance was used to estimate the association between these variables. Unadjusted analyses and analyses adjusted for sex, age, household income, smoking, and physical activity level were performed. Results: The prevalence of asthma in the sample was 13.2%. The mean total consumption of UPF was 37.9 ± 11.2% TCV (corresponding to 35.1 ± 15.1% grams). There was no association between the consumption of UPF and asthma in adults. Conclusion: This study provides no evidence for an association between the consumption of UPF and asthma in young adults.
MeSH term(s)	Young Adult ; Humans ; Food, Processed ; Diet ; Fast Foods/adverse effects ; Brazil/epidemiology ; Cross-Sectional Studies ; Energy Intake ; Food Handling ; Asthma/epidemiology ; Asthma/etiology
Language	English
Publishing date	2023-07-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu15143165
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Article ; Online: Congenital heart diseases trends in São Paulo State, Brazil: a national live birth data bank analysis.

Fernandes, Paola Soares / Magalhães, Larissa Rosario / Pezzini, Tainara Rita / de Sousa Santos, Edige Felipe / Calderon, Mauricio Giusti

World journal of pediatrics : WJP

2022 Volume 18, Issue 7, Page(s) 472–481

Abstract: ... millions of newborns every year; no prevalence data are available in São Paulo State, Brazil's most ... populous state. The objective is to identify trends in prevalence and risk factors for CHD in São Paulo ... by cesarean section. São Paulo State presented an increasing CHD trend of prevalence (APC = 18.9%). The highest CHD ...

Abstract	Background: Congenital heart diseases (CHD) are the most common type of birth defects, affecting millions of newborns every year; no prevalence data are available in São Paulo State, Brazil's most populous state. The objective is to identify trends in prevalence and risk factors for CHD in São Paulo State, Brazil. Methods: We developed a population-based study to estimate the CHD trend of prevalence in recent years, stratified by maternal age and geographical clusters, using all cases of CHD identified by the Live Births Information System (SINASC-Sistema de Informação Sobre Nascidos Vivos) from January 1, 2005, to December 31, 2018. We calculated the trends of prevalence, the regression coefficient (β), the annual percent change (APC), and 95% confidence interval using the Prais-Winsten regression model, with the Durbin-Watson test. Results: We found 10,594 cases of CHD among 8,536,101 live births (LB), a prevalence of 12.4/10,000 LB. There was no difference in the sex distribution; they are primarily Caucasian (60.2%), 75.2% born at term, and 74.4% weight > 2500 g, 66.9% of births were by cesarean section. São Paulo State presented an increasing CHD trend of prevalence (APC = 18.9%). The highest CHD prevalence rate was in mothers aged ≥ 35 years (22.2/10,000 LB). There were 12,271 specific congenital heart defects among 10,594 patients (1.16 CHD/patient). Atrial septal defect has the highest number of cases (3835), with a prevalence of 4.49/10,000 LB, corresponding to 31.3% of all CHD. Conclusion: CHD had an increasing prevalence trend in recent years, being highest in São Paulo City and ≥ 35-year mothers.
MeSH term(s)	Brazil/epidemiology ; Cesarean Section ; Female ; Heart Defects, Congenital/epidemiology ; Humans ; Infant, Newborn ; Live Birth/epidemiology ; Maternal Age ; Pregnancy ; Prevalence
Language	English
Publishing date	2022-03-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2236681-7
ISSN	1867-0687 ; 1708-8569
ISSN (online)	1867-0687
ISSN	1708-8569
DOI	10.1007/s12519-022-00543-3
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Article ; Online: São Paulo State Liver Transplantation Supply Chain Study.

de Oliveira Mota, Daniel / Monteleone, João Paulo / Erbs Pessoa, João Luis / Magalhães Girardin Pimentel, Carolina Frade

Transplantation proceedings

2020 Volume 52, Issue 5, Page(s) 1247–1250

Abstract: Background: The number of liver transplantations is increasing worldwide, and Brazil ranks in the second position. It has one of the biggest public health care systems, which is responsible for the coordination and financial funding of transplantation ... ...

Abstract	Background: The number of liver transplantations is increasing worldwide, and Brazil ranks in the second position. It has one of the biggest public health care systems, which is responsible for the coordination and financial funding of transplantation procedures. Meeting the demands of such a large system of transplantation has become a challenge, particularly when attempting to minimize costs of scarce and expensive resources. The aim of this study was to investigate the process of donation, the retrieval of organs, and the transplantation itself using engineering methods based on logistics analyses. Methods: Three steps were used: study planning, data gathering, and data analysis. Researchers surveyed professionals to acquire raw information based on their observations, experience, and knowledge. Then, a data analysis was conducted, putting together all the information gathered during the previous steps. Bias was removed, and conflicting perceptions were resolved in order to have a standard view on the transplantation process. Results: Data was gathered between 2014 and 2018 and included 5502 liver donors and 2678 (48.7%) patients who received liver transplants organs. A total of 2824 organs were refused because of logistics issues (transport and handling). Interviews of health care professionals enabled the design of a process map in which 4 stakeholders were identified: patient, physician, organ, and information. Conclusions: The liver transplantation process is analyzed based on a supply chain methodology applying this knowledge and putting together medical and engineering sciences to promote better efficiency and outcomes for the transplantation program. Future studies should focus on the implementation of these ideas aiming to promote optimization gains in any step of the process.
MeSH term(s)	Brazil ; End Stage Liver Disease/surgery ; Humans ; Liver Transplantation/economics ; Models, Organizational ; Outcome and Process Assessment, Health Care ; Postoperative Period ; Tissue and Organ Procurement/economics ; Tissue and Organ Procurement/organization & administration ; Transplants/supply & distribution ; Waiting Lists
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	82046-5
ISSN	1873-2623 ; 0041-1345
ISSN (online)	1873-2623
ISSN	0041-1345
DOI	10.1016/j.transproceed.2020.02.181
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Article ; Online: Whole-genome sequencing of 1,171 elderly admixed individuals from São Paulo, Brazil.

Naslavsky, Michel S / Scliar, Marilia O / Yamamoto, Guilherme L / Wang, Jaqueline Yu Ting / Zverinova, Stepanka / Karp, Tatiana / Nunes, Kelly / Ceroni, José Ricardo Magliocco / de Carvalho, Diego Lima / da Silva Simões, Carlos Eduardo / Bozoklian, Daniel / Nonaka, Ricardo / Dos Santos Brito Silva, Nayane / da Silva Souza, Andreia / de Souza Andrade, Heloísa / Passos, Marília Rodrigues Silva / Castro, Camila Ferreira Bannwart / Mendes-Junior, Celso T / Mercuri, Rafael L V /

Nature communications

2022 Volume 13, Issue 1, Page(s) 1004

Abstract: As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset of 1,171 highly ...

Abstract	As whole-genome sequencing (WGS) becomes the gold standard tool for studying population genomics and medical applications, data on diverse non-European and admixed individuals are still scarce. Here, we present a high-coverage WGS dataset of 1,171 highly admixed elderly Brazilians from a census-based cohort, providing over 76 million variants, of which ~2 million are absent from large public databases. WGS enables identification of ~2,000 previously undescribed mobile element insertions without previous description, nearly 5 Mb of genomic segments absent from the human genome reference, and over 140 alleles from HLA genes absent from public resources. We reclassify and curate pathogenicity assertions for nearly four hundred variants in genes associated with dominantly-inherited Mendelian disorders and calculate the incidence for selected recessive disorders, demonstrating the clinical usefulness of the present study. Finally, we observe that whole-genome and HLA imputation could be significantly improved compared to available datasets since rare variation represents the largest proportion of input from WGS. These results demonstrate that even smaller sample sizes of underrepresented populations bring relevant data for genomic studies, especially when exploring analyses allowed only by WGS.
MeSH term(s)	Aged ; Brazil/epidemiology ; Genome, Human/genetics ; Genomics/methods ; Humans ; Metagenomics ; Polymorphism, Single Nucleotide ; Whole Genome Sequencing
Language	English
Publishing date	2022-03-04
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-022-28648-3
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Article ; Online: Occurrence of Pheidole tijucana Borgmeier, 1927 (Hymenoptera, Formicidae) in the state of São Paulo, Brazil

Gonçalves, Débora Cristina de Oliveira / Pires do Prado, Lívia / Severo Magalhães, Fabrício / Abonizio-Santos, Marlina Ribeiro / Morini, Maria Santina de Castro

Check List. 2023 Mar. 14, v. 19, no. 2 p.169-175

2023

Abstract: ... Borgmeier, 1927 from the state of São Paulo, Brazil. The specimens were recorded at Parque Ibirapuera ... Conservação, an urban green area located in the southern part of the city of São Paulo. The sampling was ...

Abstract	Pheidole Westwood, 1839 is a hyperdiverse ant genus that is widely distributed in a variety of terrestrial ecosystems, especially in the tropics. The identification of Pheidole species is challenging, thus contributing to the description of several questionable morphospecies in the literature and making the geographic distribution of most species uncertain. In this work, we present the first records of Pheidole tijucana Borgmeier, 1927 from the state of São Paulo, Brazil. The specimens were recorded at Parque Ibirapuera Conservação, an urban green area located in the southern part of the city of São Paulo. The sampling was performed in 2015, 2016, and 2017 using pitfall traps. In total, 224 specimens (one major worker and 223 minor workers) of P. tijucana were recorded. Our new data help fill a distribution gap and highlights the importance of reporting species that are a challenge to identify.
Keywords	Pheidole ; geographical distribution ; green infrastructure ; morphospecies ; Brazil
Language	English
Dates of publication	2023-0314
Size	p. 169-175.
Publishing place	Pensoft Publishers
Document type	Article ; Online
ZDB-ID	2252867-2
ISSN	1809-127X
ISSN	1809-127X
DOI	10.15560/19.2.169
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Occurrence of Pheidole tijucana Borgmeier, 1927 (Hymenoptera, Formicidae) in the state of São Paulo, Brazil

Débora Cristina de Oliveira Gonçalves / Lívia Pires do Prado / Fabrício Severo Magalhães / Marlina Ribeiro Abonizio-Santos / Maria Santina de Castro Morini

Check List, Vol 19, Iss 2, Pp 169-

2023 Volume 175

Abstract	Pheidole Westwood, 1839 is a hyperdiverse ant genus that is widely distributed in a variety of terrestrial ecosystems, especially in the tropics. The identification of Pheidole species is challenging, thus contributing to the description of several questionable morphospecies in the literature and making the geographic distribution of most species uncertain. In this work, we present the first records of Pheidole tijucana Borgmeier, 1927 from the state of São Paulo, Brazil. The specimens were recorded at Parque Ibirapuera Conservação, an urban green area located in the southern part of the city of São Paulo. The sampling was performed in 2015, 2016, and 2017 using pitfall traps. In total, 224 specimens (one major worker and 223 minor workers) of P. tijucana were recorded. Our new data help fill a distribution gap and highlights the importance of reporting species that are a challenge to identify.
Keywords	Atlantic Forest ; biodiversity ; Myrmicinae ; urban g ; Biology (General) ; QH301-705.5
Subject code	590
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Pensoft Publishers
Document type	Article ; Online
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Article ; Online: Prediction of Cyanotoxin Episodes in Freshwater: A Case Study on Microcystin and Saxitoxin in the Lobo Reservoir, São Paulo State, Brazil

Moraes, Munique de Almeida Bispo / Rodrigues, Raphaella de Abreu Magalhães / Podduturi, Raju / Jørgensen, Niels Ole Gerslev / Calijuri, Maria do Carmo

Environments. 2023 Aug. 13, v. 10, no. 8

2023

Abstract: ... of potential microcystin (MC) and saxitoxin (STX)-producing cyanobacteria in the Lobo reservoir, São Paulo ...

Abstract	Freshwater reservoirs constitute an important source of drinking water, but eutrophication and higher temperatures increase the risk of more frequent blooms of cyanobacteria, including species that produce toxins. To improve the prediction of cyanotoxin episodes, we studied the annual occurrence of potential microcystin (MC) and saxitoxin (STX)-producing cyanobacteria in the Lobo reservoir, São Paulo State, Brazil. Relationships among environmental variables, cyanobacterial biomass, numbers of the mcyE and sxtA genotypes (genes encoding production of MC and STX, respectively), and concentrations of MC and STX were determined to address variables applicable for monitoring and predicting the dynamics of cyanobacteria and cyanotoxins in the reservoir. Microscopy confirmed the presence of potentially toxin-producing cyanobacteria at all sampling times, and qPCR detection showed the occurrence of both mcyE and sxtA in most samples. Concentrations of MC and STX were generally low (MC 0–1.54 µg L⁻¹; STX 0.03–0.21 µg L⁻¹). The highest MC level exceeded the recommended limit for human intake of 1 µg L⁻¹. The abundance of the mcyE and sxtA genes, as well as the toxin concentrations, were positively correlated with the biomass of Phormidium and Raphidiopsis. Among environmental variables, the abundance of potential toxic cyanobacteria was mainly affected by P limitation (high TN:TP ratios). Our data show that detection of the mcyE and sxtA genotypes serves as a useful and reliable predictor of toxin episodes but might be combined with chemical toxin detection to form an environmental toolbox for cyanotoxin monitoring.
Keywords	Phormidium ; Raphidiopsis ; biomass ; case studies ; eutrophication ; freshwater ; humans ; microcystins ; microscopy ; prediction ; risk ; saxitoxins ; toxicity ; Brazil
Language	English
Dates of publication	2023-0813
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2777960-9
ISSN	2076-3298
ISSN	2076-3298
DOI	10.3390/environments10080143
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Colonization of Panstrongylus megistus (Hemiptera:Reduvidae:Triatominae) in an urban area and its association with Didelphis marsupialis in the metropolitan region of São Paulo.

Silva, Rubens Antonio da / Zaicaner, Raquel / Rosa, Mariangela Palma / Aun, Graciela Cristina Granizo / Muniz, Júlio César / Magalhães, Alon Carlos / Pereira, Creusa / Pena, Amanda Rosa / Santos, Maysa Flexa Dos / Estevão, Vera Aparecida Oliveira / Duarte, Agnaldo Nepomuceno

Revista da Sociedade Brasileira de Medicina Tropical

2021 Volume 54, Page(s) e04712020

Abstract: ... in an urban area of the municipality of Taboão da Serra in the metropolitan region of São Paulo.: Methods: After ...

Abstract	Introduction: This communication reports the colonization of Panstrongylus megistus in an urban area of the municipality of Taboão da Serra in the metropolitan region of São Paulo. Methods: After receiving a notification from the population, entomological research comprising active search, collection, identification, and examination of triatomines was conducted. Wild animals were captured and examined. Results: A colony of triatomines was found to be associated with dogs in the backyard of the property. Conclusions: The colonization of P. megistus shows the potential for their occupation of artificial ecotopes, which may pose a risk to the human population.
MeSH term(s)	Animals ; Brazil ; Chagas Disease/veterinary ; Cities ; Didelphis ; Dogs ; Insect Vectors ; Panstrongylus ; Triatominae
Language	English
Publishing date	2021-02-26
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	1038126-0
ISSN	1678-9849 ; 0037-8682
ISSN (online)	1678-9849
ISSN	0037-8682
DOI	10.1590/0037-8682-0471-2020
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Article ; Online: Simultaneous determination of HCV genotype and NS5B resistance associated substitutions using dried serum spots from São Paulo state, Brazil.

Adeboyejo, Kazeem / Grosche, Victória Riquena / José, Diego Pandeló / Ferreira, Giulia Magalhães / Shimizu, Jacqueline Farinha / King, Barnabas J / Tarr, Alexander W / Soares, Márcia Maria Costa Nunes / Ball, Jonathan K / McClure, C Patrick / Jardim, Ana Carolina Gomes

Access microbiology

2022 Volume 4, Issue 3, Page(s) 326

Abstract: ... of genotypic analysis of HCV from DSS in a cohort of 80 patients from São Paulo state Brazil. HCV RNA was ...

Abstract	Hepatitis C virus (HCV) is responsible for more than 180 million infections worldwide, and about 80 % of infections are reported in Low and Middle-income countries (LMICs). Therapy is based on the administration of interferon (INF), ribavirin (RBV) or more recently Direct-Acting Antivirals (DAAs). However, amino acid substitutions associated with resistance (RAS) have been extensively described and can contribute to treatment failure, and diagnosis of RAS requires considerable infrastructure, not always locally available. Dried serum spots (DSS) sampling is an alternative specimen collection method, which embeds drops of serum onto filter paper to be transported by posting to a centralized laboratory. Here, we assessed feasibility of genotypic analysis of HCV from DSS in a cohort of 80 patients from São Paulo state Brazil. HCV RNA was detected on DSS specimens in 83 % of samples of HCV infected patients. HCV genotypes 1a, 1b, 2a, 2c and 3a were determined using the sequence of the palm domain of NS5B region, and RAS C316N/Y, Q309R and V321I were identified in HCV 1b samples. Concerning therapy outcome, 75 % of the patients who used INF +RBV as a previous protocol of treatment did not respond to DAAs, and 25 % were end-of-treatment responders. It suggests that therapy with INF plus RBV may contribute for non-response to a second therapeutic protocol with DAAs. One patient that presented RAS (V321I) was classified as non-responder, and combination of RAS C316N and Q309R does not necessarily imply in resistance to treatment in this cohort of patients. Data presented herein highlights the relevance of studying circulating variants for a better understanding of HCV variability and resistance to the therapy. Furthermore, the feasibility of carrying out genotyping and RAS phenotyping analysis by using DSS card for the potential of informing future treatment interventions could be relevant to overcome the limitations of processing samples in several location worldwide, especially in LMICs.
Language	English
Publishing date	2022-03-02
Publishing country	England
Document type	Journal Article
ISSN	2516-8290
ISSN (online)	2516-8290
DOI	10.1099/acmi.0.000326
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