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  1. Article ; Online: Subsidence Performance of the Bioactive Glass-Ceramic (CaO-SiO

    Jo, Myoung Lae / Son, Dong Min / Shin, Dong Ah / Moon, Bong Ju / Kim, Baek Hyun / Kim, Kyung Hyun

    World neurosurgery

    2023  Volume 180, Page(s) e1–e10

    Abstract: Objective: The objective of this study is to evaluate the subsidence performance of a bioactive glass-ceramic (CaO-SiO: Methods: Three spacer three-dimensional models (Polyether ether ketone [PEEK]-C: PEEK spacer with a small contact area; PEEK-NF: ... ...

    Abstract Objective: The objective of this study is to evaluate the subsidence performance of a bioactive glass-ceramic (CaO-SiO
    Methods: Three spacer three-dimensional models (Polyether ether ketone [PEEK]-C: PEEK spacer with a small contact area; PEEK-NF: PEEK spacer with a large contact area; and Bioactive glass [BGS]-NF: bioactive glass-ceramic spacer with a large contact area) are constructed and placed between bone blocks for compression analysis. The stress distribution, peak von Mises stress, and reaction force generated in the bone block are predicted by applying a compressive load. Subsidence tests are conducted for three spacer models in accordance with ASTM F2267. Three types of blocks measuring 8, 10, and 15 pounds per cubic foot are used to account for the various bone qualities of patients. A statistical analysis of the results is conducted using a one-way Analysis of variance and post hoc analysis (Tukey's Honestly Significant Difference) by measuring the stiffness and yield load.
    Results: The stress distribution, peak von Mises stress, and reaction force predicted via the finite element analysis are the highest for PEEK-C, whereas they are similar for PEEK-NF and BGS-NF. Results of mechanical tests show that the stiffness and yield load of PEEK-C are the lowest, whereas those of PEEK-NF and BGS-NF are similar.
    Conclusions: The main factor affecting subsidence performance is the contact area. Therefore, bioactive glass-ceramic spacers exhibit a larger contact area and better subsidence performance than conventional spacers.
    MeSH term(s) Humans ; Silicon Dioxide ; Elastic Modulus ; Finite Element Analysis ; Polyethylene Glycols ; Ketones ; Mechanical Tests ; Ceramics
    Chemical Substances polyetheretherketone (31694-16-3) ; Silicon Dioxide (7631-86-9) ; Polyethylene Glycols (3WJQ0SDW1A) ; Ketones
    Language English
    Publishing date 2023-05-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.05.034
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  2. Article: Clinical features and prognostic factors in drowning children: a regional experience.

    Son, Kyung Lae / Hwang, Su Kyeong / Choi, Hee Joung

    Korean journal of pediatrics

    2016  Volume 59, Issue 5, Page(s) 212–217

    Abstract: Purpose: This study aimed to evaluate the clinical features of children who have survived a water submersion incident, and to identify risk factors for prognosis.: Methods: We retrospectively reviewed the medical records of patients who experienced ... ...

    Abstract Purpose: This study aimed to evaluate the clinical features of children who have survived a water submersion incident, and to identify risk factors for prognosis.
    Methods: We retrospectively reviewed the medical records of patients who experienced submersion between January 2005 and December 2014. The patients were classified into 2 groups, according to complications, and prognostic factors were evaluated.
    Results: During the study period, 29 children experienced submersion (20 boys and 9 girls; mean age, 83.8±46.4 months). Submersion occurred most commonly in the summer, with the peak incidence in August. The most frequent Szpilman clinical score was grade 5 (13 patients; 44.8%), followed by grade 6 (7 patients; 24.1%), and grades 1 or 2 (3 patients; 10.3%). Five children (17.2%) in the poor prognosis group died or had hypoxic ischemic encephalopathy, and the overall mortality rate was 6.9%. Poor prognosis after submersion was associated with lower consciousness levels (P=0.003), higher Szpilman scores (P=0.007), greater need for intubation and mechanical ventilator support (P=0.001), and longer duration of oxygen therapy (P=0.015). Poor prognosis was also associated with lower bicarbonate levels (P=0.038), as well as higher sodium, aspartate transaminase (AST), and alanine transaminase (ALT) levels (P=0.034, P=0.006, and P=0.005, respectively). Szpilman clinical scores were positively correlated with consciousness levels (r=0.489, P=0.002) and serum liver enzyme levels (AST and ALT; r=0.521, P=0.004).
    Conclusion: We characterized the prognostic factors associated with submersion outcomes, using the Szpilman clinical score, which is comparable to consciousness level for predicting mortality.
    Language English
    Publishing date 2016-05-31
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2594966-4
    ISSN 2092-7258 ; 1738-1061
    ISSN (online) 2092-7258
    ISSN 1738-1061
    DOI 10.3345/kjp.2016.59.5.212
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  3. Article ; Online: Identification of Preoperative Magnetic Resonance Imaging Features Associated with Positive Resection Margins in Breast Cancer: A Retrospective Study.

    Kang, Jung-Hyun / Youk, Ji Hyun / Kim, Jeong-Ah / Gweon, Hye Mi / Eun, Na Lae / Ko, Kyung Hee / Son, Eun Ju

    Korean journal of radiology

    2018  Volume 19, Issue 5, Page(s) 897–904

    Abstract: Objective: To determine which preoperative breast magnetic resonance imaging (MRI) findings and clinicopathologic features are associated with positive resection margins at the time of breast-conserving surgery (BCS) in patients with breast cancer.: ... ...

    Abstract Objective: To determine which preoperative breast magnetic resonance imaging (MRI) findings and clinicopathologic features are associated with positive resection margins at the time of breast-conserving surgery (BCS) in patients with breast cancer.
    Materials and methods: We reviewed preoperative breast MRI and clinicopathologic features of 120 patients (mean age, 53.3 years; age range, 27-79 years) with breast cancer who had undergone BCS in 2015. Tumor size on MRI, multifocality, patterns of enhancing lesions (mass without non-mass enhancement [NME] vs. NME with or without mass), mass characteristics (shape, margin, internal enhancement characteristics), NME (distribution, internal enhancement patterns), and breast parenchymal enhancement (BPE; weak, strong) were analyzed. We also evaluated age, tumor size, histology, lymphovascular invasion, T stage, N stage, and hormonal receptors. Univariate and multivariate logistic regression analyses were used to determine the correlation between clinicopathological features, MRI findings, and positive resection margins.
    Results: In univariate analysis, tumor size on MRI, multifocality, NME with or without mass, and segmental distribution of NME were correlated with positive resection margins. Among the clinicopathological factors, tumor size of the invasive breast cancer and
    Conclusion: Non-mass enhancement with or without mass is significantly associated with a positive resection margin in patients with breast cancer. In patients with NME, segmental distribution was significantly correlated with positive resection margins.
    MeSH term(s) Adult ; Aged ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Breast Neoplasms/surgery ; Female ; Humans ; Logistic Models ; Lymphatic Metastasis ; Magnetic Resonance Imaging ; Margins of Excision ; Mastectomy, Segmental/methods ; Middle Aged ; Neoplasm Staging ; Preoperative Care ; Retrospective Studies
    Language English
    Publishing date 2018-08-06
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2046981-0
    ISSN 2005-8330 ; 1229-6929
    ISSN (online) 2005-8330
    ISSN 1229-6929
    DOI 10.3348/kjr.2018.19.5.897
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5591: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Family-Based Association Study of Pulmonary Function in a Population in Northeast Asia.

    Son, Ho-Young / Sohn, Seong-Wook / Im, Sun-Hwa / Kim, Hyun-Jin / Lee, Mi Kyeong / Gombojav, Bayasgalan / Kwon, Hyouk-Soo / Park, Daniel S / Kim, Hyung-Lae / Min, Kyung-Up / Sung, Joohon / Seo, Jeong-Sun / Kim, Jong-Il

    PloS one

    2015  Volume 10, Issue 10, Page(s) e0139716

    Abstract: The spirometric measurement of pulmonary function by measuring the forced expiratory volume in one second (FEV1) is a heritable trait that reflects the physiological condition of the lung and airways. Genome-wide linkage and association studies have ... ...

    Abstract The spirometric measurement of pulmonary function by measuring the forced expiratory volume in one second (FEV1) is a heritable trait that reflects the physiological condition of the lung and airways. Genome-wide linkage and association studies have identified a number of genes and genetic loci associated with pulmonary function. However, limited numbers of studies have been reported for Asian populations. In this study, we aimed to investigate genetic evidence of pulmonary function in a population in northeast Asia. We conducted a family-based association test with 706 GENDISCAN study participants from 72 Mongolian families to determine candidate genetic determinants of pulmonary function. For the replication, we chose seven candidate single nucleotide polymorphisms (SNPs) from the 5 loci, and tested 1062 SNPs for association with FEV1 from 2,729 subjects of the Korea Healthy Twin study. We identified TMEM132C as a potential candidate gene at 12q24.3, which is a previously reported locus of asthma and spirometric indices. We also found two adjacent candidate genes (UNC93A and TTLL2) in the 6q27 region, which has been previously identified as a pulmonary function locus in the Framingham cohort study. Our findings suggest that novel candidate genes (TMEM132C, UNC93A and TTLL2) in two different regions are associated with pulmonary function in a population in northeast Asia.
    MeSH term(s) Adolescent ; Adult ; Asia ; Female ; Humans ; Male ; Polymorphism, Single Nucleotide ; Respiratory Function Tests ; Young Adult
    Language English
    Publishing date 2015-10-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0139716
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  5. Article ; Online: Rapid increase of health care utilization and cost due to benign prostatic hyperplasia in Korean men: retrospective population-based analysis using the Health Insurance Review and Assessment service data.

    Son, Hwancheol / Park, Juhyun / Song, Sang Hoon / Kang, Jung Yoon / Hong, Sung Kyu / Lee, Hyun Moo / Kim, Sun-Hee / Park, Byung-Joo / Lee, Hyung-Lae / Lee, Kyung Seop

    Journal of Korean medical science

    2015  Volume 30, Issue 2, Page(s) 180–185

    Abstract: Using the Korean public health insurance database, we analyzed patients diagnosed as benign prostatic hyperplasia (BPH) from 2004 to 2008. Age and year-specific amount and seasonal variation of hospital visits (HV), duration of treatment (DT), the total ... ...

    Abstract Using the Korean public health insurance database, we analyzed patients diagnosed as benign prostatic hyperplasia (BPH) from 2004 to 2008. Age and year-specific amount and seasonal variation of hospital visits (HV), duration of treatment (DT), the total and per capita amount of insurance payment (TAIP, PCIP) were evaluated. A total of 12,088,995 HV were studied. Total HV increased 1.7 times and DT almost doubled in 2008 compared to those in 2004. HV, DT, and TAIP showed linearly increasing patterns year by year. In a time series analysis, HV increased in winter and demonstrated seasonality in a 12-month cycle. In a Poisson regression analysis, the annual variations of HV, DT, TAIP, and PCIP were different by age groups. In patients older than 40 yr, HV significantly increased 1.10-1.16 times compared to that of the previous year. DT markedly increased in their 60s and 80s patients. The rate of increase in PCIP was steeper in patients 50 yr and older than in the others.Health care utilization due to BPH was rapidly increasing in Korea and it was remarkable in the elderly population. Seasonal variation of HV demonstrated that health care utilization increased in winter.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Cost of Illness ; Health Care Costs ; Humans ; Insurance, Health/economics ; Insurance, Health/statistics & numerical data ; Male ; Middle Aged ; Patient Acceptance of Health Care/statistics & numerical data ; Prostatic Hyperplasia/economics ; Prostatic Hyperplasia/epidemiology ; Prostatic Hyperplasia/therapy ; Republic of Korea/epidemiology ; Retrospective Studies ; Seasons ; Young Adult
    Language English
    Publishing date 2015-02
    Publishing country Korea (South)
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639262-3
    ISSN 1598-6357 ; 1011-8934
    ISSN (online) 1598-6357
    ISSN 1011-8934
    DOI 10.3346/jkms.2015.30.2.180
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    Zs.B 3163: Show issues Location:
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  6. Article ; Online: Family-Based Association Study of Pulmonary Function in a Population in Northeast Asia.

    Ho-Young Son / Seong-Wook Sohn / Sun-Hwa Im / Hyun-Jin Kim / Mi Kyeong Lee / Bayasgalan Gombojav / Hyouk-Soo Kwon / Daniel S Park / Hyung-Lae Kim / Kyung-Up Min / Joohon Sung / Jeong-Sun Seo / Jong-Il Kim

    PLoS ONE, Vol 10, Iss 10, p e

    2015  Volume 0139716

    Abstract: The spirometric measurement of pulmonary function by measuring the forced expiratory volume in one second (FEV1) is a heritable trait that reflects the physiological condition of the lung and airways. Genome-wide linkage and association studies have ... ...

    Abstract The spirometric measurement of pulmonary function by measuring the forced expiratory volume in one second (FEV1) is a heritable trait that reflects the physiological condition of the lung and airways. Genome-wide linkage and association studies have identified a number of genes and genetic loci associated with pulmonary function. However, limited numbers of studies have been reported for Asian populations. In this study, we aimed to investigate genetic evidence of pulmonary function in a population in northeast Asia. We conducted a family-based association test with 706 GENDISCAN study participants from 72 Mongolian families to determine candidate genetic determinants of pulmonary function. For the replication, we chose seven candidate single nucleotide polymorphisms (SNPs) from the 5 loci, and tested 1062 SNPs for association with FEV1 from 2,729 subjects of the Korea Healthy Twin study. We identified TMEM132C as a potential candidate gene at 12q24.3, which is a previously reported locus of asthma and spirometric indices. We also found two adjacent candidate genes (UNC93A and TTLL2) in the 6q27 region, which has been previously identified as a pulmonary function locus in the Framingham cohort study. Our findings suggest that novel candidate genes (TMEM132C, UNC93A and TTLL2) in two different regions are associated with pulmonary function in a population in northeast Asia.
    Keywords Medicine ; R ; Science ; Q
    Subject code 616
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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