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Article ; Online: Classic Famous Prescription Kai-Xin-San Ameliorates Alzheimer's Disease via the Wnt/β-Catenin Signaling Pathway.

Shan, Xiaoxiao / Lv, Shujie / Huang, Peng / Zhang, Wei / Jin, Chuanshan / Liu, Yuanxu / Li, Yangyang / Jia, Yong / Chu, Xiaoqin / Peng, Can / Zhang, Caiyun

Molecular neurobiology

2023 Volume 61, Issue 4, Page(s) 2297–2312

Abstract: Kai-Xin-San (KXS) is a classic famous prescription composed of Polygalae Radix, Ginseng Radix et ...

Abstract	Kai-Xin-San (KXS) is a classic famous prescription composed of Polygalae Radix, Ginseng Radix et Rhizoma, Acori Tatarinowii Rhizoma, and Poria. Clinically, KXS is effective in treating amnesia and regulating cognitive dysfunction of Alzheimer's disease (AD), whereas its mechanism of action is still unclear. In this study, the AD model rats were established by combining intraperitoneal injection of D-galactose (150 mg/kg/day) and intracerebral injection of Aβ
MeSH term(s)	Rats ; Animals ; Alzheimer Disease/metabolism ; Caspase 3/metabolism ; Glycogen Synthase Kinase 3 beta/metabolism ; beta Catenin/metabolism ; Wnt Signaling Pathway ; bcl-2-Associated X Protein ; Disease Models, Animal ; Drugs, Chinese Herbal
Chemical Substances	Kai-Xin-San ; Caspase 3 (EC 3.4.22.-) ; Glycogen Synthase Kinase 3 beta (EC 2.7.11.1) ; beta Catenin ; bcl-2-Associated X Protein ; Drugs, Chinese Herbal
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03707-y
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Corrigendum: Systems pharmacology approach to investigate the mechanism of Kai-Xin-San in Alzheimer's disease.

Luo, Yunxia / Li, Dongli / Liao, Yanfang / Cai, Chuipu / Wu, Qihui / Ke, Hanzhong / Liu, Xinning / Li, Huilin / Hong, Honghai / Xu, Yumin / Wang, Qi / Fang, Jiansong / Fang, Shuhuan

Frontiers in pharmacology

2023 Volume 14, Page(s) 1239060

Abstract: This corrects the article DOI: 10.3389/fphar.2020.00381.]. ...

Abstract	[This corrects the article DOI: 10.3389/fphar.2020.00381.].
Language	English
Publishing date	2023-10-06
Publishing country	Switzerland
Document type	Published Erratum
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2023.1239060
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Article: Qing-Kai-Ling oral liquid alleviated pneumonia via regulation of intestinal flora and metabolites in rats.

Chen, Hongying / Li, Siju / Pan, Biyan / Liu, Kun / Yu, Hansheng / Ma, Chong / Qi, Huiyuan / Zhang, Yuefeng / Huang, Xinyi / Ouyang, Dongsheng / Xie, Zhiyong

Frontiers in microbiology

2023 Volume 14, Page(s) 1194401

Abstract: Background: Qing-Kai-Ling (QKL) oral liquid, evolving from a classical Chinese formula known ...

Abstract	Background: Qing-Kai-Ling (QKL) oral liquid, evolving from a classical Chinese formula known as An-Gong-Niu-Huang pills, is a well-established treatment for pneumonia with its mechanism remaining muddled. Studies have shown that the regulation of both intestinal flora and host-microbiota co-metabolism may contribute to preventing and treating pneumonia. The study aimed to investigate the potential mechanism by which QKL alleviates pneumonia from the perspective of 'microbiota-metabolites-host' interaction. Methods: We evaluated the therapeutic effects of QKL on lipopolysaccharide (LPS)-induced pneumonia rats. To explore the protective mechanism of QKL treatment, a multi-omics analysis that included 16S rDNA sequencing for disclosing the key intestinal flora, the fecal metabolome to discover the differential metabolites, and whole transcriptome sequencing of lung tissue to obtain the differentially expressed genes was carried out. Then, a Spearman correlation was employed to investigate the association between the intestinal flora, the fecal metabolome and inflammation-related indices. Results: The study demonstrated that pneumonia symptoms were significantly attenuated in QKL-treated rats, including decreased TNF-α, NO levels and increased SOD level. Furthermore, QKL was effective in alleviating pneumonia and provided protection equivalent to that of the positive drug dexamethasone. Compared with the Model group, QKL treatment significantly increased the richness and αlpha diversity of intestinal flora, and restored multiple intestinal genera (e.g., Conclusion: Our findings indicated that QKL could potentially modulate intestinal flora dysbiosis, improve host-microbiota co-metabolism dysregulation and regulate gene expression in the lungs, thereby mitigating LPS-induced pneumonia in rats. The study may provide new ideas for the clinical application and further development of QKL.
Language	English
Publishing date	2023-06-09
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2023.1194401
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Article: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1.

Chen, Chao / Xu, Yuan-Jie / Zhang, Shang-Rong / Wang, Xiao-Hui / Hu, Yuan / Guo, Dai-Hong / Zhou, Xiao-Jiang / Zhu, Wei-Yu / Wen, Ai-Dong / Tan, Qing-Rong / Dong, Xian-Zhe / Liu, Ping

Heliyon

2023 Volume 9, Issue 3, Page(s) e14265

Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

Abstract	Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
Language	English
Publishing date	2023-03-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14265
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Article: Kai-Xin-San, a Chinese Herbal Decoction, Accelerates the Degradation of

Wang, Na / Jia, Yongming / Zhang, Bo / Li, Yan / Murtaza, Ghulam / Huang, Shuming / Liu, Xuewei

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 3862342

Abstract: This study aimed to investigate the mechanisms of Kai-Xin-San (KXS, a famous Chinese herbal ...

Abstract	This study aimed to investigate the mechanisms of Kai-Xin-San (KXS, a famous Chinese herbal decoction used to treat amnesia) on the degradation of A
Language	English
Publishing date	2020-02-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/3862342
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ab Jg. 2022: Lesesaal (EG)

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Article: Systems Pharmacology Approach to Investigate the Mechanism of Kai-Xin-San in Alzheimer's Disease.

Luo, Yunxia / Li, Dongli / Liao, Yanfang / Cai, Chuipu / Wu, Qihui / Ke, Hanzhong / Liu, Xinning / Li, Huilin / Hong, Honghai / Xu, Yumin / Wang, Qi / Fang, Jiansong / Fang, Shuhuan

Frontiers in pharmacology

2020 Volume 11, Page(s) 381

Abstract: ... dysfunction. Kai-Xin-San (KXS) is a traditional Chinese medicine (TCM) formula that has been used to treat AD ...

Abstract	Alzheimer's disease (AD) is a complex neurodegenerative disease characterized by cognitive dysfunction. Kai-Xin-San (KXS) is a traditional Chinese medicine (TCM) formula that has been used to treat AD patients for over a thousand years in China. However, the therapeutic mechanisms of KXS for treating AD have not been fully explored. Herein, we used a comprehensive network pharmacology approach to investigate the mechanism of action of KXS in the treatment of AD. This approach consists of construction of multiple networks and Gene Ontology enrichment and pathway analyses. Furthermore, animal experiments were performed to validate the predicted molecular mechanisms obtained from the systems pharmacology-based analysis. As a result, 50 chemicals in KXS and 39 AD-associated proteins were identified as major active compounds and targets, respectively. The therapeutic mechanisms of KXS in treating AD were primarily related to the regulation of four pathology modules, including amyloid beta metabolism, tau protein hyperphosphorylation process, cholinergic dysfunction, and inflammation. In scopolamine-induced cognitive dysfunction mice, we validated the anti-inflammatory effects of KXS on AD by determining the levels of inflammation cytokines including interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α. We also found cholinergic system dysfunction amelioration of KXS is correlated with upregulation of the cholinergic receptor CHRNB2. In conclusion, our work proposes a comprehensive systems pharmacology approach to explore the underlying therapeutic mechanism of KXS for the treatment of AD.
Language	English
Publishing date	2020-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00381
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Effects of KAI gene expression on ferroptosis in pancreatic cancer cells.

Liu, Xu / Guo, Xiaozhong / Li, Hongyu / Chen, Jiang / Han, Hao

Molecular medicine reports

2020 Volume 23, Issue 2

Abstract: The specific role and mechanism of ferroptosis in the development of pancreatic cancer (PC) remain to be elucidated. The present study aimed to investigate the effects of the overexpression of the KAI1 gene on the ferroptosis of the human PC cell line ... ...

Abstract	The specific role and mechanism of ferroptosis in the development of pancreatic cancer (PC) remain to be elucidated. The present study aimed to investigate the effects of the overexpression of the KAI1 gene on the ferroptosis of the human PC cell line MIA PaCa‑2. MIA PaCa‑2 cells infected with pCMV‑KAI1 and selected by G418 and KAI1 protein were analyzed by western blotting. The MIA PaCa‑2 cells with a stable expression of the KAI1 gene were termed MIA PaCa‑2‑KAI1. The proliferative capacities of MIA PaCa‑2 and MIA PaCa‑2‑KAI1 cells were detected using Cell Counting Kit‑8. The reactive oxygen species (ROS) in the cells were compared by flow cytometry. The expressions of ferroportin (FPN) and glutathione peroxidase 4 (GPX4) protein were analyzed by western blotting. The KAI1 stable expression cell line was confirmed and relabeled as MIA PaCa‑2‑KAI1. No significant differences in the proliferation of MIA PaCa‑2 and MIA PaCa‑2‑KAI1 were identified. Following treatment with a ferroptosis blocker, the increase in the proliferation of MIA PaCa‑2‑KAI1 (from 2.06±0.02 to 2.75±0.02) was more evident compared with MIA PaCa‑2 (from 2.94±0.02 to 2.95±0.02; P<0.05). The ROS in MIA PaCa‑2‑KAI1 was significantly higher compared with MIA PaCa‑2 (P<0.05). FPN and GPX4 protein demonstrated higher expression levels in MIA PaCa‑2‑KAI1 compared with MIA PaCa‑2. Moreover, KAI1 exerted an obvious promotion effect on FPN expression. This study identified that the high expression of the KAI1 gene promoted the occurrence of ferroptosis in PC cells through its extensive effect on FPN and GPX4. KAI1‑induced ferroptosis did not significantly inhibit the proliferation of PC cells.
MeSH term(s)	Cation Transport Proteins/genetics ; Cell Line, Tumor ; Cell Proliferation ; Ferroptosis ; Gene Expression Regulation, Neoplastic ; Humans ; Kangai-1 Protein/genetics ; Kangai-1 Protein/metabolism ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/metabolism ; Pancreatic Neoplasms/physiopathology ; Phospholipid Hydroperoxide Glutathione Peroxidase/genetics ; Reactive Oxygen Species/metabolism
Chemical Substances	CD82 protein, human ; Cation Transport Proteins ; Kangai-1 Protein ; Reactive Oxygen Species ; metal transporting protein 1 ; Phospholipid Hydroperoxide Glutathione Peroxidase (EC 1.11.1.12)
Language	English
Publishing date	2020-12-22
Publishing country	Greece
Document type	Journal Article
ZDB-ID	2469505-1
ISSN	1791-3004 ; 1791-2997
ISSN (online)	1791-3004
ISSN	1791-2997
DOI	10.3892/mmr.2020.11802
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Chen, Chao / Xu, Yuan-jie / Zhang, Shang-rong / Wang, Xiao-hui / Hu, Yuan / Guo, Dai-hong / Zhou, Xiao-jiang / Zhu, Wei-yu / Wen, Ai-Dong / Tan, Qing-Rong / Dong, Xian-Zhe / Liu, Ping

Heliyon. 2023 Mar., v. 9, no. 3 p.e14265-

2023

Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

Abstract	Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
Keywords	Oriental traditional medicine ; antidepressants ; blood serum ; gene expression regulation ; heart ; microRNA ; microarray technology ; neurons ; pathophysiology ; signal transduction ; spleen ; Depression ; Kai-Xin-San ; miR-1281 ; ADCY1 ; DVL1
Language	English
Dates of publication	2023-03
Publishing place	Elsevier Ltd
Document type	Article ; Online
Note	Use and reproduction
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e14265
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: MiR-1281 is involved in depression disorder and the antidepressant effects of Kai-Xin-San by targeting ADCY1 and DVL1

Chao Chen / Yuan-jie Xu / Shang-rong Zhang / Xiao-hui Wang / Yuan Hu / Dai-hong Guo / Xiao-jiang Zhou / Wei-yu Zhu / Ai-Dong Wen / Qing-Rong Tan / Xian-Zhe Dong / Ping Liu

Heliyon, Vol 9, Iss 3, Pp e14265- (2023)

2023

Abstract: Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression ...

Abstract	Kai-Xin-San (KXS) is a Chinese medicine formulation that is commonly used to treat depression caused by dual deficiencies in the heart and spleen. Recent studies indicated that miRNAs were involved in the pathophysiology of depression. However, there have been few studies on the mechanism underlying the miRNAs directly mediating antidepressant at clinical level, especially in nature drugs and TCM compound. In this study, we identified circulating miRNAs defferentially expressed among the depression patients (DPs), DPs who underwent 8weeks of KXS treatment and health controls (HCs). A total of 45 miRNAs (17 were up-regulated and 28 were down-regulated) were significantly differentially expressed among three groups. Subsequently, qRT-PCR was used to verify 10 differentially expressed candidate miRNAs in more serum samples, and the results showed that 6 miRNAs (miR-1281, miR-365a-3p, miR-2861, miR-16-5p, miR-1202 and miR-451a) were consistent with the results of microarray. Among them, miR-1281, was the novel dynamically altered and appeared to be specifically related to depression and antidepressant effects of KXS. MicroRNA-gene-pathway-net analysis showed that miR-1281-regulated genes are mostly key nodes in the classical signaling pathway related to depression. Additionally, our data suggest that ADCY1 and DVL1 were the targets of miR-1281. Thus, based on the discovery of miRNA expression profiles in vivo, our findings suggest a new role for miR-1281 related to depression and demonstrated in vitro that KXS may activate cAMP/PKA/ERK/CREB and Wnt/β-catenin signal transduction pathways by down-regulating miR-1281 that targets ADCY1 and DVL1 to achieve its role in neuronal cell protection.
Keywords	Depression ; Kai-Xin-San ; miR-1281 ; ADCY1 ; DVL1 ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
Subject code	500
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Comparing the efficacy and safety of atomization of traditional Chinese medicine Kai Hou Jian and budesonide suspension in adult acute laryngitis: a randomized control trial.

Feng, Wei / Chen, Hui / Lu, Ye / Liu, Rui / Yuan, Meng Yan / An, Jie / Li, Man / Chua, Lee Suan / Kait, Joana Alcoba / Xin, Li

Annals of translational medicine

2022 Volume 10, Issue 18, Page(s) 1019

Abstract: Background: Kai Hou Jian has an outstanding therapeutic effect and clinical use against pharyngeal ... to evaluate the efficacy and safety of short-course oral inhalation of traditional Chinese medicine Kai Hou ... the inclusion criteria were randomly assigned according to the random number table method into a Kai Hou Jian ...

Abstract	Background: Kai Hou Jian has an outstanding therapeutic effect and clinical use against pharyngeal infection for many years, while a few studies reported it also had an effect in laryngitis. This study aimed to evaluate the efficacy and safety of short-course oral inhalation of traditional Chinese medicine Kai Hou Jian in adults with acute laryngitis. Methods: A total of 86 patients with acute laryngitis who met the inclusion criteria were randomly assigned according to the random number table method into a Kai Hou Jian treatment group or a budesonide control group. Patients received 2.5 mL of Kai Hou Jian via transoral atomization twice daily for 1 week, while the control group received budesonide nebulization (1 mg, bid) for 1 week. The change of symptoms scores of acute laryngitis and laryngoscopy scores before and after treatment were performed to value the effect of Kai Hou Jian and the safety was assessed by the patient's discomfort and the incidence and self-reported adverse events during treatment. Results: The symptoms of acute laryngitis were significantly reduced in patients treated with Kai Hou Jian on day-3. Forty-two patients from the Kai Hou Jian and 40 patients from budesonide treated groups both experienced notable clinical improvement after 1 week. There was no difference in the two groups at the baseline. For individual symptoms, Kai Hou Jian could significantly improve sore throat [95% confidence interval (CI): -1.81 to -0.14, P=0.03], while budesonide yielded better improvement in hoarseness (95% CI: 0.67 to 0.20, P=0.001). For laryngoscopic parameters, the scores of laryngeal mucosa were significantly decreased in both groups from baseline, and there were no statistical differences in vocal cord hyperemia, edema, sputum congestion, edema, mucus adhesion, or epiglottic congestion between the groups after 1 week. We also found that the treatment of Kai Hou Jian nebulization could reduce the extent or range of vocal cord leukoplakia after 1 week. Conclusions: The short-course treatment of Kai Hou Jian atomization had significant effect in improving adult acute laryngitis and it was also possibly exhibiting a positive effect on vocal cord leukoplakia. Trial registration: Chinese Clinical Trial Registry identifier: ChiCTR1900026660.
Language	English
Publishing date	2022-10-04
Publishing country	China
Document type	Journal Article
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-4305
Database	MEDical Literature Analysis and Retrieval System OnLINE

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