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Article ; Online: Stimuli-responsive nanozymes for biomedical applications.

Zhang, Mengli / Tong, Weijun

2023 Volume 11, Issue 17, Page(s) 5769–5780

Abstract: With the rapid development of nanotechnology, nanozymes are regarded as excellent substitutes for natural enzymes due to their high activity, convenient preparation, low cost, robust stability and other unique properties of nanomaterials. In biomedical ... ...

Abstract	With the rapid development of nanotechnology, nanozymes are regarded as excellent substitutes for natural enzymes due to their high activity, convenient preparation, low cost, robust stability and other unique properties of nanomaterials. In biomedical applications, the always-on activity of nanozymes is undesirable as it poses a potential threat to normal tissues. Stimuli-responsive nanozymes were designed to manipulate the activities of nanozymes. This review introduces two types of stimuli-responsive nanozymes. One is smart responsive nanozymes with stimuli-switchable activities, further divided into those with on/off switchable activity and one/another switchable activity. Another is nanozymes exhibiting responsive release from specific carriers. Additionally, the biomedical applications of stimuli-responsive nanozymes in cancer therapy, antibacterial therapy, biosensing and anti-inflammatory therapy are briefly reviewed. Finally, we address the challenges and prospects in this field.
MeSH term(s)	Catalysis ; Nanostructures ; Nanotechnology ; Anti-Bacterial Agents/pharmacology
Chemical Substances	Anti-Bacterial Agents
Language	English
Publishing date	2023-08-22
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2693928-9
ISSN	2047-4849 ; 2047-4830
ISSN (online)	2047-4849
ISSN	2047-4830
DOI	10.1039/d3bm00884c
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Article ; Online: Clinical observation and influence on nutritional status of intensive nutritional nursing combined with 3-day dietary diary intervention in peritoneal dialysis patients.

Shao, Zengmei / Chen, Chuanxia / Tong, Mengli / Weng, Ning

Journal of human nutrition and dietetics : the official journal of the British Dietetic Association

2023 Volume 37, Issue 2, Page(s) 484–490

Abstract: Background: Peritoneal dialysis is a commonly used treatment for chronic kidney failure patients. Studies have shown that long-term peritoneal dialysis can lead to various degrees of malnutrition. Therefore, it is of great significance to improve the ... ...

Abstract	Background: Peritoneal dialysis is a commonly used treatment for chronic kidney failure patients. Studies have shown that long-term peritoneal dialysis can lead to various degrees of malnutrition. Therefore, it is of great significance to improve the nutritional conditions of patients with peritoneal dialysis. This retrospective cohort study aimed to evaluate the clinical effects of intensive nutritional nursing combined with a 3-day diet diary intervention on the nutritional condition of peritoneal dialysis patients. Methods: In total, 163 patients were included in this study and, after 6 months of intervention, their nutritional and biochemical indicators, body weight, body mass index (BMI) and intake of dietary ingredients were analysed. Results: After the intervention, patients' serum albumin, haemoglobin, prealbumin, body weight, BMI and cholesterol levels were significantly increased (p < 0.05). Also, the daily energy and protein intake were significantly increased, whereas phosphorus intake was decreased (p < 0.05). Of note, the effective rate of intervention was 63.8%, respectively. We also found that factors such as the patient's age, education degree, income level and peritoneal dialysis age were the risk factors associated with malnutrition. Moreover, patients younger than 55 years old, with dialysis age younger than 5 years, unmarried/divorced and high school graduates, had higher chances of effective intervention, whereas the possibility of effective intervention was lower when the per capita monthly household income was less than 4000 Yuan. Conclusions: In conclusion, intensive nutritional nursing combined with a 3-day dietary diary intervention can significantly improve the nutritional condition and optimise the diet structure of peritoneal dialysis patients with malnutrition. These findings provide evidence for healthcare providers to develop personalised interventions to address malnutrition in this population.
MeSH term(s)	Humans ; Child, Preschool ; Middle Aged ; Nutritional Status ; Retrospective Studies ; Peritoneal Dialysis/adverse effects ; Malnutrition/epidemiology ; Nutrition Disorders/epidemiology ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy ; Body Weight
Language	English
Publishing date	2023-12-13
Publishing country	England
Document type	Journal Article
ZDB-ID	645183-4
ISSN	1365-277X ; 0952-3871 ; 1465-8178
ISSN (online)	1365-277X
ISSN	0952-3871 ; 1465-8178
DOI	10.1111/jhn.13270
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Zs.A 2551: Show issues

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Article: Narrow-Band Intense Pulsed Light as Treatment for Erythematotelangiectatic Rosacea: A Retrospective Study.

Shi, Hualing / Zhang, Erjia / Zhang, Mengli / Lin, Tong

Journal of drugs in dermatology : JDD

2023 Volume 22, Issue 11, Page(s) 1095–1098

Abstract: Background: Erythematotelangiectatic rosacea can be successfully treated using various laser and light-based devices. However, the use of narrow-band intense pulsed light for the treatment of erythematotelangiectatic rosacea has not been investigated in ...

Abstract	Background: Erythematotelangiectatic rosacea can be successfully treated using various laser and light-based devices. However, the use of narrow-band intense pulsed light for the treatment of erythematotelangiectatic rosacea has not been investigated in detail. This retrospective study aimed to analyze the clinical efficacy of narrow-band intense pulsed light (500-600 nm) for the treatment of erythematotelangiectatic rosacea among Chinese individuals. Methods: Patients with erythematotelangiectatic rosacea who had completed 3 sessions of treatment with narrow-band intense pulsed light and follow-up from July 2016 to December 2018 were retrospectively evaluated. Clinical improvement was assessed by 2 blinded dermatologists based on photographs obtained at each follow-up visit using the clinician erythema assessment scale and 5-grade scale. Results: Forty-five patients with erythematotelangiectatic rosacea treated with narrow-band intense pulsed light were included in this study. The effectiveness and excellent rates after 3 treatment sessions were 68.9% and 35.6%, respectively. An average of 2 treatment sessions was required among patients who achieved good or excellent clearance of erythema and telangiectasia. Except for transient erythema and edema, no severe adverse effects were observed. Conclusions: Narrow-band intense pulsed light is a safe and effective treatment for erythematotelangiectatic rosacea. Even with a small number of treatment sessions, narrow-band intense pulsed light can deliver a significant therapeutic effect, which may be applicable in clinical practice. J Drugs Dermatol. 2023;22(11):1095-1098 doi:10.36849/JDD.4920.
MeSH term(s)	Humans ; Asian People ; Erythema/diagnosis ; Erythema/therapy ; Retrospective Studies ; Rosacea/diagnosis ; Rosacea/therapy ; Intense Pulsed Light Therapy
Language	English
Publishing date	2023-11-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2145090-0
ISSN	1545-9616
ISSN	1545-9616
DOI	10.36849/JDD.4920
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Zs.A 5931: Show issues

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Article ; Online: Single-Atom Nanozymes

Haihan Song / Mengli Zhang / Weijun Tong

Molecules, Vol 27, Iss 5426, p

Fabrication, Characterization, Surface Modification and Applications of ROS Scavenging and Antibacterial

2022 Volume 5426

Abstract: Nanozymes are nanomaterials with intrinsic natural enzyme-like catalytic properties. They have received extensive attention and have the potential to be an alternative to natural enzymes. Increasing the atom utilization rate of active centers in ... ...

Abstract	Nanozymes are nanomaterials with intrinsic natural enzyme-like catalytic properties. They have received extensive attention and have the potential to be an alternative to natural enzymes. Increasing the atom utilization rate of active centers in nanozymes has gradually become a concern of scientists. As the limit of designing nanozymes at the atomic level, single-atom nanozymes (SAzymes) have become the research frontier of the biomedical field recently because of their high atom utilization, well-defined active centers, and good natural enzyme mimicry. In this review, we first introduce the preparation of SAzymes through pyrolysis and defect engineering with regulated activity, then the characterization and surface modification methods of SAzymes are introduced. The possible influences of surface modification on the activity of SAzymes are discussed. Furthermore, we summarize the applications of SAzymes in the biomedical fields, especially in those of reactive oxygen species (ROS) scavenging and antibacterial. Finally, the challenges and opportunities of SAzymes are summarized and prospected.
Keywords	nanozyme ; single-atom nanozyme ; surface modification ; ROS scavenging ; antibacterial ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Technique failure in peritoneal dialysis-related peritonitis: risk factors and patient survival.

Yu, Jin / Zhu, Lingli / Ni, Jun / Tong, Mengli / Wang, Hua

Renal failure

2023 Volume 45, Issue 1, Page(s) 2205536

Abstract: Objective: This study aimed to investigate the association between patient clinical characteristics and technique failure in peritoneal dialysis-related peritonitis (PDRP). The effect of peritonitis-associated technique failure on patient survival was ... ...

Abstract	Objective: This study aimed to investigate the association between patient clinical characteristics and technique failure in peritoneal dialysis-related peritonitis (PDRP). The effect of peritonitis-associated technique failure on patient survival was also assessed. Methods: Patients diagnosed with PDRP from January 1, 2010 to June 30, 2022 were retrospectively reviewed and analyzed. Relevant demographic, biochemical, and clinical data were collected. Univariate and multivariate logistic regression analyses were used to determine the predictors of peritonitis-associated technique failure in PD. Patients were divided into technique failure (F group) and nontechnique failure (NF group) groups. Patients were followed until death or until the date of Oct 1, 2022. Kaplan-Meier survival curves and landmark analysis were used to assess the survival of the PDRP cohort. Cox regression models were used to assess the association between potential risk factors and mortality. Results: A total of 376 patients with 648 cases of PDRP were included in this study. Multivariate logistic regression analysis demonstrated that peritoneal dialysis (PD) duration (OR = 1.12 [1.03, 1.21], Conclusions: Dialysate WBC count on Day 3, PD duration, NLR, and LDH were independent risk factors for technique failure, whereas HDL was a protective factor. Peritonitis-associated technique failure had a higher risk of mortality and adverse effects on postperitonitis survival.
MeSH term(s)	Humans ; Retrospective Studies ; Peritoneal Dialysis/adverse effects ; Dialysis Solutions ; Risk Factors ; Peritonitis/etiology ; Peritonitis/diagnosis ; Kidney Failure, Chronic/complications ; Kidney Failure, Chronic/therapy
Chemical Substances	Dialysis Solutions
Language	English
Publishing date	2023-04-06
Publishing country	England
Document type	Journal Article
ZDB-ID	632949-4
ISSN	1525-6049 ; 0886-022X
ISSN (online)	1525-6049
ISSN	0886-022X
DOI	10.1080/0886022X.2023.2205536
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Zs.A 1331: Show issues

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Article ; Online: Single-Atom Nanozymes: Fabrication, Characterization, Surface Modification and Applications of ROS Scavenging and Antibacterial.

Song, Haihan / Zhang, Mengli / Tong, Weijun

Molecules (Basel, Switzerland)

2022 Volume 27, Issue 17

Abstract	Nanozymes are nanomaterials with intrinsic natural enzyme-like catalytic properties. They have received extensive attention and have the potential to be an alternative to natural enzymes. Increasing the atom utilization rate of active centers in nanozymes has gradually become a concern of scientists. As the limit of designing nanozymes at the atomic level, single-atom nanozymes (SAzymes) have become the research frontier of the biomedical field recently because of their high atom utilization, well-defined active centers, and good natural enzyme mimicry. In this review, we first introduce the preparation of SAzymes through pyrolysis and defect engineering with regulated activity, then the characterization and surface modification methods of SAzymes are introduced. The possible influences of surface modification on the activity of SAzymes are discussed. Furthermore, we summarize the applications of SAzymes in the biomedical fields, especially in those of reactive oxygen species (ROS) scavenging and antibacterial. Finally, the challenges and opportunities of SAzymes are summarized and prospected.
MeSH term(s)	Anti-Bacterial Agents/pharmacology ; Biomimetics ; Catalysis ; Nanostructures ; Reactive Oxygen Species
Chemical Substances	Anti-Bacterial Agents ; Reactive Oxygen Species
Language	English
Publishing date	2022-08-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules27175426
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Zs.MO 81: Show issues

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Article ; Online: Constructing a Topologically Adaptable Solid Electrolyte Interphase for a Highly Reversible Zinc Anode.

Yan, Tong / Liu, Sucheng / Li, Jinye / Tao, Mengli / Liang, Jinhui / Du, Li / Cui, Zhiming / Song, Huiyu

ACS nano

2024 Volume 18, Issue 4, Page(s) 3752–3762

Abstract: The performance of aqueous zinc metal batteries is significantly compromised by the stability of the solid electrolyte interphase (SEI), which is intimately linked to the structure of the electrical double layer (EDL) between the zinc anode and ... ...

Abstract	The performance of aqueous zinc metal batteries is significantly compromised by the stability of the solid electrolyte interphase (SEI), which is intimately linked to the structure of the electrical double layer (EDL) between the zinc anode and electrolyte. Furthermore, understanding the mechanical behavior of SEI is crucial, as it governs its response to stress induced by volume changes, fracture, or deformation. In this study, we introduce l-glutamine (Gln) as an additive to regulate the adsorbed environment of the EDL and in situ produce a hybrid SEI consisting of ZnS and Gln-related species. The results of the nanoindentation test indicate that the hybrid SEI exhibits a low modulus and low hardness, alongside exceptional shape recovery capability, which effectively limits side reactions and enables topological adaptation to volume fluctuations in zinc anodes during zinc ion plating/stripping, thereby enabling Zn//Zn symmetric cells to exhibit an ultralong cycle life of 4000 h in coin cells and a high cumulative capacity of 18,000 mA h in pouch cells. More importantly, the superiority of the formulated strategy is further demonstrated in Zn//NH
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.3c11743
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Article: Clinical Characteristics of Enterococcus-Associated Peritonitis in Patients with Peritoneal Dialysis.

Ni, Jun / Zhou, Liusha / Wang, Hua / Yu, Jin / Tong, Mengli / Yu, Dongrong

Infection and drug resistance

2023 Volume 16, Page(s) 3399–3405

Abstract: Background: This study aims to investigate the clinical characteristics of enterococcus-associated peritonitis in patients with peritoneal dialysis (PD).: Methods: In this retrospective study, patients with PD-associated enterococcal peritonitis ( ... ...

Abstract	Background: This study aims to investigate the clinical characteristics of enterococcus-associated peritonitis in patients with peritoneal dialysis (PD). Methods: In this retrospective study, patients with PD-associated enterococcal peritonitis (Group E) who were treated in our center between January 2010 and September 2020 were included. Patients with PD-associated streptococcus peritonitis (Group S) and patients with coagulase-negative staphylococcus peritonitis (Group CNS) were matched 1:1 as cohort-control groups. The clinical characteristics and prognosis of these patients were analyzed. Results: A total of 21 peritonitis episodes were noted in nine males and nine females, with an average age of 60.33±14.79 years and an average dialysis duration of 63.56±35.23 months. Mixed infection was observed in 7 out of 21 cases. A total of 22 strains of enterococci were identified in bacterial culture, all sensitive to vancomycin. There were significant differences in white blood cell (WBC) count and blood urea nitrogen (BUN) level among three groups on admission ( Conclusion: Enterococcus peritonitis is a rare and severe complication of peritoneal dialysis. Although vancomycin is effective for the treatment of Enterococcus infection, Enterococcus peritonitis still has a high rate of treatment failure, poor response to treatment, and poor prognosis as compared to CNS and streptococcus-related infections.
Language	English
Publishing date	2023-05-30
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2494856-1
ISSN	1178-6973
ISSN	1178-6973
DOI	10.2147/IDR.S406437
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Article ; Online: Comparison of the 1064-nm picosecond laser with fractionated microlens array and 1565-nm non-ablative fractional laser for the treatment of enlarged pores: a randomized, split-face, controlled trial.

Liu, Xing / Zeng, Rong / Liu, Yuzhen / Guo, Lifang / Zhang, Mengli / Zheng, Huiying / Wu, Qiuju / Ge, Yiping / Lin, Tong

Lasers in medical science

2024 Volume 39, Issue 1, Page(s) 80

Abstract: Purpose: This split-face randomized study compared the efficacy and safety between 1064-nm picosecond laser with fractionated microlens array (MLA) and 1565-nm nonablative fractional laser to treat enlarged pores.: Methods: Participants with enlarged ...

Abstract	Purpose: This split-face randomized study compared the efficacy and safety between 1064-nm picosecond laser with fractionated microlens array (MLA) and 1565-nm nonablative fractional laser to treat enlarged pores. Methods: Participants with enlarged facial pores were enrolled and underwent three consecutive sessions at 2-week intervals with either a 1064-nm picosecond laser with MLA or a 1565-nm nonablative fractional laser. Images were captured at each visit. Objective (pore number) and subjective assessments, including patient self-evaluations and quartile improvement scales, were used to evaluate the treatment efficacy. The pain levels and adverse effects were recorded at each subsequent visit. Results: The participants were 3 men and 22 women with enlarged facial pores. At the initial and 2-month checkups after the last treatment, the pore numbers were significantly decreased bilaterally for both lasers. The respective quartile improvement scale scores for the 1064-nm picosecond and 1565-nm fractional lasers were 2.22 ± 1.06 and 2.14 ± 1.11, while those for patient self-assessment were 3.72 ± 0.74 and 3.68 ± 0.75. The pore number, quartile improvement scale score, and patients' self-assessments did not differ significantly between the two lasers. Treatment with the 1064-nm picosecond laser better reduced pain compared with the 1565-nm nonablative fractional laser (4.11 ± 1.33 vs. 4.83 ± 1.17). The occurrence of pigmentation did not differ significantly between the lasers. Conclusion: Both the 1064-nm picosecond laser with MLA and the 1565-nm nonablative fractional laser are viable options for treating enlarged pores, and showed comparable respective efficacies; however, the former was less likely to cause hyperpigmentation and was better tolerated.
MeSH term(s)	Male ; Humans ; Female ; Patient Satisfaction ; Lasers, Solid-State/therapeutic use ; Treatment Outcome ; Hyperpigmentation/etiology ; Pain/etiology
Language	English
Publishing date	2024-02-24
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	632808-8
ISSN	1435-604X ; 0268-8921
ISSN (online)	1435-604X
ISSN	0268-8921
DOI	10.1007/s10103-024-04028-9
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Zs.A 2148: Show issues

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Article ; Online: Probiotic-Functionalized Silk Fibroin/Sodium Alginate Scaffolds with Endoplasmic Reticulum Stress-Relieving Properties for Promoted Scarless Wound Healing.

Dou, Zhaona / Li, Binbin / Wu, Lin / Qiu, Tong / Wang, Xinyu / Zhang, Xueqiong / Shen, Ying / Lu, Mengli / Yang, Yan

ACS applied materials & interfaces

2023 Volume 15, Issue 5, Page(s) 6297–6311

Abstract: Bioactive substances such as probiotics are becoming a research hotspot in the field of tissue regeneration due to their excellent regulatory functions. Here, we proposed to ... ...

Abstract	Bioactive substances such as probiotics are becoming a research hotspot in the field of tissue regeneration due to their excellent regulatory functions. Here, we proposed to load
MeSH term(s)	Rats ; Animals ; Fibroins/pharmacology ; Alginates/pharmacology ; Rats, Sprague-Dawley ; Wound Healing ; Tissue Scaffolds ; Probiotics ; Anti-Bacterial Agents ; Silk
Chemical Substances	Fibroins (9007-76-5) ; Alginates ; Anti-Bacterial Agents ; Silk
Language	English
Publishing date	2023-01-26
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.2c17168
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