LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 533702

Search options

  1. Article: Y

    Zhao, Rui-Qiang / Wen, Yan / Gupta, Pranav / Lei, Zi-Ning / Cai, Chao-Yun / Liang, Gang / Yang, Dong-Hua / Chen, Zhe-Sheng / Xie, Yu-An

    Frontiers in pharmacology

    2019  Volume 9, Page(s) 1545

    Abstract: ... Y ...

    Abstract Multidrug resistance is reported to be related to the transmembrane transportation of chemotherapeutic drugs by adenosine triphosphate-binding cassette (ABC) transporters. ABC subfamily G member 2 (ABCG2) is a member of the ABC transporter superfamily proteins, which have been implicated as a key contributor to the development of multidrug resistance in cancers. A new epigallocatechin gallate derivative, Y
    Language English
    Publishing date 2019-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2018.01545
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Y

    Li, Juan / Du, Yang / Jiang, Zhenqi / Tian, Yuchen / Qiu, Nianxiang / Wang, Yinjie / Lqbal, Muhammad Zubair / Hu, Menying / Zou, Ruifen / Luo, Lijia / Du, Shiyu / Tian, Jie / Wu, Aiguo

    Nanoscale

    2018  Volume 10, Issue 13, Page(s) 5845–5851

    Abstract: ... ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are ...

    Abstract Due to the molecular and cellular heterogeneity of glioma, discovery of novel targeted sites and ligands for glioma imaging and therapy remains challenging. Neuropeptide Y (NPY) Y1 receptors (Y1Rs) are highly over expressed in various brain tumors including glioma, and can serve as potential targeting sites for glioma imaging and therapy. Here, we show by in vivo fluorescent imaging that a highly selective Y1R ligand, [Asn6, Pro34] NPY (AP-NPY), facilitated circumvention of the blood brain barrier (BBB) by nanomicelles specifically targeting glioma. Modification with AP-NPY stabilized doxorubicin-loaded nanomicelles in the normal physiological state and promoted drug release in the acidic tumor microenvironment. Furthermore, targeted delivery of AP-NPY nanomicelles improved the therapeutic efficacy of doxorubicin for glioma, producing a prolonged survival rate. These results suggest that Y1R is a novel targeted receptor, and its selective ligand AP-NPY improves BBB permeability and glioma targeting. Our study paves the way for developing a novel delivery system for diagnosis and treatment of glioma in which Y1Rs are over expressed.
    MeSH term(s) Animals ; Blood-Brain Barrier ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/drug therapy ; Cell Line, Tumor ; Doxorubicin/administration & dosage ; Endothelial Cells ; Glioma/diagnostic imaging ; Glioma/drug therapy ; Humans ; Ligands ; Mice ; Mice, Nude ; Micelles ; Nanoparticles ; Neoplasms, Experimental/diagnostic imaging ; Neoplasms, Experimental/drug therapy ; Optical Imaging ; Protein Binding ; Receptors, Neuropeptide Y/metabolism
    Chemical Substances Ligands ; Micelles ; Receptors, Neuropeptide Y ; neuropeptide Y-Y1 receptor ; Doxorubicin (80168379AG)
    Language English
    Publishing date 2018-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c8nr00148k
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Y

    Gao, Chunyue / Jin, Yi / Jia, Guang / Suo, Xiaomin / Liu, Huifang / Liu, Dandan / Yang, Xinjian / Ge, Kun / Liang, Xing-Jie / Wang, Shuxiang / Zhang, Jinchao

    ACS nano

    2018  Volume 13, Issue 1, Page(s) 313–323

    Abstract: Y ...

    Abstract Y
    MeSH term(s) Animals ; Apoptosis ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Cathepsins/metabolism ; Cells, Cultured ; Female ; Lysosomes/drug effects ; Lysosomes/metabolism ; Mice ; Mice, Inbred ICR ; Mitochondria/genetics ; Mitochondria/metabolism ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Phosphates/metabolism ; Yttrium/chemistry ; Yttrium/pharmacokinetics ; Yttrium/toxicity
    Chemical Substances Phosphates ; Yttrium (58784XQC3Y) ; Cathepsins (EC 3.4.-) ; yttria (X8071685XT)
    Language English
    Publishing date 2018-12-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.8b06211
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article ; Online: Y

    Yang, Zhou / Sheng, Jiangyuan / Lv, Ke / Ren, Li / Zhang, Di

    Plant science : an international journal of experimental plant biology

    2019  Volume 284, Page(s) 143–160

    Abstract: Two dehydrins from Agapanthus praecox ( ... ...

    Abstract Two dehydrins from Agapanthus praecox (ApY
    MeSH term(s) Amaryllidaceae/genetics ; Amaryllidaceae/metabolism ; Amaryllidaceae/physiology ; Escherichia coli ; Gene Expression Regulation, Plant ; Hydroxyl Radical/metabolism ; Organisms, Genetically Modified ; Phylogeny ; Plant Proteins/genetics ; Plant Proteins/physiology ; Plants, Genetically Modified ; Sequence Analysis, DNA ; Stress, Physiological/physiology
    Chemical Substances Plant Proteins ; dehydrin proteins, plant (134711-03-8) ; Hydroxyl Radical (3352-57-6)
    Language English
    Publishing date 2019-03-20
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 742010-9
    ISSN 1873-2259 ; 0168-9452
    ISSN (online) 1873-2259
    ISSN 0168-9452
    DOI 10.1016/j.plantsci.2019.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Bonn / Germany

    Z 77/717: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article ; Online: Correction: A Y

    Wang, Yinjie / Jiang, Zhenqi / Yuan, Bo / Tian, Yuchen / Xiang, Lingchao / Li, Yanying / Yang, Yong / Li, Juan / Wu, Aiguo

    Biomaterials science

    2024  Volume 12, Issue 8, Page(s) 2165–2166

    Abstract: Correction for 'A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer' by Yinjie ... ...

    Abstract Correction for 'A Y1 receptor ligand synergized with a P-glycoprotein inhibitor improves the therapeutic efficacy of multidrug resistant breast cancer' by Yinjie Wang
    Language English
    Publishing date 2024-04-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d4bm90022g
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article ; Online: A Y

    Wang, Yinjie / Jiang, Zhenqi / Yuan, Bo / Tian, Yuchen / Xiang, Lingchao / Li, Yanying / Yang, Yong / Li, Juan / Wu, Aiguo

    Biomaterials science

    2019  Volume 7, Issue 11, Page(s) 4748–4757

    Abstract: ... to develop a novel strategy for its treatment. Based on the high overexpression of Y ...

    Abstract Multidrug resistance (MDR) is one of the main reasons for the inefficiency of cancer chemotherapy. As a consequence of MDR, the expression level of membrane proteins might be changed, which can thus be used to develop a novel strategy for its treatment. Based on the high overexpression of Y
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B, Member 1/antagonists & inhibitors ; ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Antineoplastic Agents/chemical synthesis ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Breast Neoplasms/metabolism ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Doxorubicin/chemistry ; Doxorubicin/pharmacology ; Drug Resistance, Multiple/drug effects ; Drug Resistance, Neoplasm/drug effects ; Drug Screening Assays, Antitumor ; Female ; Humans ; Ligands ; MCF-7 Cells ; Mammary Neoplasms, Experimental/diagnostic imaging ; Mammary Neoplasms, Experimental/drug therapy ; Mammary Neoplasms, Experimental/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Nude ; Micelles ; Nanoparticles/chemistry ; Optical Imaging ; Quinolines/chemistry ; Quinolines/pharmacology ; Receptors, Neuropeptide Y/antagonists & inhibitors ; Receptors, Neuropeptide Y/metabolism
    Chemical Substances ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antineoplastic Agents ; Ligands ; Micelles ; Quinolines ; Receptors, Neuropeptide Y ; Doxorubicin (80168379AG) ; tariquidar (J58862DTVD)
    Language English
    Publishing date 2019-09-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/c9bm00337a
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article: Effects of Y

    Yang, Guojian / Sun, Peng / Wang, Yuezhong / Shi, Zitao / Yan, Qingwei / Li, Shasha / Yang, Guoyong / Yang, Ke / Dun, Shijie / Shang, Peng / Deng, Lifen / Li, He / Jiang, Nan

    Materials (Basel, Switzerland)

    2022  Volume 15, Issue 22

    Abstract: Sintering aid was very crucial to influence the microstructure and thus the optical property of the sintered optical ceramics. The purpose of this work was to explain the difference between the sintering aids of ... ...

    Abstract Sintering aid was very crucial to influence the microstructure and thus the optical property of the sintered optical ceramics. The purpose of this work was to explain the difference between the sintering aids of Li
    Language English
    Publishing date 2022-11-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma15228036
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Carbon quantum dots modified and Y

    Gao, Jiamin / Xie, Huidong / Zuo, Feng / Liu, Hu / Zhao, Yajuan / Yang, Chang

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2024  Volume 30, Issue 20, Page(s) e202400170

    Abstract: ... density. Herein, carbon quantum dots modified and Y ...

    Abstract Supercapacitor is an important energy storage device widely used in the automobile industry, military production, and communication equipment because of its fast charge-discharge rate, and high power density. Herein, carbon quantum dots modified and Y
    Language English
    Publishing date 2024-02-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202400170
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Roles of Y-27632 on sheep sperm metabolism.

    Fu, Yu / Shen, Wenzheng / Bai, Haiyu / Zhang, Zhiyu / Cao, Zhikun / Liu, Zibo / Yang, Chao / Sun, Shixin / Wang, Lei / Ling, Yinghui / Zhang, Zijun / Cao, Hongguo

    Journal of animal science

    2024  Volume 102

    Abstract: To investigate the effect of Y-27632 on low-temperature metabolism of sheep sperm, different ... concentrations of Y-27632 were added to sheep semen at 4 °C in this experiment to detect indicators ... metabolomics. The results showed that the addition of 20 µM Y-27632 significantly increased sperm motility ...

    Abstract To investigate the effect of Y-27632 on low-temperature metabolism of sheep sperm, different concentrations of Y-27632 were added to sheep semen at 4 °C in this experiment to detect indicators such as sperm motility, plasma membrane, acrosome, antioxidant performance, mitochondrial membrane potential (MMP), and metabolomics. The results showed that the addition of 20 µM Y-27632 significantly increased sperm motility, plasma membrane integrity rate, acrosome integrity rate, antioxidant capacity, MMP level, significantly increased sperm adenosine triphosphate (ATP) and total cholesterol content, and significantly reduced sperm Ca2+ content. In metabolomics analysis, compared with the control group, the 20 µM Y-27632 group screened 20 differential metabolites, mainly involved in five metabolic pathways, with the most significant difference in Histidine metabolism (P = 0.001). The results confirmed that Y-27632 significantly improved the quality of sheep sperm preservation under low-temperature conditions.
    MeSH term(s) Male ; Animals ; Sheep ; Semen/metabolism ; Antioxidants/metabolism ; Sperm Motility ; Spermatozoa ; Semen Preservation/veterinary ; Cryopreservation/veterinary ; Amides ; Pyridines
    Chemical Substances Y 27632 (138381-45-0) ; Antioxidants ; Amides ; Pyridines
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390959-1
    ISSN 1525-3163 ; 0021-8812
    ISSN (online) 1525-3163
    ISSN 0021-8812
    DOI 10.1093/jas/skae020
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1312: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Polycrystalline Er-doped Y

    Yu, Zhimin / Yuan, Kang / Yang, Yang / Sun, Jiaming

    Nanoscale

    2022  Volume 14, Issue 29, Page(s) 10540–10548

    Abstract: Polycrystalline erbium-doped Y ...

    Abstract Polycrystalline erbium-doped Y
    Language English
    Publishing date 2022-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d2nr03118c
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top