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  1. Book ; Online: DAN

    Cao, Yuhong / Sun, Zhanhong / Sartoretti, Guillaume

    Decentralized Attention-based Neural Network for the MinMax Multiple Traveling Salesman Problem

    2021  

    Abstract: ... approaches the mTSP as a cooperative task and introduces DAN, a decentralized attention-based neural method ... that aims at tackling this key trade-off. In DAN, agents learn fully decentralized policies ... to $1000$ cities and $5$ to $20$ agents) show that DAN is able to match or outperform state-of-the-art ...

    Abstract The multiple traveling salesman problem (mTSP) is a well-known NP-hard problem with numerous real-world applications. In particular, this work addresses MinMax mTSP, where the objective is to minimize the max tour length among all agents. Many robotic deployments require recomputing potentially large mTSP instances frequently, making the natural trade-off between computing time and solution quality of great importance. However, exact and heuristic algorithms become inefficient as the number of cities increases, due to their computational complexity. Encouraged by the recent developments in deep reinforcement learning (dRL), this work approaches the mTSP as a cooperative task and introduces DAN, a decentralized attention-based neural method that aims at tackling this key trade-off. In DAN, agents learn fully decentralized policies to collaboratively construct a tour, by predicting each other's future decisions. Our model relies on the Transformer architecture and is trained using multi-agent RL with parameter sharing, providing natural scalability to the numbers of agents and cities. Our experimental results on small- to large-scale mTSP instances ($50$ to $1000$ cities and $5$ to $20$ agents) show that DAN is able to match or outperform state-of-the-art solvers while keeping planning times low. In particular, given the same computation time budget, DAN outperforms all conventional and dRL-based baselines on larger-scale instances (more than 100 cities, more than 5 agents), and exhibits enhanced agent collaboration. A video explaining our approach and presenting our results is available at \url{https://youtu.be/xi3cLsDsLvs}.

    Comment: Submitted to the 16th International Symposium on Distributed Autonomous Robotic Systems (DARS 2022)
    Keywords Computer Science - Robotics ; Computer Science - Artificial Intelligence ; Computer Science - Multiagent Systems
    Subject code 006
    Publishing date 2021-09-09
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Book ; Online: DAN-Net

    Wang, Tao / Xia, Wenjun / Huang, Yongqiang / Sun, Huaiqiang / Liu, Yan / Chen, Hu / Zhou, Jiliu / Zhang, Yi

    Dual-Domain Adaptive-Scaling Non-local Network for CT Metal Artifact Reduction

    2021  

    Abstract: ... performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR ... module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates ...

    Abstract Metal implants can heavily attenuate X-rays in computed tomography (CT) scans, leading to severe artifacts in reconstructed images, which significantly jeopardize image quality and negatively impact subsequent diagnoses and treatment planning. With the rapid development of deep learning in the field of medical imaging, several network models have been proposed for metal artifact reduction (MAR) in CT. Despite the encouraging results achieved by these methods, there is still much room to further improve performance. In this paper, a novel Dual-domain Adaptive-scaling Non-local network (DAN-Net) for MAR. We correct the corrupted sinogram using adaptive scaling first to preserve more tissue and bone details as a more informative input. Then, an end-to-end dual-domain network is adopted to successively process the sinogram and its corresponding reconstructed image generated by the analytical reconstruction layer. In addition, to better suppress the existing artifacts and restrain the potential secondary artifacts caused by inaccurate results of the sinogram-domain network, a novel residual sinogram learning strategy and nonlocal module are leveraged in the proposed network model. In the experiments, the proposed DAN-Net demonstrates performance competitive with several state-of-the-art MAR methods in both qualitative and quantitative aspects.

    Comment: 29 pages, 11 figures
    Keywords Physics - Medical Physics ; Computer Science - Computer Vision and Pattern Recognition
    Subject code 006
    Publishing date 2021-02-16
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article: Toxicological safety evaluation of Qin-Zhi-Zhu-Dan formula in rats during the treatment and recovery periods.

    Xu, Wenxiu / Chen, Dan / Zhang, Zehan / Liu, Shuling / Chen, Congai / Sun, Chunyan / Ni, Wenchao / Kang, Xiangdong / Shang, Guojiao / Wang, Xueqian / Cheng, Fafeng / Wang, Qingguo

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 987997

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.987997
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Multiomics profiling of the therapeutic effect of Dan-deng-tong-nao capsule on cerebral ischemia-reperfusion injury.

    Shi, Yingying / Du, Qiuzheng / Li, Zhuolun / Xue, Lianping / Jia, Qingquan / Zheng, Tianyuan / Liu, Jiyun / Ren, Ruobing / Sun, Zhi

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Volume 128, Page(s) 155335

    Abstract: ... and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional Chinese medicine used ...

    Abstract Background: Stroke is a complex physiological process associated with intestinal flora dysbiosis and metabolic disorders. Dan-deng-tong-nao capsule (DDTN) is a traditional Chinese medicine used clinically to treat cerebral ischemia-reperfusion injury (CIRI) for many years. However, little is known about the effects of DDTN in the treatment of CIRI from the perspective of gut microbiota and metabolites.
    Purpose: This study aimed to investigate the regulatory roles of DDTN in endogenous metabolism and gut microbiota in CIRI rats, thus providing a basis for clinical rational drug use and discovering natural products with potential physiological activities in DDTN for the treatment of CIRI.
    Methods: The chemical composition of DDTN in vitro and in vivo was investigated using ultra-high performance liquid chromatography-high resolution mass spectrometry (UHPLCHRMS), followed by target prediction using reverse molecular docking. Secondly, a biological evaluation of DDTN ameliorating neural damage in CIRI was performed at the whole animal level. Then, an integrated omics approach based on UHPLCHRMS and 16S rRNA sequencing was proposed to reveal the anti-CIRI effect and possible mechanism of DDTN. Finally, exploring the intrinsic link between changes in metabolite profiles, changes in the intestinal flora, and targets of components to reveal DDTN for the treatment of CIRI.
    Results: A total of 112 chemical components of DDTN were identified in vitro and 10 absorbed constituents in vivo. The efficacy of DDTN in the treatment of CIRI was confirmed by alleviating cerebral infarction and neurological deficits. After the DDTN intervention, 21 and 26 metabolites were significantly altered in plasma and fecal, respectively. Based on the fecal microbiome, a total of 36 genera were enriched among the different groups. Finally, the results of the network integration analysis showed that the 10 potential active ingredients of DDTN could mediate the differential expression of 24 metabolites and 6 gut microbes by targeting 25 target proteins.
    Conclusion: This study was the first to outline the landscapes of metabolites as well as gut microbiota regulated by DDTN in CIRI rats using multi-omics data, and comprehensively revealed the systematic relationships among ingredients, targets, metabolites, and gut microbiota, thus providing new perspectives on the mechanism of DDTN in the treatment of CIRI.
    Language English
    Publishing date 2024-01-01
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2023.155335
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Qi-dan-dihuang decoction ameliorates renal fibrosis in diabetic rats via p38MAPK/AKT/mTOR signaling pathway.

    Kuang, Liuyan / You, Yanting / Qi, Jieying / Chen, Jieyu / Zhou, Xinghong / Ji, Shuai / Cheng, Jingru / Kwan, Hiu Yee / Jiang, Pingping / Sun, Xiaomin / Su, Mengting / Wang, Ming / Chen, Wenxiao / Luo, Ren / Zhao, Xiaoshan / Zhou, Lin

    Environmental toxicology

    2024  

    Abstract: Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD ...

    Abstract Context: Qi-dan-dihuang decoction (QDD) has been used to treat diabetic kidney disease (DKD), but the underlying mechanisms are poorly understood.
    Objective: This study reveals the mechanism by which QDD ameliorates DKD.
    Materials and methods: The compounds in QDD were identified by high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry (HPLC-Q-TOF-MS). Key targets and signaling pathways were screened through bioinformatics. Nondiabetic Lepr db/m mice were used as control group, while Lepr db/db mice were divided into model group, dapagliflozin group, 1% QDD-low (QDD-L), and 2% QDD-high (QDD-H) group. After 12 weeks of administration, 24 h urinary protein, serum creatinine, and blood urea nitrogen levels were detected. Kidney tissues damage and fibrosis were evaluated by pathological staining. In addition, 30 mmol/L glucose-treated HK-2 and NRK-52E cells to induce DKD model. Cell activity and migration capacity as well as protein expression levels were evaluated.
    Results: A total of 46 key target genes were identified. Functional enrichment analyses showed that key target genes were significantly enriched in the phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and mitogen-activated protein kinase (MAPK) signaling pathways. In addition, in vivo and in vitro experiments confirmed that QDD ameliorated renal fibrosis in diabetic mice by resolving inflammation and inhibiting the epithelial-mesenchymal transition (EMT) via the p38MAPK and AKT-mammalian target of rapamycin (mTOR) pathways.
    Discussion and conclusion: QDD inhibits EMT and the inflammatory response through the p38MAPK and AKT/mTOR signaling pathways, thereby playing a protective role in renal fibrosis in DKD.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1463449-1
    ISSN 1522-7278 ; 1520-4081
    ISSN (online) 1522-7278
    ISSN 1520-4081
    DOI 10.1002/tox.24179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Guan Xin Dan Shen formulation protects

    Zhang, Bin / Zhang, Chen-Yang / Zhang, Xue-Lian / Sun, Gui-Bo / Sun, Xiao-Bo

    Molecular medicine reports

    2021  Volume 24, Issue 1

    Abstract: Guan Xin Dan Shen formulation (GXDSF) is a widely used treatment for the management ...

    Abstract Guan Xin Dan Shen formulation (GXDSF) is a widely used treatment for the management of coronary heart disease in China and is composed of three primary components:
    MeSH term(s) Animals ; Apoptosis/drug effects ; Body Weight/drug effects ; Cardiomegaly/etiology ; Cardiomegaly/metabolism ; Cardiomegaly/pathology ; Cardiomegaly/prevention & control ; Cardiotonic Agents/pharmacology ; Cardiotonic Agents/therapeutic use ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/metabolism ; Diabetic Cardiomyopathies/etiology ; Diabetic Cardiomyopathies/metabolism ; Diabetic Cardiomyopathies/pathology ; Diabetic Cardiomyopathies/prevention & control ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Insulin Resistance ; Lipids/blood ; Male ; Mice, Inbred Strains ; Mice, Transgenic ; NF-E2-Related Factor 2/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Signal Transduction/drug effects ; Mice
    Chemical Substances Cardiotonic Agents ; Drugs, Chinese Herbal ; Lipids ; NF-E2-Related Factor 2 ; Nfe2l2 protein, mouse ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2021-05-26
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2469505-1
    ISSN 1791-3004 ; 1791-2997
    ISSN (online) 1791-3004
    ISSN 1791-2997
    DOI 10.3892/mmr.2021.12170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Dan-Shen-Yin Granules Prevent Hypoxia-Induced Pulmonary Hypertension

    Wang, Ran-Ran / Yuan, Tian-Yi / Chen, Di / Chen, Yu-Cai / Sun, Shu-Chan / Wang, Shou-Bao / Kong, Ling-Lei / Fang, Lian-Hua / Du, Guan-Hua

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 844400

    Abstract: ... of their multiple components. The present study aims to evaluate the effects of Dan-Shen-Yin (DSY) granules ...

    Abstract Traditional Chinese medicine (TCM) plays an important role in the treatment of complex diseases, especially cardiovascular diseases. However, it is hard to identify their modes of action on account of their multiple components. The present study aims to evaluate the effects of Dan-Shen-Yin (DSY) granules on hypoxia-induced pulmonary hypertension (HPH), and then to decipher the molecular mechanisms of DSY. Systematic pharmacology was employed to identify the targets of DSY on HPH. Furthermore, core genes were identified by constructing a protein-protein interaction (PPI) network and analyzed by Gene Ontology (GO) and Kyoto Encyclopedia of Genes (KEGG) analysis. Related genes and pathways were verified using a hypoxia-induced mouse model and hypoxia-treated pulmonary artery cells. Based on network pharmacology, 147 potential targets of DSY on HPH were found, constructing a PPI network, and 13 hub genes were predicted. The results showed that the effect of DSY may be closely associated with AKT serine/threonine kinase 1 (AKT1), signal transducer and activator of transcription 3 (STAT3), and HIF-1 signaling pathways, as well as biological processes such as cell proliferation. Consistent with network pharmacology analysis, experiments
    Language English
    Publishing date 2022-03-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.844400
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial.

    Gan, Jingwen / Zhu, Shi-Yang / Ma, Xiao / Ding, Xue-Song / Deng, Yan / Wang, Yanfang / Sun, Ai-Jun

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt B, Page(s) 116975

    Abstract: Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known ... Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and ... 4: Conclusion: Ding-kun-dan is another available, effective and safe method for patients ...

    Abstract Ethnopharmacological relevance: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD).
    Aim of the study: To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea.
    Materials and method: 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF
    Results: Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4
    Conclusion: Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents.
    MeSH term(s) Female ; Humans ; Desogestrel/therapeutic use ; Dinoprostone ; Double-Blind Method ; Dysmenorrhea/drug therapy ; Dysmenorrhea/diagnosis ; Endometriosis ; Medicine, Chinese Traditional ; Prospective Studies
    Chemical Substances Desogestrel (81K9V7M3A3) ; Dinoprostone (K7Q1JQR04M)
    Language English
    Publishing date 2023-07-29
    Publishing country Ireland
    Document type Journal Article ; Multicenter Study ; Randomized Controlled Trial
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116975
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial

    Gan, Jingwen / Zhu, Shi-yang / Ma, Xiao / Ding, Xue-song / Deng, Yan / Wang, Yanfang / Sun, Ai-jun

    Journal of Ethnopharmacology. 2024 Jan., v. 318 p.116975-

    2024  

    Abstract: Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered ... dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients ... kun-dan is another available, effective and safe method for patients with primary dysmenorrhea ...

    Abstract Ding-kun-dan (DKD), as one of well-known traditional Chinese medicine (TCM), is considered as an effective prescription to regulate menstruation, benefit Qi and nourish the blood. Previous studies had showed that DKD could improve sex hormone levels, insulin resistance, metabolism abnormalities and regulate immunity in animal models with polycystic ovary syndrome or endometriosis, however, little study conducted to reveal its clinical efficacy in Primary Dysmenorrhea (PD). To compare the effect of Ding-kun-dan (DKD) with Marvelon on relief of symptoms and change of serum pain-related factors in patients with primary dysmenorrhea. 136 patients with primary dysmenorrhea were randomly assigned to the DKD group (n = 73, take one tablet per day from 5th day of the menstrual cycle for 10 days every 28 days) and the Marvelon group (n = 63, take one tablet per day from 5th day of the menstrual cycle for 21 days every 28 days), the therapeutic effects were analyzed through evaluating the change of VAS scores, CMSS scores and the level of PGF₂ₐ, PGE₂, PGF₂ₐ/PGE₂ and NO during the 12 weeks intervention. Both DKD and Marvelon could effectively relief pain and other associated symptoms at each visit (Baseline, 4ᵗʰ week, 8ᵗʰ week and 12ᵗʰ week). Although Marvelon was significantly superior to DKD in reducing VAS scores, the total CMSS, CMSS severity and duration scores at each posttreatment follow-up (P < 0.01), VAS scores in the DKD group decreased significantly over time while scores in the COC group only dropped rapidly after the first two months of treatment. Efficacy gap between two interventions continuously narrowed over time and the efficacy of DKD became non-inferior at the 12ᵗʰ week compared to that of Marvelon (the difference between groups, – 0.78%; 95% confidence interval (CI), −13.67%–12.75%; non-inferiority margin, 15%). DKD group had better efficacy on mild pain compared to that of the COC group with no statistical difference (75% VS 61.9%, P > 0.05). DKD and Marvelon could effectively reduce PGF₂ₐ, PGE₂ and higher PGF₂ₐ/PGE₂ in patients with PD. There was no statistical difference in the level of PGF₂ₐ, PGE₂, PGF₂ₐ/PGE₂ and NO between DKD and Marvelon group at each follow-up. No serious adverse effect was observed. Ding-kun-dan is another available, effective and safe method for patients with primary dysmenorrhea to choose, especially for those who are suffered from mild pain and/or contraindicated to hormonal agents.
    Keywords Oriental traditional medicine ; adverse effects ; animals ; blood serum ; confidence interval ; endometriosis ; immunity ; insulin resistance ; menstruation ; metabolism ; pain ; polycystic ovary syndrome ; therapeutics ; Primary dysmenorrhea ; Ding-kun-dan ; Marvelon ; VAS ; CMSS ; PGF2a ; PGE2 ; PGF2a/PGE2
    Language English
    Dates of publication 2024-01
    Publishing place Elsevier B.V.
    Document type Article ; Online
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116975
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: Kun-Dan Decoction Ameliorates Insulin Resistance by Activating AMPK/mTOR-Mediated Autophagy in High-Fat Diet-Fed Rats.

    Su, Zuqing / Zeng, Kexue / Feng, Bing / Tang, Lipeng / Sun, Chaoyue / Wang, Xieqi / Li, Caiyun / Zheng, Guangjuan / Zhu, Ying

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 670151

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-05-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.670151
    Database MEDical Literature Analysis and Retrieval System OnLINE

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