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Article ; Online: Post operative analgesia after incisional infiltration of bupivacaine v/s bupivacaine with buprenorphine.

Mehta, Tanu R / Parikh, Beena K / Bhosale, Guruprasad P / Butala, Bina P / Shah, Veena R

Journal of anaesthesiology, clinical pharmacology

2011 Volume 27, Issue 2, Page(s) 211–214

Abstract: Introduction: Opioid receptors have been demonstrated in the peripheral nerve endings of afferent neurons. Blockade of these receptors with peripherally administered opioid is believed to result in analgesia.: Aim: To evaluate whether buprenorphine ... ...

Abstract	Introduction: Opioid receptors have been demonstrated in the peripheral nerve endings of afferent neurons. Blockade of these receptors with peripherally administered opioid is believed to result in analgesia. Aim: To evaluate whether buprenorphine added to bupivacaine for wound infiltration can enhance post-operative analgesia via peripheral mechanisms. Materials and methods: Forty ASA I and II adult patients scheduled for open donor nephrectomy were enrolled in this randomized double blind prospective study. In group A (n = 20) patients, the wound was infiltrated with bupivacaine 0.5% (2 mg/kg) and in group B (n = 20) with bupivacaine 0.5% (2 mg/kg) and buprenorphine (2 μg/kg). All patients were given diclofenac 75 mg IM at 8 h interval. Post-operative quality of analgesia was assessed by VAS (0-10) for 24 h and when VAS > 4 rescue analgesic was administered. Total dose of rescue analgesic and side effects were noted. Results: The time of administration of first rescue analgesic was significantly higher in group B (10.52±5.54 h) as compared to group A (3.275±1.8 h). Mean VAS was significantly lower in group B as compared to group A. The total dosage of rescue analgesic was more in group A as compared to group B patients. Conclusion: Addition of buprenorphine to the local anesthetic significantly prolonged the time to first rescue analgesic requirement and the total consumption of rescue analgesic in 24 h, thus providing evidence in support of the existence of peripheral opioid receptors.
Language	English
Publishing date	2011-06-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2253976-1
ISSN	2231-2730 ; 0970-9185
ISSN (online)	2231-2730
ISSN	0970-9185
DOI	10.4103/0970-9185.81835
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Post operative analgesia after incisional infiltration of bupivacaine v/s bupivacaine with buprenorphine

Tanu R Mehta / Beena K Parikh / Guruprasad P Bhosale / Bina P Butala / Veena R Shah

Journal of Anaesthesiology Clinical Pharmacology, Vol 27, Iss 2, Pp 211-

2011 Volume 214

Abstract	Introduction: Opioid receptors have been demonstrated in the peripheral nerve endings of afferent neurons. Blockade of these receptors with peripherally administered opioid is believed to result in analgesia. Aim: To evaluate whether buprenorphine added to bupivacaine for wound infiltration can enhance post-operative analgesia via peripheral mechanisms. Materials and Methods: Forty ASA I and II adult patients scheduled for open donor nephrectomy were enrolled in this randomized double blind prospective study. In group A ( n=20) patients, the wound was infiltrated with bupivacaine 0.5% (2 mg/kg) and in group B ( n=20) with bupivacaine 0.5% (2 mg/kg) and buprenorphine (2 μg/kg). All patients were given diclofenac 75 mg IM at 8 h interval. Post-operative quality of analgesia was assessed by VAS (0-10) for 24 h and when VAS > 4 rescue analgesic was administered. Total dose of rescue analgesic and side effects were noted. Results: The time of administration of first rescue analgesic was significantly higher in group B (10.52±5.54 h) as compared to group A (3.275±1.8 h). Mean VAS was significantly lower in group B as compared to group A. The total dosage of rescue analgesic was more in group A as compared to group B patients. Conclusion: Addition of buprenorphine to the local anesthetic significantly prolonged the time to first rescue analgesic requirement and the total consumption of rescue analgesic in 24 h, thus providing evidence in support of the existence of peripheral opioid receptors.
Keywords	Buprenorphine ; post-operative analgesia ; peripheral opioid receptors ; Medicine ; R ; Surgery ; RD1-811 ; Anesthesiology ; RD78.3-87.3
Publishing date	2011-01-01T00:00:00Z
Publisher	Medknow Publications
Document type	Article ; Online
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Article ; Online: Understanding and Addressing Mental Health Disorders: a Workplace Imperative.

Taubman, Danielle S / Parikh, Sagar V

Current psychiatry reports

2023 Volume 25, Issue 10, Page(s) 455–463

Abstract: Purpose of review: This article seeks to provide a broad overview of the workplace mental health literature, highlight practical implications of current research, and formulate key recommendations for stakeholders. Various aspects of disability related ... ...

Abstract	Purpose of review: This article seeks to provide a broad overview of the workplace mental health literature, highlight practical implications of current research, and formulate key recommendations for stakeholders. Various aspects of disability related to mental health disorders, their associated financial costs, and the impact of stigma are covered. This article also discusses key strategies for assessing mental health problems among employees and reviews different types of interventions in the workplace. Recent findings: Workplace mental health is an evolving area, particularly in the wake of the pandemic. While established national workplace mental health standards do not currently exist, mental illness continues to have a severe impact on the health of organizations, employees, and the economy. Additional research is needed to fully understand and address the diversity of mental health needs among the broad range of employees and organizations across the USA. Employers have a responsibility and an opportunity to create workplaces that support the whole person, not just the employee. While research in the area has increased in the last decade, there is still much to learn in terms of the most effective ways to support our workforce.
MeSH term(s)	Humans ; Mental Health ; Mental Disorders/diagnosis ; Mental Disorders/therapy ; Mental Disorders/psychology ; Workplace/psychology ; Social Stigma ; Disabled Persons
Language	English
Publishing date	2023-08-17
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2055376-6
ISSN	1535-1645 ; 1523-3812
ISSN (online)	1535-1645
ISSN	1523-3812
DOI	10.1007/s11920-023-01443-7
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Article ; Online: RNA sequencing and expression heterogeneity in head and neck cancer.

Parikh, Anuraag S / Puram, Sidharth V

Cancer cytopathology

2022 Volume 130, Issue 11, Page(s) 842–843

MeSH term(s)	Humans ; Head and Neck Neoplasms/genetics ; Sequence Analysis, RNA
Language	English
Publishing date	2022-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2594979-2
ISSN	1934-6638 ; 1934-662X
ISSN (online)	1934-6638
ISSN	1934-662X
DOI	10.1002/cncy.22622
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Article: Menstrual hygiene among adolescent girls studying in a university of Gujarat.

Parikh, Vidhi / Nagar, Shashwat

Journal of family medicine and primary care

2022 Volume 11, Issue 7, Page(s) 3607–3612

Abstract: Background: Menstruation marks the beginning of the reproductive life of a girl. A poor menstrual understanding and its unhealthy practices may increase the risk of reproductive infections, urinary tract infections, and even cancer. Therefore, the main ... ...

Abstract	Background: Menstruation marks the beginning of the reproductive life of a girl. A poor menstrual understanding and its unhealthy practices may increase the risk of reproductive infections, urinary tract infections, and even cancer. Therefore, the main objective of this study was studying the knowledge and attitude regarding menstrual hygiene among adolescent girls so that it can be then taken as a background for designing necessary interventions in the community. Objectives: 1) To study the knowledge and attitude towards menstruation among adolescent girls and 2) to study the menstrual hygiene practices and health-seeking behaviour of the adolescent girls. Methods: This was a university-based descriptive cross-sectional study carried out by directly interviewing the subjects using the interviewer-administered questionnaire - pre-tested and pre-designed proforma. The data were analysed statistically by simple proportions. Results: Among the study subjects, 79% had proper knowledge about menstruation. 82% had a normal menstrual pattern. Nearly 96% used sanitary pads, and 2.36% used reusable cloths. Regarding restrictions, 74.80% restrained themselves from visiting the places of worship, 21% avoided physical exercise, and 7.87% had to remain isolated with minimal social contact. Nearly 19% made conscious efforts for dietary changes during menstruation. Conclusion: A majority of the subjects had a regular menstrual cycle, but menstrual problems were found to be more among those having irregular periods, those changing absorbents infrequently, with an inadequate frequency of cleaning, and those using plain water for cleaning. The study however does reflect the fact that menstrual hygiene was unsatisfactory among adolescent girls. Therefore, they need to be educated about the facts of menstruation and proper hygienic practices.
Language	English
Publishing date	2022-07-22
Publishing country	India
Document type	Journal Article
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_2303_21
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Article: A Rare Case of Recurrent Immunotactoid Glomerulonephritis.

Doraiswamy, Mohankumar / Parikh, Samir V / Brodsky, Sergey

Cureus

2023 Volume 15, Issue 2, Page(s) e35136

Abstract: Immunotactoid glomerulopathy is an uncommon cause of glomerular disease that results from deposits derived from immunoglobulins. This rare disease can occur in native kidneys and in transplant patients. They are present only in 0.5% to 1.4% of native ... ...

Abstract	Immunotactoid glomerulopathy is an uncommon cause of glomerular disease that results from deposits derived from immunoglobulins. This rare disease can occur in native kidneys and in transplant patients. They are present only in 0.5% to 1.4% of native kidney biopsies. Treatment of this disease is directed at the underlying monoclonal gammopathy, infection, and B-cell lymphoproliferative disorders. Prognosis is very guarded with 50% of people developing ESRD within five years of diagnosis. We present an interesting, rare case of recurrent immunotactoid glomerulonephritis which responded appropriately to rituximab therapy.
Language	English
Publishing date	2023-02-18
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.35136
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Article ; Online: Analyzing the impact of close margins and extra-resection margins on failure rates in postoperative oral cavity cancers.

Shivhare, V / Rath, S / Rathod, H / Dash, N K / Parikh, A / Suryanarayan Kunikullaya, U

Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti

2023 Volume 37, Issue 6, Page(s) 467–472

Abstract: Background: Postoperative oral cancers with close margins belong to medium- to high-risk category for local failure. During re-surgery for close margins, there is sufficient doubt as to whether the re-excised tissue is from the same region as the close ... ...

Title translation	Analýza vlivu těsných a dodatečných resekčních okrajů na míru selhání léčby karcinomu ústní dutiny po operaci.
Abstract	Background: Postoperative oral cancers with close margins belong to medium- to high-risk category for local failure. During re-surgery for close margins, there is sufficient doubt as to whether the re-excised tissue is from the same region as the close margin. Therefore, we planned a retrospective review of these cases of close margins that were re-excised with extra-resection margins (ERMs). Material and methods: Details of 2011 oral cavity patients resected at our hospital were retrieved. Cases with close margins were segregated and the status of ERMs was noted. The postoperative histopathological details, radiotherapy details, and failure patterns in all these cases were documented. The primary objective of the study was to assess the overall survival (OS) and disease-free survival (DFS) in cases with ERMs. The secondary objective was to assess the local and regional control rates and variation with the number and status of close and ERMs. OS, DFS, and local failure rates were defined from the date of registration. Statistical analysis was performed with the SPSS statistical software package. All survival analyses were performed using the Kaplan-Meier method. Log-rank test was used to test the statistical significance. A P-value of 0.05 was considered statistically significant. Results: Sixty-four cases with a median age of 47 years (range: 29-76) were considered for the final analysis. The median follow-up was 40 months (range: 9.5-56.5). The 2-year OS and DFS rates were 91.5% and 88.5%, respectively. The crude local and regional failure rates were 10.9% and 3.1%, respectively. The 3-year locoregional control rate was 90.2%. The 2-year locoregional control rate for one close margin was significantly better as compared to more than one close margin (P = 0.049). No difference in survival and failure rates was found between the number of ERMs resected (one vs. two) and ≤ vs. > 3 mm close margin status. Two patients developed bone metastases. Conclusion: The survival rates and locoregional control rates did not differ much between the groups that had one or more ERMs. However, the locoregional control rates were better in cases with one close margin as compared to those with more than one close margin. A larger study with longer follow-up is needed to detect statistically significant differences in outcomes and identify the factors that portend poor prognosis in these cases with close margins and ERMs.
MeSH term(s)	Adult ; Aged ; Humans ; Middle Aged ; Margins of Excision ; Mouth Neoplasms/radiotherapy ; Mouth Neoplasms/surgery ; Neoplasm Recurrence, Local/pathology ; Retrospective Studies ; Postoperative Complications
Language	English
Publishing date	2023-12-28
Publishing country	Czech Republic
Document type	Journal Article
ZDB-ID	1217739-8
ISSN	1802-5307 ; 0862-495X
ISSN (online)	1802-5307
ISSN	0862-495X
DOI	10.48095/ccko2023467
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Article: Bitter bottle gourd poisoning: A case report and review of literature.

Chavda, Dhruvrajsinh M / Parikh, Charmy / Patel, Vishwa V / Pandya, Pankti S

Journal of family medicine and primary care

2022 Volume 11, Issue 7, Page(s) 4042–4044

Abstract: Bottle gourd juice is considered a panacea in traditional Indian medicine and used in various chronic diseases. Increased levels of Cucurbitacin can turn it bitter causing toxic effects in gastrointestinal system. We report the case of an elderly female ... ...

Abstract	Bottle gourd juice is considered a panacea in traditional Indian medicine and used in various chronic diseases. Increased levels of Cucurbitacin can turn it bitter causing toxic effects in gastrointestinal system. We report the case of an elderly female who presented with shock in few hours after consumption of bitter bottle gourd juice. After proper evaluation we considered the possibility of bottle gourd poisoning as a probable diagnosis due to the Naranjo adverse drug reactions probability scale. Since there is no specific antidote available, management is mostly supportive with intravenous fluids, control of bleeding and management of shock.
Language	English
Publishing date	2022-07-22
Publishing country	India
Document type	Case Reports
ZDB-ID	2735275-4
ISSN	2278-7135 ; 2249-4863
ISSN (online)	2278-7135
ISSN	2249-4863
DOI	10.4103/jfmpc.jfmpc_2154_21
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Article: Has Convalescent Plasma Therapy Hesitancy Increased COVID-19 Mortality?

Parikh, Purvish M / Sood, T / Agarwala, V / Kate, S

South Asian journal of cancer

2021 Volume 10, Issue 1, Page(s) 42–45

Abstract: We bring to you our viewpoint and a snapshot of the journey of convalescent plasma therapy (CPT) in the management of ongoing coronavirus disease 2019 (COVID-19) pandemic. We also discuss how best to use the updated data on this important treatment ... ...

Abstract	We bring to you our viewpoint and a snapshot of the journey of convalescent plasma therapy (CPT) in the management of ongoing coronavirus disease 2019 (COVID-19) pandemic. We also discuss how best to use the updated data on this important treatment option and maximize benefit for our patients, thereby saving lives, especially in resource constraint settings.
Language	English
Publishing date	2021-08-21
Publishing country	India
Document type	Journal Article
ZDB-ID	2719571-5
ISSN	2278-4306 ; 2278-330X
ISSN (online)	2278-4306
ISSN	2278-330X
DOI	10.1055/s-0041-1733351
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Article ; Online: Retinal nerve fiber layer thickness in amblyopia.

Parikh, Rajul / Sachdeva, Virender / Kekunnaya, Ramesh / Rao, B Venkateshwar / Parikh, Shefali / Thomas, Ravi

Indian journal of ophthalmology

2022 Volume 70, Issue 8, Page(s) 3065–3072

Abstract: Purpose: To report retinal nerve fiber layer thickness (RNFLT) in eyes with amblyopia compared with contralateral healthy eyes.: Methods: In this cross-sectional study, we included patients with anisometropic amblyopia, strabismic amblyopia, and ... ...

Abstract	Purpose: To report retinal nerve fiber layer thickness (RNFLT) in eyes with amblyopia compared with contralateral healthy eyes. Methods: In this cross-sectional study, we included patients with anisometropic amblyopia, strabismic amblyopia, and mixed amblyopia. All subjects underwent complete ophthalmic examination, including RNFLT measurement with time-domain OCT (Stratus OCT) and scanning laser polarimeter (GDX VCC). A paired "t" test was used to compare average and quadrant-wise RNFL thickness between the amblyopic and contralateral normal eyes. In addition, an analysis of variance test was used to compare various RNFL thickness parameters between the three groups. Results: A total of 33 eyes of 33 subjects with anisometropic amblyopia, 20 eyes of 20 subjects with strabismic amblyopia, and 38 eyes of 38 subjects with mixed amblyopia were included. In the anisometropic amblyopia group, the average RNFLT in the amblyopic eye was 98.2 μm and 99.8 μm in the fellow normal eye (P = 0.5), the total foveal thickness was 152.82 μm (26.78) in the anisometropic eye and 150.42 μm (23.84) in the fellow eye (P = 0.38). The difference between amblyopic and contralateral normal eye for RNFL and macular parameters was statistically insignificant in all three groups. The RNFL thickness in four quadrants was similar in the amblyopic and non-amblyopic eye between all three groups and statistically non-significant. Conclusion: Our study showed that RNFL thickness was similar in amblyopic and non-amblyopic eyes between all three amblyopia groups.
MeSH term(s)	Amblyopia/diagnosis ; Cross-Sectional Studies ; Humans ; Nerve Fibers ; Retinal Ganglion Cells ; Tomography, Optical Coherence ; Visual Acuity
Language	English
Publishing date	2022-08-01
Publishing country	India
Document type	Journal Article
ZDB-ID	187392-1
ISSN	1998-3689 ; 0301-4738
ISSN (online)	1998-3689
ISSN	0301-4738
DOI	10.4103/ijo.IJO_2875_21
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