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  1. Article ; Online: Meet the authors: Yuqiu Sun and Hui Jiang.

    Sun, Yuqiu / Jiang, Hui

    Molecular cell

    2024  Volume 84, Issue 2, Page(s) 183–185

    Abstract: We talk to first author Yuqiu Sun and corresponding author Hui Jiang about their paths in science ...

    Abstract We talk to first author Yuqiu Sun and corresponding author Hui Jiang about their paths in science, mentorship, and the exciting moments in the journey towards their paper "A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass" (this issue of Molecular Cell).
    MeSH term(s) Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mitochondrial Proteins/metabolism ; Mitochondria/metabolism ; Mitophagy/physiology
    Chemical Substances Membrane Proteins ; Mitochondrial Proteins
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1415236-8
    ISSN 1097-4164 ; 1097-2765
    ISSN (online) 1097-4164
    ISSN 1097-2765
    DOI 10.1016/j.molcel.2023.12.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Hepatitis C virus genotype diversity in Ningxia Hui autonomous region, Northwestern China.

    An, C / Ma, W / He, R F / Wu, T / Shi, J N / Sun, T T / Piao, W H

    Brazilian journal of biology = Revista brasleira de biologia

    2023  Volume 83, Page(s) e267641

    Abstract: ... to investigate the distribution of HCV genotypes in HCV infected patients, in Ningxia Hui Autonomous Region ... prevalence of 32.00%. HCV GT1b is the predominant HCV genotype in Ningxia Hui Autonomous Region. ...

    Abstract Hepatitis C virus (HCV) genotypes vary greatly in different regions. The aim of this study is to investigate the distribution of HCV genotypes in HCV infected patients, in Ningxia Hui Autonomous Region. Nucleic acid extraction and amplification were performed with test kits on 153 HCV infected patients serum samples. The HCV viral load was measured using reverse transcriptase PCR (RT-PCR) and HCV genotypes were determined. Among the 153 HCV-infected patients, 56 had genotype (GT)1b (36.60%), 45 had GT2a (29.40%), 23 had GT3a (15.00%), 14 had GT3b (9.20%),13 had GT6a (8.50%), 1 had GT1g (0.70%), 1 had GT6xa (0.70%). In GT1b, 21.40% were female and 78.60% were male; in GT2a, 42.20% were female and 57.80% were male;Males were most prevalent in genotypes 1b(39.30%), while female were most prevalent in genotype 2a(46.30%). Rare GT1g and GT6xa were also detected in males. The 41-50 year age group had the highest HCV prevalence of 32.00%. HCV GT1b is the predominant HCV genotype in Ningxia Hui Autonomous Region.
    MeSH term(s) Humans ; Male ; Female ; Hepacivirus/genetics ; Genotype ; China/epidemiology ; Prevalence ; Hepatitis C/epidemiology
    Language English
    Publishing date 2023-05-29
    Publishing country Brazil
    Document type Journal Article
    ZDB-ID 2036257-2
    ISSN 1678-4375 ; 1519-6984
    ISSN (online) 1678-4375
    ISSN 1519-6984
    DOI 10.1590/1519-6984.267641
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Spatial-temporal changes of landscape and habitat quality in typical ecologically fragile areas of western China over the past 40 years: A case study of the Ningxia Hui Autonomous Region.

    Wang, Ding / Hao, Haiguang / Liu, Hao / Sun, Lihui / Li, Yuyang

    Ecology and evolution

    2024  Volume 14, Issue 1, Page(s) e10847

    Abstract: ... to assess the habitat quality of the Ningxia Hui Autonomous Region in Western China, which has ... utilization. The research results show that the overall habitat quality of Ningxia Hui Autonomous Region was ...

    Abstract In this paper, we use the InVEST model and five periods of land use data from 1980 to 2020 to assess the habitat quality of the Ningxia Hui Autonomous Region in Western China, which has characteristics of a typical fragile ecosystem. We further analyse the spatial and temporal characteristics of habitat quality evolution and its relationship with land use and landscape pattern indices to explore the close relationship between regional habitat quality changes and human natural resource conservation and utilization. The research results show that the overall habitat quality of Ningxia Hui Autonomous Region was stable and at a moderate level (0.57-0.60) during the 40 years from 1980 to 2020; Habitat patches (2020) with low (24.89%), high (22.45%) and very high (29.81%) quality occupy a larger proportion of the area, followed by very low (13.31%) and moderate levels (9.54%). Over the past 40 years, there have been 275 sample sites in Ningxia where habitat quality has deteriorated, 1593 sample sites where the habitat quality has remained stable, and 184 sample sites where the habitat quality has increased. From 1980 to 2020, the Mean Patch Area of landscape types in Ningxia decreased by 25.9 hm
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2635675-2
    ISSN 2045-7758
    ISSN 2045-7758
    DOI 10.1002/ece3.10847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hepatitis C virus genotype diversity in Ningxia Hui autonomous region, Northwestern China

    C. An / W. Ma / R. F. He / T. Wu / J. N. Shi / T. T. Sun / W. H. Piao

    Brazilian Journal of Biology, Vol

    2023  Volume 83

    Abstract: ... is to investigate the distribution of HCV genotypes in HCV infected patients, in Ningxia Hui ... had the highest HCV prevalence of 32.00%. HCV GT1b is the predominant HCV genotype in Ningxia Hui ...

    Abstract Abstract Hepatitis C virus (HCV) genotypes vary greatly in different regions. The aim of this study is to investigate the distribution of HCV genotypes in HCV infected patients, in Ningxia Hui Autonomous Region. Nucleic acid extraction and amplification were performed with test kits on 153 HCV infected patients serum samples. The HCV viral load was measured using reverse transcriptase PCR (RT-PCR) and HCV genotypes were determined. Among the 153 HCV-infected patients, 56 had genotype (GT)1b (36.60%), 45 had GT2a (29.40%), 23 had GT3a (15.00%), 14 had GT3b (9.20%),13 had GT6a (8.50%), 1 had GT1g (0.70%), 1 had GT6xa (0.70%). In GT1b, 21.40% were female and 78.60% were male; in GT2a, 42.20% were female and 57.80% were male;Males were most prevalent in genotypes 1b(39.30%), while female were most prevalent in genotype 2a(46.30%). Rare GT1g and GT6xa were also detected in males. The 41-50 year age group had the highest HCV prevalence of 32.00%. HCV GT1b is the predominant HCV genotype in Ningxia Hui Autonomous Region.
    Keywords hepatitis C ; hepatitis C virus ; genotype ; Ningxia Hui autonomous region ; Science ; Q ; Biology (General) ; QH301-705.5 ; Zoology ; QL1-991 ; Botany ; QK1-989
    Language English
    Publishing date 2023-05-01T00:00:00Z
    Publisher Instituto Internacional de Ecologia
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Dynamic change of habitat quality and its key driving factors in Ningxia Hui Autonomous Region, China

    Wang, Ding / Hao, Haiguang / Liu, Hao / Sun, Lihui / Li, Yuyang

    Nature Conservation. 2023 Aug. 16, v. 53 p.125-155

    2023  

    Abstract: ... related to human well-being and ecosystem stability. Ningxia Hui Autonomous Region is a typical ...

    Abstract AbstractHabitat quality reflects the level of biodiversity, and habitat maintenance functions are related to human well-being and ecosystem stability. Ningxia Hui Autonomous Region is a typical ecologically fragile region in Western China with complex human-nature relationships. Maintaining good habitat is not only a fundamental requirement for biodiversity conservation but also a necessary path for sustainable regional development. In this study, we assessed and analysed the spatial and temporal patterns and changes in habitat quality in Ningxia from 2000 to 2020, and explored the driving factors of habitat quality using a geographically weighted regression (GWR) model. The results indicated: (1) The overall habitat quality level in Ningxia was low to intermediate, with an upwards and then downwards trend during the past 20 years, showing a small change in overall magnitude. (2) The high- and higher-level habitat quality patches in Ningxia were mainly distributed in areas with high vegetation cover, such as the Helan Mountain and Liupan Mountain. The patches of moderate-level habitat quality mainly included cultivated land, while the low- and lower-level patches were mainly distributed in areas subjected to more frequent human activities, such as cultivated land and construction land. (3) The spatial and temporal distribution patterns and changes in habitat quality in Ningxia from 2000 to 2020 were mainly influenced by fractional vegetation cover (FVC), soil moisture content (SMC), proportion of construction land area (PCL), and proportion of cultivated land area (CLP). Among them, FVC and SMC were positive driving factors, and PCL and CLP were negative driving factors. The results support that increasing vegetation cover and reducing anthropogenic disturbance to natural habitats are important measures to maintain fragile habitats and that key ecological function areas such as nature reserves are crucial for habitat quality protection in ecologically fragile areas.
    Keywords agricultural land ; anthropogenic activities ; biodiversity ; biodiversity conservation ; ecological balance ; ecological function ; fractional vegetation cover ; habitats ; humans ; models ; social welfare ; soil water content ; China ; Driving factors ; geographically weighted regression (GWR) ; habitat quality ; Ningxia Hui Autonomous Region ; spatiotemporal pattern
    Language English
    Dates of publication 2023-0816
    Size p. 125-155.
    Publishing place Pensoft Publishers
    Document type Article ; Online
    ZDB-ID 2667603-5
    ISSN 1314-3301
    ISSN 1314-3301
    DOI 10.3897/natureconservation.53.102810
    Database NAL-Catalogue (AGRICOLA)

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  6. Article: Male-Dominated Migration and Massive Assimilation of Indigenous East Asians in the Formation of Muslim Hui People in Southwest China.

    Wang, Qiyan / Zhao, Jing / Ren, Zheng / Sun, Jin / He, Guanglin / Guo, Jianxin / Zhang, Hongling / Ji, Jingyan / Liu, Yubo / Yang, Meiqing / Yang, Xiaomin / Chen, Jinwen / Zhu, Kongyang / Wang, Rui / Li, Yingxiang / Chen, Gang / Huang, Jiang / Wang, Chuan-Chao

    Frontiers in genetics

    2021  Volume 11, Page(s) 618614

    Abstract: The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion ... single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest ...

    Abstract The origin and diversification of Muslim Hui people in China via demic or simple cultural diffusion is a long-going debate. We here generated genome-wide data at nearly 700,000 single nucleotide polymorphisms (SNPs) from 45 Hui and 14 Han Chinese individuals collected from Guizhou province in southwest China. We applied principal component analysis (PCA), ADMIXTURE,
    Language English
    Publishing date 2021-01-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2020.618614
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Hui Medicine Moxibustion Promotes the Absorption of Lumbar Disc Herniation and the Recovery of Motor Function in Rats through Fas/FasL Signaling Pathway.

    Xu, Jianfeng / Luo, Qiang / Song, Junyao / Zhang, Yanming / Wang, Yingxu / Yang, Lei / Sha, Yinyin / Sun, Bowen / You, Na / Tian, Xinbao / Lin, Ruizhu / Wu, Yongli

    publication RETRACTED

    BioMed research international

    2022  Volume 2022, Page(s) 9172405

    Abstract: ... in the SD rats of lumbar intervertebral disc herniation treated with Hui medicine moxibustion (HMM ...

    Abstract Objectives: To study the resorption of the herniated lumbar disc (RHLD) and its mechanism in the SD rats of lumbar intervertebral disc herniation treated with Hui medicine moxibustion (HMM).
    Methods: Forty SD rats were randomly divided into four groups, normal group, lumbar disc herniation (LDH) group, HMM group, and antagonist (HMM+Met12) group, with 10 rats in each group. The rat model of LDH was prepared with the method of lumbar epidural emplacement of the caudal intervertebral disc. In the HMM group and HMM+Met12 groups, 4 weeks after modeling, HMM therapy was performed in the lumbar spine for 3 months with 1 time per day and 20 min each time, the samples were collected 8 weeks after the treatment. The histological degeneration was observed through HE staining, and the neovascularization of intervertebral disc tissues was detected by the expression of CD34 and vascular endothelial growth factor (VEGF). The apoptosis of nucleus pulpous cells was detected by TUNEL assay, and the activity of caspase-3, -8, and -9 and extracellular matrix enzymes was detected by western blotting.
    Results: HMM treatment significantly improved the behavioral ability of rats with LDH surgery. The morphological structure was obviously destroyed in the LDH group, but disc structure was significantly repaired in the HMM group, and mild structure alterations were observed in the HMM+Met12 group. Higher levels of CD34 and VEGF were detected in the HMM group indicating that neovascularization is formed. The expression level of FasL was significantly increased in the HMM group. The protein expression levels of cleaved-caspase-3, cleaved-caspase-8, and cleaved-caspase-9 in nucleus pulposus (NP) tissues were also elevated when treated with HMM, and the TUNEL staining showed the same results. The protein expression levels of matrix metalloproteinases- (MMP-) 1, MMP-2, MMP-3, MMP-13, and ADAMTS-4 were markedly promoted in the HMM group. Met12, a small peptide antagonist of FasL, significantly reduced the effects of HMM.
    Conclusion: HMM can promote the formation of neovascularization of lumbar intervertebral disc, support the apoptosis of NP cells through Fas/FasL signaling, and regulate the degradation of extracellular matrix enzyme, which then accelerates the absorption of lumbar intervertebral disc herniation and the recovery of motor function in rats.
    MeSH term(s) Animals ; Caspase 3/metabolism ; Intervertebral Disc/pathology ; Intervertebral Disc Degeneration/pathology ; Intervertebral Disc Displacement/pathology ; Intervertebral Disc Displacement/therapy ; Moxibustion ; Rats ; Rats, Sprague-Dawley ; Signal Transduction ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Caspase 3 (EC 3.4.22.-)
    Language English
    Publishing date 2022-07-23
    Publishing country United States
    Document type Journal Article ; Retracted Publication
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2022/9172405
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Interleukin-6 genotypes and serum levels in Chinese Hui population.

    Gao, Shu-Ping / Liang, Shu / Pan, Min / Sun, Rong-Liang / Chen, Chu / Luan, Hong / Jiang, Min-Hui

    International journal of clinical and experimental medicine

    2014  Volume 7, Issue 9, Page(s) 2851–2857

    Abstract: ... pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals. The Chinese Hui is one ... their effects on serum levels in Hui population. The aim of the present study is to determine the prevalence ... promoter region and their association with IL-6 serum levels in the Ningxia Hui population. A total of 96 Hui ...

    Abstract Interleukin-6 (IL-6) is a key pro-inflammatory cytokine involved in different physiologic and pathophysiologic processes, and circulating levels of IL-6 differ greatly between individuals. The Chinese Hui is one of the largest ethnic minorities, little is known about the distribution of IL-6 genetic variations and their effects on serum levels in Hui population. The aim of the present study is to determine the prevalence of -174G/C (rs1800795), -597G/A (rs1800797), and -634C/G (rs1800796) polymorphisms in the IL-6 gene promoter region and their association with IL-6 serum levels in the Ningxia Hui population. A total of 96 Hui subjects, (57 men and 39 women; mean age 49.65 ± 19.73 years) unrelated nationality residents in Ningxia Hui Autonomous Region were enrolled. Genotyping of the three polymorphisms were performed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) combined with gel electrophoresis and then confirmed by direct sequencing. The -174G/C (97.92% GG, 2.08% GC, and 0% CC) and -597G/A (98.96% GG, 1.04% GA, and 0% AA) polymorphisms were rare. The frequencies of -634C/G genotypes CC, CG, and GG were found to be 54.17%, 40.62%, and 5.21%, respectively in total studied subjects, the derived allele frequencies for the C and G alleles were 74.48% and 25.52%. Increased IL-6 levels were correlated with the IL-6 -634G allele carriers (CG+GG genotypes). The results suggest that IL-6 -174G/C and -597G/A are rare but -634C/G is common in the Ningxia Hui population, and the -634G allele is associated with circulating levels of IL-6.
    Language English
    Publishing date 2014-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2418305-2
    ISSN 1940-5901
    ISSN 1940-5901
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Genetic affinity between Ningxia Hui and eastern Asian populations revealed by a set of InDel loci.

    Zhou, Boyan / Wen, Shaoqing / Sun, Huilin / Zhang, Hong / Shi, Ruiming

    Royal Society open science

    2020  Volume 7, Issue 1, Page(s) 190358

    Abstract: According to historical records, ethnic Hui in China obtained substantial genetic components ... of Hui people were native Chinese populations. In this context, the formation of Hui is due to simple ... population genetic application of the 30 InDel loci in Hui population from Ningxia Hui Autonomous Region, Northwest ...

    Abstract According to historical records, ethnic Hui in China obtained substantial genetic components from western Eurasian populations during their Islamization. However, some scholars believed that the ancestry of Hui people were native Chinese populations. In this context, the formation of Hui is due to simple cultural diffusion rather than demic diffusion. In this study, we examined the forensic and population genetic application of the 30 InDel loci in Hui population from Ningxia Hui Autonomous Region, Northwest China. Genotype analysis of 129 unrelated individuals revealed that all loci were in the Hardy-Weinberg equilibrium in Ningxia Hui. Forensic indices calculated from genotypes demonstrated that this panel, Qiagen DIPplex
    Language English
    Publishing date 2020-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2787755-3
    ISSN 2054-5703
    ISSN 2054-5703
    DOI 10.1098/rsos.190358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Efficacy and safety of Qi-Jing Hui-Xin Decoction in the treatment of coronary microvascular angina: study protocol for a randomized, controlled, multi-center clinical trial.

    Sun, Yuanlong / Huang, Chengxin / Huo, Li / Li, Ying / Chen, Jun / Zhang, Zixiu / Jia, Meijun / Jiang, Meixian / Ruan, Xiaofen

    Trials

    2021  Volume 22, Issue 1, Page(s) 553

    Abstract: ... Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy, but there is ...

    Abstract Background: With the increased understanding of heart disease, microvascular angina (MVA) is receiving greater attention from clinicians. Studies have shown that patients with MVA have significantly higher major cardiovascular events and all-cause mortality than the control population, and the search for effective treatments is of great clinical importance. Both basic and clinical studies have shown that Qi-Jing Hui-Xin Decoction (QJHX) can relieve angina symptoms and improve clinical efficacy, but there is a lack of high-quality clinical studies to provide a research basis. This article introduces the evaluation protocol of QJHX for the adjunctive treatment of MVA.
    Methods/design: This is a prospective randomized controlled trial. The trial will enroll 150 patients with MVA. On the basis of Western drug treatment, patients will be randomized into two groups, and the experimental group will receive QJHX treatment for 12 weeks and follow-up at 24 week. The primary indicators are the clinical efficacy of angina pectoris and the evidence of traditional Chinese medicine (TCM) efficacy. Secondary indicators are the Seattle Angina Scale score, serum lipid levels, electrocardiogram, and echocardiogram diagnosis. Additional indicators are endothelial function and immunoinflammatory factors. Adverse events will be monitored throughout the trial.
    Discussion: Integrated traditional Chinese and Western medicine is commonly used for angina in China. This study will evaluate the clinical effectiveness and safety of adding QJHX based on standardized Western medications. The results of the trial will provide high-level clinical research-based evidence for the application of QJHX in MVA.
    Trial registration: Chinese Clinical Trial Registry ChiCTR1900027015 . Registered on 28 October 2019.
    MeSH term(s) Drugs, Chinese Herbal/adverse effects ; Heart ; Humans ; Medicine, Chinese Traditional ; Microvascular Angina ; Multicenter Studies as Topic ; Prospective Studies ; Randomized Controlled Trials as Topic
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2021-08-21
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-021-05508-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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