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Article ; Online: Mercury bioaccumulation and speciation in coastal invertebrates: Implications for trophic magnification in a marine food web.

Bradford, Molly A / Mallory, Mark L / O'Driscoll, Nelson J

2023 Volume 188, Page(s) 114647

Abstract: Studies on mercury bioaccumulation and biomagnification in coastal invertebrates in eastern Canada are limited, but these data are necessary to determine risk of mercury exposure effects in upper trophic level organisms. We quantified methylmercury (MeHg) ...

Abstract	Studies on mercury bioaccumulation and biomagnification in coastal invertebrates in eastern Canada are limited, but these data are necessary to determine risk of mercury exposure effects in upper trophic level organisms. We quantified methylmercury (MeHg), total mercury (THg), and stable isotopes of δ
MeSH term(s)	Animals ; Mercury/analysis ; Food Chain ; Bioaccumulation ; Water Pollutants, Chemical/analysis ; Canada ; Invertebrates ; Methylmercury Compounds ; Fishes ; Environmental Monitoring
Chemical Substances	Mercury (FXS1BY2PGL) ; Water Pollutants, Chemical ; Methylmercury Compounds
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2001296-2
ISSN	1879-3363 ; 0025-326X
ISSN (online)	1879-3363
ISSN	0025-326X
DOI	10.1016/j.marpolbul.2023.114647
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Article ; Online: Ecology and environmental characteristics influence methylmercury bioaccumulation in coastal invertebrates.

Bradford, Molly A / Mallory, Mark L / O'Driscoll, Nelson J

Chemosphere

2023 Volume 346, Page(s) 140502

Abstract: Quantifying mercury (Hg) concentrations in invertebrates is fundamental to determining risk for bioaccumulation in higher trophic level organisms in coastal food webs. Bioaccumulation is influenced by local mercury concentrations, site geochemistry, ... ...

Abstract	Quantifying mercury (Hg) concentrations in invertebrates is fundamental to determining risk for bioaccumulation in higher trophic level organisms in coastal food webs. Bioaccumulation is influenced by local mercury concentrations, site geochemistry, individual feeding ecologies, and trophic position. We sampled seven species of invertebrates from five coastal sites in the Minas Basin, Bay of Fundy, and determined body concentrations of methylmercury (MeHg), total mercury (THg), and stable isotopes of nitrogen (δ
MeSH term(s)	Animals ; Methylmercury Compounds/analysis ; Bioaccumulation ; Fishes ; Invertebrates ; Mercury/analysis ; Food Chain ; Carbon/chemistry ; Water Pollutants, Chemical/analysis ; Environmental Monitoring
Chemical Substances	Methylmercury Compounds ; Mercury (FXS1BY2PGL) ; Carbon (7440-44-0) ; Water Pollutants, Chemical
Language	English
Publishing date	2023-10-20
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.140502
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Zs.A 2540: Show issues

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Article: Pneumatosis Intestinalis of the Colon and Greater Omentum following Small Bowel Resection.

Benesch, Matthew G K / O'Driscoll, Mark F

Case reports in surgery

2022 Volume 2022, Page(s) 2670244

Abstract: Introduction: Pneumatosis intestinalis (PI) is a condition of gas collection within the bowel wall that can represent either a benign clinical finding or a forerunner to potential gastrointestinal catastrophe. As a potentially sinister discovery ... ...

Abstract	Introduction: Pneumatosis intestinalis (PI) is a condition of gas collection within the bowel wall that can represent either a benign clinical finding or a forerunner to potential gastrointestinal catastrophe. As a potentially sinister discovery typically first detected on radiographic imaging, clinicians need to astutely assess the need for additional urgent medical or surgical management in these patients. Apart from portal venous gas, PI outside of the bowel wall is an extremely rare entity that is poorly described. Hence, it is not necessarily clear if PI outside the bowel wall warrants more aggressive management. Conclusion: This case highlights that pneumatosis intestinalis can extend extraluminally and still be managed conservatively with judicious monitoring in the otherwise stable patient.
Language	English
Publishing date	2022-04-16
Publishing country	United States
Document type	Case Reports
ZDB-ID	2657697-1
ISSN	2090-6919 ; 2090-6900
ISSN (online)	2090-6919
ISSN	2090-6900
DOI	10.1155/2022/2670244
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Article ; Online: Effect of a lower target oxygen saturation range on the risk of hypoxaemia and elevated NEWS2 scores at a university hospital: a retrospective study.

O'Driscoll, B Ronan / Kirton, Louis / Weatherall, Mark / Bakerly, Nawar Diar / Turkington, Peter / Cook, Julie / Beasley, Richard

BMJ open respiratory research

2024 Volume 11, Issue 1

Abstract: Background: The optimal target oxygen saturation (SpO: Methods: In a metropolitan UK hospital, a database of electronic bedside SpO: Results: In 2019, 218 of 224 936 (0.10%) observations on room air and 162 of 11 328 (1.43%) on oxygen recorded an ... ...

Abstract	Background: The optimal target oxygen saturation (SpO Methods: In a metropolitan UK hospital, a database of electronic bedside SpO Results: In 2019, 218 of 224 936 (0.10%) observations on room air and 162 of 11 328 (1.43%) on oxygen recorded an SpO Discussion: The proportion of observations with SpO
MeSH term(s)	Humans ; Retrospective Studies ; Oxygen Saturation ; Hypoxia/etiology ; Oxygen ; Hospitals
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2024-02-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2736454-9
ISSN	2052-4439 ; 2052-4439
ISSN (online)	2052-4439
ISSN	2052-4439
DOI	10.1136/bmjresp-2023-002019
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Article ; Online: The Australian Health Informatics Competency Framework: Conceptual Design, Framework Development, and Certification Delivery.

Brommeyer, Mark / Bichel-Findlay, Jen / Tarabay, Tanija / Schaper, Louise / O'Driscoll, David / Butler-Henderson, Kerryn

Studies in health technology and informatics

2024 Volume 310, Page(s) 1211–1215

Abstract: The Australian Health Informatics Competency Framework (AHICF) guides the healthcare workforce in identifying the required competencies to perform as a health informatician, and more definitively defines the foundational body of knowledge on which the ... ...

Abstract	The Australian Health Informatics Competency Framework (AHICF) guides the healthcare workforce in identifying the required competencies to perform as a health informatician, and more definitively defines the foundational body of knowledge on which the discipline is based. The aim of this paper is to describe the conceptual foundations in developing the AHICF v1.0, detail the methods used to revise and publish AHICF v2.0, and explore the certification and workforce outcomes achieved. This paper contributes to the competency framework and certification discourse, and knowledge of the increasing importance and recognition of health informaticians through certification. Further, implications for workforce training and education, career advancement and recruitment strategies, are also discussed.
MeSH term(s)	Humans ; Australia ; Medical Informatics ; Educational Status ; Certification ; Health Personnel
Language	English
Publishing date	2024-01-25
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI231157
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Article ; Online: Hearing preservation in paediatric cochlear implantation with the Nucleus Slim Straight Electrode - our experience.

Schaefer, Simone / Sladen, Mark / Nichani, Jaya / Millward, Kerri / Lockley, Morag / O'Driscoll, Martin / Kluk, Karolina / Bruce, Iain A

International journal of audiology

2024 , Page(s) 1–8

Abstract: Objective: to evaluate the levels of successful hearing preservation and preservation of functional hearing following cochlear implantation (HPCI) in children using the Cochlear Nucleus® Slim Straight Electrode (SSE).: Design: retrospective case note ...

Abstract	Objective: to evaluate the levels of successful hearing preservation and preservation of functional hearing following cochlear implantation (HPCI) in children using the Cochlear Nucleus® Slim Straight Electrode (SSE). Design: retrospective case note review of paediatric HPCI cases in our CI centre from 2013 to 2023. Inclusion criteria were attempted hearing preservation surgery, SSE used for implantation, pre-operative hearing thresholds ≤80dBHL at 250 Hz, CI before 18 years of age. Patients were excluded if no postoperative unaided PTA was obtained (poor attendance). Primairy outcome was hearing preservation using the HEARRING group formula; secondary outcome was residual functional hearing (≤80dBHL at 250 Hz/<90dB LFPTA). Study sample: 56 patients with 94 CI's were included for review. Results: Hearing preservation was achieved in 94.7% (89/94) of ears and complete preservation in 72% (68/94)). Average functional hearing was preserved in 89% using both criteria for preservation. Long-term follow up data was available for 36 ears (average 35.2 months), demonstrating 88.9% (32/36) complete preservation. Conclusion: We have reliably achieved and maintained a high success rate of HPCI using the SSE in our paediatric population. The field of HPCI would benefit from unification of outcome reporting in order to optimise the evidence available to professionals, patients and their carers.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2073098-6
ISSN	1708-8186 ; 1499-2027
ISSN (online)	1708-8186
ISSN	1499-2027
DOI	10.1080/14992027.2024.2306191
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Zs.A 549: Show issues

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Article ; Online: The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.

O'Driscoll, Mark

The Journal of pathology

2016 Volume 241, Issue 2, Page(s) 192–207

Abstract: Accurate and efficient replication of the human genome occurs in the context of an array of constitutional barriers, including regional topological constraints imposed by chromatin architecture and processes such as transcription, catenation of the ... ...

Abstract	Accurate and efficient replication of the human genome occurs in the context of an array of constitutional barriers, including regional topological constraints imposed by chromatin architecture and processes such as transcription, catenation of the helical polymer and spontaneously generated DNA lesions, including base modifications and strand breaks. DNA replication is fundamentally important for tissue development and homeostasis; differentiation programmes are intimately linked with stem cell division. Unsurprisingly, impairments of the DNA replication machinery can have catastrophic consequences for genome stability and cell division. Functional impacts on DNA replication and genome stability have long been known to play roles in malignant transformation through a variety of complex mechanisms, and significant further insights have been gained from studying model organisms in this context. Congenital hypomorphic defects in components of the DNA replication machinery have been and continue to be identified in humans. These disorders present with a wide range of clinical features. Indeed, in some instances, different mutations in the same gene underlie different clinical presentations. Understanding the origin and molecular basis of these features opens a window onto the range of developmental impacts of suboptimal DNA replication and genome instability in humans. Here, I will briefly overview the basic steps involved in DNA replication and the key concepts that have emerged from this area of research, before switching emphasis to the pathological consequences of defects within the DNA replication network; the human disorders. Copyright © 2016 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
MeSH term(s)	Animals ; Cell Transformation, Neoplastic ; Chromatin/genetics ; DNA Repair ; DNA Replication ; Genomic Instability/genetics ; Humans ; Mutation/genetics
Chemical Substances	Chromatin
Language	English
Publishing date	2016-11-21
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3119-7
ISSN	1096-9896 ; 0022-3417
ISSN (online)	1096-9896
ISSN	0022-3417
DOI	10.1002/path.4828
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Ud II Zs.12: Show issues

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Article ; Online: Functional assays reflective of cancer hallmarks in BT-549 cells are not impacted by media supplemented with exercise-trained plasma.

Darragh, Ian A J / Martinez-Pacheco, Sarai / O'Driscoll, Lorraine / Egan, Brendan

Experimental physiology

2023

Abstract: ... trained, strength-trained or recreationally active controls impact hallmarks of cancer in BT-549 cells ... recreationally active controls (CON) impacted the results of four assays that mimic hallmarks of cancer ... reflective of cancer hallmarks in BT-549 cells, but effects of exercise on proliferation, migration ...

Abstract	New findings: What is the central question of this study? Little is known regarding the effects of media supplemented with resting plasma from exercise-trained individuals, despite the established bioactive effects of acutely exercised samples. Does media supplemented with resting plasma from endurance-trained, strength-trained or recreationally active controls impact hallmarks of cancer in BT-549 cells? What is the main finding and its importance? Supplementing media with plasma from these trained athletes did not impact proliferation, migration, invasion or anoikis resistance compared to plasma from recreationally-active controls. These findings suggest that 'anti-cancer' effects of exercise are not present in resting blood samples of exercise-trained individuals. Abstract: Media supplemented with sera from acutely exercised men has been shown to have 'anti-cancer' effects on prostate and breast cancer cell lines. This study investigated whether media supplemented with plasma samples taken at rest (≥30 h since the most recent exercise session) from men who were endurance-trained (END), strength-trained (STR) or recreationally active controls (CON) impacted the results of four assays that mimic hallmarks of cancer (proliferation, migration, extracellular matrix invasion and anoikis resistance) in the BT-549 breast cancer cell line. Compared to control conditions of either serum-free media or fetal bovine serum as appropriate, BT-549 cells cultured with plasma-supplemented media regardless of group resulted in greater cell proliferation (∼20-50%) and cell migration (∼15-20%), and lower extracellular matrix invasion (∼10-20%) and anoikis resistance (∼15-20%). Supplementing media with plasma from END or STR did not impact any outcomes of these assays compared to plasma from CON. Media supplemented with human plasma can impact functional assays reflective of cancer hallmarks in BT-549 cells, but effects of exercise on proliferation, migration, extracellular matrix invasion and anoikis resistance were not evident in resting blood samples of individuals with a prior history of exercise training.
Language	English
Publishing date	2023-11-22
Publishing country	England
Document type	Journal Article
ZDB-ID	1016295-1
ISSN	1469-445X ; 0958-0670
ISSN (online)	1469-445X
ISSN	0958-0670
DOI	10.1113/EP091383
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Article ; Online: Carcinoid heart disease of gonadal primary presenting with hypoxia: a case report.

O'Driscoll, Ronan / Prashar, Abhisheik / Youssef, George / Sader, Mark

European heart journal. Case reports

2021 Volume 5, Issue 5, Page(s) ytaa536

Abstract: Background: Carcinoid heart disease is a potential sequela of metastatic neuroendocrine tumour that has characteristic valve appearances. Patients can present with symptoms of carcinoid syndrome or be relatively asymptomatic until symptoms of ... ...

Abstract	Background: Carcinoid heart disease is a potential sequela of metastatic neuroendocrine tumour that has characteristic valve appearances. Patients can present with symptoms of carcinoid syndrome or be relatively asymptomatic until symptoms of progressive heart failure manifest. Case summary: We present a case of a 54-year-old male who was admitted to the hospital for investigation of hypoxia. Transthoracic echocardiogram was suggestive of carcinoid heart disease which subsequently led to a diagnosis of metastatic neuroendocrine (carcinoid) tumour of the testicular primary. Work-up revealed a patent foramen ovale with evidence of the right to left interatrial shunt from severe tricuspid regurgitation as the cause of his hypoxia. Prior to surgical excision of the primary tumour, percutaneous patent foramen ovale closure was performed resulting in improved arterial oxygen saturation and symptomatic improvement. Discussion: Carcinoid heart disease typically affects the right-sided cardiac valves and the tricuspid valve appearances were critical in leading to a diagnosis of a metastatic neuroendocrine tumour in our patient. This case demonstrates that percutaneous patent foramen ovale closure can be an effective intervention for hypoxia in those not managed surgically. A high index of suspicion should be maintained for gonadal primary carcinoid tumour when there is carcinoid heart disease in the absence of liver metastases.
Language	English
Publishing date	2021-05-14
Publishing country	England
Document type	Journal Article
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytaa536
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Article ; Online: Outcomes of Humeral Allograft-Prosthetic Composites with Plate Fixation in Revision Total Elbow Arthroplasty.

Cheema, Adnan N / Conyer, Ryan T / Triplet, Jacob J / O'Driscoll, Shawn W / Morrey, Mark E / Sanchez-Sotelo, Joaquín

JB & JS open access

2023 Volume 8, Issue 4

Abstract: Background: Traditionally, the reconstruction of severe distal humeral bone loss at the time of revision total elbow arthroplasty (TEA) has used allograft-prosthetic composites (APCs) stabilized with cerclage wires or cables. We have migrated to plate ... ...

Abstract	Background: Traditionally, the reconstruction of severe distal humeral bone loss at the time of revision total elbow arthroplasty (TEA) has used allograft-prosthetic composites (APCs) stabilized with cerclage wires or cables. We have migrated to plate fixation when revision TEA using a humeral APC is performed. This study shows the outcomes of patients treated with a humeral APC with plate fixation during revision TEA. Methods: Between 2009 and 2019, 41 humeral APCs with plate fixation of distal humeral allograft to the native humerus were performed in the setting of revision TEA. There were 12 male patients (29%) and 29 female patients (71%), with a mean age of 63 years (range, 41 to 87 years). The mean allograft length was 12 cm. All elbows had a minimum follow-up of 2 years (mean follow-up, 3.3 years). Patients were evaluated for visual analog scale pain scores, range of motion, the ability to perform select activities of daily living, and the Mayo Elbow Performance Score (MEPS). Outcomes including reoperations, complications, and revisions were noted. The most recent radiographs were evaluated for union at the allograft-host interface, failure of the plate-and-screw construct, or component loosening. Results: The mean postoperative flexion was 124° (range, 60° to 150°) and the mean postoperative extension was 26° (range, 0° to 90°); the mean arc of motion was 99° (range, 30° to 150°). The mean MEPS was 58 points (range, 10 to 100 points). Two surgical procedures were complicated by neurologic deficits. The overall reoperation rate was 14 (34%) of 41. Of the 33 patients with complete radiographic follow-up, 12 (36%) had evidence of nonunion at the allograft-host interface with humeral component loosening, 1 (3%) had evidence of partial union, and 1 (3%) had ulnar stem loosening. Conclusions: Revision TEA with a humeral APC using compression plating was successful in approximately two-thirds of the elbows. Further refinement of surgical techniques is needed to improve union rates in these complex cases. Level of evidence: Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
Language	English
Publishing date	2023-10-03
Publishing country	United States
Document type	Journal Article
ISSN	2472-7245
ISSN (online)	2472-7245
DOI	10.2106/JBJS.OA.22.00136
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