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  1. Book ; Online ; E-Book: Cancer biomarkers in body fluids

    Dakubo, Gabriel D.

    biomarkers in circulation

    2017  

    Author's details Gabriel D. Dakubo
    Keywords Biomarkers, Tumor ; Neoplasms / diagnosis ; Body Fluids / immunology ; Blood Circulation
    Language English
    Size 1 Online-Ressource (xix, 509 Seiten), Illustrationen
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019474957
    ISBN 978-3-319-48360-3 ; 9783319483597 ; 3-319-48360-9 ; 3319483595
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Book ; Online ; E-Book: Cancer biomarkers in body fluids

    Dakubo, Gabriel D.

    principles

    2016  

    Author's details Gabriel D. Dakubo
    Language English
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019091426
    ISBN 978-3-319-01580-4 ; 9783319015798 ; 3-319-01580-X ; 3319015796
    DOI 10.1007/978-3-319-01580-4
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Book: Mitochondrial genetics and cancer

    Dakubo, Gabriel D.

    2010  

    Author's details Gabriel D. Dakubo
    Keywords Neoplasms / genetics ; Genes, Mitochondrial ; Mutation ; Krebs ; Carcinogenese ; Mitochondriale DNS
    Subject Mitochondriale DNA ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Subject code 616.994071
    Language English
    Size XV, 356 S. : graph. Darst., 24 cm
    Publisher Springer
    Publishing place Berlin u.a.
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT016455270
    ISBN 978-3-642-11415-1 ; 9783642114168 ; 3-642-11415-6 ; 3642114164
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 3904 order for loan Magazin

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  4. Book: Cancer biomarkers in body fluids

    Dakubo, Gabriel D

    principles

    2016  

    Author's details Gabriel D. Dakubo
    MeSH term(s) Biomarkers, Tumor ; Neoplasms/diagnosis ; Body Fluids/immunology
    Language English
    Size xvi, 299 pages :, illustrations
    Document type Book
    ISBN 9783319015798 ; 3319015796 ; 9783319015804 ; 331901580X
    Database Catalogue of the US National Library of Medicine (NLM)

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  5. Article: Mitochondrial genome analysis in biofluids for early cancer detection and monitoring.

    Dakubo, Gabriel D

    Expert opinion on medical diagnostics

    2008  Volume 2, Issue 3, Page(s) 263–275

    Abstract: Background: Biofluids collected in a non-invasive fashion are potentially valuable samples for assaying genomic alterations for early detection and monitoring of cancer. The low cellularity and nucleic acid content in biofluids, the high copy number of ... ...

    Abstract Background: Biofluids collected in a non-invasive fashion are potentially valuable samples for assaying genomic alterations for early detection and monitoring of cancer. The low cellularity and nucleic acid content in biofluids, the high copy number of the mitochondrial genome (mtgenome) and its noted early imprints in cancer make this molecule theoretically more sensitive than nuclear targets to measure for early cancer detection.
    Objective: This review explores mtgenome analysis in biofluids and addresses the question of whether targeting the mtgenome in biofluids is superior or equivalent to analysis of nuclear genomic alterations.
    Methods: The literature was retrieved from PubMed using a combination of the following keywords: mtDNA, mutation, deletion, content, copy number, cancer, biofluids, bodily fluids and the specific cancers described here. Studies that analyzed mtgenome alterations in biofluids were included. Analytical methods available for assaying mtgenome changes in biofluids are discussed.
    Results: Despite the limited data available, mtgenome changes in biofluids have been demonstrated in a wide variety of cancer patients.
    Conclusion: Mtgenome analysis in biofluids is feasible and relatively easy. Despite the paucity of data, tumor-specific mtgenome changes are observed in biofluids of cancer patients. Given the multiple copies per cell of the mtgenome, future cancer detection efforts should consider complementary analysis of mtgenome changes in biofluids.
    Language English
    Publishing date 2008-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2393880-8
    ISSN 1753-0067 ; 1753-0059
    ISSN (online) 1753-0067
    ISSN 1753-0059
    DOI 10.1517/17530059.2.3.263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Mitochondrial genetics and cancer

    Dakubo, Gabriel D

    2010  

    Author's details Gabriel D. Dakubo
    MeSH term(s) Neoplasms/genetics ; Genes, Mitochondrial ; Mutation
    Language English
    Size xv, 356 p. :, ill. ;, 25 cm.
    Publisher Springer-Verlag
    Publishing place Berlin ; Heidelberg
    Document type Book
    ISBN 9783642114151 ; 3642114156 ; 9783642114168 ; 3642114164
    Database Catalogue of the US National Library of Medicine (NLM)

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  7. Article: Hedgehogs and retinal ganglion cells: organizers of the mammalian retina.

    Dakubo, Gabriel D / Wallace, Valerie A

    Neuroreport

    2004  Volume 15, Issue 3, Page(s) 479–482

    Abstract: The mature vertebrate retina develops from a population of multipotential neural progenitor cells that give rise to all of the retinal neurons and one glial cell type. Retinal histogenesis is regulated, in part, by cell extrinsic cues. A growing number ... ...

    Abstract The mature vertebrate retina develops from a population of multipotential neural progenitor cells that give rise to all of the retinal neurons and one glial cell type. Retinal histogenesis is regulated, in part, by cell extrinsic cues. A growing number of studies now implicate signaling by members of the Hedgehog (Hh) family of morphogens in vertebrate retinal development. In this review we will discuss the role of Hh signals from retinal ganglion cells (RGCs), the projection neurons of the retina, on proliferation, differentiation and lamination in the neural retina.
    MeSH term(s) Animals ; Female ; Gene Expression Regulation, Developmental/physiology ; Hedgehogs/physiology ; Neuroglia/physiology ; Pregnancy ; Retina/embryology ; Retinal Ganglion Cells/physiology ; Stem Cells ; Trans-Activators/genetics
    Chemical Substances Trans-Activators
    Language English
    Publishing date 2004-03-01
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1049746-8
    ISSN 1473-558X ; 0959-4965
    ISSN (online) 1473-558X
    ISSN 0959-4965
    DOI 10.1097/00001756-200403010-00019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3118: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice.

    Dakubo, Gabriel D / Mazerolle, Chantal J / Wallace, Valerie A

    Journal of neuro-oncology

    2006  Volume 79, Issue 3, Page(s) 221–227

    Abstract: Hedgehog (Hh), Notch, and Wingless (Wnt) signaling control normal development of the cerebellum, and dysregulation of these signaling pathways are associated with medulloblastoma (MB). As an initial step in the study of the role of interacting signaling ... ...

    Abstract Hedgehog (Hh), Notch, and Wingless (Wnt) signaling control normal development of the cerebellum, and dysregulation of these signaling pathways are associated with medulloblastoma (MB). As an initial step in the study of the role of interacting signaling pathways in MB pathogenesis, we demonstrate the expression of several components of the Notch and Wnt signaling pathways, and activation of Notch signaling in MB from Ptch +/- mice that have elevated Hh signaling. We also show a marked downregulation in the expression of Notch2, Jagged1, Hes1, mSfrp1, and mFrz7 in cerebella of developing mice with reduced Hh signaling, suggesting that Hh signaling regulates the expression of these genes. Together with recent published data, these findings indicate that Hh signaling might synergize simultaneously with Notch and Wnt signaling in MB development by controlling Notch and Wnt pathway ligand, receptor and/or target gene expression.
    MeSH term(s) Animals ; Carrier Proteins/metabolism ; Cell Transformation, Neoplastic/metabolism ; Cerebellar Neoplasms/metabolism ; Heterozygote ; Immunohistochemistry ; In Situ Hybridization ; Medulloblastoma/metabolism ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Transgenic ; Patched Receptors ; Patched-1 Receptor ; RNA, Messenger/analysis ; Receptors, Cell Surface/genetics ; Receptors, Notch/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/physiology ; Wnt Proteins/metabolism
    Chemical Substances Carrier Proteins ; Hhip protein, mouse ; Membrane Glycoproteins ; Patched Receptors ; Patched-1 Receptor ; Ptch1 protein, mouse ; RNA, Messenger ; Receptors, Cell Surface ; Receptors, Notch ; Wnt Proteins
    Language English
    Publishing date 2006-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-006-9132-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1825: Show issues Location:
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  9. Article: Analysis of potential cancer biomarkers in mitochondrial DNA.

    Jakupciak, John P / Dakubo, Gabriel D / Maragh, Samantha / Parr, Ryan L

    Current opinion in molecular therapeutics

    2006  Volume 8, Issue 6, Page(s) 500–506

    Abstract: Understanding mitochondrial biology is a fundamental research goal in human genetics and medicine. The use of mitochondria to serve as a biomarker is rapidly expanding in disciplines ranging from cancer, rare metabolic diseases, aging, the tracing of ... ...

    Abstract Understanding mitochondrial biology is a fundamental research goal in human genetics and medicine. The use of mitochondria to serve as a biomarker is rapidly expanding in disciplines ranging from cancer, rare metabolic diseases, aging, the tracing of human migration patterns in antiquity, population characterization using maternal markers, and human identification. Mitochondrial DNA (mtDNA) mutations occur frequently in cancer, and there is an important need for validating mtDNA mutations as cancer biomarkers for the detection of early-stage disease. Although a few studies have suggested tissue-specific mtDNA mutations, there is no single mutational hotspot associated with the wide spectrum of cancer patients; hence, sequencing the entire mitochondrial genome and further characterization of the multiple deletions associated with tumors is required to detect the mutation load on an individual basis. Microarray-based technology provides a reliable and rapid method to detect all mutations of the entire mitochondrial genome. In addition to microarray-based sequencing, real-time PCR is an important method for deletion analysis. Mutations throughout the mitochondrial genome are recurrent events in primary tumor tissues and in corresponding non-invasively collected body fluids. Thus, mtDNA mutation analysis may provide a molecular tool for the early detection and prognosis of cancer. Recent findings have verified that relatively simple diagnostic tests for detecting mtDNA mutations, involving mitochondrial microarray chips and/or real-time PCR bioassays, have exciting predictive potential for cancer detection and prognosis.
    MeSH term(s) Biomarkers, Tumor/genetics ; DNA, Mitochondrial/genetics ; Humans ; Mutation ; Neoplasms/genetics ; Oligonucleotide Array Sequence Analysis/statistics & numerical data ; Polymerase Chain Reaction ; Quality Control ; Sensitivity and Specificity ; Sequence Analysis, DNA/standards ; Sequence Deletion
    Chemical Substances Biomarkers, Tumor ; DNA, Mitochondrial
    Language English
    Publishing date 2006-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2022273-7
    ISSN 1464-8431
    ISSN 1464-8431
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5272: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.

    Dakubo, Gabriel D / Beug, Shawn T / Mazerolle, Chantal J / Thurig, Sherry / Wang, Yaping / Wallace, Valerie A

    Brain research

    2008  Volume 1228, Page(s) 27–42

    Abstract: The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, ...

    Abstract The development of glial precursor cells in the mammalian optic nerve depends on retinal ganglion cell (RGC) axons, but the signals that mediate this neuron-to-glia interaction have not been fully characterized. Sonic hedgehog (Shh) is expressed by RGCs, and we showed previously that it is required for the specification of astrocyte lineage cells at the optic disc. To study the role of RGC-derived Shh on astrocyte development at later developmental stages, we generated mice with a conditional ablation of Shh in the peripheral retina and analyzed gene expression and glial cell development in the optic nerve. Astrocyte development was initiated in the optic nerves of these mutant mice; however, the expression of Hedgehog (Hh) target genes, Gli1 and Ptch1 and cell cycle genes, Ccnd1 and Cdc25b in the optic nerves were downregulated. Astrocyte proliferation was markedly reduced. Oligodendrocyte precursor cells were fewer in the optic nerves of mutant mice, possibly as a consequence of reduced secretion of growth factors by astrocytes. At a later developmental stage, optic nerve axons displayed signs of Wallerian degeneration, including reduction of astrocyte processes, degenerating glial cells and formation of distended axons. We also demonstrate that the Hh pathway can be activated in optic nerve-derived astrocytes in vitro, but fails to induce cell cycle gene expression and proliferation. RGC-derived Shh signalling isthus necessary in vivo for maintenance of astrocyte proliferation, affecting both axo-glial and normal glial cell development in the optic nerve.
    MeSH term(s) Animals ; Astrocytes/cytology ; Astrocytes/metabolism ; Blotting, Western ; Cell Cycle/genetics ; Cell Cycle/physiology ; Cell Differentiation/genetics ; Cell Differentiation/physiology ; Cell Proliferation ; Cells, Cultured ; Cyclin D ; Cyclins/genetics ; Cyclins/metabolism ; Hedgehog Proteins/genetics ; Hedgehog Proteins/metabolism ; Hedgehog Proteins/physiology ; Immunohistochemistry ; In Situ Hybridization ; Kruppel-Like Transcription Factors/genetics ; Kruppel-Like Transcription Factors/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microscopy, Electron, Transmission ; Neuroglia/cytology ; Neuroglia/metabolism ; Oligodendroglia/cytology ; Oligodendroglia/metabolism ; Optic Nerve/growth & development ; Optic Nerve/metabolism ; Optic Nerve/ultrastructure ; Patched Receptors ; Patched-1 Receptor ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Retinal Ganglion Cells/cytology ; Retinal Ganglion Cells/metabolism ; Retinal Ganglion Cells/ultrastructure ; Reverse Transcriptase Polymerase Chain Reaction ; Signal Transduction/genetics ; Signal Transduction/physiology ; Zinc Finger Protein GLI1 ; cdc25 Phosphatases/genetics ; cdc25 Phosphatases/metabolism
    Chemical Substances Cyclin D ; Cyclins ; Gli protein, mouse ; Hedgehog Proteins ; Kruppel-Like Transcription Factors ; Patched Receptors ; Patched-1 Receptor ; Ptch1 protein, mouse ; Receptors, Cell Surface ; Shh protein, mouse ; Zinc Finger Protein GLI1 ; Cdc25b protein, mouse (EC 3.1.3.48) ; cdc25 Phosphatases (EC 3.1.3.48)
    Language English
    Publishing date 2008-09-04
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2008.06.058
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 161: Show issues Location:
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