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  1. Book ; Online ; E-Book: Epilepsy

    Cascino, Gregory D. / Sirven, Joseph I. / Tatum, William O.

    2021  

    Author's details edited by Gregory D. Cascino, Joseph I. Sirven, William O. Tatum
    Keywords Electronic books ; Epilepsy
    Language English
    Size 1 Online-Ressource (xxxi, 511 Seiten), Illustrationen, Diagramme
    Edition Second edition
    Publisher Wiley Blackwell
    Publishing place Hoboken, NJ
    Publishing country United States
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT020867808
    ISBN 978-1-119-43193-0 ; 978-1-119-43200-5 ; 9781119431824 ; 1-119-43193-X ; 1-119-43200-6 ; 1119431824
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: The Argument for a More Patient Attitude Toward a Single Unprovoked Seizure: Wait for It?

    Feyissa, Anteneh M / Cascino, Gregory D

    Mayo Clinic proceedings

    2022  Volume 98, Issue 1, Page(s) 23–30

    MeSH term(s) Humans ; Seizures ; Epilepsy ; Electroencephalography ; Recurrence ; Risk Factors
    Language English
    Publishing date 2022-12-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2022.10.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Epilepsy case studies

    Tatum, William O. / Sirven, Joseph I. / Cascino, Gregory D.

    pearls for patient care

    2014  

    Author's details William O. Tatum ; Joseph I. Sirven ; Gregory D. Cascino ed
    Language English
    Size XVI, 192 S. : Ill., graph. Darst.
    Publisher Springer
    Publishing place Cham u.a.
    Publishing country Germany
    Document type Book
    HBZ-ID HT017897096
    ISBN 978-3-319-01365-7 ; 3-319-01365-3 ; 9783319013664 ; 3319013661
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 A 3514 available for loan (reading room) Lesesaal EG

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  4. Book: Adult epilepsy

    Cascino, Gregory D. / Sirven, Joseph I.

    2011  

    Author's details ed. by Gregory Cascino ; Joseph I. Sirven
    Keywords Epilepsy ; Adult
    Language English
    Size XV, 307 S. : Ill., 25 cm
    Edition 1. Impr.
    Publisher Wiley-Blackwell
    Publishing place Chichester
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT016785895
    ISBN 978-0-470-74122-1 ; 0-470-74122-8
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  5. Article ; Online: Functional neurological seizures and migraine: A systematic review and case series.

    Duque, Laura / Garza, Ivan / Cascino, Gregory D / Staab, Jeffrey P

    Epilepsy & behavior : E&B

    2023  Volume 147, Page(s) 109437

    Abstract: Background: The seizure subtype of functional neurological disorder (FND-seizures) is a common neuropsychiatric condition manifesting with episodic epilepsy-like events. Despite the common belief that FND-seizures are precipitated by psychological ... ...

    Abstract Background: The seizure subtype of functional neurological disorder (FND-seizures) is a common neuropsychiatric condition manifesting with episodic epilepsy-like events. Despite the common belief that FND-seizures are precipitated by psychological stressors, neurological disorders may also be triggers. In 1890, Babinski described four cases of FND symptoms associated with migraine attacks. Despite the passing of more than 130 years since this first clinical observation, the relationship between FND-seizures and migraine is not fully elucidated.
    Objectives: (1) To complete a systematic review of the literature that investigated potential associations between FND-seizures and migraine and the response of FND seizures to treatment with migraine prophylactic medications (2). To undertake a retrospective study of patients with FND-seizures and migraine, including response to migraine prophylaxis.
    Methods: (1) Using PRISMA methods, we completed a systematic review of EMBASE and Scopus databases from inception to March 31, 2021, for literature on FND-seizures and migraine. (2) Our multi-disciplinary team, including subspecialists in psychosomatic medicine, epilepsy, and headache disorders, reviewed consecutive patients diagnosed with FND-seizures and migraine to assess potential causal associations and responses to standard migraine prophylactic medications.
    Results: (1) The search yielded seven studies from 126 screened manuscripts (N = 1,186 patients with FND-seizures; mean age 38.7 years; 72.6% female). They varied substantially in design, population, diagnostic measures, and outcomes. Nevertheless, all studies found associations between FND-seizures and migraine, which were stronger than those between epileptic seizures and migraine in comparative investigations, but provided limited information on treatment response. (2) In our case series, investigators reached unanimous consensus that migraine attacks triggered FND-seizures in 28/43 (65.1%) patients reviewed (mean age, 38.8 years; 74% female). In 19/26 (73%) patients with adequate follow-up data, treatment with migraine prophylactic medications alone (no behavioral interventions) concomitantly reduced FND-seizure and headache frequency by >50%.
    Conclusion: Our systematic review and case series indicate that migraine attacks may trigger FND-seizures, perhaps more often that currently understood, and suggest that migraine prophylaxis may reduce FND-seizure frequency in such cases. To validate these observations, fully powered prospective investigations are required.
    Language English
    Publishing date 2023-09-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2023.109437
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  6. Article ; Online: Advances in the Surgical Management of Epilepsy: Drug-Resistant Focal Epilepsy in the Adult Patient.

    Cascino, Gregory D / Brinkmann, Benjamin H

    Neurologic clinics

    2020  Volume 39, Issue 1, Page(s) 181–196

    Abstract: Pharmacoresistant seizures occur in nearly one-third of people with epilepsy. Medial temporal lobe and lesional epilepsy are the most favorable surgically remediable epileptic syndromes. Successful surgery may render the patient seizure-free, reduce ... ...

    Abstract Pharmacoresistant seizures occur in nearly one-third of people with epilepsy. Medial temporal lobe and lesional epilepsy are the most favorable surgically remediable epileptic syndromes. Successful surgery may render the patient seizure-free, reduce antiseizure drug(s) adverse effects, improve quality of life, and decrease mortality. Surgical management should not be considered a procedure of "last resort." Despite the results of randomized controlled trials, surgery remains an underutilized treatment modality for patients with drug-resistant epilepsy (DRE). Important disparities affect patient referral and selection for surgical treatment. This article discusses the advances in surgical treatment of DRE in adults with focal seizures.
    MeSH term(s) Adult ; Drug Resistant Epilepsy/surgery ; Epilepsies, Partial/surgery ; Humans ; Neurosurgical Procedures/trends ; Treatment Outcome
    Language English
    Publishing date 2020-11-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2020.09.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: MRI endophenotypes of heritability and cognitive dysfunction in juvenile myoclonic epilepsy.

    Cendes, Fernando / Cascino, Gregory D

    Neurology

    2019  Volume 93, Issue 13, Page(s) 571–572

    MeSH term(s) Adolescent ; Cognitive Dysfunction ; Endophenotypes ; Humans ; Magnetic Resonance Imaging ; Myoclonic Epilepsy, Juvenile ; Siblings
    Language English
    Publishing date 2019-08-29
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000008162
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Book: Neuroimaging in epilepsy

    Cascino, Gregory D.

    principles and practice

    1996  

    Author's details ed. by Gregory D. Cascino
    Keywords Epilepsy / diagnosis ; Magnetic Resonance Imaging ; Tomography, X-Ray Computed ; Tomography, Emission-Computed ; Epilepsy / surgery ; Epilepsie ; Neuroradiologie
    Subject Fallsucht
    Language English
    Size XIII, 289 S. : zahlr. Ill., graph. Darst.
    Publisher Butterworth-Heinemann
    Publishing place Boston u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007495689
    ISBN 0-7506-9716-4 ; 978-0-7506-9716-3
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1997 A 2999 order for loan Magazin

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  9. Article: Cenobamate in Generalized Epilepsy and Combined Generalized and Focal Epilepsy.

    Agashe, Shruti / Worrell, Gregory / Britton, Jeffrey / Noe, Katherine / Ritaccio, Anthony / Wirrell, Elaine C / Nickels, Katherine C / Cascino, Gregory D / Burkholder, David

    Neurology. Clinical practice

    2023  Volume 13, Issue 2, Page(s) e200133

    Abstract: Background and objectives: Cenobamate (CNB) is a United States Food and Drug Administration-approved antiseizure medication (ASM) for focal-onset seizures; however, its potential clinical effectiveness as a broad-spectrum ASM is not established. CNB has ...

    Abstract Background and objectives: Cenobamate (CNB) is a United States Food and Drug Administration-approved antiseizure medication (ASM) for focal-onset seizures; however, its potential clinical effectiveness as a broad-spectrum ASM is not established. CNB has a proposed dual mechanism of action with preferential blockade of persistent sodium currents and positive allosteric modulation of the γ-aminobutyric acid-A (GABA-A) receptor. We evaluated the efficacy of CNB in drug refractory patients with genetic generalized epilepsies (GGE) or combined generalized and focal epilepsies (CGFE), including developmental and epileptic encephalopathies.
    Methods: We performed a retrospective review and identified the following: cohort 1 (n = 4) with GGE, of which 2 patients had idiopathic generalized epilepsy, and cohort 2 with CGFE (n = 9), of which 4 patients had Lennox-Gastaut syndrome and 1 had Dravet syndrome.
    Results: In cohort 1, all 3 patients with frequent generalized tonic-clonic seizures (GTCs) had a greater than 50% reduction in GTCs. In cohort 2, reduction in both generalized and focal-onset seizures was noted. In these groups together, the mean reduction of all seizure types was 58%, and ≥50% responder rate was 70% (SD = ±34.16, median = 50%). No worsening of generalized-onset seizures occurred in either cohort. Seventy-seven percent of patients experienced side effects, warranting a modification of treatment managed by slower titration, dose reduction of CNB, or discontinuing other ASMs.
    Discussion: In our retrospective case series, CNB seems to be an effective ASM for patients with drug-resistant GGE and CGFE. The ongoing CNB trial assessing effectiveness for primary GTCs will provide more data on generalized-onset seizures.
    Classification of evidence: This study provides Class IV evidence that CNB in generalized epilepsy and combined generalized and focal epilepsy reduces seizure frequency.
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2645818-4
    ISSN 2163-0933 ; 2163-0402
    ISSN (online) 2163-0933
    ISSN 2163-0402
    DOI 10.1212/CPJ.0000000000200133
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Patients with generalized epilepsy are also at risk for SUDEP.

    Pavlova, Milena / Gerard, Elizabeth E / Cascino, Gregory D

    Neurology

    2020  Volume 94, Issue 16, Page(s) 689–690

    MeSH term(s) Epilepsies, Partial ; Epilepsy, Generalized ; Humans ; Prevalence ; Registries ; Sudden Unexpected Death in Epilepsy ; United States
    Language English
    Publishing date 2020-03-26
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000009286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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