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Article: Network pharmacological and molecular docking study of the effect of Liu-Wei-Bu-Qi capsule on lung cancer.

Yang, Qing / Li, Li-Yuan

World journal of clinical cases

2023 Volume 11, Issue 31, Page(s) 7593–7609

Abstract: Background: Although Liu-Wei-Bu-Qi capsule (LBC) inhibits tumor progression by improving ...

Abstract	Background: Although Liu-Wei-Bu-Qi capsule (LBC) inhibits tumor progression by improving the physical condition and immunity of patients with lung cancer (LC), its exact mechanism of action is unknown. Aim: To through compound multi-dimensional network of chemical ingredient-target-disease-target- protein-protein interaction (PPI) network, the principle of action of Chinese medicine prescription was explained from molecular level. Methods: Network pharmacology and molecular docking simulations were used to analyze the relationship among the main components, targets, and signaling pathways of LBC in treatment of LC. Results: From the analysis, 360 LBC active ingredient-related targets and 908 LC-related targets were identified. PPI network analysis of the LBC and LC overlapping targets identified 16 hub genes. Kyoto Encyclopedia of Genes and Genomes analysis suggested that LBC can target the vascular endothelial growth factor signaling pathway, Toll-like receptor signaling pathway, prolactin signaling pathway, FoxO signaling pathway, PI3K-Akt signaling pathway and HIF-1 signaling pathway in the treatment of LC. Molecular docking simulations showed that quercetin had the best affinity for MAPK3, suggesting that quercetin in LBC may play an important role in the treatment of LC. Conclusion: The results showed that the active ingredients in LBC can play a crucial role in the treatment of LC by regulating multiple signaling pathways. These results provide insights into further studies on the mechanism of action of LBC in the treatment of LC.
Language	English
Publishing date	2023-11-23
Publishing country	United States
Document type	Journal Article
ISSN	2307-8960
ISSN	2307-8960
DOI	10.12998/wjcc.v11.i31.7593
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Article: [Clinical Study of San Wei Sheng Huo Decoction in the Treatment of Refractory Chemotherapy-Induced Thrombocytopenia].

Li, Ru / Xiong, Shao-Quan / He, Li-Fang / Wu, Guo-Yu / Yuan, Yan-Wen

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition

2023 Volume 54, Issue 1, Page(s) 161–164

Abstract: ... thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula.: Methods ...

Abstract	Objective: To investigate the efficacy and safety of treating refractory chemotherapy-induced thrombocytopenia (RCIT) with San Wei Sheng Huo Decoction (SWSHD) as the main formula. Methods: A retrospective study was conducted and the data of RCIT patients treated with SWSHD as the main formula were collected. Changes in peripheral blood platelet (PLT) levels at different time points of treatment were examined and the significant effective rate (SER) and effective rate (ER) were analyzed. We measured the increase in peripheral blood PLT count before and after treatment, analyzed the differences in PLT count increase for different degrees of RCIT treatment, and evaluated the safety of the treatment. Results: A total of 35 cases of RCIT were included in the study. With SWSHD as the main treatment formula, the 2-week ER and SER were 74.29% and 14.29%, respectively, the 2-month ER and SER were 84.38% and 60.50, respectively, and the 1-year ER and SER were 92.31% and 80.77%, respectively. PLT count increased at all time points after treatment compared with that before treatment ( Conclusion: SWSHD takes effect rapidly and its effect is long-lasting and stable. Furthermore, SWSHD has a more significant effect on severe RCIT.
MeSH term(s)	Humans ; Retrospective Studies ; Thrombocytopenia/chemically induced ; Thrombocytopenia/drug therapy ; Platelet Count ; Blood Platelets ; Antineoplastic Agents/adverse effects
Chemical Substances	Antineoplastic Agents
Language	Chinese
Publishing date	2023-01-16
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2106840-9
ISSN	1672-173X
ISSN	1672-173X
DOI	10.12182/20230160506
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Article: Jia-Wei-Si-Miao-Yong-An decoction modulates intestinal flora and metabolites in acute coronary syndrome model.

Zhao, Ning / Wang, Ying / Ma, Yan / Liang, Xiaoxue / Zhang, Xi / Gao, Yuan / Dong, Yingying / Bai, Dong / Hu, Jingqing

Frontiers in cardiovascular medicine

2023 Volume 9, Page(s) 1038273

Abstract: Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao ...

Abstract	Aims: We assessed the efficacy of the traditional Chinese medicine formulation Jia-Wei-Si-Miao-Yong-An decoction (HJ11) in the treatment of acute coronary syndrome and evaluated its impact on the intestinal microbiota and their metabolites. Methods: An acute coronary syndrome model was established in rats, which were randomly assigned to the model, HJ11 treatment, and atorvastatin treatment groups. Rats were then administered saline solution (model and sham operation control groups) or drugs by oral gavage for 28 d. Echocardiography was performed and serum creatine kinase-MB and cardiac troponin I levels were monitored to examine the cardiac function. Inflammation was evaluated using hematoxylin and eosin staining of heart tissue, and serum interleukin-2, interleukin-6, tumor necrosis factor alpha, and high-sensitivity C-reactive protein measurements. Gut microbiota composition was analyzed Results: HJ11 improved cardiac function and attenuated inflammation in rats with acute coronary syndrome. Relative to the untreated model group, the HJ11-treated group presented normalized Firmicutes/Bacteroidetes ratio and reduced abundances of the bacterial genera Conclusion: This work demonstrated that HJ11 effectively treats acute coronary syndrome. HJ11 seems to increase the abundance of beneficial bacterial taxa (
Language	English
Publishing date	2023-01-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.1038273
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Article ; Online: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia.

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology

2022 Volume 298, Page(s) 115679

Abstract: Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal ...

Abstract	Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. Aims of the study: To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. Materials and methods: A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Results: Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. Conclusion: MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Medicine, Tibetan Traditional ; Mice ; NF-kappa B ; NLR Proteins ; Network Pharmacology ; Powders/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; NLR Proteins ; Powders
Language	English
Publishing date	2022-09-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
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Article: A research on the mechanism of NSAID-related gastric ulcer treated by jia wei wu qi san based on the p38mapk signal pathway.

Zheng, Liang / Wang, Pei / Wang, Yuan-Yuan / Li, Zhen / Tian, Ye

Pakistan journal of pharmaceutical sciences

2021 Volume 34, Issue 2, Page(s) 585–589

Abstract: This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI ... was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg ... D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has ...

Abstract	This study aims to explore the mechanism of NSAID-related gastric ulcer treated by JIA WEI WU QI SAN. Clean-grade SD rats were randomly divided into four groups. Group A was assigned as the control group. Groups B, C and D were intragastrically administered with 2.5mg/kg of indomethacin solution QD after 48 hours. After 15 days of treatment, group B was administered with 0.9% sodium chloride, group C was given rabeprazole (2mg/kg), and group D was administered with JIA WEI WU QI SAN (2g/kg). Abdominal aorta sampling was performed, and gastric tissues were isolated on the 29th day. The protein expression of p-P38MAPK and COX-2 were detected by western blot, while the concentration of PGE2 and IL-1 were determined by ELISA. (1) The expression of IL-1ingroup B dramatically declined in group D (P<0.01). (2)The expression of PGE-2dramatically increased in group D(P<0.01). (3) The expression of COX-2 increased in group D (P<0.05). (4) The expression of p-P38MAPK decreased in group D (P<0.05). JIA WEI WU QI SAN has multiple functions, including the activation of the p-P38MAPK signaling pathway, which promote the activation of COX-2, induce the arachidonic acid to increase the level of PG, and decrease the concentration of IL-1, thereby inducing an inflammatory reaction, and promote gastric mucosa repair.
MeSH term(s)	Animals ; Anti-Inflammatory Agents, Non-Steroidal/adverse effects ; Arachidonic Acid/metabolism ; Cyclooxygenase 2/drug effects ; Cyclooxygenase 2/metabolism ; Dinoprostone/metabolism ; Drugs, Chinese Herbal/pharmacology ; Indomethacin/adverse effects ; Interleukin-1/metabolism ; Rats ; Rats, Sprague-Dawley ; Signal Transduction/drug effects ; Stomach/drug effects ; Stomach/metabolism ; Stomach Ulcer/chemically induced ; Stomach Ulcer/metabolism ; p38 Mitogen-Activated Protein Kinases/drug effects ; p38 Mitogen-Activated Protein Kinases/metabolism
Chemical Substances	Anti-Inflammatory Agents, Non-Steroidal ; Drugs, Chinese Herbal ; Interleukin-1 ; Arachidonic Acid (27YG812J1I) ; Cyclooxygenase 2 (EC 1.14.99.1) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Dinoprostone (K7Q1JQR04M) ; Indomethacin (XXE1CET956)
Language	English
Publishing date	2021-07-19
Publishing country	Pakistan
Document type	Journal Article
ZDB-ID	885131-1
ISSN	1011-601X
ISSN	1011-601X
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Article ; Online: Efficacy and safety of Jiu-Wei-Xi-Feng granules for treating tic disorders in children: study protocol for a randomized controlled equivalence trial.

Guo, Sheng-Xuan / Li, Rui-Ben / Hu, Si-Yuan / Cai, Qiu-Han / Zhong, Cheng-Liang / Hao, Rui-Min

Trials

2022 Volume 23, Issue 1, Page(s) 898

Abstract: ... in childhood. Jiu-Wei-Xi-Feng granules has been marketed in China for treating children with TD. As Long Gu (Os ... between Jiu-Wei-Xi-Feng granules (Os Draconis replaced by Concha Ostreae) (JWXFD) and Jiu-Wei-Xi-Feng ...

Abstract	Background: Tic disorders (TD) is a neuropsychiatric disease with twitch as the main manifestation in childhood. Jiu-Wei-Xi-Feng granules has been marketed in China for treating children with TD. As Long Gu (Os Draconis) in the composition of this Chinese patent medicine is a rare and expensive medicinal material protected by the Chinese government, therefore, we consider replacing it with Mu Li (Concha Ostreae) that has the same effect and is cheaper. This study is designed to evaluate the clinical equivalence between Jiu-Wei-Xi-Feng granules (Os Draconis replaced by Concha Ostreae) (JWXFD) and Jiu-Wei-Xi-Feng granules (original formula) (JWXFO) in children with TD (consumption of renal yin and liver wind stirring up internally syndrome). Methods/design: This is a multicenter, randomized, double-blind, equivalence trial comparing the efficacy and safety of JWXFD and JWXFO in treating Children with tic disorders (consumption of renal yin and liver wind stirring up internally syndrome). A total of 288 patients will be recruited and randomly assigned to two groups in a 1:1 ratio. The treatment course is 6 weeks, with a 2 weeks follow-up. The primary outcome is the mean change value from baseline to 6th week by the Yale Global Tic Severity Scale total tic score (YGTSS-TTS). Secondary outcomes include total effective rate of tic, Yale Global Tic Severity Scale (YGTSS) scores and its factor scores (the degree of motor tics, phonic tics and social function damage), Clinical Global Impression-Severity scale, and TCM syndrome efficacy. Discussion: The design of this study refers to a large number of similar research design points, and asked for opinions of peer experts, and finally reached a consensus. This trial will provide high-quality evidence on the clinical equivalence between JWXFD and JWXFO and provide a basis for the marketing of JWXFD. Trial registration: ChiCTR2000032312 Registered on 25 April 2020, http://www.chictr.org.cn/showproj.aspx?proj=52630.
MeSH term(s)	Child ; Humans ; Tics/therapy ; Treatment Outcome ; Tic Disorders/diagnosis ; Tic Disorders/drug therapy ; Double-Blind Method ; Syndrome ; Nonprescription Drugs ; Randomized Controlled Trials as Topic ; Multicenter Studies as Topic
Chemical Substances	Nonprescription Drugs
Language	English
Publishing date	2022-10-22
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article
ZDB-ID	2040523-6
ISSN	1745-6215 ; 1468-6694 ; 1745-6215
ISSN (online)	1745-6215
ISSN	1468-6694 ; 1745-6215
DOI	10.1186/s13063-022-06802-y
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Article: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology. 2022 Nov. 15, v. 298

2022

Abstract: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect ...

Abstract	Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
Keywords	cold ; flavonoids ; hyperuricemia ; kidney diseases ; mechanism of action ; mice ; mitogen-activated protein kinase ; models ; pharmacology ; terpenoids ; therapeutics ; traditional medicine ; transcription factor NF-kappa B
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	NAL-Catalogue (AGRICOLA)

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Article: The Mechanisms of Improving IVF Outcomes of Liu-Wei-Di-Huang Pill Acting on DOR Patients.

Xiao, Jimei / Song, Jingyan / Sa, Yuanhong / Yuan, Lihua / Guo, Jiayin / Sun, Zhengao

Evidence-based complementary and alternative medicine : eCAM

2020 Volume 2020, Page(s) 5183017

Abstract: ... markers are still incompletely understood. Liu-Wei-Di-Huang (LWDH) pill, a traditional Chinese medicine ...

Abstract	Diminished ovarian reserve (DOR) is the weakening of ovarian oocyte production and quality. It will further become premature ovarian failure without timely cure. However, disease pathology and diagnostic markers are still incompletely understood. Liu-Wei-Di-Huang (LWDH) pill, a traditional Chinese medicine formula, is commonly used in the treatment of DOR in China. To explore the mechanism of the effect of LWDH on in vitro fertilization (IVF) outcomes in patients with DOR, a pseudotargeted metabolomics study combined with multivariate data processing strategy was carried out. A liquid chromatography tandem mass spectrometry-based metabolomics approach was applied to characterize metabolic biomarker candidates. Multiple pattern recognition was used to determine groups and confirm important variables. A total of 21 potential biomarkers were characterized, and related metabolic pathways were identified. The study displayed that the established pseudotargeted metabolomics strategy is a powerful approach for investigating the mechanism of DOR and LWDH. In addition, the approach may highlight biomarkers and metabolic pathways and can capture subtle metabolite changes from headache, which may lead to an improved mechanism understanding of DOR diseases and LWDH treatment.
Language	English
Publishing date	2020-10-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2020/5183017
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Zs.A 5995: Show issues

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Article: Jia-Wei-Si-Miao-Wan alleviates acute gouty arthritis by targeting NLRP3 inflammasome.

Yuan, X / Fan, Y S / Xu, L / Xie, G Q / Feng, X H / Qian, K

Journal of biological regulators and homeostatic agents

2019 Volume 33, Issue 1, Page(s) 63–71

Abstract: ... complications. Jia-Wei-Si-Miao-Wan is a newly developed drug for treating acute gouty arthritis ... of Jia-Wei-Si-Miao-Wan on NLRP3 inflammasome and TLR/NF-κB signaling, which are two important ... Colchicine and Jia-Wei-Si-Miao-Wan were administrated by gavage. The circumference of the knee was measured ...

Abstract	Gout is a common metabolic disease and acute gouty arthritis (AGA) is one of the important complications. Jia-Wei-Si-Miao-Wan is a newly developed drug for treating acute gouty arthritis, but the molecular mechanism has not been completely clarified. Thus, this study was aimed to explore the regulation of Jia-Wei-Si-Miao-Wan on NLRP3 inflammasome and TLR/NF-κB signaling, which are two important signaling pathways in inflammation. AGA rat model was established by injecting monosodium urate into the right knee. Colchicine and Jia-Wei-Si-Miao-Wan were administrated by gavage. The circumference of the knee was measured. IL-1β and IL-18 level in the flushing fluid was detected by enzyme linked immunosorbent assay (ELISA). Western blot, immunohistochemistry and quantitative real-time RT-PCR were used to detect the protein and mRNA expression of TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB. The results showed that IL-1β and IL-18 level in the flushing fluid was increased and TLR4, NLRP3, ASC, caspase-1, NF-κB and p-NF-κB expressions were up-regulated after the establishment of AGA rat model. Colchicine and Jia-Wei-Si-Miao-Wan administration could alleviate the inflammation in the knee by inhibiting NLRP3 inflammasome and TLR/NF-κB signaling. In vivo data showed that the therapeutic effect of Jia-Wei-Si-Miao-Wan could be comparable with colchicine but had lower hepatic and renal toxicity. In conclusion, Targeting NLRP3 inflammasome and TLR/NF-κB signaling by Jia-Wei-Si-Miao-Wan could be effective in treating AGA.
MeSH term(s)	Animals ; Arthritis, Gouty/drug therapy ; Caspase 1/metabolism ; Drugs, Chinese Herbal/pharmacology ; Inflammasomes/drug effects ; Interleukin-1beta/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Rats ; Signal Transduction ; Toll-Like Receptor 4/metabolism
Chemical Substances	Drugs, Chinese Herbal ; Inflammasomes ; Interleukin-1beta ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nlrp3 protein, rat ; Tlr4 protein, rat ; Toll-Like Receptor 4 ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2019-02-20
Publishing country	Italy
Document type	Journal Article
ZDB-ID	639196-5
ISSN	1724-6083 ; 0393-974X
ISSN (online)	1724-6083
ISSN	0393-974X
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Article: Evaluating the Cost of Failure Risk: A Case Study of the Kang-Wei-Kou Stream Diversion Project

Liang, Chung-Yuan / Wang, Yuan-Heng / You, Gene Jiing-Yun / Chen, Po-Chun / Lo, Emilie

Water. 2021 Oct. 14, v. 13, no. 20

2021

Abstract: ... the Kang-Wei-Kou (KWK) Diversion project, which collapsed due to an unexpected hydraulic jump resulting ...

Abstract	For water resource engineering projects, some potential risks that are unclear and difficult to investigate are the most crucial problem for engineers. This study presents a unique case of unknown risks, the Kang-Wei-Kou (KWK) Diversion project, which collapsed due to an unexpected hydraulic jump resulting from uneven regional rainfall. We used HEC-RAS incorporating Monte Carlo simulations for analyzing the potential risks to the original design of the KWK Diversion, concerning boundary conditions. An extreme value type I distribution was selected as the form of probability density function (PDF) to upstream discharge, whereas a normal distribution was selected as the form of PDF to downstream water depth, as boundary conditions. Applying the Monte Carlo method, the analysis revealed that the probability of failure was 7.5%, which was non-negligible and should have been considered in the design plan. This case study indicates that overlooking downstream conditions can lead a major facility to fail, and a stochastic analysis could be a way to find out potential risks. We also applied the cost–benefit analysis to review whether the design plans were appropriately estimated with careful risk based consideration.
Keywords	Monte Carlo method ; case studies ; cost benefit analysis ; normal distribution ; rain ; risk ; streams ; water
Language	English
Dates of publication	2021-1014
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2521238-2
ISSN	2073-4441
ISSN	2073-4441
DOI	10.3390/w13202881
Database	NAL-Catalogue (AGRICOLA)

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