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  1. Article: Microbiota metabolites in the female reproductive system: Focused on the short-chain fatty acids.

    Mirzaei, Rasoul / Kavyani, Batoul / Nabizadeh, Edris / Kadkhoda, Hiva / Asghari Ozma, Mahdi / Abdi, Milad

    Heliyon

    2023  Volume 9, Issue 3, Page(s) e14562

    Abstract: Several disorders have been linked to modifications in the gut microbial imbalance, intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain fatty acids (SCFAs) play a key function in the regulation of histone ... ...

    Abstract Several disorders have been linked to modifications in the gut microbial imbalance, intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain fatty acids (SCFAs) play a key function in the regulation of histone deacetylases (HDACs), which affect modulation of immunity and regulation of inflammatory responses in the intestine and other organs. Studies examining the metabolites produced by polymicrobial bacterial vaginosis (BV) states and
    Language English
    Publishing date 2023-03-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14562
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Gut Microbiota Exchange in Domestic Animals and Rural-urban People Axis.

    Nezhadi, Javad / Ahangarzadeh Rezaee, Mohammad / Asghari Ozma, Mahdi / Ganbarov, Khudaverdi / Samadi Kafil, Hossein

    Current pharmaceutical biotechnology

    2023  

    Abstract: In recent years, one of the most critical topics in microbiology that can be addressed is microbiome and microbiota. The term microbiome contains both the microbiota and structural elements, metabolites/signal molecules, and the surrounding environmental ...

    Abstract In recent years, one of the most critical topics in microbiology that can be addressed is microbiome and microbiota. The term microbiome contains both the microbiota and structural elements, metabolites/signal molecules, and the surrounding environmental conditions, and the microbiota consists of all living members forming the microbiome. Among; the intestinal microbiota is one of the most important microbiota, also called the gut microbiota. After colonization, the gut microbiota can have different functions, including resistance to pathogens, maintaining the intestinal epithelium, metabolizing dietary and pharmaceutical compounds, and controlling immune function. Recently, studies have shown that the gut microbiota can prevent the formation of fat in the body. In this study, we examined the gut microbiota in various animals, including dogs, cats, dairy cows, sheep, chickens, horses, and people who live in urban and rural areas. Based on the review of various studies, it has been determined that the population of microbiota in animals and humans is different, and various factors such as the environment, nutrition, and contact with animals can affect the microbiota of people living in urban and rural areas.
    Language English
    Publishing date 2023-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/0113892010261535230920062107
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  3. Article ; Online: Microbiota metabolites in the female reproductive system

    Rasoul Mirzaei / Batoul Kavyani / Edris Nabizadeh / Hiva Kadkhoda / Mahdi Asghari Ozma / Milad Abdi

    Heliyon, Vol 9, Iss 3, Pp e14562- (2023)

    Focused on the short-chain fatty acids

    2023  

    Abstract: Several disorders have been linked to modifications in the gut microbial imbalance, intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain fatty acids (SCFAs) play a key function in the regulation of histone ... ...

    Abstract Several disorders have been linked to modifications in the gut microbial imbalance, intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain fatty acids (SCFAs) play a key function in the regulation of histone deacetylases (HDACs), which affect modulation of immunity and regulation of inflammatory responses in the intestine and other organs. Studies examining the metabolites produced by polymicrobial bacterial vaginosis (BV) states and Lactobacillus-dominated microbiota have noted a dramatic reduction of lactic acid and a shift toward SCFA synthesis. Along with higher levels of SCFAs, acetate is typically the main metabolite in the cervicovaginal fluid of women with symptomatic bacterial vaginosis. The fact that SCFAs made by the vaginal microbiota have been shown to exhibit antibacterial and immune-modulating properties suggests that they may have promise as indicators of disease and/or disease susceptibility. In this review, we overview and summarize the current findings on the detrimental or protective roles of microbiota metabolites especially SCFAs in the health and disease of the female reproductive system.
    Keywords Microbiota metabolites ; SCFAs ; Acetate ; Propionate ; Butyrate ; HDACs ; Science (General) ; Q1-390 ; Social sciences (General) ; H1-99
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Microbiota metabolites in the female reproductive system: Focused on the short-chain fatty acids

    Mirzaei, Rasoul / Kavyani, Batoul / Nabizadeh, Edris / Kadkhoda, Hiva / Asghari Ozma, Mahdi / Abdi, Milad

    Heliyon. 2023 Mar., v. 9, no. 3 p.e14562-

    2023  

    Abstract: Several disorders have been linked to modifications in the gut microbial imbalance, intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain fatty acids (SCFAs) play a key function in the regulation of histone ... ...

    Abstract Several disorders have been linked to modifications in the gut microbial imbalance, intestinal epithelium, and host immune system. In this regard, microbiota derived short-chain fatty acids (SCFAs) play a key function in the regulation of histone deacetylases (HDACs), which affect modulation of immunity and regulation of inflammatory responses in the intestine and other organs. Studies examining the metabolites produced by polymicrobial bacterial vaginosis (BV) states and Lactobacillus-dominated microbiota have noted a dramatic reduction of lactic acid and a shift toward SCFA synthesis. Along with higher levels of SCFAs, acetate is typically the main metabolite in the cervicovaginal fluid of women with symptomatic bacterial vaginosis. The fact that SCFAs made by the vaginal microbiota have been shown to exhibit antibacterial and immune-modulating properties suggests that they may have promise as indicators of disease and/or disease susceptibility. In this review, we overview and summarize the current findings on the detrimental or protective roles of microbiota metabolites especially SCFAs in the health and disease of the female reproductive system.
    Keywords acetates ; disease susceptibility ; female reproductive system ; histone deacetylase ; immune system ; immunity ; immunomodulators ; intestinal microorganisms ; intestinal mucosa ; lactic acid ; metabolites ; Microbiota metabolites ; SCFAs ; Acetate ; Propionate ; Butyrate ; HDACs ; Bacterial vaginosis
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    Note Use and reproduction
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2023.e14562
    Database NAL-Catalogue (AGRICOLA)

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  5. Article ; Online: Interaction of the viral infectious agents in the development and exacerbation of the multiple sclerosis.

    Mahdavi, Sina / Ozma, Mahdi Asghari / Azadi, Arezou / Sadeghi, Javid / Bannazadeh Baghi, Hossein / Ahangar Oskouee, Mahin

    Le infezioni in medicina

    2023  Volume 31, Issue 4, Page(s) 476–487

    Abstract: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS). The underlying cause of MS is still unknown. Multiple risk factors have been suggested that involve a combination of genetic, environmental, and ...

    Abstract Multiple sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS). The underlying cause of MS is still unknown. Multiple risk factors have been suggested that involve a combination of genetic, environmental, and infectious factors that contribute along with a weakened immune system. There is growing evidence supporting the potential role of viral infections in the development of the disease. Viruses like human immunodeficiency virus (HIV), John Cunningham virus (JCV), Varicella-Zoster virus (VZV), human herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), and human endogenous retroviruses (HERVs) have been proposed in the pathogenesis of MS. Their pathogenetic mechanisms are not well known, but several possibilities have been discussed. The present study highlights the proposed potential molecular and genetic mechanisms underlying this viral interaction and its implications for the development of MS.
    Language English
    Publishing date 2023-12-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3104-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5576: Show issues Location:
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  6. Article ; Online: Can food matrices be considered as a potential carrier for COVID-19?

    Abbasi, Amin / Kafil, Hossein Samadi / Ozma, Mahdi Asghari / Sangtarash, Narges / Sabahi, Sahar

    Le infezioni in medicina

    2022  Volume 30, Issue 1, Page(s) 59–72

    Abstract: Humanity is currently facing a life-threatening challenge from the infectious and epidemic disease SARS-CoV-2. To date, the various modes of transmission of the virus have not been fully elucidated. In this regard, there is a possibility of transmission ... ...

    Abstract Humanity is currently facing a life-threatening challenge from the infectious and epidemic disease SARS-CoV-2. To date, the various modes of transmission of the virus have not been fully elucidated. In this regard, there is a possibility of transmission of the virus through food products. The COVID-19 pandemic disease, like those associated with SARS and MERS, is transmitted mainly through the respiratory tract and airborne aerosol particles, but the presence of fragments of the genetic virus (RNA) in the feces of numerous patients proposes that their fecal-oral pathway may be expanded. In addition, people with gastrointestinal disorders such as atrophic gastritis and metaplasia may be susceptible to COVID-19 infection. Accordingly, food may act as a potential carrier of COVID-19 due to environmental or cross-contamination. According to the available evidence, the spread and possibility of transmission of COVID-19 contamination from humans to food products are possible. Beyond that, there is some evidence that some food sources of animal origin, such as pigs and rabbits, can be contaminated by COVID-19. Therefore, the transmission of the virus through some meat products may be conceivable. Due to the rapid release rate of COVID-19 and its stability in various milieus, especially food manufacturing circumstances, it may enter the matrix during different stages of traditional or industrial food processing. Therefore, preventive measures are recommended to be utilized in the food manufacturing sector. The present study explored the risk of different food matrices, including dairy products, bread, meat and meat products, vegetables, fruits, and processed foods, as potential carriers for the transmission of COVID-19.
    Language English
    Publishing date 2022-03-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3001-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  7. Article ; Online: Antibiotic therapy for pan-drug-resistant infections.

    Ozma, Mahdi Asghari / Abbasi, Amin / Asgharzadeh, Mohammad / Pagliano, Pasquale / Guarino, Amedeo / Köse, Şükran / Samadi Kafil, Hossein

    Le infezioni in medicina

    2022  Volume 30, Issue 4, Page(s) 525–531

    Abstract: Antibiotic resistance occurs when microorganisms resist the drugs used against the infection caused by them and neutralize their effects over time using various mechanisms. These mechanisms include preventing drug absorption, changing drug targets, drug ... ...

    Abstract Antibiotic resistance occurs when microorganisms resist the drugs used against the infection caused by them and neutralize their effects over time using various mechanisms. These mechanisms include preventing drug absorption, changing drug targets, drug inactivating, and using efflux pumps, which ultimately cause drug resistance, which is named pan-drug-resistant (PDR) infection if it is resistant to all antimicrobial agents. This type of drug resistance causes many problems in society and faces the health system with difficulties; therefore their treatment is crucial and encourages doctors to develop new drugs to treat them. PDR Gram-negative bacteria, including
    Language English
    Publishing date 2022-12-01
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2041081-5
    ISSN 2532-8689 ; 1124-9390
    ISSN (online) 2532-8689
    ISSN 1124-9390
    DOI 10.53854/liim-3004-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Postbiotics as the new frontier in food and pharmaceutical research.

    Sabahi, Sahar / Homayouni Rad, Aziz / Aghebati-Maleki, Leili / Sangtarash, Narges / Ozma, Mahdi Asghari / Karimi, Atefeh / Hosseini, Hedayat / Abbasi, Amin

    Critical reviews in food science and nutrition

    2022  Volume 63, Issue 26, Page(s) 8375–8402

    Abstract: Food is the essential need of human life and has nutrients that support growth and health. Gastrointestinal tract microbiota involves valuable microorganisms that develop therapeutic effects and are characterized as probiotics. The investigations on ... ...

    Abstract Food is the essential need of human life and has nutrients that support growth and health. Gastrointestinal tract microbiota involves valuable microorganisms that develop therapeutic effects and are characterized as probiotics. The investigations on appropriate probiotic strains have led to the characterization of specific metabolic byproducts of probiotics named postbiotics. The probiotics must maintain their survival against inappropriate lethal conditions of the processing, storage, distribution, preparation, and digestion system so that they can exhibit their most health effects. Conversely, probiotic metabolites (postbiotics) have successfully overcome these unfavorable conditions and may be an appropriate alternative to probiotics. Due to their specific chemical structure, safe profile, long shelf-life, and the fact that they contain various signaling molecules, postbiotics may have anti-inflammatory, immunomodulatory, antihypertensive properties, inhibiting abnormal cell proliferation and antioxidative activities. Consequently, present scientific literature approves that postbiotics can mimic the fundamental and clinical role of probiotics, and due to their unique characteristics, they can be applied in an oral delivery system (pharmaceutical/functional foods), as a preharvest food safety hurdle, to promote the shelf-life of food products and develop novel functional foods or/and for developing health benefits, and therapeutic aims. This review addresses the latest postbiotic applications with regard to pharmaceutical formulations and commercial food-based products. Potential postbiotic applications in the promotion of host health status, prevention of disease, and complementary treatment are also reviewed.
    MeSH term(s) Humans ; Pharmaceutical Research ; Functional Food ; Nutrients ; Antihypertensive Agents ; Pharmaceutical Preparations ; Probiotics
    Chemical Substances Antihypertensive Agents ; Pharmaceutical Preparations
    Language English
    Publishing date 2022-03-29
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2022.2056727
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    Zs.A 1459: Show issues Location:
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  9. Article ; Online: A Critical Review on Akkermansia muciniphila: Functional Mechanisms, Technological Challenges, and Safety Issues.

    Abbasi, Amin / Bazzaz, Sara / Da Cruz, Adriano G / Khorshidian, Nasim / Saadat, Yalda Rahbar / Sabahi, Sahar / Ozma, Mahdi Asghari / Lahouty, Masoud / Aslani, Ramin / Mortazavian, Amir M

    Probiotics and antimicrobial proteins

    2023  

    Abstract: Due to its physiological benefits from in vitro and in vivo points of view, Akkermansia muciniphila, a common colonizer in the human gut mucous layer, has consistently been identified as an option for the next-generation probiotic. A. muciniphila is a ... ...

    Abstract Due to its physiological benefits from in vitro and in vivo points of view, Akkermansia muciniphila, a common colonizer in the human gut mucous layer, has consistently been identified as an option for the next-generation probiotic. A. muciniphila is a significant bacterium that promotes host physiology. However, it also has a great deal of potential to become a probiotic due to its physiological advantages in a variety of therapeutic circumstances. Therefore, it can be established that the abundance of A. muciniphila in the gut environment, which is controlled by many genetic and dietary variables, is related to the biological behaviors of the intestinal microbiota and gut dysbiosis/eubiosis circumstances. Before A. muciniphila is widely utilized as a next-generation probiotic, regulatory obstacles, the necessity for significant clinical trials, and the sustainability of manufacturing must be eliminated. In this review, the outcomes of recent experimental and clinical reports are comprehensively reviewed, and common colonization patterns, main factors involved in the colonization of A. muciniphila in the gut milieu, their functional mechanisms in establishing homeostasis in the metabolic and energy pathways, the promising delivery role of microencapsulation, potential genetic engineering strategies, and eventually safety issues of A. muciniphila have been discussed.
    Language English
    Publishing date 2023-07-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2487792-X
    ISSN 1867-1314 ; 1867-1306
    ISSN (online) 1867-1314
    ISSN 1867-1306
    DOI 10.1007/s12602-023-10118-x
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  10. Article ; Online: A critical review of novel antibiotic resistance prevention approaches with a focus on postbiotics.

    Ozma, Mahdi Asghari / Moaddab, Seyyed Reza / Hosseini, Hedayat / Khodadadi, Ehsaneh / Ghotaslou, Reza / Asgharzadeh, Mohammad / Abbasi, Amin / Kamounah, Fadhil S / Aghebati Maleki, Leili / Ganbarov, Khudaverdi / Samadi Kafil, Hossein

    Critical reviews in food science and nutrition

    2023  , Page(s) 1–19

    Abstract: Antibiotic resistance is a significant public health issue, causing illnesses that were once easily treatable with antibiotics to develop into dangerous infections, leading to substantial disability and even death. To help fight this growing threat, ... ...

    Abstract Antibiotic resistance is a significant public health issue, causing illnesses that were once easily treatable with antibiotics to develop into dangerous infections, leading to substantial disability and even death. To help fight this growing threat, scientists are developing new methods and techniques that play a crucial role in treating infections and preventing the inappropriate use of antibiotics. These effective therapeutic methods include phage therapies, quorum-sensing inhibitors, immunotherapeutics, predatory bacteria, antimicrobial adjuvants, haemofiltration, nanoantibiotics, microbiota transplantation, plant-derived antimicrobials, RNA therapy, vaccine development, and probiotics. As a result of the activity of probiotics in the intestine, compounds derived from the structure and metabolism of these bacteria are obtained, called postbiotics, which include multiple agents with various therapeutic applications, especially antimicrobial effects, by using different mechanisms. These compounds have been chosen in particular because they don't promote the spread of antibiotic resistance and don't include substances that can increase antibiotic resistance. This manuscript provides an overview of the novel approaches to preventing antibiotic resistance with emphasis on the various postbiotic metabolites derived from the gut beneficial microbes, their activities, recent related progressions in the food and medical fields, as well as concisely giving an insight into the new concept of postbiotics as "hyperpostbiotic".
    Language English
    Publishing date 2023-05-19
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1037504-1
    ISSN 1549-7852 ; 1040-8398
    ISSN (online) 1549-7852
    ISSN 1040-8398
    DOI 10.1080/10408398.2023.2214818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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